LOCUS       NM_001270811            2915 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Rattus norvegicus sphingosine kinase 1 (Sphk1), transcript variant
            1, mRNA.
ACCESSION   NM_001270811
VERSION     NM_001270811.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2915)
  AUTHORS   Coant,N., Rendja,K., Bellini,L., Flamment,M., Lherminier,J.,
            Portha,B., Codogno,P. and Le Stunff,H.
  TITLE     Role of Sphingosine Kinase 1 in Glucolipotoxicity-Induced Early
            Activation of Autophagy in INS-1 Pancreatic beta Cells
  JOURNAL   Cells 13 (7), 636 (2024)
   PUBMED   38607078
  REMARK    GeneRIF: Role of Sphingosine Kinase 1 in Glucolipotoxicity-Induced
            Early Activation of Autophagy in INS-1 Pancreatic beta Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2915)
  AUTHORS   Zeng,Y., Zhang,W., Xue,T., Zhang,D., Lv,M. and Jiang,Y.
  TITLE     Sphk1-induced autophagy in microglia promotes neuronal injury
            following cerebral ischaemia-reperfusion
  JOURNAL   Eur J Neurosci 56 (4), 4287-4303 (2022)
   PUBMED   35766986
  REMARK    GeneRIF: Sphk1-induced autophagy in microglia promotes neuronal
            injury following cerebral ischaemia-reperfusion.
REFERENCE   3  (bases 1 to 2915)
  AUTHORS   Wang,C., Xu,T., Lachance,B.B., Zhong,X., Shen,G., Xu,T., Tang,C.
            and Jia,X.
  TITLE     Critical roles of sphingosine kinase 1 in the regulation of
            neuroinflammation and neuronal injury after spinal cord injury
  JOURNAL   J Neuroinflammation 18 (1), 50 (2021)
   PUBMED   33602274
  REMARK    GeneRIF: Critical roles of sphingosine kinase 1 in the regulation
            of neuroinflammation and neuronal injury after spinal cord injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2915)
  AUTHORS   Tian,T., Yao,D., Zheng,L., Zhou,Z., Duan,Y., Liu,B., Wang,P. and
            Li,Y.
  TITLE     Sphingosine kinase 1 regulates HMGB1 translocation by directly
            interacting with calcium/calmodulin protein kinase II-delta in
            sepsis-associated liver injury
  JOURNAL   Cell Death Dis 11 (12), 1037 (2020)
   PUBMED   33281190
  REMARK    GeneRIF: Sphingosine kinase 1 regulates HMGB1 translocation by
            directly interacting with calcium/calmodulin protein kinase
            II-delta in sepsis-associated liver injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2915)
  AUTHORS   Lv,M.H., Li,S., Jiang,Y.J. and Zhang,W.
  TITLE     The Sphkl/SlP pathway regulates angiogenesis via NOS/NO synthesis
            following cerebral ischemia-reperfusion
  JOURNAL   CNS Neurosci Ther 26 (5), 538-548 (2020)
   PUBMED   31814336
  REMARK    GeneRIF: The Sphkl/SlP pathway regulates angiogenesis via NOS/NO
            synthesis following cerebral ischemia-reperfusion.
REFERENCE   6  (bases 1 to 2915)
  AUTHORS   Gijsbers,S., Asselberghs,S., Herdewijn,P. and Van Veldhoven,P.P.
  TITLE     1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human
            sphingosine kinase
  JOURNAL   Biochim Biophys Acta 1580 (1), 1-8 (2002)
   PUBMED   11923095
REFERENCE   7  (bases 1 to 2915)
  AUTHORS   Imamura,T., Ohgane,J., Ito,S., Ogawa,T., Hattori,N., Tanaka,S. and
            Shiota,K.
  TITLE     CpG island of rat sphingosine kinase-1 gene: tissue-dependent DNA
            methylation status and multiple alternative first exons
  JOURNAL   Genomics 76 (1-3), 117-125 (2001)
   PUBMED   11560121
REFERENCE   8  (bases 1 to 2915)
  AUTHORS   Pitson,S.M., D'andrea,R.J., Vandeleur,L., Moretti,P.A., Xia,P.,
            Gamble,J.R., Vadas,M.A. and Wattenberg,B.W.
