LOCUS       NM_001127538            2268 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus spire-type actin nucleation factor 2 (Spire2),
            mRNA.
ACCESSION   NM_001127538 XM_001078003 XM_003751892 XM_226553
VERSION     NM_001127538.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2268)
  AUTHORS   Belin,B.J., Lee,T. and Mullins,R.D.
  TITLE     DNA damage induces nuclear actin filament assembly by Formin -2 and
            Spire-(1/2) that promotes efficient DNA repair. [corrected]
  JOURNAL   Elife 4, e07735 (2015)
   PUBMED   26287480
  REMARK    Erratum:[Elife. 2015;4. doi: 10.7554/eLife.11935. PMID: 26437453]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2268)
  AUTHORS   Schuh,M.
  TITLE     An actin-dependent mechanism for long-range vesicle transport
  JOURNAL   Nat Cell Biol 13 (12), 1431-1436 (2011)
   PUBMED   21983562
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2268)
  AUTHORS   Pfender,S., Kuznetsov,V., Pleiser,S., Kerkhoff,E. and Schuh,M.
  TITLE     Spire-type actin nucleators cooperate with Formin-2 to drive
            asymmetric oocyte division
  JOURNAL   Curr Biol 21 (11), 955-960 (2011)
   PUBMED   21620703
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001127538.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166756.1, SRR26643291.42172.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               JAXUCZ010000019.1  68281878-68282139
            263-306             JAXUCZ010000019.1  68295404-68295447
            307-663             JAXUCZ010000019.1  68302664-68303020
            664-744             JAXUCZ010000019.1  68305327-68305407
            745-909             JAXUCZ010000019.1  68305518-68305682
            910-996             JAXUCZ010000019.1  68306299-68306385
            997-1120            JAXUCZ010000019.1  68306745-68306868
            1121-1290           JAXUCZ010000019.1  68308011-68308180
            1291-1480           JAXUCZ010000019.1  68309180-68309369
            1481-1581           JAXUCZ010000019.1  68310710-68310810
            1582-1716           JAXUCZ010000019.1  68314249-68314383
            1717-1784           JAXUCZ010000019.1  68314486-68314553
            1785-1812           JAXUCZ010000019.1  68317921-68317948
            1813-1928           JAXUCZ010000019.1  68319453-68319568
            1929-2268           JAXUCZ010000019.1  68320088-68320427
FEATURES             Location/Qualifiers
     source          1..2268
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2268
                     /gene="Spire2"
                     /note="spire-type actin nucleation factor 2"
                     /db_xref="GeneID:307925"
                     /db_xref="RGD:1305837"
     exon            1..262
                     /gene="Spire2"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..2151
                     /gene="Spire2"
                     /note="spire homolog 2"
                     /codon_start=1
                     /product="protein spire homolog 2"
                     /protein_id="NP_001121010.2"
                     /db_xref="GeneID:307925"
                     /db_xref="RGD:1305837"
                     /translation="MARAGGGGAAAPERAGGAARPEPWELSLEEVLKVYEQPINEEQA
                     WAVCFQGCRGLRGEPGGVRRIRDTADILLRRDGSVGARLEPEPSTMVVPPANSEAQMV
                     QSLGFAIYRALDWGLDENEERELSPQLERLIDLMANSDCEDSSCGAADEGYGGPEEEE
                     EAEGGPRAVRTFAQAMRLCASRLTDPHGAQAHYQAVCRALFVETLELRAFLARVREAK
                     EMLQKLGEDEPRVEKPLAELDHLGHTDWARLWVQLMRELRHGVKLKKVQEKEFNPLPT
                     EFQLTPFEMLMQDIRARNYKLRKVMVDGDIPPRVKKDAHELILDFIRSRPPLKQVSER
                     RLRPVPQKQRTLHEKILEEIKQERRLRPVGAEHLGARGFGSLPCILNACSGDIKSTSC
                     INLSVTDAGSGSQRPRPRVLLKAPTLAEMEEMSTPEEEESPCGEVALKRDRSFSEHDL
                     AQLRSEMGSGLQSATQPPGGTEPPRVRAGSMHSWRPSTRDQGLCSVSGQSQPHPSNLS
                     SADGPEASAPDARHLWLEFSHPVESLALTVEEVVDVRRVLVKAEMEKFLQDKELFSSL
                     KRGKICCCCRTKFPLFSWPPTCLFCKRAVCTSCSVKMKMPSKKHGHIPVYTLGFESLQ
                     RVPTTKASPALRRDAFQCLQGPKWRSVEEEFPHIYAHGCVLKDVCSDCTSFVADVVCS
                     SRKSVDVLNATPRRSRQTQSLYVPNTRTLNFQ"
     exon            263..306
                     /gene="Spire2"
