LOCUS       NM_001082549            1401 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus serine peptidase inhibitor, Kunitz type, 2
            (Spint2), transcript variant 1, mRNA.
ACCESSION   NM_001082549
VERSION     NM_001082549.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1401)
  AUTHORS   Koivuniemi R, Makela J, Hokkanen ME, Bruelle C, Ho TH, Ola R,
            Korhonen L, Schroder J, Kataoka H and Lindholm D.
  TITLE     Hepatocyte growth factor activator inhibitor-1 is induced by bone
            morphogenetic proteins and regulates proliferation and cell fate of
            neural progenitor cells
  JOURNAL   PLoS One 8 (2), e56117 (2013)
   PUBMED   23409135
REFERENCE   2  (bases 1 to 1401)
  AUTHORS   Huang HP, Chang MH, Chen YT, Hsu HY, Chiang CL, Cheng TS, Wu YM, Wu
            MZ, Hsu YC, Shen CC, Lee CN, Chuang YH, Hong CL, Jeng YM, Chen PH,
            Chen HL and Lee MS.
  TITLE     Persistent elevation of hepatocyte growth factor activator
            inhibitors in cholangiopathies affects liver fibrosis and
            differentiation
  JOURNAL   Hepatology 55 (1), 161-172 (2012)
   PUBMED   21898507
REFERENCE   3  (bases 1 to 1401)
  AUTHORS   Szabo R, Hobson JP, Christoph K, Kosa P, List K and Bugge TH.
  TITLE     Regulation of cell surface protease matriptase by HAI2 is essential
            for placental development, neural tube closure and embryonic
            survival in mice
  JOURNAL   Development 136 (15), 2653-2663 (2009)
   PUBMED   19592578
REFERENCE   4  (bases 1 to 1401)
  AUTHORS   Heinz-Erian P, Muller T, Krabichler B, Schranz M, Becker C,
            Ruschendorf F, Nurnberg P, Rossier B, Vujic M, Booth IW, Holmberg
            C, Wijmenga C, Grigelioniene G, Kneepkens CM, Rosipal S, Mistrik M,
            Kappler M, Michaud L, Doczy LC, Siu VM, Krantz M, Zoller H,
            Utermann G and Janecke AR.
  TITLE     Mutations in SPINT2 cause a syndromic form of congenital sodium
            diarrhea
  JOURNAL   Am J Hum Genet 84 (2), 188-196 (2009)
   PUBMED   19185281
REFERENCE   5  (bases 1 to 1401)
  AUTHORS   Itoh H, Kataoka H, Yamauchi M, Naganuma S, Akiyama Y, Nuki Y,
            Shimomura T, Miyazawa K, Kitamura N and Koono M.
  TITLE     Identification of hepatocyte growth factor activator inhibitor type
            2 (HAI-2)-related small peptide (H2RSP): its nuclear localization
            and generation of chimeric mRNA transcribed from both HAI-2 and
            H2RSP genes
  JOURNAL   Biochem Biophys Res Commun 288 (2), 390-399 (2001)
   PUBMED   11606055
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN934634.1 and BC061768.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-747               DN934634.1         30-776
            748-1401            BC061768.1         577-1230
FEATURES             Location/Qualifiers
     source          1..1401
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1401
                     /gene="Spint2"
                     /gene_synonym="HAI-2; Pb"
                     /note="serine peptidase inhibitor, Kunitz type, 2"
                     /db_xref="GeneID:292770"
                     /db_xref="RGD:735123"
     exon            1..391
                     /gene="Spint2"
                     /gene_synonym="HAI-2; Pb"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..1038
                     /gene="Spint2"
                     /gene_synonym="HAI-2; Pb"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; hepatocyte growth factor activator inhibitor
