LOCUS       NM_001415924            7650 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus SPG11 vesicle trafficking associated, spatacsin
            (Spg11), mRNA.
ACCESSION   NM_001415924 XM_006234855
VERSION     NM_001415924.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7650)
  AUTHORS   Varga,R.E., Khundadze,M., Damme,M., Nietzsche,S., Hoffmann,B.,
            Stauber,T., Koch,N., Hennings,J.C., Franzka,P., Huebner,A.K.,
            Kessels,M.M., Biskup,C., Jentsch,T.J., Qualmann,B., Braulke,T.,
            Kurth,I., Beetz,C. and Hubner,C.A.
  TITLE     In Vivo Evidence for Lysosome Depletion and Impaired Autophagic
            Clearance in Hereditary Spastic Paraplegia Type SPG11
  JOURNAL   PLoS Genet 11 (8), e1005454 (2015)
   PUBMED   26284655
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7650)
  AUTHORS   Perez-Branguli,F., Mishra,H.K., Prots,I., Havlicek,S., Kohl,Z.,
            Saul,D., Rummel,C., Dorca-Arevalo,J., Regensburger,M., Graef,D.,
            Sock,E., Blasi,J., Groemer,T.W., Schlotzer-Schrehardt,U.,
            Winkler,J. and Winner,B.
  TITLE     Dysfunction of spatacsin leads to axonal pathology in SPG11-linked
            hereditary spastic paraplegia
  JOURNAL   Hum Mol Genet 23 (18), 4859-4874 (2014)
   PUBMED   24794856
REFERENCE   3  (bases 1 to 7650)
  AUTHORS   Murmu,R.P., Martin,E., Rastetter,A., Esteves,T., Muriel,M.P., El
            Hachimi,K.H., Denora,P.S., Dauphin,A., Fernandez,J.C.,
            Duyckaerts,C., Brice,A., Darios,F. and Stevanin,G.
  TITLE     Cellular distribution and subcellular localization of spatacsin and
            spastizin, two proteins involved in hereditary spastic paraplegia
  JOURNAL   Mol Cell Neurosci 47 (3), 191-202 (2011)
   PUBMED   21545838
REFERENCE   4  (bases 1 to 7650)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   5  (bases 1 to 7650)
  AUTHORS   Stevanin,G., Santorelli,F.M., Azzedine,H., Coutinho,P.,
            Chomilier,J., Denora,P.S., Martin,E., Ouvrard-Hernandez,A.M.,
            Tessa,A., Bouslam,N., Lossos,A., Charles,P., Loureiro,J.L.,
            Elleuch,N., Confavreux,C., Cruz,V.T., Ruberg,M., Leguern,E.,
            Grid,D., Tazir,M., Fontaine,B., Filla,A., Bertini,E., Durr,A. and
            Brice,A.
  TITLE     Mutations in SPG11, encoding spatacsin, are a major cause of
            spastic paraplegia with thin corpus callosum
  JOURNAL   Nat Genet 39 (3), 366-372 (2007)
   PUBMED   17322883
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 5, 2023 this sequence version replaced XM_006234855.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.12763.1,
                                           SRR26643284.4649.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               JAXUCZ010000003.1  129526185-129526444 c
            261-442             JAXUCZ010000003.1  129522612-129522793 c
            443-667             JAXUCZ010000003.1  129521149-129521373 c
            668-860             JAXUCZ010000003.1  129518575-129518767 c
            861-998             JAXUCZ010000003.1  129515064-129515201 c
            999-1444            JAXUCZ010000003.1  129514396-129514841 c
