LOCUS       NP_001258015             392 aa            linear   ROD 30-MAR-2024
DEFINITION  leukosialin precursor [Rattus norvegicus].
ACCESSION   NP_001258015 XP_001080140 XP_003749037 XP_003753385 XP_344965
VERSION     NP_001258015.1
DBSOURCE    REFSEQ: accession NM_001271086.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 392)
  AUTHORS   Dong,E., Guidotti,A., Zhang,H. and Pandey,S.C.
  TITLE     Prenatal stress leads to chromatin and synaptic remodeling and
            excessive alcohol intake comorbid with anxiety-like behaviors in
            adult offspring
  JOURNAL   Neuropharmacology 140, 76-85 (2018)
   PUBMED   30016666
REFERENCE   2  (residues 1 to 392)
  AUTHORS   Velazquez,F., Grodecki-Pena,A., Knapp,A., Salvador,A.M., Nevers,T.,
            Croce,K. and Alcaide,P.
  TITLE     CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and
            Is Required for Rolling on the Vascular Endothelium and Th17 Cell
            Recruitment during Inflammation In Vivo
  JOURNAL   J Immunol 196 (3), 1305-1316 (2016)
   PUBMED   26700769
REFERENCE   3  (residues 1 to 392)
  AUTHORS   Cannon,J.L., Asperti-Boursin,F., Letendre,K.A., Brown,I.K.,
            Korzekwa,K.E., Blaine,K.M., Oruganti,S.R., Sperling,A.I. and
            Moses,M.E.
  TITLE     PKCtheta; regulates T cell motility via ezrin-radixin-moesin
            localization to the uropod
  JOURNAL   PLoS One 8 (11), e78940 (2013)
   PUBMED   24250818
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 392)
  AUTHORS   Cannon,J.L., Mody,P.D., Blaine,K.M., Chen,E.J., Nelson,A.D.,
            Sayles,L.J., Moore,T.V., Clay,B.S., Dulin,N.O., Shilling,R.A.,
            Burkhardt,J.K. and Sperling,A.I.
  TITLE     CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates
            T-cell trafficking and CD43 phosphorylation
  JOURNAL   Mol Biol Cell 22 (7), 954-963 (2011)
   PUBMED   21289089
REFERENCE   5  (residues 1 to 392)
  AUTHORS   Hickey,T.B., Ziltener,H.J., Speert,D.P. and Stokes,R.W.
  TITLE     Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds
            CD43 on the macrophage surface
  JOURNAL   Cell Microbiol 12 (11), 1634-1647 (2010)
   PUBMED   20633027
REFERENCE   6  (residues 1 to 392)
  AUTHORS   Cheng,A.M., Rowley,B., Pao,W., Hayday,A., Bolen,J.B. and Pawson,T.
  TITLE     Syk tyrosine kinase required for mouse viability and B-cell
            development
  JOURNAL   Nature 378 (6554), 303-306 (1995)
   PUBMED   7477353
REFERENCE   7  (residues 1 to 392)
  AUTHORS   Manjunath,N., Correa,M., Ardman,M. and Ardman,B.
  TITLE     Negative regulation of T-cell adhesion and activation by CD43
  JOURNAL   Nature 377 (6549), 535-538 (1995)
   PUBMED   7566153
REFERENCE   8  (residues 1 to 392)
  AUTHORS   Shiota,J., Nishimura,H., Okamoto,H., Yu,B., Hattori,S., Abe,M.,
            Okada,T., Nozawa,S., Tsurui,H., Hirose,S. et al.
  TITLE     A unique murine CD43 epitope Lp-3: distinct distribution from
            another CD43 epitope S7
  JOURNAL   Cell Immunol 155 (2), 402-413 (1994)
   PUBMED   7514104
REFERENCE   9  (residues 1 to 392)
  AUTHORS   Cyster,J.G. and Williams,A.F.
  TITLE     The importance of cross-linking in the homotypic aggregation of
            lymphocytes induced by anti-leukosialin (CD43) antibodies
  JOURNAL   Eur J Immunol 22 (10), 2565-2572 (1992)
   PUBMED   1382990
REFERENCE   10 (residues 1 to 392)
  AUTHORS   Killeen,N., Barclay,A.N., Willis,A.C. and Williams,A.F.
  TITLE     The sequence of rat leukosialin (W3/13 antigen) reveals a molecule
            with O-linked glycosylation of one third of its extracellular amino
            acids
  JOURNAL   EMBO J 6 (13), 4029-4034 (1987)
   PUBMED   2965006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Sep 1, 2012 this sequence version replaced
            XP_003749037.1, XP_344965.3, XP_003753385.1, XP_001080140.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.1434.1,
                                           SRR26643292.4016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676788 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..392
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     Protein         1..392
                     /product="leukosialin precursor"
                     /note="W3/13 antigen; leukocyte sialoglycoprotein;
                     leukosialin; leukosianin"
                     /calculated_mol_wt=37755
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2263
     Region          39..>240
                     /region_name="Chi1"
                     /note="Chitinase [Carbohydrate transport and metabolism];
                     COG3469"
                     /db_xref="CDD:442692"
     CDS             1..392
                     /gene="Spn"
                     /gene_synonym="Cd43; gpL115; Lsn; Lsn1"
                     /coded_by="NM_001271086.1:97..1275"
                     /db_xref="GeneID:24796"
                     /db_xref="RGD:3750"
ORIGIN      
        1 memalhllll fggfwaqvvs qenlpntmtm lpftpnsesp stsealstys siatvpvted
       61 pkesispwgq ttapassipl gtpelssfff tsagasgntp vpelttsqev steaslvlfp
      121 kssgvasdpp vtitnpatss avastsletf kgtsappvtv tsstmtsgpf vattvssets
      181 gppvtmatgs lgpskethgl satiatssge sssvaggtpv fstkisttst pnpittvppr
      241 pgssgmllvs mlialtvvlv lvallllwrq rqkrrtgalt lsrggkrngt vdawagparv
      301 pdeeattasg sggnkssgap etdgsgqrpt lttffsrrks rqgsvaleel kpgtgpnlkg
      361 eeeplvgsed eavetptsdg pqakdgaapq sl
//
