LOCUS       NM_012674                377 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus serine peptidase inhibitor, Kazal type 1
            (Spink1), mRNA.
ACCESSION   NM_012674 XM_346511
VERSION     NM_012674.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 377)
  AUTHORS   Chang,C.F., Yang,J., Li,X.F., Zhao,W.M., Chen,S.S., Wang,G.P. and
            Xu,C.S.
  TITLE     [SPINK3: A novel growth factor that promotes rat liver
            regeneration]
  JOURNAL   Mol Biol (Mosk) 50 (3), 457-465 (2016)
   PUBMED   27414783
  REMARK    GeneRIF: SPINK3 along with Ccna2 and EGFR accelerated cell
            proliferation during rat liver regeneration via P38 MAPK, PKC,
            JAK-STAT and AKT pathways.
REFERENCE   2  (bases 1 to 377)
  AUTHORS   Romac,J.M., Shahid,R.A., Choi,S.S., Karaca,G.F., Westphalen,C.B.,
            Wang,T.C. and Liddle,R.A.
  TITLE     Pancreatic secretory trypsin inhibitor I reduces the severity of
            chronic pancreatitis in mice overexpressing interleukin-1beta in
            the pancreas
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 302 (5), G535-G541 (2012)
   PUBMED   22173919
REFERENCE   3  (bases 1 to 377)
  AUTHORS   Zalazar,L., Saez Lancellotti,T.E., Clementi,M., Lombardo,C.,
            Lamattina,L., De Castro,R., Fornes,M.W. and Cesari,A.
  TITLE     SPINK3 modulates mouse sperm physiology through the reduction of
            nitric oxide level independently of its trypsin inhibitory activity
  JOURNAL   Reproduction 143 (3), 281-295 (2012)
   PUBMED   22228629
REFERENCE   4  (bases 1 to 377)
  AUTHORS   Pickrell,A.M., Fukui,H., Wang,X., Pinto,M. and Moraes,C.T.
  TITLE     The striatum is highly susceptible to mitochondrial oxidative
            phosphorylation dysfunctions
  JOURNAL   J Neurosci 31 (27), 9895-9904 (2011)
   PUBMED   21734281
  REMARK    GeneRIF: This study created a novel mouse model of mtDNA depletion
            by expressing relatively low levels of mito-PstI in CNS neurons,
            which leads to a chronic OXPHOS deficiency.
REFERENCE   5  (bases 1 to 377)
  AUTHORS   Romac,J.M., Ohmuraya,M., Bittner,C., Majeed,M.F., Vigna,S.R.,
            Que,J., Fee,B.E., Wartmann,T., Yamamura,K. and Liddle,R.A.
  TITLE     Transgenic expression of pancreatic secretory trypsin inhibitor-1
            rescues SPINK3-deficient mice and restores a normal pancreatic
            phenotype
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 298 (4), G518-G524 (2010)
   PUBMED   20110462
REFERENCE   6  (bases 1 to 377)
  AUTHORS   Tsuzuki,S., Miura,Y., Fushiki,T., Oomori,T., Satoh,T., Natori,Y.
            and Sugimoto,E.
  TITLE     Molecular cloning and characterization of genes encoding rat
            pancreatic cholecystokinin (CCK)-releasing peptide (monitor
            peptide) and pancreatic secretory trypsin inhibitor (PSTI)
  JOURNAL   Biochim Biophys Acta 1132 (2), 199-202 (1992)
   PUBMED   1390891
REFERENCE   7  (bases 1 to 377)
  AUTHORS   Tsuzuki,S., Kondo,A., Fushiki,T. and Sugimoto,E.
  TITLE     Monitor peptide gene expression is increased by exogenous CCK in
            the rat pancreas and in a rat pancreatic acinar cell line (AR4-2J)
  JOURNAL   FEBS Lett 307 (3), 386-388 (1992)
   PUBMED   1379547
REFERENCE   8  (bases 1 to 377)
  AUTHORS   Liddle,R.A., Misukonis,M.A., Pacy,L. and Balber,A.E.
