LOCUS       NM_001004265            2321 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus serine peptidase inhibitor, Kunitz type 1
            (Spint1), mRNA.
ACCESSION   NM_001004265 XM_230470
VERSION     NM_001004265.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2321)
  AUTHORS   Walentin,K., Hinze,C., Werth,M., Haase,N., Varma,S., Morell,R.,
            Aue,A., Potschke,E., Warburton,D., Qiu,A., Barasch,J., Purfurst,B.,
            Dieterich,C., Popova,E., Bader,M., Dechend,R., Staff,A.C.,
            Yurtdas,Z.Y., Kilic,E. and Schmidt-Ott,K.M.
  TITLE     A Grhl2-dependent gene network controls trophoblast branching
            morphogenesis
  JOURNAL   Development 142 (6), 1125-1136 (2015)
   PUBMED   25758223
REFERENCE   2  (bases 1 to 2321)
  AUTHORS   Koivuniemi,R., Makela,J., Hokkanen,M.E., Bruelle,C., Ho,T.H.,
            Ola,R., Korhonen,L., Schroder,J., Kataoka,H. and Lindholm,D.
  TITLE     Hepatocyte growth factor activator inhibitor-1 is induced by bone
            morphogenetic proteins and regulates proliferation and cell fate of
            neural progenitor cells
  JOURNAL   PLoS One 8 (2), e56117 (2013)
   PUBMED   23409135
  REMARK    GeneRIF: HAI-1 and HAI-2 influence proliferation and cell fate of
            NPCs and their expression levels are linked to BMP sign
REFERENCE   3  (bases 1 to 2321)
  AUTHORS   Huang,H.P., Chang,M.H., Chen,Y.T., Hsu,H.Y., Chiang,C.L.,
            Cheng,T.S., Wu,Y.M., Wu,M.Z., Hsu,Y.C., Shen,C.C., Lee,C.N.,
            Chuang,Y.H., Hong,C.L., Jeng,Y.M., Chen,P.H., Chen,H.L. and
            Lee,M.S.
  TITLE     Persistent elevation of hepatocyte growth factor activator
            inhibitors in cholangiopathies affects liver fibrosis and
            differentiation
  JOURNAL   Hepatology 55 (1), 161-172 (2012)
   PUBMED   21898507
REFERENCE   4  (bases 1 to 2321)
  AUTHORS   Inouye,K., Tsuzuki,S., Yasumoto,M., Kojima,K., Mochida,S. and
            Fushiki,T.
  TITLE     Identification of the matriptase second CUB domain as the secondary
            site for interaction with hepatocyte growth factor activator
            inhibitor type-1
  JOURNAL   J Biol Chem 285 (43), 33394-33403 (2010)
   PUBMED   20682770
  REMARK    GeneRIF: Identification of the matriptase second CUB domain as the
            secondary site for interaction with hepatocyte growth factor
            activator inhibitor type-1.
REFERENCE   5  (bases 1 to 2321)
  AUTHORS   Szabo,R., Hobson,J.P., Christoph,K., Kosa,P., List,K. and
            Bugge,T.H.
  TITLE     Regulation of cell surface protease matriptase by HAI2 is essential
            for placental development, neural tube closure and embryonic
            survival in mice
  JOURNAL   Development 136 (15), 2653-2663 (2009)
   PUBMED   19592578
REFERENCE   6  (bases 1 to 2321)
  AUTHORS   Kaido,T., Oe,H., Yoshikawa,A., Okajima,A. and Imamura,M.
  TITLE     Expressions of molecules associated with hepatocyte growth factor
            activation after hepatectomy in liver cirrhosis
  JOURNAL   Hepatogastroenterology 51 (56), 547-551 (2004)
   PUBMED   15086199
REFERENCE   7  (bases 1 to 2321)
  AUTHORS   Parr,C., Watkins,G., Mansel,R.E. and Jiang,W.G.
  TITLE     The hepatocyte growth factor regulatory factors in human breast
            cancer
  JOURNAL   Clin Cancer Res 10 (1 Pt 1), 202-211 (2004)
   PUBMED   14734471
REFERENCE   8  (bases 1 to 2321)
  AUTHORS   Kirchhofer,D., Peek,M., Li,W., Stamos,J., Eigenbrot,C.,
            Kadkhodayan,S., Elliott,J.M., Corpuz,R.T., Lazarus,R.A. and
            Moran,P.