  TITLE     Human sphingosine kinase: purification, molecular cloning and
            characterization of the native and recombinant enzymes
  JOURNAL   Biochem J 350 Pt 2 (Pt 2), 429-441 (2000)
   PUBMED   10947957
REFERENCE   9  (bases 1 to 2915)
  AUTHORS   Melendez,A.J., Carlos-Dias,E., Gosink,M., Allen,J.M. and Takacs,L.
  TITLE     Human sphingosine kinase: molecular cloning, functional
            characterization and tissue distribution
  JOURNAL   Gene 251 (1), 19-26 (2000)
   PUBMED   10863092
REFERENCE   10 (bases 1 to 2915)
  AUTHORS   Kohama,T., Olivera,A., Edsall,L., Nagiec,M.M., Dickson,R. and
            Spiegel,S.
  TITLE     Molecular cloning and functional characterization of murine
            sphingosine kinase
  JOURNAL   J Biol Chem 273 (37), 23722-23728 (1998)
   PUBMED   9726979
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1 and BC081738.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ486894.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1279              JAXUCZ010000010.1  102258975-102260253
            1280-2915           BC081738.1         1499-3134
FEATURES             Location/Qualifiers
     source          1..2915
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1-q32.2"
     gene            1..2915
                     /gene="Sphk1"
                     /note="sphingosine kinase 1"
                     /db_xref="GeneID:170897"
                     /db_xref="RGD:620048"
     exon            1..1279
                     /gene="Sphk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1249..2625
                     /gene="Sphk1"
                     /EC_number="2.7.1.91"
                     /note="isoform a is encoded by transcript variant 1; SK 1;
                     SPK 1; acetyltransferase SPHK1"
                     /codon_start=1
                     /product="sphingosine kinase 1 isoform a"
                     /protein_id="NP_001257740.1"
                     /db_xref="GeneID:170897"
                     /db_xref="RGD:620048"
                     /translation="MQLDSPPTSKDLAASGNDEGALTAQGGGEGEPHGQSPDTRLGNT
                     DKQLHTGAAVTSSSAGAASVAPCQREPRDLAMQPADCPRGLLPRPCRVLVLLNPRGGK
                     GKALKLFQSRVRPLLEEAEVSFKLMLTERQNHARELVCAEELGHWDALAVMSGDGLMH
                     EVVNGLMERPDWESAIQKPLCSLPGGSGNALAASLNYYAGHEQVTNEDLLINCTLLLC
                     CRQLSPMNLLSLHTASGRQLYSVLSLSWGFVADVDLESEKYRSLGEIRFTVGTFFRLA
                     SLRIYQGQLAYLPVGKAASKIPASSLAQKGPANTYLVPLEEPVPPHWTVVPEQDFVLV
                     LVLLHTHLSTEMFAAPMGRCEAGVMHLFYIRAGVSRAMLLRLFLAMQKGKHMDLDCPY
                     LVHVPVVAFRLEPRNQRGVFSVDGELMVCEAVQGQVHPNYLWMVSGSSDSPSGRDSQR
                     RPPPEEPI"
     exon            1280..1483
                     /gene="Sphk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1636
                     /gene="Sphk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1731
                     /gene="Sphk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1847
                     /gene="Sphk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2892
                     /gene="Sphk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctgtccac actgctgggt tcctccagtt ggtgaggatc gtggatccgg atcgtccgct
       61 gcaggcagct ccccaggcct ccatagtgtt ctctggggga agactccacc tttggaggtt
      121 gctgacaagg ctcccgcctc tcgacttcgt ccccaaaccg gttcagcttt ctcctgaaag
      181 gcgtgccaga ctgcttcaga ctcggcggct gagtgatcca gaggctgcat ctggaagcta
