LOCUS       NM_172067               4030 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus spondin 1 (Spon1), mRNA.
ACCESSION   NM_172067 XM_346550
VERSION     NM_172067.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4030)
  AUTHORS   Didangelos,A., Yin,X., Mandal,K., Baumert,M., Jahangiri,M. and
            Mayr,M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   2  (bases 1 to 4030)
  AUTHORS   Clemitson,J.R., Dixon,R.J., Haines,S., Bingham,A.J., Patel,B.R.,
            Hall,L., Lo,M., Sassard,J., Charchar,F.J. and Samani,N.J.
  TITLE     Genetic dissection of a blood pressure quantitative trait locus on
            rat chromosome 1 and gene expression analysis identifies SPON1 as a
            novel candidate hypertension gene
  JOURNAL   Circ Res 100 (7), 992-999 (2007)
   PUBMED   17332427
  REMARK    GeneRIF: These findings justify further investigation of this novel
            positional candidate gene in BP control in hypertensive rat models
            and humans.
REFERENCE   3  (bases 1 to 4030)
  AUTHORS   Hoe,H.S., Wessner,D., Beffert,U., Becker,A.G., Matsuoka,Y. and
            Rebeck,G.W.
  TITLE     F-spondin interaction with the apolipoprotein E receptor ApoEr2
            affects processing of amyloid precursor protein
  JOURNAL   Mol Cell Biol 25 (21), 9259-9268 (2005)
   PUBMED   16227578
REFERENCE   4  (bases 1 to 4030)
  AUTHORS   Ho,A. and Sudhof,T.C.
  TITLE     Binding of F-spondin to amyloid-beta precursor protein: a candidate
            amyloid-beta precursor protein ligand that modulates amyloid-beta
            precursor protein cleavage
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2548-2553 (2004)
   PUBMED   14983046
  REMARK    GeneRIF: F-spondin may be an endogenous regulator of APP cleavage.
REFERENCE   5  (bases 1 to 4030)
  AUTHORS   Feinstein,Y., Borrell,V., Garcia,C., Burstyn-Cohen,T., Tzarfaty,V.,
            Frumkin,A., Nose,A., Okamoto,H., Higashijima,S., Soriano,E. and
            Klar,A.
  TITLE     F-spondin and mindin: two structurally and functionally related
            genes expressed in the hippocampus that promote outgrowth of
            embryonic hippocampal neurons
  JOURNAL   Development 126 (16), 3637-3648 (1999)
   PUBMED   10409509
REFERENCE   6  (bases 1 to 4030)
  AUTHORS   Klar,A., Baldassare,M. and Jessell,T.M.
  TITLE     F-spondin: a gene expressed at high levels in the floor plate
            encodes a secreted protein that promotes neural cell adhesion and
            neurite extension
  JOURNAL   Cell 69 (1), 95-110 (1992)
   PUBMED   1555244
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_172067.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M88469.1, BC107655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-463               JAXUCZ010000001.1  177363526-177363988
            464-570             JAXUCZ010000001.1  177385392-177385498
            571-704             JAXUCZ010000001.1  177442386-177442519
            705-778             JAXUCZ010000001.1  177487410-177487483
            779-901             JAXUCZ010000001.1  177494891-177495013
            902-1050            JAXUCZ010000001.1  177533250-177533398
            1051-1115           JAXUCZ010000001.1  177639335-177639399
            1116-1317           JAXUCZ010000001.1  177651780-177651981
