LOCUS       NM_001395746             586 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus serine peptidase inhibitor, Kazal type 6
            (Spink6), transcript variant 1, mRNA.
ACCESSION   NM_001395746 XM_003752044
VERSION     NM_001395746.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 586)
  AUTHORS   Fischer,J., Wu,Z., Kantyka,T., Sperrhacke,M., Dimitrieva,O.,
            Koblyakova,Y., Ahrens,K., Graumann,N., Baurecht,H., Reiss,K.,
            Schroder,J.M., Proksch,E. and Meyer-Hoffert,U.
  TITLE     Characterization of Spink6 in mouse skin: the conserved inhibitor
            of kallikrein-related peptidases is reduced by barrier injury
  JOURNAL   J Invest Dermatol 134 (5), 1305-1312 (2014)
   PUBMED   24352040
REFERENCE   2  (bases 1 to 586)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Aug 4, 2021 this sequence version replaced XM_003752044.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               JAXUCZ010000018.1  36648725-36648859
            136-158             JAXUCZ010000018.1  36651492-36651514
            159-233             JAXUCZ010000018.1  36657220-36657294
            234-349             JAXUCZ010000018.1  36659541-36659656
            350-586             JAXUCZ010000018.1  36660666-36660902
FEATURES             Location/Qualifiers
     source          1..586
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..586
                     /gene="Spink6"
                     /gene_synonym="Spink5l1"
                     /note="serine peptidase inhibitor, Kazal type 6"
                     /db_xref="GeneID:408235"
                     /db_xref="RGD:1303338"
     exon            1..135
                     /gene="Spink6"
                     /gene_synonym="Spink5l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..395
                     /gene="Spink6"
                     /gene_synonym="Spink5l1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; serine protease inhibitor Kazal-type 6; Kazal
                     type serine protease inhibitor 1; serine protease
                     inhibitor Kazal-type 6-like"
                     /codon_start=1
                     /product="serine protease inhibitor Kazal-type 6 isoform 1
                     precursor"
                     /protein_id="NP_001382675.1"
                     /db_xref="GeneID:408235"
                     /db_xref="RGD:1303338"
                     /translation="MKVAGVFLLLSLALLCFFSGAFSQGGQDKRGWITRSEGRFPGKG
                     VLRHRLFQINCGEFRDPKVFCTRESDPLCGSDGQTYGNKCAFCKALEKSSGKINLKHR
                     GKC"
     exon            136..158
                     /gene="Spink6"
                     /gene_synonym="Spink5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            159..233
                     /gene="Spink6"
                     /gene_synonym="Spink5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            234..349
                     /gene="Spink6"
                     /gene_synonym="Spink5l1"
                     /inference="alignment:Splign:2.1.0"
     exon            350..586
                     /gene="Spink6"
                     /gene_synonym="Spink5l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggtttctg ggaagtatct tgacagagaa cctaagctga gcaaagcagc cttgatctga
       61 gtgagctaac tggcaccatg aaagtagcag gtgtctttct gctcctctct ctggctcttc
      121 tctgcttttt ctcaggtgcc ttcagtcaag gaggacagga caaaagaggc tggatcacaa
      181 gatcagaggg ccgatttcca gggaaaggtg tcttaaggca tcgtctcttt caaattaatt
      241 gtggtgagtt ccgtgatccc aaggtcttct gcactcggga atctgaccca ctctgtggct
      301 ctgatggcca gacatatggg aataaatgtg ccttctgcaa ggcattggag aaaagttctg
      361 gaaagatcaa cctgaagcat cgtgggaaat gctgaattag agctggtgtt ttatgccagc
      421 ttccctgtct tctctcatcc ttattttttt atttttcctt tttttctcta acaaacacca
      481 taaattcata aataataaaa cagagcttct tctccatatg agtcttatgt aggtcacaat
      541 gtctatttcc tttgatttgt caataaagaa aattctgcag aattga
//
