LOCUS       NP_001012066             616 aa            linear   ROD 24-JUN-2024
DEFINITION  sphingosine kinase 2 [Rattus norvegicus].
ACCESSION   NP_001012066 XP_218558
VERSION     NP_001012066.1
DBSOURCE    REFSEQ: accession NM_001012066.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 616)
  AUTHORS   Dominguez,G., Maddelein,M.L., Pucelle,M., Nicaise,Y., Maurage,C.A.,
            Duyckaerts,C., Cuvillier,O. and Delisle,M.B.
  TITLE     Neuronal sphingosine kinase 2 subcellular localization is altered
            in Alzheimer's disease brain
  JOURNAL   Acta Neuropathol Commun 6 (1), 25 (2018)
   PUBMED   29615132
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 616)
  AUTHORS   Zhang,R., Li,L., Yuan,L. and Zhao,M.
  TITLE     Hypoxic preconditioning protects cardiomyocytes against
            hypoxia/reoxygenation-induced cell apoptosis via sphingosine kinase
            2 and FAK/AKT pathway
  JOURNAL   Exp Mol Pathol 100 (1), 51-58 (2016)
   PUBMED   26621495
  REMARK    GeneRIF: hypoxic preconditioning significantly increased SphK2
            expression in primary cardiomyocytes
REFERENCE   3  (residues 1 to 616)
  AUTHORS   Sivasubramanian,M., Kanagaraj,N., Dheen,S.T. and Tay,S.S.
  TITLE     Sphingosine kinase 2 and sphingosine-1-phosphate promotes
            mitochondrial function in dopaminergic neurons of mouse model of
            Parkinson's disease and in MPP+ -treated MN9D cells in vitro
  JOURNAL   Neuroscience 290, 636-648 (2015)
   PUBMED   25637806
REFERENCE   4  (residues 1 to 616)
  AUTHORS   Gandy,K.A., Canals,D., Adada,M., Wada,M., Roddy,P., Snider,A.J.,
            Hannun,Y.A. and Obeid,L.M.
  TITLE     Sphingosine 1-phosphate induces filopodia formation through S1PR2
            activation of ERM proteins
  JOURNAL   Biochem J 449 (3), 661-672 (2013)
   PUBMED   23106337
REFERENCE   5  (residues 1 to 616)
  AUTHORS   Hisano,Y., Kobayashi,N., Kawahara,A., Yamaguchi,A. and Nishi,T.
  TITLE     The sphingosine 1-phosphate transporter, SPNS2, functions as a
            transporter of the phosphorylated form of the immunomodulating
            agent FTY720
  JOURNAL   J Biol Chem 286 (3), 1758-1766 (2011)
   PUBMED   21084291
REFERENCE   6  (residues 1 to 616)
  AUTHORS   Mizugishi,K., Yamashita,T., Olivera,A., Miller,G.F., Spiegel,S. and
            Proia,R.L.
  TITLE     Essential role for sphingosine kinases in neural and vascular
            development
  JOURNAL   Mol Cell Biol 25 (24), 11113-11121 (2005)
   PUBMED   16314531
REFERENCE   7  (residues 1 to 616)
  AUTHORS   Maceyka,M., Sankala,H., Hait,N.C., Le Stunff,H., Liu,H., Toman,R.,
            Collier,C., Zhang,M., Satin,L.S., Merrill,A.H. Jr., Milstien,S. and
            Spiegel,S.
  TITLE     SphK1 and SphK2, sphingosine kinase isoenzymes with opposing
            functions in sphingolipid metabolism
  JOURNAL   J Biol Chem 280 (44), 37118-37129 (2005)
   PUBMED   16118219
REFERENCE   8  (residues 1 to 616)
  AUTHORS   Kharel,Y., Lee,S., Snyder,A.H., Sheasley-O'neill,S.L., Morris,M.A.,
            Setiady,Y., Zhu,R., Zigler,M.A., Burcin,T.L., Ley,K., Tung,K.S.,
            Engelhard,V.H., Macdonald,T.L., Pearson-White,S. and Lynch,K.R.
  TITLE     Sphingosine kinase 2 is required for modulation of lymphocyte
            traffic by FTY720
  JOURNAL   J Biol Chem 280 (44), 36865-36872 (2005)
   PUBMED   16093248
REFERENCE   9  (residues 1 to 616)
  AUTHORS   Okada,T., Ding,G., Sonoda,H., Kajimoto,T., Haga,Y.,
            Khosrowbeygi,A., Gao,S., Miwa,N., Jahangeer,S. and Nakamura,S.
  TITLE     Involvement of N-terminal-extended form of sphingosine kinase 2 in
            serum-dependent regulation of cell proliferation and apoptosis
  JOURNAL   J Biol Chem 280 (43), 36318-36325 (2005)
   PUBMED   16103110
REFERENCE   10 (residues 1 to 616)
  AUTHORS   Liu,H., Sugiura,M., Nava,V.E., Edsall,L.C., Kono,K., Poulton,S.,
            Milstien,S., Kohama,T. and Spiegel,S.
  TITLE     Molecular cloning and functional characterization of a novel
            mammalian sphingosine kinase type 2 isoform
  JOURNAL   J Biol Chem 275 (26), 19513-19520 (2000)
   PUBMED   10751414
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079120.1.
            
            On Feb 11, 2005 this sequence version replaced XP_218558.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079120.1, SRR8487227.212730.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..616
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     Protein         1..616
                     /product="sphingosine kinase 2"
                     /EC_number="2.7.1.91"
                     /calculated_mol_wt=65392
     Region          <152..607
                     /region_name="PLN02958"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase"
                     /db_xref="CDD:215517"
     CDS             1..616
                     /gene="Sphk2"
                     /coded_by="NM_001012066.1:97..1947"
                     /db_xref="GeneID:308589"
                     /db_xref="RGD:1307757"
ORIGIN      
        1 mapppllpva astpilhgef gsypahgprf altlttqalh iqrlrpkpea rprdglvpld
       61 evsgcgtlqs rspedtaayf ciytyprgrr ggrrratrtf radgaatyve nraeaqrwat
      121 almcllrgvp lsgdqeitpe llprkprlll lvnpfggrgl awqrcmdhvv pmiseaglsf
      181 nliqterqnh arelvqglsl sewegivtvs gdgllyevln glldrpdwed avrmpigvlp
      241 cgsgnalaga vnhhggfeqt vgvdlllncs lllcrggshp ldllsvtlas gsrcfsflsv
      301 awgflsdvdi hserfralgs arftlgavlg latlhtyrgr lsylpattep alpipghglp
      361 rakselalap apapaathsp lhrsvsdlpl plpqpalasp gspeplpdls lngggpeltg
      421 dwggagdapl spdpllpssp nafktaqlsp iaegpsempa sgllppihna peastwgpad
      481 hllpplgspl pqdwvtiege fvlmlailps hlcadlmaap harfddgvvh lcwvrsgisr
      541 aallrillam ehgnhfslgc phlgyaaara frlepltprg vltvdgelve ygpiqaqvhp
      601 slatlltgpa gqkpra
//