            1445-1590           JAXUCZ010000003.1  129510846-129510991 c
            1591-1723           JAXUCZ010000003.1  129508442-129508574 c
            1724-1879           JAXUCZ010000003.1  129506030-129506185 c
            1880-2055           JAXUCZ010000003.1  129505105-129505280 c
            2056-2232           JAXUCZ010000003.1  129503146-129503322 c
            2233-2304           JAXUCZ010000003.1  129502241-129502312 c
            2305-2432           JAXUCZ010000003.1  129501134-129501261 c
            2433-2608           JAXUCZ010000003.1  129500723-129500898 c
            2609-2819           JAXUCZ010000003.1  129499906-129500116 c
            2820-3023           JAXUCZ010000003.1  129496204-129496407 c
            3024-3130           JAXUCZ010000003.1  129494907-129495013 c
            3131-3276           JAXUCZ010000003.1  129493001-129493146 c
            3277-3438           JAXUCZ010000003.1  129491573-129491734 c
            3439-3505           JAXUCZ010000003.1  129489954-129490020 c
            3506-3671           JAXUCZ010000003.1  129488567-129488732 c
            3672-3877           JAXUCZ010000003.1  129484593-129484798 c
            3878-3986           JAXUCZ010000003.1  129483744-129483852 c
            3987-4146           JAXUCZ010000003.1  129482031-129482190 c
            4147-4398           JAXUCZ010000003.1  129481442-129481693 c
            4399-4599           JAXUCZ010000003.1  129480036-129480236 c
            4600-4707           JAXUCZ010000003.1  129479079-129479186 c
            4708-4870           JAXUCZ010000003.1  129477866-129478028 c
            4871-5085           JAXUCZ010000003.1  129474137-129474351 c
            5086-5833           JAXUCZ010000003.1  129472815-129473562 c
            5834-5973           JAXUCZ010000003.1  129468121-129468260 c
            5974-6172           JAXUCZ010000003.1  129467237-129467435 c
            6173-6310           JAXUCZ010000003.1  129466782-129466919 c
            6311-6444           JAXUCZ010000003.1  129466506-129466639 c
            6445-6552           JAXUCZ010000003.1  129465808-129465915 c
            6553-6721           JAXUCZ010000003.1  129464006-129464174 c
            6722-6810           JAXUCZ010000003.1  129463664-129463752 c
            6811-6966           JAXUCZ010000003.1  129463329-129463484 c
            6967-7118           JAXUCZ010000003.1  129462354-129462505 c
            7119-7650           JAXUCZ010000003.1  129461477-129462008 c
FEATURES             Location/Qualifiers
     source          1..7650
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..7650
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /note="SPG11 vesicle trafficking associated, spatacsin"
                     /db_xref="GeneID:311372"
                     /db_xref="RGD:1562529"
     exon            1..260
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..7299
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /note="spastic paraplegia 11 (autosomal recessive); SPG11,
                     spatacsin vesicle trafficking associated"
                     /codon_start=1
                     /product="spatacsin"
                     /protein_id="NP_001402853.1"
