LOCUS       NM_001271086            3866 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus sialophorin (Spn), mRNA.
ACCESSION   NM_001271086 XM_001080140 XM_003748989 XM_003753337 XM_344964
VERSION     NM_001271086.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3866)
  AUTHORS   Dong,E., Guidotti,A., Zhang,H. and Pandey,S.C.
  TITLE     Prenatal stress leads to chromatin and synaptic remodeling and
            excessive alcohol intake comorbid with anxiety-like behaviors in
            adult offspring
  JOURNAL   Neuropharmacology 140, 76-85 (2018)
   PUBMED   30016666
REFERENCE   2  (bases 1 to 3866)
  AUTHORS   Velazquez,F., Grodecki-Pena,A., Knapp,A., Salvador,A.M., Nevers,T.,
            Croce,K. and Alcaide,P.
  TITLE     CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and
            Is Required for Rolling on the Vascular Endothelium and Th17 Cell
            Recruitment during Inflammation In Vivo
  JOURNAL   J Immunol 196 (3), 1305-1316 (2016)
   PUBMED   26700769
REFERENCE   3  (bases 1 to 3866)
  AUTHORS   Cannon,J.L., Asperti-Boursin,F., Letendre,K.A., Brown,I.K.,
            Korzekwa,K.E., Blaine,K.M., Oruganti,S.R., Sperling,A.I. and
            Moses,M.E.
  TITLE     PKCtheta; regulates T cell motility via ezrin-radixin-moesin
            localization to the uropod
  JOURNAL   PLoS One 8 (11), e78940 (2013)
   PUBMED   24250818
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3866)
  AUTHORS   Cannon,J.L., Mody,P.D., Blaine,K.M., Chen,E.J., Nelson,A.D.,
            Sayles,L.J., Moore,T.V., Clay,B.S., Dulin,N.O., Shilling,R.A.,
            Burkhardt,J.K. and Sperling,A.I.
  TITLE     CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates
            T-cell trafficking and CD43 phosphorylation
  JOURNAL   Mol Biol Cell 22 (7), 954-963 (2011)
   PUBMED   21289089
REFERENCE   5  (bases 1 to 3866)
  AUTHORS   Hickey,T.B., Ziltener,H.J., Speert,D.P. and Stokes,R.W.
  TITLE     Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds
            CD43 on the macrophage surface
  JOURNAL   Cell Microbiol 12 (11), 1634-1647 (2010)
   PUBMED   20633027
REFERENCE   6  (bases 1 to 3866)
  AUTHORS   Cheng,A.M., Rowley,B., Pao,W., Hayday,A., Bolen,J.B. and Pawson,T.
  TITLE     Syk tyrosine kinase required for mouse viability and B-cell
            development
  JOURNAL   Nature 378 (6554), 303-306 (1995)
   PUBMED   7477353
REFERENCE   7  (bases 1 to 3866)
  AUTHORS   Manjunath,N., Correa,M., Ardman,M. and Ardman,B.
  TITLE     Negative regulation of T-cell adhesion and activation by CD43
  JOURNAL   Nature 377 (6549), 535-538 (1995)
   PUBMED   7566153
REFERENCE   8  (bases 1 to 3866)
  AUTHORS   Shiota,J., Nishimura,H., Okamoto,H., Yu,B., Hattori,S., Abe,M.,
            Okada,T., Nozawa,S., Tsurui,H., Hirose,S. et al.
  TITLE     A unique murine CD43 epitope Lp-3: distinct distribution from
            another CD43 epitope S7
  JOURNAL   Cell Immunol 155 (2), 402-413 (1994)
   PUBMED   7514104
REFERENCE   9  (bases 1 to 3866)
  AUTHORS   Cyster,J.G. and Williams,A.F.
  TITLE     The importance of cross-linking in the homotypic aggregation of
            lymphocytes induced by anti-leukosialin (CD43) antibodies
  JOURNAL   Eur J Immunol 22 (10), 2565-2572 (1992)
   PUBMED   1382990
REFERENCE   10 (bases 1 to 3866)
  AUTHORS   Killeen,N., Barclay,A.N., Willis,A.C. and Williams,A.F.