                     /inference="alignment:Splign:2.1.0"
     exon            307..663
                     /gene="Spire2"
                     /inference="alignment:Splign:2.1.0"
     exon            664..744
                     /gene="Spire2"
                     /inference="alignment:Splign:2.1.0"
     exon            745..909
                     /gene="Spire2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..996
                     /gene="Spire2"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1120
                     /gene="Spire2"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1290
                     /gene="Spire2"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1480
                     /gene="Spire2"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1581
                     /gene="Spire2"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1716
                     /gene="Spire2"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1784
                     /gene="Spire2"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1812
                     /gene="Spire2"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1928
                     /gene="Spire2"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2268
                     /gene="Spire2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccatgg cccgggcggg cggcggcggc gcagcagctc ccgaacgcgc ggggggcgcg
       61 gcgcggcccg agccgtggga gctgtccctg gaggaagtgc tgaaggtgta cgagcagccc
      121 atcaacgagg agcaggcctg ggcggtgtgc ttccagggct gccgcgggct gcggggcgag
      181 ccgggcggcg tgcggcgcat ccgggacacg gcagacatcc tcctgcgtag ggacggctcg
      241 gttggcgcgc ggctggagcc cgagccttcg accatggtgg tcccacccgc caactcagaa
      301 gcccagatgg tgcagtcact gggctttgcc atctaccgtg cgctggactg ggggttagac
      361 gagaatgagg agcgagagct cagcccgcag ctggagaggc tcatcgacct catggccaac
      421 agcgactgtg aagacagcag ctgcggggca gcagatgagg gctacggggg tccagaagag
      481 gaggaggagg ctgagggcgg cccccgagct gtgcgcacct ttgctcaggc catgcggctg
      541 tgtgcctcac gcctgacgga tccccacggt gcgcaggccc actaccaggc agtgtgccga
      601 gctctctttg tggagacgct tgagctccgt gccttcttgg cccgggtgag ggaggccaaa
      661 gagatgctgc agaagctagg agaggatgag ccacgggtag agaagccgct ggccgagctc
      721 gaccacctgg gacacacaga ctgggcccgg ctgtgggtcc agctcatgcg ggagctccgt
      781 cacggggtga agctgaagaa ggtgcaagag aaggagttca accccctgcc caccgagttc
      841 cagctcacgc ccttcgagat gctgatgcag gatatccgtg ccaggaacta taagctgcga
      901 aaggtcatgg tcgatggcga catccctccc cgagtgaaga aagacgccca tgagctcatc
      961 ctggacttca tccgttcacg gcctccactg aagcaggtct cagagagacg gcttcgccct
     1021 gtgccacaga agcaaagaac actgcacgag aagatcctgg aggaaatcaa acaggagcgg
     1081 aggcttcgtc cagtaggggc cgagcacttg ggagcccgtg ggtttggttc tctgccctgc
     1141 atcctcaacg cctgctccgg ggacatcaag tccacttcct gcatcaacct gtctgtcaca
     1201 gatgctggga gtgggagtca gcgcccacgg ccccgggtcc tgctgaaagc cccgacctta
     1261 gcagagatgg aagagatgag cacgcctgag gaagaagagt ccccatgtgg tgaggtggcg
     1321 ctgaagcggg accgctcttt ttcggaacac gacctggccc agcttcggag tgagatggga
     1381 tctggccttc agtcagccac tcagccccca ggagggacag agcctcctcg ggtcagagca
     1441 ggcagcatgc actcctggag gcccagcacc cgagaccagg gtctctgttc tgtgagtggc
     1501 cagtctcagc ctcaccccag caacttgagc tcagcggatg gacctgaggc ttctgcacca
     1561 gatgccagac atctatggct ggagttcagc catcctgtgg agagcctggc tctgactgta
     1621 gaagaggtgg tagatgtgcg gagggtgctg gtgaaggcag agatggagaa gtttctgcag
     1681 gacaaggagc tcttcagcag ccttaagagg gggaagattt gttgctgctg ccgaaccaag
     1741 tttcccctat tttcctggcc acctacctgt ctcttctgca agagagccgt gtgcacttcc
     1801 tgtagcgtaa agatgaagat gccttccaag aagcatggac acatccctgt gtacacactt
     1861 ggtttcgaga gtctccagag ggtgccaact accaaagcct cgccagcact gaggagagac
     1921 gccttccaat gcctgcaggg accgaagtgg cggagcgtgg aggaggagtt cccccacatc
     1981 tatgcccacg gctgtgtcct caaggacgtc tgcagtgact gcaccagctt tgtggctgac
     2041 gtagtgtgct ccagccgcaa gagcgtggat gtcctcaatg ccacgccacg gcgcagccgc
     2101 cagacgcagt ccctctatgt ccccaacacc aggactctca acttccaatg actgtttgat
     2161 ggcctccctg caccccaccc tggaacacag ctgccatcag cccccctcgc gcatgtacat
     2221 atatacatat atagatacat ttataatata tatatggcct atatttat
//
