LOCUS       NM_138533               1773 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Rattus norvegicus spondin 2 (Spon2), mRNA.
ACCESSION   NM_138533 XM_346466
VERSION     NM_138533.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1773)
  AUTHORS   Zhu,L.H., Huang,L., Zhang,X., Zhang,P., Zhang,S.M., Guan,H.,
            Zhang,Y., Zhu,X.Y., Tian,S., Deng,K. and Li,H.
  TITLE     Mindin regulates vascular smooth muscle cell phenotype and prevents
            neointima formation
  JOURNAL   Clin Sci (Lond) 129 (2), 129-145 (2015)
   PUBMED   25751394
  REMARK    GeneRIF: Mindin protects against vascular hyperplasia by
            suppression of abnormal VSMC proliferation, migration and
            phenotypic switching in an AKT-dependent manner.
REFERENCE   2  (bases 1 to 1773)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 1773)
  AUTHORS   Cheng,Y.C., Chen,T.A., Chen,C.Y., Liang,C.M. and Liang,S.M.
  TITLE     3'poly-G-tailed ODNs inhibit F-spondin to induce cell death and
            neurite retraction in rat embryonic neurons
  JOURNAL   Mol Neurobiol 45 (3), 536-549 (2012)
   PUBMED   22592270
  REMARK    GeneRIF: 3'G-oligodeoxyribonucleotides enhance nucleus YB-1 to
            inhibit F-spondin leading to cell death and neurite retraction of
            embryonic neuron cells.
REFERENCE   4  (bases 1 to 1773)
  AUTHORS   Liao,C.H., Yeh,S.C., Huang,Y.H., Chen,R.N., Tsai,M.M., Chen,W.J.,
            Chi,H.C., Tai,P.J., Liao,C.J., Wu,S.M., Cheng,W.L., Pai,L.M. and
            Lin,K.H.
  TITLE     Positive regulation of spondin 2 by thyroid hormone is associated
            with cell migration and invasion
  JOURNAL   Endocr Relat Cancer 17 (1), 99-111 (2010)
   PUBMED   19903741
  REMARK    GeneRIF: Spon2 protein was 9.2-fold & mRNA 16.5-fold higher in the
            T3-treated thyroidectomized (Tx)rats compared with the Tx group.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1773)
  AUTHORS   Fevre-Montange,M., Champier,J., Durand,A., Wierinckx,A.,
            Honnorat,J., Guyotat,J. and Jouvet,A.
  TITLE     Microarray gene expression profiling in meningiomas: differential
            expression according to grade or histopathological subtype
  JOURNAL   Int J Oncol 35 (6), 1395-1407 (2009)
   PUBMED   19885562
REFERENCE   6  (bases 1 to 1773)
  AUTHORS   Attur,M.G., Palmer,G.D., Al-Mussawir,H.E., Dave,M., Teixeira,C.C.,
            Rifkin,D.B., Appleton,C.T., Beier,F. and Abramson,S.B.
  TITLE     F-spondin, a neuroregulatory protein, is up-regulated in
            osteoarthritis and regulates cartilage metabolism via TGF-beta
            activation
  JOURNAL   FASEB J 23 (1), 79-89 (2009)
   PUBMED   18780763
  REMARK    GeneRIF: These studies identify F-spondin as a novel protein in
            osteoarthritis cartilage, where it may act in situ at lesional
            areas to activate latent TGF-beta and induce cartilage degradation.
            Erratum:[FASEB J. 2009 Aug;23(8):2790]
REFERENCE   7  (bases 1 to 1773)
  AUTHORS   Paakkonen,K., Tossavainen,H., Permi,P., Rakkolainen,H., Rauvala,H.,
            Raulo,E., Kilpelainen,I. and Guntert,P.
  TITLE     Solution structures of the first and fourth TSR domains of
            F-spondin
  JOURNAL   Proteins 64 (3), 665-672 (2006)
   PUBMED   16736493
  REMARK    GeneRIF: NMR solution structures of TSR domains of F-spondin showed
            that they have an unusual fold that is characterized by a long,
            nonglobular shape, consisting of two beta-strands and one irregular
            extended strand.
REFERENCE   8  (bases 1 to 1773)
  AUTHORS   Schubert,D., Klar,A., Park,M., Dargusch,R. and Fischer,W.H.
  TITLE     F-spondin promotes nerve precursor differentiation
  JOURNAL   J Neurochem 96 (2), 444-453 (2006)
   PUBMED   16300627
  REMARK    GeneRIF: F-spondin can alter cell differentiation in multiple ways,
            depending upon its concentration and distribution between
            substrate-attached and soluble forms.
REFERENCE   9  (bases 1 to 1773)
  AUTHORS   He,Y.W., Li,H., Zhang,J., Hsu,C.L., Lin,E., Zhang,N., Guo,J.,
            Forbush,K.A. and Bevan,M.J.
  TITLE     The extracellular matrix protein mindin is a pattern-recognition
            molecule for microbial pathogens
  JOURNAL   Nat Immunol 5 (1), 88-97 (2004)
   PUBMED   14691481
REFERENCE   10 (bases 1 to 1773)
  AUTHORS   Feinstein,Y., Borrell,V., Garcia,C., Burstyn-Cohen,T., Tzarfaty,V.,
            Frumkin,A., Nose,A., Okamoto,H., Higashijima,S., Soriano,E. and
            Klar,A.
