LOCUS       NM_001389255            3280 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SPNS lysolipid transporter 2,
            sphingosine-1-phosphate (Spns2), mRNA.
ACCESSION   NM_001389255 XM_006246563
VERSION     NM_001389255.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3280)
  AUTHORS   Vanderhaeghen,T., Vandewalle,J. and Libert,C.
  TITLE     Spns2/S1P: it takes two to tango with inflammation and metabolic
            rewiring during sepsis
  JOURNAL   EMBO Rep 24 (8), e57615 (2023)
   PUBMED   37358010
  REMARK    GeneRIF: Spns2/S1P: it takes two to tango with inflammation and
            metabolic rewiring during sepsis.
REFERENCE   2  (bases 1 to 3280)
  AUTHORS   Nagahashi,M., Kim,E.Y., Yamada,A., Ramachandran,S., Allegood,J.C.,
            Hait,N.C., Maceyka,M., Milstien,S., Takabe,K. and Spiegel,S.
  TITLE     Spns2, a transporter of phosphorylated sphingoid bases, regulates
            their blood and lymph levels, and the lymphatic network
  JOURNAL   FASEB J 27 (3), 1001-1011 (2013)
   PUBMED   23180825
REFERENCE   3  (bases 1 to 3280)
  AUTHORS   Nijnik,A., Clare,S., Hale,C., Chen,J., Raisen,C., Mottram,L.,
            Lucas,M., Estabel,J., Ryder,E., Adissu,H., Adams,N.C.,
            Ramirez-Solis,R., White,J.K., Steel,K.P., Dougan,G. and
            Hancock,R.E.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     The role of sphingosine-1-phosphate transporter Spns2 in immune
            system function
  JOURNAL   J Immunol 189 (1), 102-111 (2012)
   PUBMED   22664872
REFERENCE   4  (bases 1 to 3280)
  AUTHORS   Fukuhara,S., Simmons,S., Kawamura,S., Inoue,A., Orba,Y.,
            Tokudome,T., Sunden,Y., Arai,Y., Moriwaki,K., Ishida,J., Uemura,A.,
            Kiyonari,H., Abe,T., Fukamizu,A., Hirashima,M., Sawa,H., Aoki,J.,
            Ishii,M. and Mochizuki,N.
  TITLE     The sphingosine-1-phosphate transporter Spns2 expressed on
            endothelial cells regulates lymphocyte trafficking in mice
  JOURNAL   J Clin Invest 122 (4), 1416-1426 (2012)
   PUBMED   22406534
REFERENCE   5  (bases 1 to 3280)
  AUTHORS   Bassett,J.H., Gogakos,A., White,J.K., Evans,H., Jacques,R.M., van
            der Spek,A.H., Ramirez-Solis,R., Ryder,E., Sunter,D., Boyde,A.,
            Campbell,M.J., Croucher,P.I. and Williams,G.R.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Rapid-throughput skeletal phenotyping of 100 knockout mice
            identifies 9 new genes that determine bone strength
  JOURNAL   PLoS Genet 8 (8), e1002858 (2012)
   PUBMED   22876197
REFERENCE   6  (bases 1 to 3280)
  AUTHORS   Hisano,Y., Kobayashi,N., Kawahara,A., Yamaguchi,A. and Nishi,T.
