LOCUS       NM_001005892            1373 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus Spi-1 proto-oncogene (Spi1), mRNA.
ACCESSION   NM_001005892 XM_345402
VERSION     NM_001005892.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1373)
  AUTHORS   Yu,M., Ou,Y., Wang,H. and Gu,W.
  TITLE     PU.1 interaction with p50 promotes microglial-mediated inflammation
            in secondary spinal cord injury in SCI rats
  JOURNAL   Int J Neurosci 133 (4), 389-402 (2023)
   PUBMED   33970748
  REMARK    GeneRIF: PU.1 interaction with p50 promotes microglial-mediated
            inflammation in secondary spinal cord injury in SCI rats.
REFERENCE   2  (bases 1 to 1373)
  AUTHORS   Cai,X., Hong,L., Liu,Y., Huang,X., Lai,H. and Shao,L.
  TITLE     Salmonella pathogenicity island 1 knockdown confers protection
            against myocardial fibrosis and inflammation in uremic
            cardiomyopathy via down-regulation of S100 Calcium Binding Protein
            A8/A9 transcription
  JOURNAL   Ren Fail 44 (1), 1819-1832 (2022)
   PUBMED   36299239
  REMARK    GeneRIF: Salmonella pathogenicity island 1 knockdown confers
            protection against myocardial fibrosis and inflammation in uremic
            cardiomyopathy via down-regulation of S100 Calcium Binding Protein
            A8/A9 transcription.
REFERENCE   3  (bases 1 to 1373)
  AUTHORS   Lipponen,A., El-Osta,A., Kaspi,A., Ziemann,M., Khurana,I., Kn,H.,
            Navarro-Ferrandis,V., Puhakka,N., Paananen,J. and Pitkanen,A.
  TITLE     Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA
            methylation regulate chronic transcriptomics changes after
            experimental traumatic brain injury
  JOURNAL   Acta Neuropathol Commun 6 (1), 17 (2018)
   PUBMED   29482641
  REMARK    GeneRIF: Four upregulated transcription factors Pax6, Tp73, Cebpd,
            and Spi1, appeared as potent regulators of chronic post-traumatic
            brain injury (TBI) gene expression. They regulate molecular
            networks contributing to post-injury secondary damage, including
            apoptosis and inflammation, strengthening the feasibility of
            therapeutically targeting these molecular networks even after the
            acute post-TBI period.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1373)
  AUTHORS   Staitieh,B.S., Fan,X., Neveu,W. and Guidot,D.M.
  TITLE     Nrf2 regulates PU.1 expression and activity in the alveolar
            macrophage
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 308 (10), L1086-L1093 (2015)
   PUBMED   25840997
  REMARK    GeneRIF: Nrf2 regulates the expression and activity of PU.1 and
            that antioxidant response and immune activation are coordinately
            regulated within the AM.
REFERENCE   5  (bases 1 to 1373)
  AUTHORS   Delatte,B., Deplus,R. and Fuks,F.
  TITLE     Playing TETris with DNA modifications
  JOURNAL   EMBO J 33 (11), 1198-1211 (2014)
   PUBMED   24825349
  REMARK    Review article
REFERENCE   6  (bases 1 to 1373)
  AUTHORS   Guerriero,A., Langmuir,P.B., Spain,L.M. and Scott,E.W.
  TITLE     PU.1 is required for myeloid-derived but not lymphoid-derived
            dendritic cells
  JOURNAL   Blood 95 (3), 879-885 (2000)
   PUBMED   10648399
REFERENCE   7  (bases 1 to 1373)
  AUTHORS   Egan,B.S., Lane,K.B. and Shepherd,V.L.
  TITLE     PU.1 and USF are required for macrophage-specific mannose receptor
            promoter activity
  JOURNAL   J Biol Chem 274 (13), 9098-9107 (1999)
   PUBMED   10085160
REFERENCE   8  (bases 1 to 1373)
  AUTHORS   Scott,E.W., Fisher,R.C., Olson,M.C., Kehrli,E.W., Simon,M.C. and
            Singh,H.
  TITLE     PU.1 functions in a cell-autonomous manner to control the
            differentiation of multipotential lymphoid-myeloid progenitors
  JOURNAL   Immunity 6 (4), 437-447 (1997)
   PUBMED   9133423
REFERENCE   9  (bases 1 to 1373)
  AUTHORS   Borras,F.E., Lloberas,J., Maki,R.A. and Celada,A.
  TITLE     Repression of I-A beta gene expression by the transcription factor
            PU.1
  JOURNAL   J Biol Chem 270 (41), 24385-24391 (1995)
   PUBMED   7592651
REFERENCE   10 (bases 1 to 1373)
  AUTHORS   Hagman,J. and Grosschedl,R.