                     /db_xref="GeneID:311372"
                     /db_xref="RGD:1562529"
                     /translation="MAAKPGPGSAASPGCAGAMERVLPMLLVRIPAEETAQLGPRAQL
                     HRELEALGSLTAAGSLQVLSLAPGSRGGSSCRLQGPFRQFLWEESQNSTSADKPRVLV
                     AREDCGLLIYEFDLRDGRCDAALLHSCCGRTLQKLTEDQGVSISFKSLRILSFDNSTS
                     LLLINECLVVRVVFPGRESGIGVLGCLSLPLPAQAVDTIIDVQLCKRFLFLLSTLGWI
                     HIFDTVKGMHVARVDLALPREDSEQQEPASISSFMSLKVSRDLDVLLLVSSSSTAVAL
                     NLHLYFRLHPGHLLCEGTLQDLPIEGPTGIDEDDLVNSAHNMKLTKVSFQVDRSWRAQ
                     LASLNESVRSSEPELSCYPPWFQGALCLESLESGNHSPIVPNHVFIPGDVPSGQYAFP
                     QKEHSKTSEPRPWRTMHLSEQEQPTELTCLSVTGFTALFIQAVGTTSCTVVLWDLETQ
                     SMQCFSLSQKCTPVDISGDQQLCLALTENGLSLILFGLTQEEFLNRLMIHGSASTVDS
                     LCHLNGWGRCSIPIHALEAGIENRQLDTVDFFLKSKENLLTPSSKSPAPDQQQHFSSQ
                     LYLRQVEEMTPALDLLCSAIRESDSETQSKHFAEQLLHLTLSFLNKQMRELFDHTEEL
                     DEHLQKGAAILTSYINELRTFMIKFPWKPGDAIDESDENEEVLTVKEGQVWEELRSEE
                     VIADAILNNRIPEAQTFFRITGHSAQRLEELVRIGLDLAFDSLKKNSVEEASRLLRNM
                     GFSVEDELLKISFYTTDKNIRDFLVEILKEKECFSEKERRTVDFVHQAERLYSGHFQE
                     NAPMQAFPRYWIKEQDCFKHKSVLDTFLKCDTKDEFTKQDHRIALNWAHWWDRQTQEC
                     ILLPRISSEEYKAHSPEALWRHLTARHDWSSISLWMEEFQAQETVSPQQSKWPPLSAA
                     VIEQNTCCSRHMRNAILDQLARCGIFLASELEDFELLLLRLSRIGGVMQDALPVQSYR
                     SSAGCNFDSQVILYCLEHGLQHLLYVYLDYYKLSPGNCPFLEKKELHEAHPWLEFLVQ
                     CRQVSSNLTDPKLIFQASLANAQISIPTNQASVSSMLLEGHTLLALATTMYAPGGVSQ
                     VIQHEDSENCLKKVDPQLLKMALTPYPKLKAALFPQCTAPSILPSDITLYHLIQSLPP
                     FDPSRLFGWQSANTLAIGDAAGQLPHFSSPDLVSKYAVVEQLSYTYYLHHGRPSFAFG
                     TFLVQELIKSKTPKQLIQQVGKEAYTLGLSSFHNPSVGAACVCFLELLGLSSLKLRVD
                     LKMANVVLGSRRRNEDAHPSFIRESLAEKLSKLADGDRATTEELLVLLEEGVWDSIEQ
                     QGFNRLSSESSSQWSLVLQFCMLHDMKLSVSYLRECAKANDWLQFLVHSQLHNYHPEE
                     VETLLQYFSPVLQSHLKLASEKLSSGSISKDDSCLQELQKNKETSDFFEILHRCSDES
                     ASWCWLLAEAVRHRVPILSVLASCIQGASAVPCLCVWIVTSVEDKVAAEAIEHIQISV
                     EDHHWSLEDLSIIWRTVLTRRKIHTLIRGFRLFIKDSPLLLIMEMYELCVFFKNYGKA
                     KVKLVEFQKSLEMLDTVATRVLPVIPATWMREQVCFLLKLMPQQCETQYELQKVLQLF
                     VGMEQLFSDGPDVQKLYRLSQVLKDTPITISPAVISSYSTESLQRECRSILEKLKADG
                     QFAVARRVAELASLPVDGLVIEQLTQEMQMLTHTQQWSLKQARLDFWRKCHENFKKNS
                     VSNRAASSFFSSQAPEASEHPAEQGSLEERHLLLTLAGHWLAQEEPVPVEELEELEKQ
                     IWLCRIAQHTCGGAEEETKPSLSQHKLAPAELSSDSSASEFSFSKLAALNTSKYLDLN
                     GLPSKEMCENTLEHREQESLNTLIGQLLDGGCVHEASRVCRYFRVYSQDLVLLLHCRA
                     LASAEASMEDLHSEIRALLSNATLPEDLESPGVPLRKVHSTSSLDSLSFAMVPPTDEV
                     ARSLQTLISRCLHGKDYCRQVLCLYELAKELGCSYGDVATRDSEAMLRAILASQRPDR
                     CRQAQVFINTQGLEPDTVAELVAEEVTRELLTPSEGAGEKQPFNLAEESQTFLQLTAL
                     CQDRTLVGMKLLDKIPSVPHGELSCTTELLILAHHCFTCACYMEGIIRVLQAARMLTD
                     NHLAPNEEYGLVVRLLTGIGRYNEMTYIFDLLHQKHYFEVLMRKKLDPTGTLKTALLD
                     YIKRCHPGDSEKHNMIALCFSMCREIGENHEAAACIQLKLIESQPWEESLKDGAQLKQ
