LOCUS       NM_001413543            1651 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus SPG21 abhydrolase domain containing, maspardin
            (Spg21), transcript variant 1, mRNA.
ACCESSION   NM_001413543 XM_006243251
VERSION     NM_001413543.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1651)
  AUTHORS   Simpson,M.A., Cross,H., Proukakis,C., Pryde,A., Hershberger,R.,
            Chatonnet,A., Patton,M.A. and Crosby,A.H.
  TITLE     Maspardin is mutated in mast syndrome, a complicated form of
            hereditary spastic paraplegia associated with dementia
  JOURNAL   Am J Hum Genet 73 (5), 1147-1156 (2003)
   PUBMED   14564668
REFERENCE   2  (bases 1 to 1651)
  AUTHORS   Zeitlmann,L., Sirim,P., Kremmer,E. and Kolanus,W.
  TITLE     Cloning of ACP33 as a novel intracellular ligand of CD4
  JOURNAL   J Biol Chem 276 (12), 9123-9132 (2001)
   PUBMED   11113139
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000198.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001413543.2.
            
            On Nov 3, 2022 this sequence version replaced XM_006243251.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487227.121663.1,
                                           SRR8487230.37937.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               JACYVU010000198.1  27794303-27794498
            197-283             JACYVU010000198.1  27798401-27798487
            284-445             JACYVU010000198.1  27801301-27801462
            446-526             JACYVU010000198.1  27806362-27806442
            527-672             JACYVU010000198.1  27808770-27808915
            673-781             JACYVU010000198.1  27814393-27814501
            782-889             JACYVU010000198.1  27816004-27816111
            890-1030            JACYVU010000198.1  27818792-27818932
            1031-1651           JACYVU010000198.1  27821228-27821848
FEATURES             Location/Qualifiers
     source          1..1651
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1651
                     /gene="Spg21"
                     /note="SPG21 abhydrolase domain containing, maspardin"
                     /db_xref="GeneID:300791"
                     /db_xref="RGD:1359141"
     exon            1..196
                     /gene="Spg21"
                     /inference="alignment:Splign:2.1.0"
     exon            197..283
                     /gene="Spg21"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1147
                     /gene="Spg21"
                     /note="isoform 1 is encoded by transcript variant 1;
                     maspardin; spastic paraplegia 21 autosomal recessive Mast
                     syndrome protein homolog; acid cluster protein 33; spastic
                     paraplegia 21 homolog-like; SPG21, maspardin"
                     /codon_start=1
                     /product="maspardin isoform 1"
                     /protein_id="NP_001400472.1"
                     /db_xref="GeneID:300791"
                     /db_xref="RGD:1359141"
                     /translation="MGEIKVSPDYNWFRSTVPLKKIIVDDDDSKIWSLYDAGPRSIRC
                     PLIFLPPVSGTADVFFQQILALTGWGYRVIALQYPVYWDHLEFCDGFRKLLDHLQLDK
                     VHLFGASLGGFLAQKFAEYTHKSPRVHSLILCNAFSDTSIFNQTWTANSFWLMPAFML
                     KKIVLGNFSSGPVDPMMADAIDFMVDRLESLGQSELASRLTLNCQNSYVEPHKIRDIP
                     VTIMDVFDQSALSMEAKEEMYKLYPNARRAHLKTGGNFPYLCRSAEVNLYVQIHLLQF
                     HGTKYAAIDPSVVSAEELDVQKGQLDLSQEEP"
     exon            284..445
                     /gene="Spg21"
                     /inference="alignment:Splign:2.1.0"
     exon            446..526
                     /gene="Spg21"
                     /inference="alignment:Splign:2.1.0"
     exon            527..672
                     /gene="Spg21"
                     /inference="alignment:Splign:2.1.0"
     exon            673..781
                     /gene="Spg21"
                     /inference="alignment:Splign:2.1.0"
     exon            782..889
                     /gene="Spg21"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1030
                     /gene="Spg21"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1651
                     /gene="Spg21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttctagac ttgggaggcg gcggcctctg gctgctcggc cgcgcgcccc ctctgcccgc
       61 tgctcccaag gggcctctgc tctgcagccg cccgtcccac ccacgccccc cccccccgac
      121 tacatccgct gcgcccaaat aggggcgaag agccgtctag gctggaaaga aagggacgcg
      181 ggagcggcca cggcagggtt aacctctgtt tctgctcatc atgggagaga ttaaagtctc
      241 tccagattat aattggttta gaagtaccgt tcccctcaaa aagataatcg tggatgatga
      301 tgacagtaag atctggtcac tctatgatgc tggccccaga agcatcaggt gtcctctcat
      361 ctttcttcct cccgtcagtg gaactgcaga tgtgtttttc cagcagattt tggctttgac
      421 tggatggggt taccgggtta tagctttgca gtatccagtt tattgggacc atcttgaatt
      481 ctgtgatgga ttcagaaaac ttttagacca cttacagttg gataaagtcc atctgtttgg
      541 ggcatctttg ggaggctttt tggctcagaa atttgctgaa tacactcaca agtctcccag
      601 agtgcactct ctgatcctgt gcaatgcctt cagtgacacg tctatcttca accaaacatg
      661 gactgcaaac agcttctggc tgatgccagc gtttatgctc aagaaaatag ttctggggaa
      721 cttttcctct ggcccagtgg acccgatgat ggctgatgcc atcgatttca tggtggacag
      781 gctggagagt ttgggtcaaa gtgaactggc ttcaagacta actctcaatt gtcaaaattc
      841 ctatgtggaa cctcataaaa ttcgggatat ccctgtcacc atcatggatg tgtttgacca
      901 gagtgcactg tcaatggaag ccaaggaaga aatgtacaaa ctgtacccta atgcccggag
      961 agctcacctt aagacaggag gcaatttccc ctatctgtgc aggagtgcag aggtcaatct
     1021 ttatgtgcag atacatttgc tgcagttcca tggaaccaag tacgctgcca tcgacccgtc
     1081 ggtggtcagt gcagaggagc tggacgtgca gaagggccag ctcgacctca gccaggagga
     1141 gccatagaag ggcccaacag cgagccaccc tgctcctgca caatcagttc aggtccatcg
     1201 ggcacactgg ttctcactct tctggaagta ggactgattg tcaatctcat gacaggcgtc
     1261 agcccttcta ggccagtgtg actgtcccct ctccacgttt atttttgctt taaacttttg
     1321 aatttgaaga acttttaaag actcccattt taagaattgt gaaaattttg ctaccaaaag
     1381 tcttctccac actgtgttca tctcgaaggc ttggggtcgg tcatgtgaca tttttctttt
     1441 cctgctttgt aagactgctg cacctccggg ttggaagagg aacacggtca tttttatgtt
     1501 ttcttgagca taaccagagt atcgaggctg gcagcttgct ggccactccc tacacatcag
     1561 ctcttttagt ttccagttga gcacaccatt ttgagtatta gctgttgtat ttctagacat
     1621 tacatttgga ataaaaattg aatttcagcc a
//
