LOCUS       NM_152936                379 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus serine peptidase inhibitor, Kazal type 1-like
            (Spink1l), mRNA.
ACCESSION   NM_152936
VERSION     NM_152936.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 379)
  AUTHORS   Nathan,J.D., Romac,J., Peng,R.Y., Peyton,M., Rockey,D.C. and
            Liddle,R.A.
  TITLE     Protection against chronic pancreatitis and pancreatic fibrosis in
            mice overexpressing pancreatic secretory trypsin inhibitor
  JOURNAL   Pancreas 39 (1), e24-e30 (2010)
   PUBMED   19904222
REFERENCE   2  (bases 1 to 379)
  AUTHORS   Paju,A., Hotakainen,K., Cao,Y., Laurila,T., Gadaleanu,V.,
            Hemminki,A., Stenman,U.H. and Bjartell,A.
  TITLE     Increased expression of tumor-associated trypsin inhibitor, TATI,
            in prostate cancer and in androgen-independent 22Rv1 cells
  JOURNAL   Eur Urol 52 (6), 1670-1679 (2007)
   PUBMED   17306443
REFERENCE   3  (bases 1 to 379)
  AUTHORS   Hotakainen,K., Bjartell,A., Sankila,A., Jarvinen,R., Paju,A.,
            Rintala,E., Haglund,C. and Stenman,U.H.
  TITLE     Differential expression of trypsinogen and tumor-associated trypsin
            inhibitor (TATI) in bladder cancer
  JOURNAL   Int J Oncol 28 (1), 95-101 (2006)
   PUBMED   16327984
REFERENCE   4  (bases 1 to 379)
  AUTHORS   Shariat,S.F., Herman,M.P., Casella,R., Lotan,Y., Karam,J.A. and
            Stenman,U.H.
  TITLE     Urinary levels of tumor-associated trypsin inhibitor (TATI) in the
            detection of transitional cell carcinoma of the urinary bladder
  JOURNAL   Eur Urol 48 (3), 424-431 (2005)
   PUBMED   15963628
REFERENCE   5  (bases 1 to 379)
  AUTHORS   Paju,A., Vartiainen,J., Haglund,C., Itkonen,O., von Boguslawski,K.,
            Leminen,A., Wahlstrom,T. and Stenman,U.H.
  TITLE     Expression of trypsinogen-1, trypsinogen-2, and tumor-associated
            trypsin inhibitor in ovarian cancer: prognostic study on tissue and
            serum
  JOURNAL   Clin Cancer Res 10 (14), 4761-4768 (2004)
   PUBMED   15269150
REFERENCE   6  (bases 1 to 379)
  AUTHORS   Coronel,C.E., Winnica,D.E., Novella,M.L. and Lardy,H.A.
  TITLE     Purification, structure, and characterization of caltrin proteins
            from seminal vesicle of the rat and mouse
  JOURNAL   J Biol Chem 267 (29), 20909-20915 (1992)
   PUBMED   1400406
REFERENCE   7  (bases 1 to 379)
  AUTHORS   Tsuzuki,S., Miura,Y., Fushiki,T., Oomori,T., Satoh,T., Natori,Y.
            and Sugimoto,E.
  TITLE     Molecular cloning and characterization of genes encoding rat
            pancreatic cholecystokinin (CCK)-releasing peptide (monitor
            peptide) and pancreatic secretory trypsin inhibitor (PSTI)
  JOURNAL   Biochim Biophys Acta 1132 (2), 199-202 (1992)
   PUBMED   1390891
REFERENCE   8  (bases 1 to 379)
  AUTHORS   Leminen,A.
  TITLE     Tumor markers CA 125, carcinoembryonic antigen and tumor-associated
            trypsin inhibitor in patients with cervical adenocarcinoma
  JOURNAL   Gynecol Oncol 39 (3), 358-363 (1990)
   PUBMED   2258083
REFERENCE   9  (bases 1 to 379)
  AUTHORS   Kido,H., Yokogoshi,Y. and Katunuma,N.
  TITLE     A low-molecular-mass Kazal-type protease inhibitor isolated from
            rat hepatocytes is identical to rat pancreatic secretory trypsin
            inhibitor II. Purification and amino acid sequence
  JOURNAL   Eur J Biochem 188 (3), 501-506 (1990)
   PUBMED   2110056
REFERENCE   10 (bases 1 to 379)
  AUTHORS   Horii,A., Tomita,N., Yokouchi,H., Doi,S., Uda,K., Ogawa,M., Mori,T.
            and Matsubara,K.
  TITLE     On the cDNA's for two types of rat pancreatic secretory trypsin
            inhibitor
  JOURNAL   Biochem Biophys Res Commun 162 (1), 151-159 (1989)
   PUBMED   2751646
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M27883.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M27883.1, FQ106158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..379
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..379
                     /gene="Spink1l"
                     /gene_synonym="Psti; PSTI-56; Spink1; Spink3"
                     /note="serine peptidase inhibitor, Kazal type 1-like"
                     /db_xref="GeneID:266602"
                     /db_xref="RGD:708468"
     exon            1..117
                     /gene="Spink1l"
                     /gene_synonym="Psti; PSTI-56; Spink1; Spink3"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..302
                     /gene="Spink1l"
                     /gene_synonym="Psti; PSTI-56; Spink1; Spink3"
                     /note="serine protease inhibitor Kazal-type 3; serine
                     peptidase inhibitor, Kazal type 3; pancreatic secretory
                     trypsin inhibitor type II (PSTI-II); caltrin; calcium
                     transport inhibitor; pancreatic secretory trypsin
                     inhibitor II; serine protease inhibitor Kazal-type 3-like;
                     serine peptidase inhibitor, Kazal type 1; serine protease
                     inhibitor Kazal-type 1-like; pancreatic secretory trypsin
                     inhibitor-56"
                     /codon_start=1
                     /product="serine protease inhibitor Kazal-type 1-like
                     precursor"
                     /protein_id="NP_690919.1"
                     /db_xref="GeneID:266602"
                     /db_xref="RGD:708468"
                     /translation="MKVAIIFLLSALALLNLAGNTTAKVIGKKANCPNTLIGCPRDYD
                     PVCGTDGKTYANECILCFENRKFGTSIRIQRRGLC"
     exon            118..149
                     /gene="Spink1l"
                     /gene_synonym="Psti; PSTI-56; Spink1; Spink3"
                     /inference="alignment:Splign:2.1.0"
     exon            150..256
                     /gene="Spink1l"
                     /gene_synonym="Psti; PSTI-56; Spink1; Spink3"
                     /inference="alignment:Splign:2.1.0"
     exon            257..379
                     /gene="Spink1l"
                     /gene_synonym="Psti; PSTI-56; Spink1; Spink3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcagtttctg aagagaagca ccctgcacag ttcttctgag ttttggacct aggtctacaa
       61 ccatgaaggt agcaattatc tttcttctca gtgctttggc cctgctcaat ttagcaggta
      121 acactacagc taaggtgatt gggaaaaagg ctaattgccc taatacactt attggatgcc
      181 ccagggatta tgatcctgtg tgtggtactg acggaaaaac ttacgccaat gaatgcattc
      241 tatgctttga aaacaggaaa tttggaacat ctatccgcat tcagaggaga gggctttgct
      301 gaatgtcctg atttcgaaat cttttagggc taccataatg tttagcaaga aggtttgctg
      361 aataaatgca tctgaacat
//