            1318-1458           JAXUCZ010000001.1  177653554-177653694
            1459-1534           JAXUCZ010000001.1  177654229-177654304
            1535-1717           JAXUCZ010000001.1  177655236-177655418
            1718-1888           JAXUCZ010000001.1  177655633-177655803
            1889-2056           JAXUCZ010000001.1  177655910-177656077
            2057-2221           JAXUCZ010000001.1  177656875-177657039
            2222-2485           JAXUCZ010000001.1  177658777-177659040
            2486-4030           JAXUCZ010000001.1  177661145-177662689
FEATURES             Location/Qualifiers
     source          1..4030
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..4030
                     /gene="Spon1"
                     /gene_synonym="Sponf"
                     /note="spondin 1"
                     /db_xref="GeneID:64456"
                     /db_xref="RGD:619918"
     exon            1..463
                     /gene="Spon1"
                     /gene_synonym="Sponf"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..2649
                     /gene="Spon1"
                     /gene_synonym="Sponf"
                     /note="f-spondin; spondin 1, (f-spondin) extracellular
                     matrix protein; spondin 1, extracellular matrix protein"
                     /codon_start=1
                     /product="spondin-1 precursor"
                     /protein_id="NP_742064.2"
                     /db_xref="GeneID:64456"
                     /db_xref="RGD:619918"
                     /translation="MRLSPAPLRLSRGPALLALALPLAAALAFSDETLDKVAKSEGYC
                     SRILRAQGTRREGYTEFSLRVEGDPDFYKPGSSYRVTLSAAPPSYFRGFTLIALKENR
                     EGDKEEDHAGTFQIIDEEETQFMSNCPVAVTESTPRRRTRIQVFWIAPPTGTGCVILK
                     ASIVQKRIIYFQDEGSLTKKLCEQDPTLDGVTDRPILDCCACGTAKYRLTFYGNWSEK
                     THPKDYPRRANHWSAIIGGSHSKNYVLWEYGGYASEGVKQVAELGSPVKMEEEIRQQS
                     DEVLTVIKAKAQWPAWQPVNVRAAPSAEFSVDRTRHLMSFLTMMGPSPDWNVGLSAED
                     LCTKECGWVQKVVQDLIPWDAGTDSGVTYESPNKPTIPQEKIRPLTSLDHPQSPFYDP
                     EGGSITQVARVVIERIARKGEQCNIVPDNVDDIVADLAPEEKDEDDTPETCIYSNWSP
                     WSACSSSTCEKGKRMRQRMLKAQLDLSVPCPDTQDFQPCMGPGCSDEDGSTCTMSEWI
                     TWSPCSVSCGMGMRSRERYVKQFPEDGSVCMLPTEETEKCTVNEECSPSSCLVTEWGE
                     WDDCSATCGMGMKKRHRMVKMSPADGSMCKAETSQAEKCMMPECHTIPCLLSPWSEWS
                     DCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQAEKCMLPECPIDCELSEWSQWSECNK
                     SCGKGHMIRTRTIQMEPQFGGAPCPETVQRKKCRARKCLRSPSIQKLRWREARESRRS
                     EQLREESDGEQFPGCRMRPWTAWSECTKLCGGGIQERYMTVKKRFKSSQFTSCKDKKE
                     IRACNVHPC"
     exon            464..570
                     /gene="Spon1"
                     /gene_synonym="Sponf"
                     /inference="alignment:Splign:2.1.0"
     exon            571..704
                     /gene="Spon1"
                     /gene_synonym="Sponf"
                     /inference="alignment:Splign:2.1.0"
     exon            705..778
                     /gene="Spon1"
                     /gene_synonym="Sponf"
                     /inference="alignment:Splign:2.1.0"
     exon            779..901
                     /gene="Spon1"
                     /gene_synonym="Sponf"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1050
