LOCUS       NM_001100496            2836 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus speckle type BTB/POZ protein (Spop), mRNA.
ACCESSION   NM_001100496 XM_001072862 XM_001081261 XM_001081265 XM_001081267
            XM_006247182 XM_213437
VERSION     NM_001100496.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2836)
  AUTHORS   He,W., Zhang,J., Liu,B., Liu,X., Liu,G., Xie,L., He,J., Wei,M.,
            Li,K., Ma,J., Dong,R., Ma,D., Dong,K. and Ye,M.
  TITLE     S119N Mutation of the E3 Ubiquitin Ligase SPOP Suppresses SLC7A1
            Degradation to Regulate Hepatoblastoma Progression
  JOURNAL   Mol Ther Oncolytics 19, 149-162 (2020)
   PUBMED   33209975
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2836)
  AUTHORS   Gong,H., Liu,F., Liu,X., Min,S., Wu,N., Liu,X., Liu,Y., Han,S.,
            Zhang,Y., Zhang,Y., Hu,Y., Liu,X. and Wang,X.
  TITLE     APPBP2 enhances non-small cell lung cancer proliferation and
            invasiveness through regulating PPM1D and SPOP
  JOURNAL   EBioMedicine 44, 138-149 (2019)
   PUBMED   31105033
  REMARK    Erratum:[EBioMedicine. 2019 Jun 17;:. PMID: 31221585]
REFERENCE   3  (bases 1 to 2836)
  AUTHORS   Yao,S., Chen,X., Chen,J., Guan,Y., Liu,Y., Chen,J. and Lv,X.
  TITLE     Speckle-type POZ protein functions as a tumor suppressor in
            non-small cell lung cancer due to DNA methylation
  JOURNAL   Cancer Cell Int 18, 213 (2018)
   PUBMED   30607139
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2836)
  AUTHORS   Li,J.J., Zhang,J.F., Yao,S.M., Huang,H., Zhang,S., Zhao,M. and
            Huang,J.A.
  TITLE     Decreased expression of speckle-type POZ protein for the prediction
            of poor prognosis in patients with non-small cell lung cancer
  JOURNAL   Oncol Lett 14 (3), 2743-2748 (2017)
   PUBMED   28927035
REFERENCE   5  (bases 1 to 2836)
  AUTHORS   Zhi,X., Tao,J., Zhang,L., Tao,R., Ma,L. and Qin,J.
  TITLE     Silencing speckle-type POZ protein by promoter hypermethylation
            decreases cell apoptosis through upregulating Hedgehog signaling
            pathway in colorectal cancer
  JOURNAL   Cell Death Dis 7 (12), e2569 (2016)
   PUBMED   28032859
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2836)
  AUTHORS   Reece,S.T., Loddenkemper,C., Askew,D.J., Zedler,U.,
            Schommer-Leitner,S., Stein,M., Mir,F.A., Dorhoi,A.,
            Mollenkopf,H.J., Silverman,G.A. and Kaufmann,S.H.
  TITLE     Serine protease activity contributes to control of Mycobacterium
            tuberculosis in hypoxic lung granulomas in mice
  JOURNAL   J Clin Invest 120 (9), 3365-3376 (2010)
   PUBMED   20679732
REFERENCE   7  (bases 1 to 2836)
  AUTHORS   Chen,M.H., Wilson,C.W., Li,Y.J., Law,K.K., Lu,C.S., Gacayan,R.,
            Zhang,X., Hui,C.C. and Chuang,P.T.
  TITLE     Cilium-independent regulation of Gli protein function by Sufu in
            Hedgehog signaling is evolutionarily conserved
  JOURNAL   Genes Dev 23 (16), 1910-1928 (2009)
   PUBMED   19684112
REFERENCE   8  (bases 1 to 2836)
  AUTHORS   Liu,A., Desai,B.M. and Stoffers,D.A.
  TITLE     Identification of PCIF1, a POZ domain protein that inhibits PDX-1
            (MODY4) transcriptional activity
  JOURNAL   Mol Cell Biol 24 (10), 4372-4383 (2004)
   PUBMED   15121856
REFERENCE   9  (bases 1 to 2836)
  AUTHORS   Furukawa,M., He,Y.J., Borchers,C. and Xiong,Y.
