LOCUS       NM_001395750             391 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus serine peptidase inhibitor, Kazal type 4
            (Spink4), transcript variant 1, mRNA.
ACCESSION   NM_001395750 XM_006238095
VERSION     NM_001395750.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 391)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
REFERENCE   2  (bases 1 to 391)
  AUTHORS   Fuxe,K., Ostenson,C.G., Aguirre,J.A., Efendic,S., Agerberth,B. and
            Mutt,V.
  TITLE     Reserpine treatment increases PEC-60-like immunoreactivity in the
            substantia nigra of the male rat as determined by radioimmunoassay
  JOURNAL   Acta Physiol Scand 143 (3), 357-358 (1991)
   PUBMED   1772043
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Aug 5, 2021 this sequence version replaced XM_006238095.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1857896.1,
                                           SRR26643288.21808.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676788 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JAXUCZ010000005.1  60849060-60849161
            103-143             JAXUCZ010000005.1  60854635-60854675
            144-256             JAXUCZ010000005.1  60858641-60858753
            257-391             JAXUCZ010000005.1  60860689-60860823
FEATURES             Location/Qualifiers
     source          1..391
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..391
                     /gene="Spink4"
                     /gene_synonym="PEC-60"
                     /note="serine peptidase inhibitor, Kazal type 4"
                     /db_xref="GeneID:408233"
                     /db_xref="RGD:1303188"
     exon            1..102
                     /gene="Spink4"
                     /gene_synonym="PEC-60"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..302
                     /gene="Spink4"
                     /gene_synonym="PEC-60"
                     /note="Kazal type serine protease inhibitor 4; serine
                     protease inhibitor Kazal-type 4"
                     /codon_start=1
                     /product="serine protease inhibitor Kazal-type 4
                     precursor"
                     /protein_id="NP_001382679.1"
                     /db_xref="GeneID:408233"
                     /db_xref="RGD:1303188"
                     /translation="MAMHLWLVTLTLVPLLAMDRELPVSAARLVFSRMPICEHMAEFP
                     NCPRSPNLICGTDGLTYENECHLCVTRMKTKKDIQIMKDGKC"
     exon            103..143
                     /gene="Spink4"
                     /gene_synonym="PEC-60"
                     /inference="alignment:Splign:2.1.0"
     exon            144..256
                     /gene="Spink4"
                     /gene_synonym="PEC-60"
                     /inference="alignment:Splign:2.1.0"
     exon            257..391
                     /gene="Spink4"
                     /gene_synonym="PEC-60"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagcccaca gttggctgag gtcacacagc tcacaagcag aatggcgatg catctgtggt
       61 tggtcaccct gaccttggtt cccctccttg ccatggacag ggaactgccg gtgtccgcag
      121 cgaggcttgt tttctccaga atgcccatct gtgagcacat ggccgagttt ccaaactgtc
      181 cccggtcacc taacctgatc tgtggcacag atggcctcac atatgagaat gaatgccacc
      241 tctgcgtgac ccggatgaaa accaaaaagg acattcagat catgaaggac ggcaaatgct
      301 aagcccagag gagtactcaa gccatgaaac tgtatcctgg agaacggaga cgctccagag
      361 gctaggatat gaaataaagg atgcagctca a
//
