LOCUS       NM_001271297            2001 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus sparc/osteonectin, cwcv and kazal like domains
            proteoglycan 1 (Spock1), mRNA.
ACCESSION   NM_001271297 XM_001067546 XM_225160
VERSION     NM_001271297.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2001)
  AUTHORS   Li,P., Xiao,Z., Luo,J., Zhang,Y. and Lin,L.
  TITLE     MiR-139-5p, miR-940 and miR-193a-5p inhibit the growth of
            hepatocellular carcinoma by targeting SPOCK1
  JOURNAL   J Cell Mol Med 23 (4), 2475-2488 (2019)
   PUBMED   30710422
REFERENCE   2  (bases 1 to 2001)
  AUTHORS   Bocock,J.P., Edgell,C.J., Marr,H.S. and Erickson,A.H.
  TITLE     Human proteoglycan testican-1 inhibits the lysosomal cysteine
            protease cathepsin L
  JOURNAL   Eur J Biochem 270 (19), 4008-4015 (2003)
   PUBMED   14511383
REFERENCE   3  (bases 1 to 2001)
  AUTHORS   Marr,H.S. and Edgell,C.J.
  TITLE     Testican-1 inhibits attachment of Neuro-2a cells
  JOURNAL   Matrix Biol 22 (3), 259-266 (2003)
   PUBMED   12853036
REFERENCE   4  (bases 1 to 2001)
  AUTHORS   Nakada,M., Yamada,A., Takino,T., Miyamori,H., Takahashi,T.,
            Yamashita,J. and Sato,H.
  TITLE     Suppression of membrane-type 1 matrix metalloproteinase
            (MMP)-mediated MMP-2 activation and tumor invasion by testican 3
            and its splicing variant gene product, N-Tes
  JOURNAL   Cancer Res 61 (24), 8896-8902 (2001)
   PUBMED   11751414
REFERENCE   5  (bases 1 to 2001)
  AUTHORS   Cifuentes-Diaz,C., Alliel,P.M., Charbonnier,F., de la Porte,S.,
            Molgo,J., Goudou,D., Rieger,F. and Perin,J.P.
  TITLE     Regulated expression of the proteoglycan SPOCK in the neuromuscular
            system
  JOURNAL   Mech Dev 94 (1-2), 277-282 (2000)
   PUBMED   10842087
REFERENCE   6  (bases 1 to 2001)
  AUTHORS   Charbonnier,F., Chanoine,C., Cifuentes-Diaz,C., Gallien,C.L.,
            Rieger,F., Alliel,P.M. and Perin,J.P.
  TITLE     Expression of the proteoglycan SPOCK during mouse embryo
            development
  JOURNAL   Mech Dev 90 (2), 317-321 (2000)
   PUBMED   10640720
REFERENCE   7  (bases 1 to 2001)
  AUTHORS   Kohfeldt,E., Maurer,P., Vannahme,C. and Timpl,R.
  TITLE     Properties of the extracellular calcium binding module of the
            proteoglycan testican
  JOURNAL   FEBS Lett 414 (3), 557-561 (1997)
   PUBMED   9323035
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB608950.1, CB713141.1, JAXUCZ010000017.1 and BC092615.1.
            
            On or before Sep 15, 2012 this sequence version replaced
            XM_225160.6, XM_001067546.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.68293.1,
                                           SRR26360194.648202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-555               CB608950.1         10-564
            556-713             CB713141.1         251-408
            714-751             JAXUCZ010000017.1  7145358-7145395
            752-868             JAXUCZ010000017.1  7209732-7209848
            869-887             JAXUCZ010000017.1  7212681-7212699
            888-1996            BC092615.1         15-1123
            1997-2001           JAXUCZ010000017.1  7224462-7224466
FEATURES             Location/Qualifiers
     source          1..2001
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..2001
                     /gene="Spock1"
                     /note="sparc/osteonectin, cwcv and kazal like domains
                     proteoglycan 1"
                     /db_xref="GeneID:306759"
                     /db_xref="RGD:1311496"
     exon            1..156
                     /gene="Spock1"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1482
                     /gene="Spock1"
                     /note="sparc/osteonectin, cwcv and kazal-like domains
                     proteoglycan (testican) 1"
                     /codon_start=1
                     /product="testican-1"
                     /protein_id="NP_001258226.1"
                     /db_xref="GeneID:306759"
                     /db_xref="RGD:1311496"
                     /translation="MPAIAVLAAAAAAWCFLQVDSRHLDALAGGAALNNANFLDNDQW