  TITLE     Cholecystokinin cells purified by fluorescence-activated cell
            sorting respond to monitor peptide with an increase in
            intracellular calcium
  JOURNAL   Proc Natl Acad Sci U S A 89 (11), 5147-5151 (1992)
   PUBMED   1594624
REFERENCE   9  (bases 1 to 377)
  AUTHORS   Tsuzuki,S., Fushiki,T., Kondo,A., Murayama,H. and Sugimoto,E.
  TITLE     Effect of a high-protein diet on the gene expression of a
            trypsin-sensitive, cholecystokinin-releasing peptide (monitor
            peptide) in the pancreas
  JOURNAL   Eur J Biochem 199 (1), 245-252 (1991)
   PUBMED   2065678
REFERENCE   10 (bases 1 to 377)
  AUTHORS   Leminen,A.
  TITLE     Tumor markers CA 125, carcinoembryonic antigen and tumor-associated
            trypsin inhibitor in patients with cervical adenocarcinoma
  JOURNAL   Gynecol Oncol 39 (3), 358-363 (1990)
   PUBMED   2258083
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X59696.1 and M27882.1.
            
            On Oct 19, 2007 this sequence version replaced NM_012674.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X59696.1, M35299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               X59696.1           1-301
            302-377             M27882.1           284-359
FEATURES             Location/Qualifiers
     source          1..377
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     gene            1..377
                     /gene="Spink1"
                     /gene_synonym="Psti-1; PSTI-61; Spink3; Tilp"
                     /note="serine peptidase inhibitor, Kazal type 1"
                     /db_xref="GeneID:24833"
                     /db_xref="RGD:3749"
     exon            1..115
                     /gene="Spink1"
                     /gene_synonym="Psti-1; PSTI-61; Spink3; Tilp"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..300
                     /gene="Spink1"
                     /gene_synonym="Psti-1; PSTI-61; Spink3; Tilp"
                     /note="trypsin inhibitor-like protein, pancreatic;
                     pancreatic secretory trypsin inhibitor I; pancreatic
                     cholecystokinin(CCK) releasing peptide; PSTI-I;
                     cholecystokinin-releasing peptide; serine protease
                     inhibitor Kazal-type 1; serine peptidase inhibitor, Kazal
                     type 3; pancreatic secretory trypsin inhibitor-61; monitor
                     peptide; Serine protease inhibitor, kanzal type 1/ Trypsin
                     inhibitor-like protein, pancreatic"
                     /codon_start=1
                     /product="serine protease inhibitor Kazal-type 1
                     precursor"
                     /protein_id="NP_036806.1"
                     /db_xref="GeneID:24833"
                     /db_xref="RGD:3749"
                     /translation="MKVAIIFLLSALALLSLAGNPPAEVNGKTPNCPKQIMGCPRIYD
                     PVCGTNGITYPSECSLCFENRKFGTSIHIQRRGTC"
     exon            116..147
                     /gene="Spink1"
                     /gene_synonym="Psti-1; PSTI-61; Spink3; Tilp"
                     /inference="alignment:Splign:2.1.0"
     exon            148..254
                     /gene="Spink1"
                     /gene_synonym="Psti-1; PSTI-61; Spink3; Tilp"
                     /inference="alignment:Splign:2.1.0"
     exon            255..377
                     /gene="Spink1"
                     /gene_synonym="Psti-1; PSTI-61; Spink3; Tilp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      359..364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Spink1"
                     /gene_synonym="Psti-1; PSTI-61; Spink3; Tilp"
ORIGIN      
        1 agtttctgaa gagaagcacc ctgcacagtt cgtctgagtt ttggacctag gtctacaacc
       61 atgaaggtag caattatctt tcttctcagt gctttggccc tgctcagttt agcaggtaac
      121 cctccagctg aggtgaatgg aaaaacgcct aattgcccta agcaaattat gggatgtccc
      181 aggatttatg accctgtgtg tgggactaac ggaattactt accccagtga atgcagtctg
      241 tgctttgaaa acaggaaatt cggaacatct atccacattc agaggagagg gacttgctga
      301 atgtcctgat tttgaaatct tttagggcta ccataatgtt tagcaagaag gtttgctgaa
      361 taaatgcatc tgaacat
//