  TITLE     The sequence of rat leukosialin (W3/13 antigen) reveals a molecule
            with O-linked glycosylation of one third of its extracellular amino
            acids
  JOURNAL   EMBO J 6 (13), 4029-4034 (1987)
   PUBMED   2965006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Sep 1, 2012 this sequence version replaced
            XM_003748989.1, XM_344964.5, XM_003753337.1, XM_001080140.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.1434.1,
                                           SRR26643292.4016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676788 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                JAXUCZ010000001.1  191181609-191181676 c
            69-3866             JAXUCZ010000001.1  191177449-191181246 c
FEATURES             Location/Qualifiers
     source          1..3866
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..3866
                     /gene="Spn"
                     /gene_synonym="Cd43; gpL115; Lsn; Lsn1"
                     /note="sialophorin"
                     /db_xref="GeneID:24796"
                     /db_xref="RGD:3750"
     exon            1..68
                     /gene="Spn"
                     /gene_synonym="Cd43; gpL115; Lsn; Lsn1"
                     /inference="alignment:Splign:2.1.0"
     exon            69..3866
                     /gene="Spn"
                     /gene_synonym="Cd43; gpL115; Lsn; Lsn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1275
                     /gene="Spn"
                     /gene_synonym="Cd43; gpL115; Lsn; Lsn1"
                     /note="W3/13 antigen; leukocyte sialoglycoprotein;
                     leukosialin; leukosianin"
                     /codon_start=1
                     /product="leukosialin precursor"
                     /protein_id="NP_001258015.1"
                     /db_xref="GeneID:24796"
                     /db_xref="RGD:3750"
                     /translation="MEMALHLLLLFGGFWAQVVSQENLPNTMTMLPFTPNSESPSTSE
                     ALSTYSSIATVPVTEDPKESISPWGQTTAPASSIPLGTPELSSFFFTSAGASGNTPVP
                     ELTTSQEVSTEASLVLFPKSSGVASDPPVTITNPATSSAVASTSLETFKGTSAPPVTV
                     TSSTMTSGPFVATTVSSETSGPPVTMATGSLGPSKETHGLSATIATSSGESSSVAGGT
                     PVFSTKISTTSTPNPITTVPPRPGSSGMLLVSMLIALTVVLVLVALLLLWRQRQKRRT
                     GALTLSRGGKRNGTVDAWAGPARVPDEEATTASGSGGNKSSGAPETDGSGQRPTLTTF
                     FSRRKSRQGSVALEELKPGTGPNLKGEEEPLVGSEDEAVETPTSDGPQAKDGAAPQSL
                     "
ORIGIN      
        1 agtcctgaca aagcctcagg aagaactgga ggtactcgcc ctgtccgtgt gccttagcca
       61 ttaagctggt cccaactcct gctcccggct gtcactatgg agatggcctt gcatcttctc
      121 ctcctctttg ggggcttctg ggcccaggtg gtgagccaag aaaatctgcc gaatacgatg
      181 acgatgttgc catttactcc gaatagcgag tccccaagta cctctgaagc cttgagtacc
      241 tactcatcaa ttgctacagt gccagtgaca gaggacccta aggagagtat cagcccctgg
      301 gggcagacca ctgccccagc ttcctcaatc cccttgggaa ctccagaatt gtcttctttt
      361 ttttttacat cagctggtgc cagcgggaac accccagtac ctgagcttac aacctctcag
      421 gaagtttcca ccgaggcatc attagtactg tttccaaaat catcaggtgt agccagtgac
      481 cctcctgtca ctataactaa tcctgcgaca agcagtgctg tggcatctac ctctttagaa
      541 acttttaaag ggaccagtgc acctcctgtc actgtgacaa gctcgaccat gaccagtgga
      601 ccctttgtgg ctacaactgt aagctccgag accagtggtc ctccagtcac tatggctact
      661 gggtctctgg ggccctccaa agagacacat ggactctctg ccaccatagc aaccagttct
      721 ggtgagagtt ctagtgtggc cggtggcacc ccagtcttca gtacaaaaat atccacaacg
      781 tctaccccaa atcccataac caccgtgcca ccacgcccag gatcgagtgg catgttgctg
      841 gtttccatgc tcattgcctt gacggtggtt ttggtccttg tggcgctact gctgctgtgg
      901 cgccagaggc agaagcggag gactggggcc ctgaccctga gcagaggtgg aaaacgaaat