  TITLE     Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin
            ligases
  JOURNAL   Nat Cell Biol 5 (11), 1001-1007 (2003)
   PUBMED   14528312
REFERENCE   10 (bases 1 to 2836)
  AUTHORS   Zapata,J.M., Pawlowski,K., Haas,E., Ware,C.F., Godzik,A. and
            Reed,J.C.
  TITLE     A diverse family of proteins containing tumor necrosis factor
            receptor-associated factor domains
  JOURNAL   J Biol Chem 276 (26), 24242-24252 (2001)
   PUBMED   11279055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Dec 5, 2020 this sequence version replaced
            XM_006247182.3, NM_001100496.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.45076.1,
                                           SRR26643289.29170.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                JAXUCZ010000010.1  80854936-80854978
            44-116              JAXUCZ010000010.1  80855131-80855203
            117-260             JAXUCZ010000010.1  80913708-80913851
            261-382             JAXUCZ010000010.1  80914379-80914500
            383-534             JAXUCZ010000010.1  80917414-80917565
            535-662             JAXUCZ010000010.1  80917662-80917789
            663-840             JAXUCZ010000010.1  80924711-80924888
            841-896             JAXUCZ010000010.1  80928079-80928134
            897-1019            JAXUCZ010000010.1  80928657-80928779
            1020-1162           JAXUCZ010000010.1  80932735-80932877
            1163-2836           JAXUCZ010000010.1  80934108-80935781
FEATURES             Location/Qualifiers
     source          1..2836
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..2836
                     /gene="Spop"
                     /note="speckle type BTB/POZ protein"
                     /db_xref="GeneID:287643"
                     /db_xref="RGD:1311613"
     exon            1..43
                     /gene="Spop"
                     /inference="alignment:Splign:2.1.0"
     exon            44..116
                     /gene="Spop"
                     /inference="alignment:Splign:2.1.0"
     exon            117..260
                     /gene="Spop"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1307
                     /gene="Spop"
                     /codon_start=1
                     /product="speckle-type POZ protein"
                     /protein_id="NP_001093966.1"
                     /db_xref="GeneID:287643"
                     /db_xref="RGD:1311613"
                     /translation="MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFC
                     REEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKF
                     KFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCE
                     VSVVQDSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAIL
                     AARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAA
                     ADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLE
                     TSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS"
     exon            261..382
                     /gene="Spop"
                     /inference="alignment:Splign:2.1.0"
     exon            383..534
                     /gene="Spop"
                     /inference="alignment:Splign:2.1.0"
     exon            535..662
                     /gene="Spop"
                     /inference="alignment:Splign:2.1.0"
     exon            663..840
                     /gene="Spop"
                     /inference="alignment:Splign:2.1.0"
     exon            841..896
                     /gene="Spop"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1019
                     /gene="Spop"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1162