                     LLLKALTLMLDAAESYAKDSCVRQALHCNRLTKLITLQIHFLNSGQNTMLINLGHQKL
                     MDCIMTLPRFYQASIVAEAYDFVPDWAEVLYQQVILKGDFSYLEEFKQQKLLKPNIFE
                     DISKKYKQHQPTDRVTENLKKLLSYCEDIYLYYKLAYEHKFFEIVNMLLKDPQTGCCL
                     KDMLAG"
     exon            261..442
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            443..667
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            668..860
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            861..998
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1444
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1590
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1723
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1879
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2055
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2232
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2304
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2432
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2608
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2819
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..3023
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3130
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3276
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3438
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3505
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            3506..3671
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            3672..3877
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            3878..3986
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            3987..4146
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            4147..4398
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            4399..4599
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            4600..4707
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            4708..4870
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            4871..5085
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            5086..5833
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            5834..5973
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            5974..6172
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            6173..6310
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            6311..6444
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            6445..6552
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            6553..6721
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            6722..6810
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            6811..6966
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            6967..7118
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
     exon            7119..7650
                     /gene="Spg11"
                     /gene_synonym="RGD1562529"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccgggcca agatggctgc caagccaggg cccggaagtg ctgcctcccc cggctgtgcc
       61 ggcgccatgg agcgagttct acccatgctg ctggtgcgga tccctgccga ggagacggcg