  TITLE     The sphingosine 1-phosphate transporter, SPNS2, functions as a
            transporter of the phosphorylated form of the immunomodulating
            agent FTY720
  JOURNAL   J Biol Chem 286 (3), 1758-1766 (2011)
   PUBMED   21084291
REFERENCE   7  (bases 1 to 3280)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Dec 5, 2020 this sequence version replaced XM_006246563.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.39166.1,
                                           SRR26643288.41483.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760433,
                                           SAMN12840115 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-532               JAXUCZ010000010.1  57603967-57604498   c
            533-598             JAXUCZ010000010.1  57589550-57589615   c
            599-735             JAXUCZ010000010.1  57578018-57578154   c
            736-887             JAXUCZ010000010.1  57573126-57573277   c
            888-954             JAXUCZ010000010.1  57572857-57572923   c
            955-1097            JAXUCZ010000010.1  57571479-57571621   c
            1098-1250           JAXUCZ010000010.1  57571038-57571190   c
            1251-1440           JAXUCZ010000010.1  57570764-57570953   c
            1441-1506           JAXUCZ010000010.1  57570584-57570649   c
            1507-1605           JAXUCZ010000010.1  57568603-57568701   c
            1606-1769           JAXUCZ010000010.1  57568357-57568520   c
            1770-1816           JAXUCZ010000010.1  57567808-57567854   c
            1817-3280           JAXUCZ010000010.1  57565909-57567372   c
FEATURES             Location/Qualifiers
     source          1..3280
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..3280
                     /gene="Spns2"
                     /note="SPNS lysolipid transporter 2,
                     sphingosine-1-phosphate"
                     /db_xref="GeneID:100270678"
                     /db_xref="RGD:2303312"
     exon            1..532
                     /gene="Spns2"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1812
                     /gene="Spns2"
                     /note="protein spinster homolog 2; sphingolipid
                     transporter 2"
                     /codon_start=1
                     /product="sphingosine-1-phosphate transporter SPNS2"
                     /protein_id="NP_001376184.1"
                     /db_xref="GeneID:100270678"
                     /db_xref="RGD:2303312"
                     /translation="MMCLECASAAAGGAEEEEADAERRRRRRGAQPGAGGSACCGARG
                     VGGAGVVSADEEVQTLSGSVRRVPSGLPSIPSTPGCAAAAKGPGAPQPKPASLGRGRG
                     AAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGY
                     LGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTII
                     GDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTL
                     ILILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGM
                     WIPLYLHRAQVVQKTAETCNSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRT
                     QRADPLVCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVGETLLFSNWAITADILMYV
                     VIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQSTKDSPLWEFLSLGYALMLC
                     PFVVVLGGMFFLATALFFLSDRAKAEQQVNQLVMPPASVKI"
     exon            533..598
                     /gene="Spns2"
                     /inference="alignment:Splign:2.1.0"
     exon            599..735
                     /gene="Spns2"
                     /inference="alignment:Splign:2.1.0"
     exon            736..887
                     /gene="Spns2"
                     /inference="alignment:Splign:2.1.0"
     exon            888..954
                     /gene="Spns2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1097
                     /gene="Spns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1250
                     /gene="Spns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1440
                     /gene="Spns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1506
                     /gene="Spns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1605
                     /gene="Spns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1769
                     /gene="Spns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1816
