LOCUS       NP_001382675             105 aa            linear   ROD 30-APR-2025
DEFINITION  serine protease inhibitor Kazal-type 6 isoform 1 precursor [Rattus
            norvegicus].
ACCESSION   NP_001382675 XP_003752092
VERSION     NP_001382675.1
DBSOURCE    REFSEQ: accession NM_001395746.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 105)
  AUTHORS   Fischer,J., Wu,Z., Kantyka,T., Sperrhacke,M., Dimitrieva,O.,
            Koblyakova,Y., Ahrens,K., Graumann,N., Baurecht,H., Reiss,K.,
            Schroder,J.M., Proksch,E. and Meyer-Hoffert,U.
  TITLE     Characterization of Spink6 in mouse skin: the conserved inhibitor
            of kallikrein-related peptidases is reduced by barrier injury
  JOURNAL   J Invest Dermatol 134 (5), 1305-1312 (2014)
   PUBMED   24352040
REFERENCE   2  (residues 1 to 105)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Aug 4, 2021 this sequence version replaced XP_003752092.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..105
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     Protein         1..105
                     /product="serine protease inhibitor Kazal-type 6 isoform 1
                     precursor"
                     /note="serine protease inhibitor Kazal-type 6; Kazal type
                     serine protease inhibitor 1; serine protease inhibitor
                     Kazal-type 6-like"
                     /calculated_mol_wt=9192
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2435
     mat_peptide     24..105
                     /product="Serine protease inhibitor Kazal-type 6.
                     /id=PRO_0000016577"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IE47.1)"
                     /calculated_mol_wt=9192
     Site            24
                     /site_type="pyrrolidone-carboxylic-acid"
                     /note="Pyrrolidone carboxylic acid.
                     /evidence=ECO:0000250|UniProtKB:P01001; propagated from
                     UniProtKB/Swiss-Prot (Q6IE47.1)"
     Region          61..105
                     /region_name="Kazal_1"
                     /note="Kazal-type serine protease inhibitor domain;
                     pfam00050"
                     /db_xref="CDD:395004"
     Site            67..68
                     /site_type="other"
                     /note="Reactive bond.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00798; propagated
                     from UniProtKB/Swiss-Prot (Q6IE47.1)"
     CDS             1..105
                     /gene="Spink6"
                     /gene_synonym="Spink5l1"
                     /coded_by="NM_001395746.1:78..395"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="GeneID:408235"
                     /db_xref="RGD:1303338"
ORIGIN      
        1 mkvagvflll slallcffsg afsqggqdkr gwitrsegrf pgkgvlrhrl fqincgefrd
       61 pkvfctresd plcgsdgqty gnkcafckal ekssgkinlk hrgkc
//