      121 cagctgggac cgcgggcgca gctgcaccga gagctggagg ccctggggag cctgacggct
      181 gcgggcagtc tccaagtgct ttccttggcg ccgggcagta ggggtggaag cagctgccgc
      241 ctccaaggcc cctttaggca gttcctgtgg gaggagtctc agaacagcac atcagcagac
      301 aagcccagag tgcttgttgc tcgagaagat tgtgggctgc tcatatatga atttgacttg
      361 agagatggaa gatgtgacgc agccttacta cacagctgtt gtgggaggac cctgcagaag
      421 ctcactgaag atcaaggtgt cagcatttcc ttcaagtctt tgaggattct gtcatttgac
      481 aacagcacgt ccttactgct catcaatgag tgtctcgtcg tacgtgtcgt gtttccgggg
      541 agagaatctg ggattggagt gctgggctgc ctctcactgc ccttgcctgc acaggcagtg
      601 gacacgataa ttgacgtgca gctctgcaag aggtttcttt tccttctgag tacattaggc
      661 tggatccata tttttgacac tgtaaagggc atgcatgtag cccgcgtgga cttggctctt
      721 ccccgagaag attctgagca gcaggagcct gccagcattt cttcctttat gtcactgaaa
      781 gtgtctcggg acttagatgt tttgctactc gtcagctcgt ccagtactgc agttgctctt
      841 aaccttcact tgtatttcag gctacaccca gggcacctgc tgtgtgaagg aactctgcaa
      901 gacctcccta ttgaagggcc tacaggaata gatgaagatg accttgttaa ttctgcccac
      961 aacatgaaac tgaccaaggt gtccttccaa gttgataggt cctggagagc ccagctggca
     1021 tcactgaatg aatctgtgag gagctcagaa ccagagcttt cctgctatcc tccgtggttc
     1081 cagggtgctt tgtgtttgga gtccctggaa tctggtaacc actcccccat tgtgccaaac
     1141 cacgttttca ttccagggga tgtcccgagt ggccagtatg cttttcctca gaaggagcac
     1201 agcaagacca gtgagccaag gccgtggagg acaatgcacc tgagtgaaca agagcagccc
     1261 acagagctca cgtgtctgtc tgtgacggga tttacggccc tgtttattca ggcagtagga
     1321 acgaccagct gcaccgtcgt cctctgggac ttggagaccc agagcatgca gtgtttttct
     1381 ctcagccaga agtgtactcc tgtagacatc agcggagacc agcagctgtg ccttgctttg
     1441 acagagaacg gcctgtctct gattttgttt ggtttaactc aagaggagtt tctgaacaga
     1501 ctgatgatcc atggcagtgc cagcactgtg gactcccttt gtcatctcaa cggttgggga
     1561 cggtgctcaa tccccatcca cgctctagag gctggcatag aaaatcgtca gctggacacg
     1621 gtagatttct tcctgaagag caaggaaaat cttcttactc catcttcaaa atctcctgcc
     1681 cctgatcagc agcagcactt ctcctcccag ctctacctaa ggcaggtgga agagatgacc
     1741 ccagccctgg acttactctg ctcagcaatt agagaaagcg actccgaaac ccaaagcaag
     1801 cactttgcag agcagctgct tcacctcaca ctgtctttcc ttaacaagca aatgagggag
     1861 ctttttgatc acactgaaga gctagatgag catttacaga aaggagcagc cattttgacc
     1921 agctacatca atgaacttcg gacttttatg ataaagtttc cttggaagcc aggagatgcc
     1981 atagatgaat ctgatgaaaa tgaagaggtc ctcacagtga aagaaggcca ggtttgggag
     2041 gaactccgct ctgaggaagt tattgctgat gccattttaa ataacagaat accagaggca
     2101 caaactttct tcaggattac tggtcattcc gctcaacgac ttgaggaact ggttaggata
     2161 ggcctagatt tggcatttga cagtttaaaa aagaacagcg tggaggaggc ctccaggctc
     2221 ttgaggaaca tgggcttcag tgtggaagac gagctgctta agataagctt ttatacgact
     2281 gataaaaaca tacgggactt tttggttgaa attttaaaag aaaaggaatg tttttctgaa
     2341 aaagaaagaa gaactgtgga ctttgtccat caagctgaaa ggctttactc aggacacttc
     2401 caggaaaatg cgccgatgca ggcttttccc aggtattgga taaaggaaca ggactgtttc
     2461 aaacacaaat ctgtcttgga cacgttcctc aaatgtgata caaaagatga gtttaccaaa
     2521 caggaccata gaattgcact gaattgggct cactggtggg atcggcaaac acaggagtgt
     2581 atccttctcc ccagaataag ttcagaagaa tataaagcac attccccaga agccctgtgg