  TITLE     F-spondin and mindin: two structurally and functionally related
            genes expressed in the hippocampus that promote outgrowth of
            embryonic hippocampal neurons
  JOURNAL   Development 126 (16), 3637-3648 (1999)
   PUBMED   10409509
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078734.1.
            
            On Jun 10, 2007 this sequence version replaced NM_138533.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078734.1, SRR8487231.139517.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1773
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1773
                     /gene="Spon2"
                     /note="spondin 2"
                     /db_xref="GeneID:171569"
                     /db_xref="RGD:708584"
     exon            1..199
                     /gene="Spon2"
                     /inference="alignment:Splign:2.1.0"
     exon            200..419
                     /gene="Spon2"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1195
                     /gene="Spon2"
                     /note="F-spondin; mindin; spondin 2, extracellular matrix
                     protein; spondin-2-like"
                     /codon_start=1
                     /product="spondin-2 precursor"
                     /protein_id="NP_612542.1"
                     /db_xref="GeneID:171569"
                     /db_xref="RGD:708584"
                     /translation="MENVSFSLDRTLWVFLLAMLGSTAGQPLGGESVCTARPLARYSI
                     TFTGKWSQTAFPKQYPLFRPPAQWSSLLGAAHSSDYSMWRKNEYVSNGLRDFAERGEA
                     WALMKEIEAAGEKLQSVHAVFSAPAVPSGTGQTSAELEVHPRHSLVSFVVRIVPSPDW
                     FVGIDSLDLCEGGRWKEQVVLDLYPHDAGTDSGFTFSSPNFATIPQDTVTEITASSPS
                     HPANSFYYPRLKSLPPIAKVTFVRLRQSPRAFAPPSLDLASRGNEIVDSLSVPETPLD
                     CEVSLWSSWGLCGGPCGKLGAKSRTRYVRVQPANNGTPCPELEEEAECAPDNCV"
     exon            420..643
                     /gene="Spon2"
                     /inference="alignment:Splign:2.1.0"
     exon            644..835
                     /gene="Spon2"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1010
                     /gene="Spon2"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1743
                     /gene="Spon2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctgccac agaaaagctt cttgcttcct ggtctcaagc cccttctttc tgggaccagg
       61 cactgaggca gcagacagga agagctgggg cccgtctgct ggccagaggc actaatcttg
      121 ggcataaaca ggatctccaa gctctgggac cagtcctgca gctgacagcc cagcagcctg
      181 cccctgacgc tcttgctagg tgatggaaaa cgtgagtttt tccctggaca gaactctttg
      241 ggtcttcctc ctggccatgc taggctccac cgcaggccag ccgctggggg gagaatctgt
      301 ctgcacagcc cggcctctgg ctagatacag catcactttc actggcaagt ggagccagac
      361 agcatttccc aagcagtatc ctctgttccg gccccctgca cagtggtcct ctctgctggg
      421 ggcagcacac agctctgact acagcatgtg gcggaagaat gagtacgtca gcaatgggct
      481 gagggacttc gctgagcgtg gtgaggcctg ggcactgatg aaagagatcg aagcagcagg
      541 agagaagctc cagagtgtgc acgcggtatt ctcggctccc gccgtgccta gtggtaccgg
      601 gcagacttct gcagagttag aggtgcaccc taggcactcg ctggtgtcct tcgtggtacg
      661 cattgtcccc agtccggact ggtttgtggg catcgacagt ctggacctgt gcgagggagg
      721 ccgctggaag gagcaggtgg tccttgatct ttacccacac gatgcaggga cagacagtgg
      781 cttcaccttc tcctccccca actttgcaac catcccacaa gacacagtga ctgagataac
      841 cgcctcatcg cccagtcacc cagccaactc attctactac ccacgcctca agtccttgcc
      901 acccattgcc aaagtgacct tcgtgcggct acggcagagt cccagagcct ttgccccacc
      961 ttccctggac ctggccagca gaggaaatga aatcgttgac agcctctcag ttccagagac
     1021 accgctggac tgtgaagttt ccctgtggtc atcctgggga ctgtgcggag ggccatgtgg
     1081 aaagttggga gccaagagca gaactcgcta tgtgcgtgtt cagcctgcta acaatgggac
     1141 tccctgtccc gagcttgaag aagaggctga gtgtgcccca gataactgtg tctaaaccca
     1201 gaccccagta gccagccctt aggatccctc gagccttgga ctctgatctg ggccacaaag
     1261 tgttttcagg aggcccgtgt aggcagggat gagagcatgg gcaattttgc accatttccc
     1321 accattcctg ggttgacaga tggtcttgat acagaggccc tcagtgacag gtaagacaca
     1381 gactgcctct cccactgtgt gattcctgag gatcatgggt ttgatctaca taaattcctt
     1441 tgtaatttat tactgtggtg ggagggaggc tgcctttgat acagagagaa ggcattccag
     1501 gaacaggtga gaggatgccc taagcctgtg agccccacaa ccacactgct gtcagatacc
     1561 tcagacctgc tgccactgca cttgctcctg gaggccaaga agtcaacctt cacaccactc
     1621 ttgagctcac cctggggtga ccacaggagg ggcaaatgaa gaggggcagt tttggaaact
     1681 tggagctttt gtgtcactga tccctttgca ttcaaataaa ggttatgttc ccgaaaaatg
     1741 tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