      241 aaagtaaagg caccaccgag gagcagggga ggaagagaag ttcgtgggtg gcgggtgacc
      301 cgacctggcc cagagccggg acagcaggaa gggtctgggt gtggaattct gatcaggcta
      361 gggtcagggg acgccaaaga ggcgctgcct ccctactgtg agccgcggtt tcgagggtcc
      421 tcagccagcg cagaaccacg cgtgcccgaa gcccactcgg attctgggcg ccggtatctg
      481 ggctgcgccc tcactttcgc gctccgtgga tgcgctgctt caggccgagc tcggaacccc
      541 gcgccttgcc cacttcctga gttgctcctc cagcgtcggg gtgcacaatt ctgtccaggg
      601 atccagcccc tcatctgcgc gtggccgagc cctgggtggc ggcgactgtg tttggggcgg
      661 tacagcgaga tcccgggcgg gtgggggacc agggctgcgc tcaaccttgg ttccacccgg
      721 agagaacaag gaacgcgggg cgtggtcagg cccgcccaga ggctcagcgc cttccccggg
      781 ccgtggcgaa gttgagcaaa aagtttgagg ctggagggga gcgatccctt ggagtctgtg
      841 tgagaccagt gcttcagttg tccctccgtc gcggagctga gcccgagaag agttgctttc
      901 cgtccctggc cgctagaggg acagactggg tagggacctc caccggtagt tggcggcgcc
      961 ttcgtgggtc tgtgagggag acggccccac gcctgtgcct tggcgcgaac tcgcgctcta
     1021 gcagggcaga ctgcagctgt gggttcatca gcacgggcag gtttggcggg actttgggcg
     1081 ctgttctcac cagcgcgtct tgcaccagcc ctcccccacc ccgccctcct ggagactcgg
     1141 agacctagcg gcttccgagc tcaggcaggg gaccgggcga cccggcaggt tgagacgcgg
     1201 ttcttcgtcc cagagtatgc gcctcgcaat gccggttctg ggaattttat gcaactggac
     1261 tctccaccaa cctcaaagga tctggccgcc tccgggaatg acgagggcgc tctcacagcc
     1321 cagggaggtg gagagggcga gccccacggc cagtcaccag acacccgcct gggcaacacc
     1381 gataagcagc tgcacactgg agccgccgtt acctctagca gcgccggggc agcatcggtg
     1441 gctccttgtc agcgggagcc ccgggacctg gctatgcaac cagcagactg tccccgggga
     1501 ctgctcccac ggccatgcag agtgttggtg ctgctgaacc cccggggtgg caagggcaag
     1561 gctctgaagc tctttcagag ccgtgtgcgg ccccttctgg aggaggctga ggtatccttt
     1621 aaactgatgc tcaccgaacg gcagaaccat gccagggagc tggtgtgtgc agaagaactg
     1681 ggtcactggg atgccttggc ggtcatgtcc ggtgacggtc tgatgcacga ggtggtgaat
     1741 gggctaatgg aacgacctga ctgggagagt gccatccaga aacccctatg tagcctccct
     1801 ggaggctctg gcaatgcgct ggcagcttct ttgaactact atgctgggca cgagcaggtc
     1861 actaatgaag atctcctgat caactgcaca ctgctgttat gctgccggca gctgtcaccc
     1921 atgaatctgc tgtccctgca caccgcttcc ggacggcaac tctattctgt tctcagtctg
     1981 tcctggggtt tcgttgctga cgtggacttg gagagtgaga aatacaggag cttgggggag
     2041 attcgtttca cggtgggaac cttttttcgc ctagcaagcc tgcgcattta ccaaggccaa
     2101 ctggcctacc ttcctgtagg gaaggctgcc tctaagatac ctgcttcctc actggcacag
     2161 aagggccctg ccaacacata cctcgttcct ctggaggagc cagtgccacc tcattggact
     2221 gtggtgccag agcaggactt cgttctggtg ctggtgctgc ttcacaccca cctgagcaca
     2281 gagatgtttg cagcacccat gggccgctgc gaggctggtg ttatgcatct gttctatata
     2341 cgtgcggggg tgtcaagggc catgctgctg cgcctcttcc tggccatgca gaagggcaag
     2401 catatggacc tcgactgccc gtacttggtt catgtgccag tggttgcctt ccgcctggaa
     2461 cccaggaacc agaggggagt gttttctgtg gacggggagc tgatggtgtg tgaagctgtg
     2521 cagggccaag tgcacccaaa ctacctttgg atggtctctg gtagcagtga ctccccgtcc
     2581 ggccgggact cccagcggag gccacctcca gaagaaccaa tatgactctg tgcctttgtc
     2641 tactatgtct acactgagat gggaccctcc ctctcatcca tctcctggta tgggaggtta
     2701 tttctaaagc tcatatggag gtggtgggga cccctgtaga gaaagctgga aggtggggct
     2761 atgttttgga aagactctac cctctagtta gaatgagact ggggtcagag tcccactggc
     2821 tgggccagtt gcatacagtt gctcttggag ccctgtcctg agaaccaaat tcaaataaag
     2881 agacttttcc aaaaaaaaaa aaaaaaaaaa aaaaa
//