                     /gene="Spop"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..2836
                     /gene="Spop"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgctcgctg cgtcgacgtg ctgacgacag gacgcccagg ccggtcccgg atgttgcggg
       61 cagtatgagg cgagcgcagg gggacaggga ccagcagctg tcgccgccgt tctcagggtg
      121 aagaaagacc agaaatcttt gccccctgac tttggagacc cagtttaacc ttcaaactgg
      181 cgatgtcaag ggttccaagt cctccacctc cggcagaaat gtcgagtggt cctgttgctg
      241 agagctggtg ctatacacag atcaaggtag tgaagttctc ctacatgtgg accatcaata
      301 actttagttt ttgccgggag gaaatgggtg aagtcataaa aagttcaact ttttcatcag
      361 gagccaatga taagctgaaa tggtgtttgc gagtaaaccc gaaggggctg gatgaggaaa
      421 gcaaagatta cctgtcgctc tacctgttgt tggtcagctg tccaaagagt gaggttcggg
      481 ccaagttcaa gttctccatc ctgaatgcca agggagaaga aaccaaagct atggagagcc
      541 agcgagctta taggttcgtg caaggcaaag actggggatt caaaaaattc atccgtagag
      601 attttctctt ggacgaggcc aatggacttc tccctgatga caagctcacc ctcttctgcg
      661 aggtgagtgt agtccaagac tctgtcaata tctctgggca gaacactatg aacatggtaa
      721 aggtccctga atgccggttg gctgacgagt taggagggct gtgggagaac tctcgattca
      781 cagactgctg cttgtgtgtg gctggccaag aattccaggc tcacaaggct atcttagcag
      841 ctcggtctcc agttttcagt gccatgtttg aacatgaaat ggaggagagc aaaaagaatc
      901 gggttgaaat taacgatgta gaacctgaag tttttaagga aatgatgtgc ttcatctaca
      961 cggggaaggc accaaacctt gacaaaatgg ctgatgattt gctggcagct gctgacaagt
     1021 acgccctgga gcgtttgaag gtcatgtgcg aggatgccct ctgcagtaac ctctctgtgg
     1081 agaacgctgc agagattctc atcctggctg acctccacag cgcagatcag ctgaaaaccc
     1141 aggcagtgga tttcatcaac tatcatgctt cggatgtctt ggagacctct gggtggaagt
     1201 caatggtggt gtcacatccc cacttagtgg cagaagcgta ccgctctctg gcttccgcac
     1261 aatgcccttt cctggggccc ccgcgcaaac gcctgaagca atcctaagat cctgcctgtt
     1321 gggagactcc attcattttc cagcagcagc agccaccgtt gctgccactg actgccaggt
     1381 agaccgcgcg gtctgtgcgg cttttactct gtgtcggggg agatggcacc atggccaccc
     1441 agactttaac agcactaaat aacttagggg agctggggga gggaagggcc caggactcgg
     1501 gccactcagc ctaatgaaac cctgttgctc tgtcaccgtg tgccctttgg cctgaccaag
     1561 tttgacactg ggattcagtt taggcgccag cctcaagcac atcccagcag tggtacttcg
     1621 gagaaatcag catctgactg agcagaacaa atcgtcaggt gcctggagca aaaaggaaaa
     1681 aaaaagcaga aacaagtgga catttagttt taagagatgg aaaaaggaaa gaagaaagat
     1741 tttttttcga aaatcagttt gtggattcca gtagtattta tgttgaaaga agcaaatttt
     1801 agttcaactg tggatatttg tgaaaactcc tcaccaccac ccaagtgtca gaagagctct
     1861 ctcgctagca cttactgttt gcaagaagcc atcctttatc ctctgaaagg tggcccatgg
     1921 cggcagaagg gaggaagtca tctgatctgg aaagcgagtg tttgacagta gtggcttctg
     1981 cagaaattct tactggtatt aaaaactgga aaaaataatt catccagaat tcatactgtc
     2041 ttgataaaaa ctatgattct gttttttaga tatcgtggaa aatggatttt tttggcattt
     2101 ttctctgatt ttatgttttc ttcccttccc tttttctgag agagagggag agagagagga
     2161 gagagagaga gagagagaga gagagagaaa gagaaagaga ggagaaacaa atacagaaaa
     2221 tacataaaac gaaaagaaga gaaaaggaaa ttttattatt attgctatgt gaaaaaaaat
     2281 cccagcccag atggcctggc tgtttgtacc tgactcgtcg cctgcatagg agccggtcct
     2341 gtcacttctg attagcccct cttccaaagg ggagacttca aatgttaact ttttcttttt
     2401 gaaaatataa ataattacta ttttgtactg tgtggtatct ctggtctttt gtttcattca
     2461 cttggcttgc ctcttgggtc tcagtttctt gcttgtgaga tttcgaagcc ctggtttgag
     2521 cttcgtcttg cagggattat gttcagaatg tctaagaagc agtagggagt tatttactct
     2581 ccatagtctc aagttttctt tgtgagctca gcatctgcca gtcttttgtc ctccttgagg
     2641 ttctgccaac catgtcctgg tgagagtctg ggaccaggtc ccactccacc aaggcaaaca
     2701 attgtagtgg gcttcttctg caccctgtgt gtgttaatac ctgatcccaa atctcctttc
     2761 tcctaacaaa ataaaaagaa atatttaggg gtcatgaaca tggagattaa ataaagggaa
     2821 attgttgtgt cttctg
//
