LOCUS       NP_001102003             423 aa            linear   ROD 03-APR-2024
DEFINITION  testican-2 precursor [Rattus norvegicus].
ACCESSION   NP_001102003 XP_001055082 XP_001055146 XP_006256481 XP_342135
VERSION     NP_001102003.2
DBSOURCE    REFSEQ: accession NM_001108533.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 423)
  AUTHORS   Wang,C., Xu,Y., Xu,M., Sun,C., Zhang,X., Tao,X. and Song,T.
  TITLE     SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to
            regulate astrocytic MMP-2 activation in rats with chronic
            constriction injury
  JOURNAL   J Neuroinflammation 21 (1), 57 (2024)
   PUBMED   38388415
  REMARK    GeneRIF: SPOCK2 modulates neuropathic pain by interacting with
            MT1-MMP to regulate astrocytic MMP-2 activation in rats with
            chronic constriction injury.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 423)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   3  (residues 1 to 423)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   4  (residues 1 to 423)
  AUTHORS   Vannahme,C., Schubel,S., Herud,M., Gosling,S., Hulsmann,H.,
            Paulsson,M., Hartmann,U. and Maurer,P.
  TITLE     Molecular cloning of testican-2: defining a novel calcium-binding
            proteoglycan family expressed in brain
  JOURNAL   J Neurochem 73 (1), 12-20 (1999)
   PUBMED   10386950
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On or before Sep 17, 2022 this sequence version replaced
            XP_006256481.1, NP_001102003.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..423
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     Protein         1..423
                     /product="testican-2 precursor"
                     /note="testican-2; sparc/osteonectin, cwcv and kazal-like
                     domains proteoglycan 2; sparc/osteonectin, cwcv and
                     kazal-like domains proteoglycan (testican) 2"
                     /calculated_mol_wt=44448
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2389
     Region          <147..180
                     /region_name="KAZAL"
                     /note="Kazal type serine protease inhibitors; smart00280"
                     /db_xref="CDD:197624"
     Region          199..309
                     /region_name="EFh_SPARC_EC"
                     /note="EF-hand, extracellular calcium-binding (EC) motif,
                     found in secreted protein acidic and rich in cysteine
                     (SPARC)-like proteins; cl25349"
                     /db_xref="CDD:330171"
     Region          245..276
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320009"
     Site            order(257,261,268,289,291,293,300)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:320009"
     Region          277..307
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320009"
     Region          312..375
                     /region_name="Thyroglobulin_1"
                     /note="Thyroglobulin type-1 repeat; pfam00086"
                     /db_xref="CDD:459665"
     Site            order(316,331,349,353)
                     /site_type="active"
                     /note="protease interaction site [active]"
                     /db_xref="CDD:238114"
     CDS             1..423
                     /gene="Spock2"
                     /coded_by="NM_001108533.4:259..1530"
                     /db_xref="GeneID:361840"
                     /db_xref="RGD:1308568"
ORIGIN      
        1 mrapgsgrla lpllllavva laegdakglk egetpgnfme deqwlssisq ysgkikhwnr
       61 frdeveddyi kswednqqgd ealdttkdpc qkvkcsrhkv cvaqgyqram cisrkklehr
      121 ikqpslklhg gkdsickpch maqlasvcgs dghtyssvck leqqaclsnk hlavrcegpc
      181 pcpteqstas ttdsksetct gqdladlgdr lrdwfqllre nskqngsass ssspagldks
      241 lgasckdsig wmfskldtsg dlfldqtela ainldkyevc irpffnscdt ykdgrvstae
      301 wcfcfwrekp pclaelertq iqeaakkkpg ifipscdedg yyrkmqcdqs sgdcwcvdql
      361 gleltgtrmh gnpdcddivg fsgdfgsgvg wedeeekete eageeaeeee geageaddgg
      421 yiw
//