                     /gene="Spns2"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..3280
                     /gene="Spns2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcagcgca gccagggctg gagcccgagc gcagaagccg acgggccggg ccgggatggt
       61 gcagcggcgg ctccgcggcg cgcgcacgca ctgagcgggc ccgggctggg cctcgcgtcc
      121 cccgcgcccc ccgcgccccc cgccgccccg gtcctggcgg gcatgatgtg cctggaatgc
      181 gcctcggcgg cggcgggcgg cgcggaggag gaggaggcgg acgccgaacg gcggcgccgg
      241 cgccgggggg cgcagccagg ggctggaggt agcgcttgct gcggggcgcg gggtgttggg
      301 ggcgctggag tcgtgtccgc ggacgaagag gtgcagacgt tgtccggcag cgtgaggagg
      361 gtcccgtccg gactccccag catccccagt accccgggct gcgcagccgc tgccaagggc
      421 cccggcgcgc cgcagcccaa acccgccagc ttgggccgag ggcggggggc agccgctgcc
      481 atcctgagct tgggcaacgt gctcaactac ctggacaggt acactgtggc aggtgttctt
      541 ctggacatcc agcagcactt tggggtcaag gaccggggcg ctggcttgct gcagtcagtg
      601 ttcatctgca gcttcatggt ggctgccccc atctttggct acctgggcga tcgcttcaat
      661 agaaaggtga tcctcagctg cggcatcttc ttctggtcgg ccgtcacctt ctctagttct
      721 ttcatccctc agcagtactt ctggctgctg gtcctgtccc gggggctagt aggtattggt
      781 gaagctagct attccaccat agcacccacc atcatcggcg acttatttac caagaacaca
      841 cgcacactga tgctatcagt cttctatttt gccatccctc tgggcagtgg cctgggctac
      901 atcacaggtt ccagcgtgaa gcaggcagct ggagactggc attgggccct gcgggtttcc
      961 cctgtcctgg gcatgatcac aggaacactc atcctcatct tggtcccagc cactaagaga
     1021 ggccatgctg atcaacttgg ggggcagctc aaagcacgga cctcctggct ccgagacatg
     1081 aaggccctga tccggaaccg cagttacgtc ttctcctccc tggccacatc cgctgtgtcc
     1141 ttcgccacag gagccctggg catgtggatt cccctctatc tgcaccgtgc tcaagttgta
     1201 caaaagacag cagagacttg caacagcccg ccctgtggag ccaaagacag cctcatcttt
     1261 ggggccatta cctgctttac tggctttctg ggcgtagtca caggcgcggg agccactcgc
     1321 tggtgccgct tgcgcactca gcgcgctgac cccttggtgt gcgccgtggg catgctggga
     1381 tctgccatct tcatctgcct catctttgtg gctgccaaga ccagcatcgt gggcgcctat
     1441 atctgcatct ttgttggcga gacactgctg ttttctaact gggccatcac tgcagacatc
     1501 ctcatgtatg tggtcatccc cactcgacga gccactgctg tggccttgca gagcttcacc
     1561 tcccatctgc tgggggacgc tggaagcccc tacctcattg gctttatctc ggacctaatc
     1621 cgccagagca ccaaggactc cccactctgg gagtttctga gcctgggcta tgccctcatg
     1681 ctgtgccctt ttgttgtggt cctgggtggc atgttcttcc ttgccactgc tctcttcttc
     1741 ctcagcgatc gtgccaaggc tgagcagcag gtgaaccagc tggtgatgcc gcctgcatcc
     1801 gtgaaaatct gaggtggtgc cgctgggaca gcaatgaact gcagtttaga ttgggagagg
     1861 ttctccagca tcctggacct gcaggacggt cgcaaagctt cctgtgtgac tcacagttgg
     1921 gtacacaccc tctttggcct aggactgcca ggactgagtg gccctatctt caagaagctg
     1981 catcctcagt gaacctagaa ggctgtgtgt gctggagtca ctcagttgga cacaactcca
     2041 gccctggttg ggggctgaag ggccaagata gaagcagcca ccctgcagtg ggtatttggg
     2101 gagattctgg tccaccctta gctcatgtga tcttgaggga gccactatcc tccctagaca
     2161 gtggaaccaa ggagctggag cttcctccat tgtgtgccat gcatggcacc ctccacaact
     2221 ttgaagaaac aggcccgggg ctgtacacag aagacaccgc tcaggtctca ggacctcagt
     2281 tccggttctg aggtctgcct aaggctctgg tggacgggga ccacttcccc acttgtaggc
     2341 gctaaccttg ggaacagcaa attcagcctg gcatgcgtag ctgggcacac acctctgggt
     2401 gttcgtgggt gggacagtct cccaggagga tactgtctct gctgtcttca gctagttctt
     2461 tgcctggaag tttttctcag atgggatcac cctccttaaa ggaagctgta gccctagggg
     2521 gtgaaggccc catggtaggc tgagaatttg agaacctccc ttcctcatcc cagcccccaa
     2581 acttctgcag tcccccagaa gtcacctcct cctccaggat gagcccttcc caatgagggg
     2641 tcagatagga tgctaaagga ctcaccagct gtccacacta ctcctcggcc taggtgtgaa
     2701 actgctggag attgcccacc agtgcctgta ggtatcatac cccaactgac tctcttgggg
     2761 ccaggccttc accccagcct ttgatcacac tattcccata tacatacaac cctcaccccc
     2821 ctgcagccac cctagtcacc tttgggcact taccccagct ttactccttg cacgctgtaa
     2881 ccaaggtggc tctggtcctg gggtaccatt gtaacttagg gaaacttcca gaaccagcca
     2941 gcgtggacaa cagtctctgt ggctgtaccc cacttgctgt ggcttcagtg gtgtgatacc
     3001 caccccaaca agttctgggg caccctgggg gtttggacat gggtttgcag agggtgctat
     3061 ccctaaagac cagcctggct cccaccctag ccccagcagg ggccctagca atgttttctt
     3121 gttgtacaag aaccaggtcc aagtgttgcc tcctcttcct tccggaagct gaactgctcc
     3181 tttatttttt agagctgctg attgtgaatc tcagagtctt aagagagaag ccaaatatat
     3241 attcctcttg taaatgaaga aataaaccta tttaaatgtt
//