     2641 agacacctca cagctcgcca tgactggtca agcatcagct tgtggatgga agaatttcag
     2701 gcccaggaaa ctgtgtcacc tcagcagagc aagtggcctc ctctgagtgc tgccgtcatc
     2761 gagcagaaca cttgctgcag caggcacatg aggaacgcga tcttagacca gctggccaga
     2821 tgtggcattt ttcttgcatc tgagctggaa gactttgaac ttctcctcct gagactgagc
     2881 cggattgggg gtgtaatgca ggatgccctc cccgtgcaga gctacagatc ctcggcaggg
     2941 tgcaactttg attcccaagt catcctctac tgtttagagc acggcctgca gcatcttctc
     3001 tacgtctacc ttgactatta caaacttagc cctggaaatt gtcccttttt ggaaaagaaa
     3061 gaactacatg aagctcaccc ttggcttgaa tttttggttc agtgtcggca agtttccagt
     3121 aacttgacag atcccaaact gatctttcag gccagtcttg caaatgctca gatttcgatt
     3181 cccaccaatc aagccagtgt gagcagcatg ctgttggaag gacacaccct cttggctctt
     3241 gctaccacca tgtatgctcc tgggggcgtc agccaggtca ttcagcatga agacagcgag
     3301 aactgtttga agaaagtgga cccccagcta ctgaagatgg ccttaacgcc ttacccaaag
     3361 ctcaaagccg cgctcttccc tcagtgcact gctcctagta ttctgccctc tgacattaca
     3421 ctctaccacc tcatccagtc cttaccaccc tttgatccca gcagactgtt tggctggcag
     3481 tctgccaaca ctctagctat cggagatgcg gccggtcagc tcccacactt ctccagtcct
     3541 gacctggtga gtaaatacgc cgtggtggag cagctgagct acacgtatta cttacatcac
     3601 ggacgcccat ccttcgcctt cggcaccttt ctggtccagg agttaatcaa gagtaagact
     3661 cccaagcagc tgatccagca agtaggcaag gaggcctata ccttagggct ctcctccttc
     3721 cacaaccctt cggtaggggc cgcctgtgtc tgcttcttag aattgcttgg cctcagcagc
     3781 ctcaagctca gagttgacct gaaaatggca aacgtagttc tgggctccag gcgtagaaat
     3841 gaagatgcac atcccagctt catcagagag tctctggctg agaagctgtc taagcttgct
     3901 gacggtgaca gggcaaccac agaagagctg ctcgttctct tggaggaagg cgtgtgggac
     3961 agcattgagc agcagggctt taacaggttg tccagcgaat ccagcagcca gtggtcatta
     4021 gtgttacagt tctgcatgct ccatgatatg aaactgagcg tgtcctacct tagagaatgt
     4081 gccaaagcaa atgattggct gcagtttctg gttcacagcc agctccataa ctaccaccca
     4141 gaagaggtgg aaaccctgct tcagtatttc agtcctgtcc ttcagagtca cttgaagctg
     4201 gcttctgaga aactgtcatc agggtccatc tctaaggacg acagctgcct ccaggaactc
     4261 cagaaaaaca aagaaacaag tgatttcttt gaaattctcc accggtgctc ggatgagtca
     4321 gcttcctggt gctggctcct ggctgaagca gtgagacatc gggttcccat cctcagtgtc
     4381 ctggcctcgt gtatccaggg tgccagtgct gtcccctgtc tctgtgtttg gattgtcacc
     4441 tctgtggagg acaaggttgc agctgaagca atagaacaca ttcagatctc tgtagaggac
     4501 catcattgga gcctcgagga cctgtccatt atctggagaa ctgtattgac aagacggaag
     4561 atccacactc tcatccgagg cttccggctt ttcattaagg attccccact tctcttgatt
     4621 atggaaatgt atgaactgtg tgtgttcttc aagaactacg gaaaagccaa agttaagctt
     4681 gtggagttcc agaaaagcct tgaaatgctt gacacagtgg ctactcgggt ccttcctgtc
     4741 atacctgcca cgtggatgag ggagcaggtg tgcttccttt tgaaacttat gccacagcag
     4801 tgcgagacac agtatgagct gcagaaagtc ctccaactgt ttgtcgggat ggagcagctc
     4861 ttctccgatg ggccagacgt gcagaagctg tatcggctca gccaagtact gaaggacaca
     4921 cctatcacca tcagccctgc agtcatttcc agctacagca ctgagagttt gcagcgtgag
     4981 tgtagatcta ttttggagaa gctaaaggca gatggacagt ttgctgtggc caggagagtg
     5041 gcagaattag catccctgcc tgtggacggc ttggtgattg aacagttaac gcaggaaatg
     5101 caaatgctaa cacacaccca gcagtggtcc ctgaaacaag caagacttga cttctggaga