  TITLE     An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates
            differential binding of ETS family factors to promoter sequences of
            the mb-1 gene
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 8889-8893 (1992)
   PUBMED   1409581
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091185.1.
            
            On Mar 27, 2005 this sequence version replaced NM_001005892.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091185.1, AB154364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1373
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1373
                     /gene="Spi1"
                     /gene_synonym="Pu.1; Sfpi1"
                     /note="Spi-1 proto-oncogene"
                     /db_xref="GeneID:366126"
                     /db_xref="RGD:1359607"
     exon            1..200
                     /gene="Spi1"
                     /gene_synonym="Pu.1; Sfpi1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..971
                     /gene="Spi1"
                     /gene_synonym="Pu.1; Sfpi1"
                     /note="hematopoietic transcription factor PU.1; SFFV
                     proviral integration 1; spleen focus forming virus
                     proviral integration oncogene spi1; spleen focus forming
                     virus (SFFV) proviral integration oncogene spi1"
                     /codon_start=1
                     /product="transcription factor PU.1"
                     /protein_id="NP_001005892.1"
                     /db_xref="GeneID:366126"
                     /db_xref="RGD:1359607"
                     /translation="MLQACKMEGFPLVAPPSDELVTYESELYQRQTHDYYSLIGGDGD
                     SHSDHYWDFSTHHVHSEFESFPENHFTELQSVQPPQLQQLYRHMELEQMHVLDTPMAP
                     PHASLSHQVSYMPRVCFPYPPLSPAHQQSSDEEEGERQSPPLEVSDGEADGLEPGPGL
                     LHGETGSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQK
                     GNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFSGEVLGRGGLAERRLPPH"
     exon            201..297
                     /gene="Spi1"
                     /gene_synonym="Pu.1; Sfpi1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..485
                     /gene="Spi1"
                     /gene_synonym="Pu.1; Sfpi1"
                     /inference="alignment:Splign:2.1.0"
     exon            486..651
                     /gene="Spi1"
                     /gene_synonym="Pu.1; Sfpi1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..1341
                     /gene="Spi1"
                     /gene_synonym="Pu.1; Sfpi1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctcaccca gggctcctgt agctcagggg gcaggcctga gccctgcgtc tgacccacga
       61 ccgtccagcc cccccgacgg ggcacctggt cctgaggggg atccgcattg atccccaccg
      121 aagcagggga tctgaccaac ctggagctca gctggatgtt acaggcgtgc aaaatggaag
      181 ggtttcccct cgtcgcccct ccatcggatg agctggttac ttatgaatca gaactatacc
      241 aacgtcaaac acatgactac tattccttga ttggtggtga tggagacagc catagcgatc
      301 actattggga tttctccaca caccatgtac acagcgagtt tgagagcttc cctgagaacc
      361 acttcacgga gctgcagagc gtgcagcccc cgcagctaca gcagctctac cgccacatgg
      421 agctggagca gatgcacgtc cttgacaccc ccatggcacc gccccatgcc agcctcagtc
      481 accaggtttc ctacatgccc cgggtgtgct tcccttatcc acccttgtcc ccagcccacc
      541 agcagagctc agatgaggag gagggtgaga ggcagagccc tccactggag gtgtctgatg
      601 gagaagctga tggcttggag cctgggccag gccttctgca tggggagaca ggcagcaaga
      661 agaagattcg tttgtaccag ttcctgctgg acctgctgcg tagcggagac atgaaggaca
      721 gcatctggtg ggtggacaag gacaaaggta ccttccagtt ctcgtccaag cacaaggagg
      781 cgctggcgca ccgctggggc atccagaagg gaaaccgcaa gaagatgacc taccagaaga
      841 tggcgcgcgc gctgcgcaac tacggcaaga cgggcgaggt gaagaaagtc aagaagaagc
      901 tcacttacca gttcagcggc gaggtgctgg gccgtggggg cctggctgag cggcgcctcc
      961 cgccccactg atcgcctgca gagcccgcca ggctcccggc ccccgccggc catagcatta
     1021 acctgtcgcc cggcccggac acagggagga cattcccagg gccgaggcag gactggggac
     1081 ccggcctcgc cccgccatgc cccgcctggc cggccccgcc cgcttcgcct cccaccagga
     1141 ctctagccag gcccaagggc tgcctgggcc tcggacctca cccgagggtc agcctggctt
     1201 agtggccacg gtgcttcttt gggagtctgg cgttggcacc tttttgtata ttgaatgctt
     1261 tttaaaaagc tcttcatctt cccaccccac cccccatccc cattagcctc aaaagtaaaa
     1321 ttattgctgg ctattctccc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