                     /gene="Spon1"
                     /gene_synonym="Sponf"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1115
                     /gene="Spon1"
                     /gene_synonym="Sponf"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1317
                     /gene="Spon1"
                     /gene_synonym="Sponf"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1458
                     /gene="Spon1"
                     /gene_synonym="Sponf"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1534
                     /gene="Spon1"
                     /gene_synonym="Sponf"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1717
                     /gene="Spon1"
                     /gene_synonym="Sponf"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1888
                     /gene="Spon1"
                     /gene_synonym="Sponf"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2056
                     /gene="Spon1"
                     /gene_synonym="Sponf"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2221
                     /gene="Spon1"
                     /gene_synonym="Sponf"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2485
                     /gene="Spon1"
                     /gene_synonym="Sponf"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..4030
                     /gene="Spon1"
                     /gene_synonym="Sponf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctccctct tcgcgctcct tcgccaccgc ccgcccctca gctccgctgc tcggctccgc
       61 tcagagcagc gcagctccgc agccaaagcg aggcgggctc gggctcccca ccgccagtgc
      121 cacccgggct cctccagctt tcgcctctgc agctcccgtc acttggagta aaagtgtcct
      181 gacaggggtc tgcaacatca gcataaagtt gggaggtcct cgagaatgag gctatctccc
      241 gcgcccctga ggcttagccg gggtccggcg ctgctggccc tggcgctgcc cctggccgca
      301 gcgctcgctt tctcggatga gaccctggac aaagtggcca agtcggaggg ctactgcagc
      361 cgcatcttgc gcgcccaggg cacacggcgt gagggataca cagagttcag cctccgcgtg
      421 gaaggcgacc ctgacttcta taagccagga agcagctacc gagtgacact ctcggctgcc
      481 cctccctcct acttcagagg cttcacgtta attgctctca aagagaaccg cgaaggcgat
      541 aaggaagaag accacgcggg caccttccag atcatagatg aagaagaaac ccagtttatg
      601 agtaactgtc ctgtggcagt cactgaaagc acccctcgga ggaggacacg gatccaggtg
      661 ttttggatag cgccacccac agggacaggc tgtgtgattc tgaaggccag cattgtacag
      721 aaacgcatta tctattttca agacgagggc tccctgacca agaagctgtg tgaacaggat
      781 cccacacttg atggagtgac ggacagaccg atcttagact gctgcgcctg cggaactgcc
      841 aagtacagac tcacgtttta tgggaactgg tcggagaaga ctcatccaaa ggattaccct
      901 cgtcgggcta atcactggtc tgccatcatt ggcggatccc actccaagaa ctacgtgctg
      961 tgggagtacg gagggtatgc cagtgaaggg gtcaagcaag ttgctgaact tggctcacca
     1021 gtaaaaatgg aggaagaaat tcgacaacag agtgatgaag tcctcactgt catcaaagcc
     1081 aaagcccagt ggccagcctg gcagcctgtc aatgtgagag cagcaccctc agccgaattc
     1141 tcagtggaca ggacacgcca cttgatgtcc ttcctaacca tgatgggccc cagtcctgac
     1201 tggaacgtgg gcctatctgc agaggatctg tgcaccaagg agtgtggctg ggtccagaaa
     1261 gtggtgcagg acctaattcc ctgggatgct ggcacggaca gcggggtgac ctacgagtca
     1321 ccaaacaagc ccacaattcc tcaggaaaaa atccgacccc tgactagtct ggaccatcct
     1381 cagagtcctt tctatgaccc ggaaggtggg tccatcacac aagtggccag agtcgtcatc
