LOCUS       NM_001415681            5078 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus spire-type actin nucleation factor 1 (Spire1),
            transcript variant 1, mRNA.
ACCESSION   NM_001415681 XM_006254862
VERSION     NM_001415681.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5078)
  AUTHORS   Wen,Q., Li,N., Xiao,X., Lui,W.Y., Chu,D.S., Wong,C.K.C., Lian,Q.,
            Ge,R., Lee,W.M., Silvestrini,B. and Cheng,C.Y.
  TITLE     Actin nucleator Spire 1 is a regulator of ectoplasmic
            specialization in the testis
  JOURNAL   Cell Death Dis 9 (2), 208 (2018)
   PUBMED   29434191
  REMARK    GeneRIF: Spire 1 is an ES regulator to support germ cell
            development during spermatogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5078)
  AUTHORS   Manor,U., Bartholomew,S., Golani,G., Christenson,E., Kozlov,M.,
            Higgs,H., Spudich,J. and Lippincott-Schwartz,J.
  TITLE     A mitochondria-anchored isoform of the actin-nucleating spire
            protein regulates mitochondrial division
  JOURNAL   Elife 4, e08828 (2015)
   PUBMED   26305500
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5078)
  AUTHORS   Belin,B.J., Lee,T. and Mullins,R.D.
  TITLE     DNA damage induces nuclear actin filament assembly by Formin -2 and
            Spire-(1/2) that promotes efficient DNA repair. [corrected]
  JOURNAL   Elife 4, e07735 (2015)
   PUBMED   26287480
  REMARK    Erratum:[Elife. 2015 Oct 05;4. doi: 10.7554/eLife.11935. PMID:
            26437453]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5078)
  AUTHORS   Pleiser,S., Banchaabouchi,M.A., Samol-Wolf,A., Farley,D., Welz,T.,
            Wellbourne-Wood,J., Gehring,I., Linkner,J., Faix,J.,
            Riemenschneider,M.J., Dietrich,S. and Kerkhoff,E.
  TITLE     Enhanced fear expression in Spir-1 actin organizer mutant mice
  JOURNAL   Eur J Cell Biol 93 (5-6), 225-237 (2014)
   PUBMED   24345451
REFERENCE   5  (bases 1 to 5078)
  AUTHORS   Schuh,M.
  TITLE     An actin-dependent mechanism for long-range vesicle transport
  JOURNAL   Nat Cell Biol 13 (12), 1431-1436 (2011)
   PUBMED   21983562
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5078)
  AUTHORS   Pfender,S., Kuznetsov,V., Pleiser,S., Kerkhoff,E. and Schuh,M.
  TITLE     Spire-type actin nucleators cooperate with Formin-2 to drive
            asymmetric oocyte division
  JOURNAL   Curr Biol 21 (11), 955-960 (2011)
   PUBMED   21620703
REFERENCE   7  (bases 1 to 5078)
  AUTHORS   Kerkhoff,E., Simpson,J.C., Leberfinger,C.B., Otto,I.M., Doerks,T.,
            Bork,P., Rapp,U.R., Raabe,T. and Pepperkok,R.