                     type 2; placental bikunin; serine protease inhibitor,
                     Kunitz type 2; kunitz-type protease inhibitor 2"
                     /codon_start=1
                     /product="kunitz-type protease inhibitor 2 isoform a
                     precursor"
                     /protein_id="NP_001076018.1"
                     /db_xref="GeneID:292770"
                     /db_xref="RGD:735123"
                     /translation="MAQLCEPRRGRALLALLASLLLSGAQAASRDLDVHESCGVSKVV
                     GKCRASIPRWWYNVTDGTCQPFVYGGCEGNGNNYPSKEECLDKCAGITENTIDGLARS
                     SDGASALSVPRKQDSADLAGEIFNYEEYCVPKAVTGPCRAAFPRWYYDVEKNSCSSFI
                     YGGCRGNKNSYLSQEACMQHCSGKQMYPFLTPGTKAVILVGLFIMVLILLLGSSMVFL
                     IRMVRRKQERALRTVWSTADDKEQLVKNTCVL"
     exon            392..562
                     /gene="Spint2"
                     /gene_synonym="HAI-2; Pb"
                     /inference="alignment:Splign:2.1.0"
     exon            563..616
                     /gene="Spint2"
                     /gene_synonym="HAI-2; Pb"
                     /inference="alignment:Splign:2.1.0"
     exon            617..670
                     /gene="Spint2"
                     /gene_synonym="HAI-2; Pb"
                     /inference="alignment:Splign:2.1.0"
     exon            671..832
                     /gene="Spint2"
                     /gene_synonym="HAI-2; Pb"
                     /inference="alignment:Splign:2.1.0"
     exon            833..871
                     /gene="Spint2"
                     /gene_synonym="HAI-2; Pb"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1345
                     /gene="Spint2"
                     /gene_synonym="HAI-2; Pb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcccctcca acgggtggag gcctccctag tctggggaga gtggcagagt gttgccgggc
       61 gtccagggac cgtgttggga ggcaactaag gcgtcgcacg cgccaaaagc cagaaaaagg
      121 ggcttccggg aacccgggcg cctcgaagtc ctctgcgggg cgaagccgca cctgagctcg
      181 cgggcctgca gtgcgcgtgc gcggccgtgg gctttcccgc acctgctcgc gagaccctca
      241 acggccggcg gctcgacgac tggcgcgcgg cgcgggcagc aggttatggc gcagctatgt
      301 gagccgcggc ggggccgggc gcttctcgcc ctgttagcct cgctgcttct ctccggggcc
      361 caggcggcca gcagagacct agacgtccac gagtcttgtg gagtttcgaa ggtagtgggg
      421 aaatgccggg cttccatccc caggtggtgg tacaatgtca ctgatgggac ctgccagccc
      481 tttgtttatg gaggctgtga gggaaatggt aacaactatc caagcaagga ggagtgtctt
      541 gacaagtgtg ctggtatcac tgagaacacc attgatggtc tggccaggag cagtgatggc
      601 gcttctgccc tgagcgttcc cagaaagcag gattctgcgg acctcgctgg tgagatcttc
      661 aactatgaag aatactgtgt cccaaaggcg gtcactgggc cttgccgcgc agccttccct
      721 cgctggtact atgatgttga aaagaattcc tgtagcagct tcatctatgg cgggtgcaga
      781 ggcaacaaga acagttacct ctcccaggaa gcgtgcatgc agcactgctc tgggaagcag
      841 atgtatcctt tcctgacccc gggcacaaaa gcggtgatcc tggtggggct gttcatcatg
      901 gtcctgatcc tcctcctggg atcctccatg gtgttcctga tccgaatggt tcgcagaaag
      961 caggagcgtg ctctccgcac tgtttggagc actgcggatg acaaggagca gctggtgaag
     1021 aatacctgtg tcttgtagag gccccagttc tcagagagcc tgggggacac catgacagag
     1081 caacgcttgt gcctgagatc attagggagt ttggtctttg tttcccagcc tgtgggctgc
     1141 gtagagcctc ttcctgacct ccctccccac agccctctgc ccttccccac ctatcgcctc
     1201 cttcagcgtc actaggagcc ccattcctgt agtcttaact gtttgcttga tttatatgtc
     1261 tgttttttag tagataaagg ttttttaaaa atcaggattc tgaaagaaag aatgtgttta
     1321 ataaagtggg ccttttaaat taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1381 aaaaaaaaaa aaaaaaaaaa a
//