     5161 aaatgccatg aaaattttaa gaaaaactct gtttcaaaca gagcagcctc ttccttcttc
     5221 tccagccaag ccccggaggc gagtgagcac cctgctgagc agggcagcct tgaggagcgc
     5281 catctgctgc tcactctggc gggccactgg cttgcccaag aagagccagt tcccgtggag
     5341 gaactggagg agctggagaa acagatttgg ctctgccgca tcgcccagca cacatgtgga
     5401 ggggctgaag aagaaaccaa gcccagcctc tcgcaacaca agttggcccc tgctgaactt
     5461 tcttctgata gctcagccag tgagttctcc ttctccaagc ttgctgcttt gaacacatcc
     5521 aaatacttag accttaatgg tcttccatcc aaggagatgt gtgagaacac actggaacac
     5581 agagagcagg agtcactgaa cactttgatt gggcagctgc tggatggtgg ctgtgtgcat
     5641 gaagcgagca gagtgtgccg gtatttccgt gtctatagtc aggatctagt gctgctgctg
     5701 cactgcagag ccttggcctc cgcagaggcc agcatggaag atctgcactc agagatccgt
     5761 gccctcctct caaatgccac actacctgag gacctggaga gccctggcgt ccctcttcgg
     5821 aaagtccata gcacttcgag tttggacagt ctgtcatttg cgatggtacc acctactgat
     5881 gaagtggcca ggagtctcca aactctcata agcaggtgcc tccatgggaa ggattactgt
     5941 cggcaggtcc tctgtctgta tgaacttgcc aaggagttgg gctgttccta tggagatgtt
     6001 gctaccaggg acagtgaagc catgctccga gcaatcttgg cttctcagcg gcctgaccga
     6061 tgcagacaag cccaggtctt catcaacacc cagggccttg aaccagacac tgtggctgaa
     6121 cttgtggctg aagaggtgac acgagagcta ctgaccccat cagagggagc aggagaaaag
     6181 cagcctttca acctagcaga ggaaagccag acatttcttc agctaactgc tttgtgtcaa
     6241 gaccgtacat tggtaggcat gaagttgttg gacaagattc catctgtccc ccatggggag
     6301 ctgtcatgca ccacagagct cctgatcctg gcccatcact gctttacctg tgcgtgttac
     6361 atggagggca tcatcagagt cctacaggct gcccggatgc ttacagataa ccacttggct
     6421 cccaatgagg agtatggatt ggtggtacgc ctcctcactg gcattggacg gtacaatgag
     6481 atgacgtaca tattcgactt gctgcatcaa aagcattatt ttgaagttct gatgaggaag
     6541 aagctagatc caaccggcac cctgaaaaca gccctactag actacatcaa acgctgccac
     6601 cctggagaca gtgaaaagca caatatgatc gccctgtgct tcagcatgtg tcgggagata
     6661 ggagagaacc acgaggccgc agcctgcatc caactgaagc tgatcgaatc tcagccctgg
     6721 gaggaaagtc tcaaggatgg agcccaacta aaacagctcc tgcttaaagc cctgactttg
     6781 atgctggacg cagcagagag ttacgcaaag gactcctgtg tgcggcaggc cctgcattgt
     6841 aaccggctca ccaagttgat aacactacag attcactttc tcaacagtgg ccagaacaca
     6901 atgctcatca acttgggcca tcagaagcta atggactgta tcatgaccct acctcggttc
     6961 taccaggctt ctattgtagc tgaggcctat gactttgttc ctgattgggc tgaagtactc
     7021 taccaacaag tgattcttaa aggagacttt agttacttgg aagaatttaa gcagcagaag
     7081 ttactaaaac ccaatatatt tgaagacatt tccaaaaaat ataaacaaca ccagcctact
     7141 gacagggtca cagaaaacct gaagaagtta ctttcatatt gtgaagacat ctacctgtat
     7201 tacaagttgg catatgaaca caagtttttt gaaattgtaa atatgcttct gaaggatcct
     7261 caaacaggat gctgtcttaa agatatgctc gcgggttaga aggtctgaaa ggtgcttgac
     7321 tgttcgtacc tatacggctc taagggtgtt ccatcacaat aaagtacttg gataccttta
     7381 tccccacttg agttgaaaag cccagaaata taccacactg caccagtcgt ttgtgtctgt
     7441 aggaaatgga gagattagta ttgagatcaa aagtgtcttg ttagaatggc ttctacatag
     7501 agaaacaata gtgcttaaag aacacctgtg cctgcaggtt ccagtttcaa agcaatttaa
     7561 tcttatttac acagttaagg aacgggtgat acattttcat gagttagaaa ctgatctttc
     7621 tgtaataaaa tagattttaa ctcagtgtca
//