  TITLE     The Spir actin organizers are involved in vesicle transport
            processes
  JOURNAL   Curr Biol 11 (24), 1963-1968 (2001)
   PUBMED   11747823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Dec 22, 2022 this sequence version replaced XM_006254862.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.50549.1,
                                           SRR26643287.35192.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-490               JAXUCZ010000018.1  63441045-63441534   c
            491-525             JAXUCZ010000018.1  63418551-63418585   c
            526-759             JAXUCZ010000018.1  63378876-63379109   c
            760-885             JAXUCZ010000018.1  63372156-63372281   c
            886-963             JAXUCZ010000018.1  63354090-63354167   c
            964-1128            JAXUCZ010000018.1  63351672-63351836   c
            1129-1215           JAXUCZ010000018.1  63345995-63346081   c
            1216-1345           JAXUCZ010000018.1  63345327-63345456   c
            1346-1518           JAXUCZ010000018.1  63333094-63333266   c
            1519-1609           JAXUCZ010000018.1  63329124-63329214   c
            1610-1752           JAXUCZ010000018.1  63326820-63326962   c
            1753-1926           JAXUCZ010000018.1  63324609-63324782   c
            1927-2064           JAXUCZ010000018.1  63320825-63320962   c
            2065-2135           JAXUCZ010000018.1  63320026-63320096   c
            2136-2163           JAXUCZ010000018.1  63318604-63318631   c
            2164-2300           JAXUCZ010000018.1  63318379-63318515   c
            2301-5078           JAXUCZ010000018.1  63311800-63314577   c
FEATURES             Location/Qualifiers
     source          1..5078
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..5078
                     /gene="Spire1"
                     /note="spire-type actin nucleation factor 1"
                     /db_xref="GeneID:307348"
                     /db_xref="RGD:1305892"
     exon            1..490
                     /gene="Spire1"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..2559
                     /gene="Spire1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein spire homolog 1"
                     /codon_start=1
                     /product="protein spire homolog 1 isoform 1"
                     /protein_id="NP_001402610.1"
                     /db_xref="GeneID:307348"
                     /db_xref="RGD:1305892"
                     /translation="MAQPSSPGGEGPQLGATGDPRDALSLEEILRLYNQPINEEQAWA
                     VCFQCCGSLRAAARRQPHRRVRSAAQIRVWRDGAVTLAPAADEEGEPPPASGKLGYSH
                     CTETEVIESLGIIIYKALDYGLKENEERELSPPLEQLIDQMANTSEADGSNDEGYEAA
                     DEGPDEEDGERRSSAAIRSYQDVMKICAAHLPTESEAPNHYQAVCRALFAETMELHTF
                     LTKIKSAKENLKKIQEMEKSDDCSTDLEDLKNADWARFWVQVMRDLRNGVKLKKVQQR
                     QYNPLPIEYQLTPYEMLMDDIRCKRYTLRKVMVNGDIPPRLRKSAHEIILDFIRSRPP
                     LNPASARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLDVTTPESPKNVG
                     KSSVVNGDLTSQTKENGLGAAQPGPAQPKRLLKAPTLAELDSSDSEEETLHKSTSSSS
                     ASPSLYEDPVLEAMCSKKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPP
                     SRQSSRSLVPRITSVWPRTPFRPLFSAIQTASLLSSHPFEAAMFGVAGAMYYLFERAF
                     TSRWKPSKEEFCYPVECLALTVEEVMHIRQVLVKAELEKYQQYKDVYTALKKGKLCFC
                     CRTRRFSFFTWSYTCQFCKRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESCSR
                     SEKPSTGHHRPLRSITRFSSKSKSVDKSDEELQFPKEFMEDWSTMEVCVDCKKFISEI
                     ISSSRRSLVLANKRARLKRKTQSFYMSSAGPSEYCPSERTINEI"
     exon            491..525
                     /gene="Spire1"
                     /inference="alignment:Splign:2.1.0"
     exon            526..759
                     /gene="Spire1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..885
                     /gene="Spire1"