  TITLE     Tissue expression, protease specificity, and Kunitz domain
            functions of hepatocyte growth factor activator inhibitor-1B
            (HAI-1B), a new splice variant of HAI-1
  JOURNAL   J Biol Chem 278 (38), 36341-36349 (2003)
   PUBMED   12815039
REFERENCE   9  (bases 1 to 2321)
  AUTHORS   Oberst,M.D., Johnson,M.D., Dickson,R.B., Lin,C.Y., Singh,B.,
            Stewart,M., Williams,A., al-Nafussi,A., Smyth,J.F., Gabra,H. and
            Sellar,G.C.
  TITLE     Expression of the serine protease matriptase and its inhibitor
            HAI-1 in epithelial ovarian cancer: correlation with clinical
            outcome and tumor clinicopathological parameters
  JOURNAL   Clin Cancer Res 8 (4), 1101-1107 (2002)
   PUBMED   11948120
REFERENCE   10 (bases 1 to 2321)
  AUTHORS   Yamada,T., Tsujioka,Y., Taguchi,J., Takahashi,M., Tsuboi,Y. and
            Shimomura,T.
  TITLE     White matter astrocytes produce hepatocyte growth factor activator
            inhibitor in human brain tissues
  JOURNAL   Exp Neurol 153 (1), 60-64 (1998)
   PUBMED   9743567
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097253.1.
            
            [WARNING] On Aug 9, 2024 this sequence was replaced by
            NM_001004265.3.
            
            On Jun 12, 2005 this sequence version replaced NM_001004265.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097253.1, AB154834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2321
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..2321
                     /gene="Spint1"
                     /gene_synonym="HAI-1"
                     /note="serine peptidase inhibitor, Kunitz type 1"
                     /db_xref="GeneID:311331"
                     /db_xref="RGD:1303138"
     exon            1..684
                     /gene="Spint1"
                     /gene_synonym="HAI-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1751
                     /gene="Spint1"
                     /gene_synonym="HAI-1"
                     /note="hepatocyte growth factor activator inhibitor-1;
                     serine protease inhibitor, Kunitz type 1; kunitz-type
                     protease inhibitor 1"
                     /codon_start=1
                     /product="kunitz-type protease inhibitor 1 precursor"
                     /protein_id="NP_001004265.2"
                     /db_xref="GeneID:311331"
                     /db_xref="RGD:1303138"
                     /translation="MAARRLAQASISTVCVWLLCALGLQGTETELPSAPPEFSGGAAC
                     LNRFTSGVPAFVLDTEASVSNGATFLGSPTVHRGWDCVRACCTTQNCNLALVELQPDG
                     GEDAISACFLMNCLYEQNFVCKFAPKDGFINYLTQDLYNSYRELRTRGFGGSRIPRIW
                     MGIDLKVQLQKPLVLRDADNTDWHLLQGDQDVSVKRNHPEEVELWGLKEGTYLFQLTR
                     TDSDQLEETVNLTITVLTAEQTEDYCLASYKVGRCRGSFPRWYYDPKEQICKSFTFGG
                     CLGNKNNYLREEECMLACKDVKGISPKRHHPVCTGSCHSTQFQCSNGCCIDGFLECDD
                     TPDCPDGSDEATCEKYSSGFDELQSIHFLSDKGYCAELPDTGFCKENIPRWYYNPFSE
                     RCARFTYGGCYGNKNNFEKEQQCLESCRGISKKDVFGLRRESSVPSAGSVEVAIAVLL
                     AVCIIVVLTILGYCFFKNQKKNFHSPLHQPPPTPASSTVSTTEDTEHLVYNHTTQPL"
     exon            685..812
                     /gene="Spint1"
                     /gene_synonym="HAI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            813..951
                     /gene="Spint1"
                     /gene_synonym="HAI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1122
                     /gene="Spint1"
                     /gene_synonym="HAI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1149
                     /gene="Spint1"