                     LSTVSQYDRDKYWNRFRDDDYFRNWNPNKPFDQALDPSKDPCLKVKCSPHKVCVTQDY
                     QTALCVSRKHLLPRQKKGSVAHKHWVGPSNLVKCKPCPVAQSAMVCGSDGHTYTSKCK
                     LEFHACSTGKSLSSLCDGPCPCLPEPEPEPQKPKAEKSACTDKELRNLASRLKDWFGA
                     LHEDANRVIKPTSSDTTQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDHSEINAIYL
                     DKYEPCIKPLFNSCDSFKDGKLSNNEWCYCFQKPGGLPCQNEMNRIQKLSKGKSLLGA
                     FIPRCNEEGYYKATQCHGSTGQCWCVDKYGNELAGSRKQGTVSCEEEQETSGDFGSGG
                     SVVLLDDLDDERELGPKDKEGKLRVHTRAVREDDEDEDDDKEDEVGYIW"
     exon            157..342
                     /gene="Spock1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..388
                     /gene="Spock1"
                     /inference="alignment:Splign:2.1.0"
     exon            389..503
                     /gene="Spock1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..630
                     /gene="Spock1"
                     /inference="alignment:Splign:2.1.0"
     exon            631..751
                     /gene="Spock1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..868
                     /gene="Spock1"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1090
                     /gene="Spock1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1153
                     /gene="Spock1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1291
                     /gene="Spock1"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..2001
                     /gene="Spock1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggctcaca aagcggccgg acgcgcggcg gcggcggcgg cggcggcagc ggcagcggca
       61 ggtgcgcagg ggaacgagcc gggcagcagc cttcccagcc accgcggtac aggaacacca
      121 gcaactcggg cgccgggact cgggcgggct cccaagatgc cagcgatcgc ggtgctcgcg
      181 gcggctgccg cggcgtggtg cttcctccaa gtggacagcc ggcacctgga cgcgctggcc
      241 ggtggcgcgg ccctcaacaa cgccaatttc ctagacaatg accagtggct gagcaccgtc
      301 tcccagtatg accgtgacaa gtactggaac cgcttccgag atgatgacta tttcagaaac
      361 tggaatccca acaagccctt cgaccaagcc ctggacccat ccaaggaccc ctgcctgaaa
      421 gtgaaatgca gccctcacaa agtctgtgtg acccaggact accagacagc cctgtgtgtc
      481 agccgaaagc acctgttgcc caggcaaaag aaggggagtg tggctcacaa gcactgggtt
      541 ggaccttcga atctggttaa atgcaagcct tgccccgtgg cacagtcagc gatggtctgc
      601 gggtctgacg gccacacgta cacgtccaag tgcaagttgg aattccatgc ttgttctaca
      661 ggcaaaagcc tcagctccct ctgcgatggg ccctgtccgt gtctgcctga gcccgagcca
      721 gagccacaga agcccaaggc agaaaagagt gcctgcacag acaaggagct gcggaacctt
      781 gcttcccggc tgaaggactg gttcggggct cttcacgagg atgccaacag agtcatcaag
      841 cctaccagct ctgacacaac ccaaggaagg tttgacacca gcatcctgcc catttgcaag
      901 gactccttgg gctggatgtt caacaagctg gacatgaact atgacctctt gctggaccac
      961 tcggagatca atgccatcta cctagacaaa tatgagccct gtatcaaacc tctcttcaac
     1021 tcgtgtgact ccttcaagga cggcaaactc tccaacaacg agtggtgtta ctgcttccag
     1081 aagccaggag gcctcccttg ccagaacgaa atgaacagaa ttcagaagct gagcaagggg
     1141 aaaagcctat tgggggcatt catacctcgg tgtaacgagg aaggctacta caaagccaca
     1201 cagtgccacg gcagcacggg gcagtgctgg tgcgtggata aatatgggaa cgagctggct
     1261 ggctccagga aacagggcac tgtaagctgt gaagaggagc aggaaacctc cggggacttc
     1321 ggcagcggag gctccgtggt tctgctggat gacctagacg acgagaggga gctgggacca
     1381 aaggacaaag aggggaagct gagggtgcac acccgggccg tgagggaaga tgatgaggat
     1441 gaggatgacg acaaagaaga cgaggtcggg tacatatggt agcgcccacg aggaagagga
     1501 cacgcttttg acacagatct gcaagtcgtt tcctttgcct gcgttgtatc taagactccg
     1561 aggcaccggg gtcttttctc ccctgttgct ctctgtaccg gcctgaggtt tgggagaccc
     1621 tcttcccaga gcgtctgaat ttgcatacag ttgtgtggga gaaaggatgc tattttttgt
     1681 tccttgtttc tttgttttca ttggatgaga ggatggctgg cttaattaaa gcctccttct
     1741 ctccccgcga ggttttcgca actagcatgt gatttatgtg aattccaaca gtgcggggag
     1801 ccccaccctc tcaagcgtca aagaccctct ctgattaccc acatcggtgg ttcttacagc
     1861 atggttccca gccttctgat gtctacgtgc ttttcttgtg tcctgtagat gttgtggaaa
     1921 acgtaccagg ctgttccctt tccctcccac ttccaccacc tctggtgttt attattaaaa
     1981 attaattttc atgtcactgt a
//