                     /inference="alignment:Splign:2.1.0"
     exon            886..963
                     /gene="Spire1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1128
                     /gene="Spire1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1215
                     /gene="Spire1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1345
                     /gene="Spire1"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1518
                     /gene="Spire1"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1609
                     /gene="Spire1"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1752
                     /gene="Spire1"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1926
                     /gene="Spire1"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2064
                     /gene="Spire1"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2135
                     /gene="Spire1"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2163
                     /gene="Spire1"
                     /inference="alignment:Splign:2.1.0"
     exon            2164..2300
                     /gene="Spire1"
                     /inference="alignment:Splign:2.1.0"
     exon            2301..5078
                     /gene="Spire1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggacgcc atcgccgtgc taccggccgg ctgcgtgctg gtcagcaccg agcgccgcgg
       61 tgtccccgcc tagtccccgc ggcggcgcgc agccggcctg ggcggcggca gcccgggatg
      121 cggaggcggc ggctcgtaga gacgatgctc cagcgctgag gagacgcggc agccgagcgc
      181 cggcggcgca gcgacgtggg ccgcatggcg cagccctcaa gcccgggcgg cgaggggccg
      241 cagctcggcg cgacagggga cccgcgcgac gcgctgagct tggaagagat cctgcggctc
      301 tacaaccagc ccatcaacga ggagcaggcg tgggccgtgt gcttccagtg ctgcggctcc
      361 ctgcgcgccg ccgcccgccg ccagccccac cgccgcgtgc gctcggccgc gcagatccgc
      421 gtctggaggg acggcgccgt caccctggcg cccgccgcgg acgaggaggg agagccgccc
      481 cctgcctccg gtaaattggg atattcacat tgtacagaaa cagaggttat cgaatccctg
      541 ggaattatta tttataaagc actggactat ggcttgaagg aaaatgaaga gagggagctg
      601 agccctcctc tcgagcagct catcgaccaa atggccaata cctcggaggc ggatggaagc
      661 aatgatgaag ggtacgaggc agcagatgaa ggcccagacg aggaagatgg agagaggaga
      721 agcagcgcag ccattcggtc ctatcaagat gtcatgaaga tatgtgctgc tcatctcccc
      781 actgagtcgg aggcaccgaa tcattatcag gcagtatgtc gggcactgtt tgcagaaacc
      841 atggaactgc atacgtttct gaccaaaatt aagagtgcga aggagaacct taagaagatt
      901 caagaaatgg aaaagagtga tgactgtagc acagatctgg aggacctgaa aaatgcagac
      961 tgggcacggt tctgggtaca ggtgatgagg gatttgcgaa atggggtaaa acttaagaaa
     1021 gtccaacagc ggcagtacaa cccattgccc attgaatacc agctcacccc gtatgagatg
     1081 ctcatggacg acattcggtg caaaagatac accttgagaa aagtaatggt aaatggtgac
     1141 attccccctc ggttaagaaa gagtgctcat gagatcatcc tcgacttcat cagatcaaga
     1201 ccccctttaa atccagcttc agccagaaaa ctgaaaccaa ccccaccacg gccacggagc
     1261 ctccatgaaa gaatactaga agaaattaaa gcagaaagaa agcttcggcc tgtctcacca
     1321 gaagaaatta gacggagcag actagatgtt actacaccag aatctccaaa gaatgtgggg
     1381 aaatcatctg tggtgaatgg agacttaaca tctcaaacga aagaaaatgg gctgggtgct
     1441 gcccagccgg ggcctgcaca gccaaagagg ctcctcaaag ccccgacgct ggctgagctg
     1501 gacagctctg actctgagga ggaaactctg cacaagtcaa ccagcagcag cagtgcatct
     1561 ccctccctct atgaggaccc agtactggag gccatgtgct ccaagaagaa gcctccaaaa
     1621 ttcttgccca tctcatcaac accccagccc gagagaaggc aaccaccaca gaggcgccac
     1681 tccattgaga aggaaactcc tacaaatgtg aggcagtttc tgcccccatc caggcagagc
     1741 tcacgttctc ttgttcctag gataaccagt gtatggccaa ggacgccttt ccgaccactt
     1801 ttctctgcca tacaaacagc ttctctgctg agctctcatc cttttgaagc agccatgttt
     1861 ggggtagcag gggctatgta ttatctgttt gagagagctt ttaccagcag gtggaaaccc
     1921 tcaaaggagg aattctgcta cccagtggaa tgcctcgctc tcactgtgga ggaagtgatg