      961 ggtacggtgg atgcctgggc tgggccagct cgggttcctg acgaagaggc caccaccgca
     1021 tcagggtcag ggggcaacaa gagctccgga gcgccggaga cggatggctc cgggcagcgg
     1081 cccacgctca ccactttctt cagcagacgg aagtctcgcc agggctcggt agcactagaa
     1141 gagctgaagc ctgggacggg tcccaacctg aagggggagg aagagcctct ggtaggcagt
     1201 gaggacgaag ctgtggaaac cccaacttct gacgggccac aagccaaaga tggggctgca
     1261 cctcaatccc tatgagtaac ggtattcatc tagtctgctc cttgacccca gatcctgctg
     1321 tcagctgcct ctcactctgc atttgtgaat atttgtgggc caggtccatt cgttcattca
     1381 ttattcagcc attcattcct ctccaacccc cgctgttttc cacctcccct tcctctgtgc
     1441 tccctttgaa tctccagaag ataagcttag ttgacccaca ttttccaagc atcccccttg
     1501 gaatgctggg atccgacaag aagaatgaaa atgataagcc agaaaactcc ggaggagggg
     1561 ccccctgagg actgcctctc aactaccatt tgctttgggg acagcttaga gctggatgta
     1621 gccattcagt ttgctcttgg gtgaactgtg acctgtgact tttcccagag cactccgatt
     1681 ttgggctggc cggtagctgc ttggggtagc ctgccagaga tcagtcactt ctcctggagg
     1741 tggggatggg gagacttcct ggctccatgt ggtccctgca cctgttttgt ccactcggaa
     1801 gtatggttta tgtgcaagat aggacaattt aggcgatggc tgtgaacagt actggtgagt
     1861 atagaccatg gagagagcag gggagatgca aaaggagggg cacgggagct gccgagccct
     1921 cagatccctt cattgtgctc agacaggata tggctgaaaa cctaagtttg tctgtagttc
     1981 cccaaaagaa tgcaaacatg atggggacta aatgtctcca tacttgtgcc atcaagaatg
     2041 agttcttcag cttagctgcc acagcctttc ctcaaaggct ccctcagacc agcacacacc
     2101 aagcacccat gcaagaaggg gagaagaatc agcccaatgc agggactggg tggtgcaaaa
     2161 ccactgcttt tgatgatgct ttccctacag gctcaatttg tccgtttcct ctgaagtcct
     2221 tcccatctct ggaataagaa agagttaaat gaaagacagg ctcagggggt gggacatgga
     2281 tgcccaaagg gtctgaggta gagaggggac agaccacaat tgtgctgttt ctgactctga
     2341 taccagcccg gctcgtggtc caaagctggt tgctggaaga gctgtgcaag gggaagtcgt
     2401 tgagtcagag gacactgtcc ttgagaacag cctgacctac aaaaagatgt gtgtgtgcgg
     2461 ctgtgtggcc tgggtggaaa aggggaaggt gggtaggagg gaggggacga ggagtggaaa
     2521 gggacaagga tcagctgcca ccacatcatc atctcctccc caagtctgtg ggaagaggaa
     2581 gggccaagat gggcacacct gagccatacc gaacccattt cttataggcg cagtgtggag
     2641 cagctctaac agatggctag tgagttgcaa gtgtccctta aggaacataa caactgttgt
     2701 ggctgatttt tgccaaaccg aatgtcccta tttcaggctt agaggagaat gttaccaagc
     2761 tgagaggtca atggctctac ccatcatgtt ccactgacac tcctgaggta ttacaggttt
     2821 ccaggtacag ggaggaagac aaggaaatgg ggtagggatg gtggatggca cgcaatagga
     2881 cctcagccct gacagacaaa atgtcacaag aggctaggac atgattggta ttccacctcc
     2941 gaaggaggac aaggaagctt aatgtttgtc ccagggtctt ggccatatct ctctttctag
     3001 tggctccagt acctggcaag cagcaaggac tgagtgcatg ctccgatgga tggatggatg
     3061 gatggatgga tggatggatg gatggatgtt ggatggatgg atggatggat gaatggacag
     3121 atggatagat gaggtattgg cagctagcaa gagagaaggc atttaacaca aagattagta
     3181 atgcaaaaat atataagtga gtggaacaga gatcatggtg gatacacaca gctgtctttc
     3241 agctcaggag agcgagcacc cagtaagcaa tagaaaagca aaaatagaag aagaaaaaga
     3301 agaaaaaagc aggcaaacag aaacagggaa atgtaaaaca cagagaccgt ttgaactccg
     3361 tcagttatga aaccatagta agtggcttgt gtttgtgaca tcctggcctt gtcttcagaa
     3421 atgtgtaatg acttcagaaa tgcctgcggc tgacacgggg tagggaagta aatgatctgt
     3481 aaatacatgt gtgttattgc atttgtgata gcagctacat cctgaatgtt tagtacggtc
     3541 ctcctaaagg ggaatttaag tgtgattttt ttcacctaac ttgtctttgt tttacacaat
     3601 aaatgtcttt acttttacag ttatgaaaaa tattggtgag ggggctggga aatggctcat
     3661 tggttacgag caccggttgc tcttccaggg gtcccaggtt ctattcccag cacctaagat
     3721 ggccgctccc aaatgtttgc aactccagtt ccaggagatc cagtgccctg ttctgaccct
     3781 caagggcaca aggtacacag gtggcacaca tacatacgca caggcaaaat atctatatgc
     3841 ataaaaataa atctttttaa aaatgg
//