                     /gene_synonym="HAI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1275
                     /gene="Spint1"
                     /gene_synonym="HAI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1326
                     /gene="Spint1"
                     /gene_synonym="HAI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1497
                     /gene="Spint1"
                     /gene_synonym="HAI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1545
                     /gene="Spint1"
                     /gene_synonym="HAI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..2290
                     /gene="Spint1"
                     /gene_synonym="HAI-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagctcccga gcggtgctct gcccgacgtc gggttcgagt gtgcgtggac ggataggccc
       61 gcgtgcgcct gctcgttccc agtgccccgc gccactaccc gagctgatca ggtgcgtctc
      121 ttgtgtctcc tcccctctca ggtcacaagc accctcggaa cccagaggcc cgcactgtga
      181 aggtgactcc cgccttgggg aggagggcga cggcccctgg gagcacgatg gcggcccgcc
      241 gcctggcgca ggccagcatc tctacggtct gcgtatggct cctttgcgcg cttggtctcc
      301 agggcactga gaccgagctg ccgtccgcac cccctgagtt ttccggggga gccgcctgct
      361 tgaaccgctt taccagcggg gtgccggctt ttgtgttgga caccgaagct tcagtcagca
      421 acggggccac cttcctgggt tccccgacgg tgcaccgcgg ctgggactgc gtgcgtgcct
      481 gctgcaccac ccaaaactgt aacctggcgc tggtggagct gcagccggac ggaggcgagg
      541 acgccatctc tgcctgcttc ctcatgaact gcctgtatga gcagaacttc gtgtgcaaat
      601 tcgctccgaa ggacggcttc atcaactatc ttacccaaga tctttacaac tcctaccgcg
      661 agctgcgaac tcgaggcttt ggaggttccc ggatccctcg aatctggatg ggcatagact
      721 tgaaggtgca gctgcagaag cccctggtac tgagagatgc agacaacaca gactggcatc
      781 tactgcaagg tgaccaagat gtcagtgtta agagaaacca tccagaagaa gttgagctgt
      841 ggggacttaa ggagggaacc tacctgttcc aactgacaag aaccgactca gaccagctag
      901 aggaaacagt caacctgact atcaccgtgc taactgccga gcagacggaa gattattgcc
      961 tcgcatccta caaggtgggc cgctgccggg gctccttccc acgctggtac tatgacccca
     1021 aggaacagat ctgcaaaagt ttcacttttg gaggttgcct aggcaacaag aacaactacc
     1081 ttcgtgagga agagtgcatg ctagcctgca aggatgtgaa aggaatctca cctaaaaggc
     1141 atcatccagt gtgcaccggc agctgccata gcacgcagtt ccagtgcagc aatggctgct
     1201 gtatcgacgg cttcctggag tgtgatgaca cgcctgactg ccctgatggc tccgatgagg
     1261 ccacttgtga aaaatatagc agcggctttg atgaacttca gagtatccac ttcctcagtg
     1321 acaaagggta ctgtgcagag ctgccagaca ctggattttg caaggagaac atcccacgct
     1381 ggtattacaa cccattcagt gaacgctgtg cccgcttcac ctatggtggt tgctacggga
     1441 acaagaacaa ctttgagaag gaacagcagt gtcttgagtc ctgtcgtggc atctccaaga
     1501 aggatgtgtt cggtcttcgg agggaaagct ccgttcccag tgcaggctct gtggaggtag
     1561 ctattgctgt attgctggcc gtctgcatca tagtggtctt gaccatcctg ggctactgtt
     1621 tcttcaagaa ccaaaaaaag aacttccaca gccccctgca ccaaccacct cccacaccag
     1681 ccagctccac tgtttccacc actgaggaca cagagcacct ggtctataat cacacaaccc
     1741 agcctctctg agcctgggac tcttgccagt ctcaccaggt tctgtcttaa gacagaagcc
     1801 agacctggga aaacttgggg accagaatct ttctacctct tcctgggcat acttactctg
     1861 tctcaggaga cagatctctg ggcctctcag aggactctca gctgcactca ggccagttct
     1921 ggagaaggcc caggagtctg ggagaagcaa cagccttgag ccaggaatac tatacataga
     1981 aggacctgct tatccaggag ccagaggaag tttgtgtttt tcatcttgtt caaagctgcc
     2041 tgcccccatc caatgacgct agggccgtga gtggagtcgg aggccagaag ccacacactg
     2101 ccttccacga tgtcctccac tctgcacagg cctgcactga aggacatggc tttgtagttt
     2161 atgctgtaaa taattgcttt tggggcccca gggtcatagc tcagtggtag cgtgtgtatg
     2221 gtcaccctca gtgctctaca cggcaccaca aattacatta aattaaagaa taaaatgttg
     2281 tgtttgtcca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