     1441 gagagaattg cccggaaggg agaacaatgc aacattgtac ctgacaatgt ggatgatatt
     1501 gtagccgacc tggctccaga agagaaagat gaagatgaca cccctgaaac ctgcatctac
     1561 tccaactggt ccccatggtc ggcctgcagc tcttccactt gtgaaaaggg taagaggatg
     1621 cggcaacgca tgctgaaggc acagctggac ctcagtgtcc cctgtcctga cacccaggac
     1681 ttccagccct gcatgggccc cggctgcagc gatgaagatg gctccacctg taccatgtcg
     1741 gagtggatca cctggtcacc ctgcagtgtc tcgtgtggca tgggtatgag gtcccgggag
     1801 aggtacgtga agcagttccc ggaagacggc tcggtgtgca tgctgcccac ggaagagaca
     1861 gagaagtgca cggtcaacga ggagtgctct cctagcagct gcctggtgac tgagtggggt
     1921 gagtgggatg actgcagcgc cacctgtgga atgggcatga agaagcggca ccgcatggtc
     1981 aagatgagcc ccgcggacgg ctccatgtgc aaggcggaga cttcgcaggc ggagaaatgc
     2041 atgatgcctg agtgccatac catcccgtgc ttgctgtctc cttggtccga gtggagcgac
     2101 tgtagcgtga cctgtgggaa gggcatgcgg acgcgccagc ggatgctcaa gtctctggca
     2161 gagctggggg actgtaatga ggatctggag caggcggaga agtgtatgct gccagagtgc
     2221 cccattgact gcgaactcag cgagtggtcc cagtggtctg aatgtaacaa gtcctgtggg
     2281 aaaggtcaca tgattcgaac ccggacaatc caaatggaac ctcagtttgg aggtgcaccc
     2341 tgcccagaga ctgtgcaacg caagaagtgc cgtgcccgga aatgccttcg cagcccatcg
     2401 atccagaagc tgcgctggag ggaggcccga gagagcagga ggagtgagca gctgagggaa
     2461 gagtcagatg gagagcagtt cccaggctgt cggatgcgcc cgtggacagc ctggtcagag
     2521 tgcaccaaac tgtgcggagg tgggatccaa gaacgctaca tgactgtgaa gaagaggttc
     2581 aaaagctccc agtttaccag ctgcaaagac aagaaggaga tcagagcgtg caacgtgcac
     2641 ccttgttagt aggggttcaa ctccccaggg ctgcattcca gattctagtc accaatggtt
     2701 gggtggtgta tttgcttgtt taagatgatt taaattgtgt ccactagttt tcatttttac
     2761 ggtgtggttt gcccaatagt cttatggagg ccgagggaca tcttgtctga atacttcttg
     2821 gtgagtacag gccaagcggg gcatcttgtc cccaggcgcc atcttcctgc actgagttga
     2881 gtagtgttgg ttcaccttgt actaaactga atcgtgtccc tctggagcat ccccctggtc
     2941 aagcagggtg gagactttgg ccatccacaa ggagaagcaa ccaggatgca gcatgcggga
     3001 gacacagcca ttaattgcaa aggacagatc ctcctctctc acctttggcc tgctcactct
     3061 tacagaaacc tgtttgtccg cctccttttt tatttagcac aactccaggc atcttggtaa
     3121 gtctccaggg tcatgggttc ttcggtgccc tgaaggagaa gccctgaggt gaggtggcat
     3181 ttgttacaaa cctcccaata ctgctttact ggcatcacaa ggtcagcagg tgatgatggc
     3241 tacttcattt cattgtgagc cgtgatttcc gttgagtttt gattgttggt gccataaatg
     3301 tcctaggatg ctggacggac acatcagcct tgtcagcaga tccttctttg agccaatgta
     3361 gacagtaagc tgggcactgg ttccaaagcc aacttaaaat cttcctacac atatccagac
     3421 cttttaggtt gcccaaactt ccttagaata aagcatttta gctctgagaa ctacttgata
     3481 agtctgccag gaagccccca agtcaattct tcaacaaaaa tactatcttc cctacttaat
     3541 tttttttaag tcatgatatt ttatagttag aggagagaga gacaatctat tcccatgact
     3601 aagacacaaa cctacaagaa agggttactc agtcaagcct gtgcctgact tctggaccag
     3661 gcccctgatt ttcatggata gtccaaagga aggccagggg ttcccactga cttccaagcc
     3721 atcagcagca ccctaaaccc aggagtcaac aaatattcag agcaagagga tgtttatctc
     3781 agctatgagc tcattggcag gtttgtactc atgcatctgt taaaagcacc accacatcct
     3841 tttgcaagtc tgtttattac cgcttcatcc aaatacattt tgtggtcaag atgcacacag
     3901 tgctatgaat acagtacttt aaggatctgc attaaacaca tcagaatatt tcctgccaca
     3961 tctatgtaca acccctgaat atgtattttt ccttaacaca agagagcctg ttcaattaaa
     4021 aaaaaaaaaa
//
