LOCUS       NM_001024286            2583 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus Spi-B transcription factor (Spib), mRNA.
ACCESSION   NM_001024286 XM_574441
VERSION     NM_001024286.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2583)
  AUTHORS   Dahl,R., Ramirez-Bergeron,D.L., Rao,S. and Simon,M.C.
  TITLE     Spi-B can functionally replace PU.1 in myeloid but not lymphoid
            development
  JOURNAL   EMBO J 21 (9), 2220-2230 (2002)
   PUBMED   11980719
REFERENCE   2  (bases 1 to 2583)
  AUTHORS   Rao,S., Matsumura,A., Yoon,J. and Simon,M.C.
  TITLE     SPI-B activates transcription via a unique proline, serine, and
            threonine domain and exhibits DNA binding affinity differences from
            PU.1
  JOURNAL   J Biol Chem 274 (16), 11115-11124 (1999)
   PUBMED   10196196
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089881.1.
            
            On May 27, 2005 this sequence version replaced XM_574441.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089881.1, CO555547.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680423 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2583
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2583
                     /gene="Spib"
                     /note="Spi-B transcription factor"
                     /db_xref="GeneID:499146"
                     /db_xref="RGD:1565899"
     exon            1..31
                     /gene="Spib"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..818
                     /gene="Spib"
                     /note="Spi-B transcription factor (Spi-1/PU.1 related)"
                     /codon_start=1
                     /product="transcription factor Spi-B"
                     /protein_id="NP_001019457.1"
                     /db_xref="GeneID:499146"
                     /db_xref="RGD:1565899"
                     /translation="MLALEAAQLDGPHLSCLQYPEGVFYDLDSCKSFSYPDSDGGPDS
                     TWGWTEAPPAPAIAAYEAFDPAATAAFAHTQAVQLCYGHGPSPSTYSPVGTLDPAPSL
                     EASGPGLQVYPSEDFTSQTLGSLAYAPYPSPVLSEEEDILLDSPALEVSDSESDEALL
                     AGSEGRGSEAGARKKLRLYQFLLELLLRGDMRECVWWVEPGAGVFQFSSKHKELLARR
                     WGQQKGNRKRMTYQKLARALRNYAKTGEIRKVKRKLTYQFDSALLPAARRA"
     exon            32..59
                     /gene="Spib"
                     /inference="alignment:Splign:2.1.0"
     exon            60..135
                     /gene="Spib"
                     /inference="alignment:Splign:2.1.0"
     exon            136..368
                     /gene="Spib"
                     /inference="alignment:Splign:2.1.0"
     exon            369..519
                     /gene="Spib"
                     /inference="alignment:Splign:2.1.0"
     exon            520..2562
                     /gene="Spib"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaccaccat gcttgctctg gaggctgcac agctggatgg cccacactta agctgtttgc
       61 agtacccaga aggtgtcttc tatgacctgg acagctgcaa gtccttcagt tacccagatt
      121 cagatggggg ccctgactcc acatggggct ggacagaggc cccgcctgcc cctgccatcg
      181 ctgcctatga agctttcgac cctgctgcta cggcagcctt tgcccacacc caggctgtgc
      241 agctctgtta tggtcatggt cctagcccct ccacctacag tcccgtggga acccttgacc
      301 cagcccccag cttggaggct tcggggcctg gcctccaggt atacccctca gaggacttca
      361 ccagccagac cctgggctcc ttggcttatg ctccgtaccc cagccctgtg ctatcagagg
      421 aggaagacat tctgctggac agccctgccc tggaggtctc ggacagtgag tcagacgagg
      481 ccctcttggc tggctccgag gggaggggat ctgaggcagg tgcacgcaag aagctgcgcc
      541 tgtaccagtt cttgctggag ttactcctgc gcggggacat gcgcgagtgc gtgtggtggg
      601 tggagccagg tgctggcgtc ttccagttct cctccaagca caaggagttg ttggctcgcc
      661 gctggggcca gcagaagggc aaccgcaaac gcatgacgta tcagaagctg gcccgagcgc
      721 tgcgcaacta tgccaagaca ggcgaaatcc gcaaggtcaa acgcaagctc acctaccagt
      781 ttgacagcgc gctgctgcca gccgcccggc gtgcctgagc gccccgctgg gacccctttc
      841 tgatccctaa gtcccagtgc ccatagaacc ccatattggg gatcagcagg ctgccagggt
      901 cctcagctct caccagggcc tccccagagt ctcctgtgcc atgtatggga ttccaaccca
      961 ggatggtcct gtttgagggc tcactggcca ttctacgctg ttccaaaatg gcaagttttt
     1021 ctttgggggc ccttggtgtt gtctgcggtt ccagaatccg cagatacttc ttgtgagccc
     1081 tgtaagctca cacgctatcg caccagcagg tggcgctgtc tacagccccc aaacccctgt
     1141 atctgttggc cggatgggtc cctctgttct cccctgaggc ccttgtcaga tctgagatct
     1201 agttatgttt ggagctccct gagaacactg tgccacctgt gtgtgacttt tctctgtatc
     1261 catttatgac ttttatttgt ttgagacagg gtctcactat gtagttcagg ctggccccca
     1321 acctgtgaca atcctcctgc ctcagcctcc tgaatcctgg ggattacaaa ggtgcaccat
     1381 cagaccaggc attttccatt tttgagagaa gattttacta tgtaacccag gctgtcctcg
     1441 agcttgcctc agccatccct cgggtccctc tgggatctat gtcccagatg aattgttggg
     1501 tagggtaggg atggtgtgtt cggtgaatct tataggttgg accctccctt ctggggtctt
     1561 ttgattatat gggaagttct ctaggctctt agcagccctg cattcacaca ctgatggtcc
     1621 cgtttgaagt gtgatctgtg tatggtgttt gagggtcata ctggcacttg gccagtttgg
     1681 gatgtggggc agaggtatgg ctgtgacaag gcttcggttt ttgagattgg gtctcatgta
     1741 tctcagtctg gccttgaact ccctatatag ctgaggatga ccttgaaccc ttgcctcagc
     1801 cagaatgctc agattccagg cagcactata ttactatttc ccttttctta cgtcaaggtc
     1861 tgtctatgta gcccaggcta gctttaatct cataacactc ttcctgcctc tgtgactgga
     1921 aagctagggc tacggacatg ttttaccaca ctggtttagc caagcatacc cctgttttat
     1981 cacccttgcc atggctaaac agacttctag agctggtcac cccccaccca caaggcaggc
     2041 aaattaagtc cctgcaggtg ttttcttcag aggaaagccc ccttttacag tcatctttca
     2101 aactagagag cattcccaca atccagatat ctgaatgtga atttttggac aactggtaac
     2161 ctctggccag cttttctgga gccagccttt gtccagatgt tggctcagga ccctgctcag
     2221 tgcctgcctg tctcacacca gtgacttctc acaactgccc gtccgggccc agtgttttac
     2281 ctgctgcagg tcaagcagac tcaaactgtg ggcttctctt gggcctccat ggcagaatca
     2341 gaactcagag ttttgaagcc tgagtgagct gggccaccat gaagaggccc ttaaaactct
     2401 gccacccaga tgggcagcac ctcagtgggt ggccaggggg caggaaagga tcatggaaga
     2461 tccagatgtt catgtggtta aggttaaact ggtaccaaat aaaattattt cttaaaaccc
     2521 aacatcatca atctacatgc ataataaagc cctacatcaa aaaaaaaaaa aaaaaaaaaa
     2581 aaa
//