     1981 cacattcgtc aggtcctggt gaaagcggag ctggaaaagt accaacagta taaggatgtc
     2041 tacactgccc tgaaaaaagg aaagctctgc ttctgttgcc gaacccggag gttttccttc
     2101 ttcacctggt cctacacctg tcagttctgt aagaggcccg tgtgctcaca gtgttgcaaa
     2161 aagatgcggc tgccttcgaa gccatactcc actttaccta tcttctcttt gggaccttct
     2221 gccttgcaaa gaggggaaag ttgttcgagg tcagaaaaac cttctactgg tcaccatcgg
     2281 ccgcttcgaa gtattaccag attctcttca aaatcaaagt ctgtggacaa atcagatgaa
     2341 gaactccagt ttcccaaaga gttcatggaa gattggagca caatggaggt gtgtgtagac
     2401 tgcaaaaagt tcatttcaga gatcatcagc tcaagccggc gcagcctggt gttggccaac
     2461 aaaagagcca ggttgaaaag gaagacacag tctttctaca tgtcctcagc gggcccctcg
     2521 gagtactgcc cttcagaacg gactatcaac gagatctgag ccctgtgcct tcccgttctt
     2581 tgtgtccaga ggcgggcagt gcagcagggc tgcaggactg actctcttcc caggggttta
     2641 cttcccaggc tccgtcggca gcagctcagg cttgggctgt accatgagac acagactcaa
     2701 ggctgtattc ctatcagctg atggtacgcg gcaggtcagc cacttgttca tttgcactca
     2761 gaaagcctaa aacttgattt tgtgtatgtg agtagggaag ccagaaactt ccttagttcg
     2821 gttcctcaat gttcttcgga taatttcctg actaaggcaa aaagcttctt gtgtgtgaag
     2881 tcagtctgct ggagtgttga cgttagcaca gttgtaagca gtaagtcaca ctgcattcca
     2941 caccacagtg tccctatctc atgcacagac agagtggccc aaagccctgc cacacaccgg
     3001 ctccctgggg tgggccaggt tggttcagtc tcacagcaca agtctagaag gccttgatga
     3061 taattctctt ttggggctct gctacatcca gtgcggaaca atcatgtaag ctgtacactg
     3121 catgggtagc cacttctctg agctcggggt ctgcccaggc acaagcctca gtgtttcctg
     3181 agctgctaac aggcctattg tgaatgtatt acggttttgg atagttttat aacacatgtc
     3241 taagaattaa gactttgtgg acgtttgagg aaaaaggaag actacagttt tgtcaagcag
     3301 ctgagcaggt gtggtaactg ataggctgta acagcagggg tgccagcaga aaggagctgt
     3361 gtctcctacc ttttcaccta cattttccat aactttatag tgtggccatc gtgactaaat
     3421 taaccacagt ttggtacctg agtctcaaac tgaaatttat ttttataaat gaattttaaa
     3481 agaaaaacct tggctgtttt aaaatttcaa gaaaattaat ctgctgccat gcataatttt
     3541 ttgatgcttt ttgcactagt tgtcttgtaa atgtcactga gtttctgatg aagggtgact
     3601 gacaggtagt gttgtgtgcc tgaaattcct cagctcctgt gacacatatc atggctgccc
     3661 ctcacttcca caagcttagt tagaaataac cagtcaacca aatcaccact aatgtttgga
     3721 aaatgatgta aagcacatgc acagtctaac tcctgaaagc tataaaaacc caccatcgta
     3781 atcaccactg atgacagttc tgtttaataa aaggcatgac agctgcattt cataccaaca
     3841 tccagacagt aacatttccc attaaattga cagcaacacc tcagaaatgc tccaacagtc
     3901 atttctaatg cactggaatt tatagtttag taaatggctt taaattcctt atactgacga
     3961 aataaacttt accagttgac tgatttaatg catgttagta gttcatctgt atgcatgtag
     4021 aagtgggccg ccagaaaacc ctcacattcc agctattttt aagactaaga gctgtaaaaa
     4081 ttgcagtgtg tgaattccgt ttctacagtt ttcctgaaga ccaccagaac tttagactgc
     4141 agttaggtgg gaccactgct gctatggccc caggtctgta ttctaaaatg atctcctgga
     4201 aggaagcaag gaagaaggag tatacctgtg tgggtttata agcatgcata tagggtaaca
     4261 tgcttctgca aaatggtgac tagtgtttga cttcccacgt aagatacgga gcccacaact
     4321 ccacaagtga aaattgtatt cacattcaca actcagtgat ctagtaactg tcacacattt
     4381 gactccattc cttcaggcgc acagcactgt gcacagtgtt ttgaacatta cggccccttg
     4441 taccagaaca tcaggatata aattcttcag cacattaatg gatttgccaa ctgtgttagg
     4501 agttcaagta tatgccatgc ccagtaaaca acctgcaggg aatagtggaa aaaatggcag
     4561 gtggcaaggt agaaattaca gaaataaaat taacattgtt tgggagacac caaaaaaaaa
     4621 aaaatgtgca tttaactgtg tcttttctgc aagactgact cttcccctca gcactcatac
     4681 taaactaggg ttccataggc tagggctttg gccagagagc gggtgctgcc agtgtggctc
     4741 gattaaagtc ctagctgaca acagttagag tttcctgctc ctccagtaac cttgtgcagg
     4801 gccccttgtc ctgcttccct gctgtgttgc tctctccgat caacagttgt ttatggctga
     4861 ccccagagtc cgatgcctct cctggataca gctgtacgtc gttcctgagc ctccaagtgt
     4921 gagcaccaac cagtggtccc atgtccctga ggtcgagtat gtaaaactgc tgtaaatatt
     4981 gtaacatact cattaatatt tgaaaggcat tttgtcattg gcaatggaaa ttaattctcc
     5041 caagataagt aaaattaaat aattgatttg cacattga
//
