LOCUS       NM_001108802           10978 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus striated muscle enriched protein kinase (Speg),
            transcript variant 1, mRNA.
ACCESSION   NM_001108802 XM_001058207 XM_343596
VERSION     NM_001108802.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10978)
  AUTHORS   Kusic,D., Connolly,J., Kainulainen,H., Semenova,E.A., Borisov,O.V.,
            Larin,A.K., Popov,D.V., Generozov,E.V., Ahmetov,I.I., Britton,S.L.,
            Koch,L.G. and Burniston,J.G.
  TITLE     Striated muscle-specific serine/threonine-protein kinase beta
            segregates with high versus low responsiveness to endurance
            exercise training
  JOURNAL   Physiol Genomics 52 (1), 35-46 (2020)
   PUBMED   31790338
  REMARK    GeneRIF: Striated muscle-specific serine/threonine-protein kinase
            beta segregates with high versus low responsiveness to endurance
            exercise training.
REFERENCE   2  (bases 1 to 10978)
  AUTHORS   Liu,X., Ramjiganesh,T., Chen,Y.H., Chung,S.W., Hall,S.R.,
            Schissel,S.L., Padera,R.F. Jr., Liao,R., Ackerman,K.G.,
            Kajstura,J., Leri,A., Anversa,P., Yet,S.F., Layne,M.D. and
            Perrella,M.A.
  TITLE     Disruption of striated preferentially expressed gene locus leads to
            dilated cardiomyopathy in mice
  JOURNAL   Circulation 119 (2), 261-268 (2009)
   PUBMED   19118250
REFERENCE   3  (bases 1 to 10978)
  AUTHORS   Hsieh,C.M., Fukumoto,S., Layne,M.D., Maemura,K., Charles,H.,
            Patel,A., Perrella,M.A. and Lee,M.E.
  TITLE     Striated muscle preferentially expressed genes alpha and beta are
            two serine/threonine protein kinases derived from the same gene as
            the aortic preferentially expressed gene-1
  JOURNAL   J Biol Chem 275 (47), 36966-36973 (2000)
   PUBMED   10973969
REFERENCE   4  (bases 1 to 10978)
  AUTHORS   Hsieh,C.M., Yoshizumi,M., Endege,W.O., Kho,C.J., Jain,M.K.,
            Kashiki,S., de los Santos,R., Lee,W.S., Perrella,M.A. and Lee,M.E.
  TITLE     APEG-1, a novel gene preferentially expressed in aortic smooth
            muscle cells, is down-regulated by vascular injury
  JOURNAL   J Biol Chem 271 (29), 17354-17359 (1996)
   PUBMED   8663449
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 9, 2022 this sequence version replaced NM_001108802.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760386,
                              SAMEA5760475 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-552               JAXUCZ010000009.1  84314387-84314938
            553-642             JAXUCZ010000009.1  84323873-84323962
            643-979             JAXUCZ010000009.1  84324045-84324381
            980-2286            JAXUCZ010000009.1  84327057-84328363
            2287-2430           JAXUCZ010000009.1  84330079-84330222
            2431-2613           JAXUCZ010000009.1  84330740-84330922
            2614-2789           JAXUCZ010000009.1  84340290-84340465
            2790-2878           JAXUCZ010000009.1  84340786-84340874
            2879-3054           JAXUCZ010000009.1  84341600-84341775
            3055-3315           JAXUCZ010000009.1  84344227-84344487
            3316-3474           JAXUCZ010000009.1  84345606-84345764
            3475-3664           JAXUCZ010000009.1  84345871-84346060
            3665-3888           JAXUCZ010000009.1  84346158-84346381
            3889-4008           JAXUCZ010000009.1  84349461-84349580
            4009-4113           JAXUCZ010000009.1  84349951-84350055
            4114-4320           JAXUCZ010000009.1  84350220-84350426
            4321-4444           JAXUCZ010000009.1  84350777-84350900
            4445-4620           JAXUCZ010000009.1  84350985-84351160
            4621-4733           JAXUCZ010000009.1  84354372-84354484
            4734-4902           JAXUCZ010000009.1  84355050-84355218
            4903-4999           JAXUCZ010000009.1  84355369-84355465
            5000-5200           JAXUCZ010000009.1  84355584-84355784
            5201-5258           JAXUCZ010000009.1  84357096-84357153
            5259-5336           JAXUCZ010000009.1  84357696-84357773
            5337-5515           JAXUCZ010000009.1  84357860-84358038
            5516-5542           JAXUCZ010000009.1  84358460-84358486
            5543-5695           JAXUCZ010000009.1  84358925-84359077
            5696-5738           JAXUCZ010000009.1  84359641-84359683
            5739-5807           JAXUCZ010000009.1  84360687-84360755
            5808-7767           JAXUCZ010000009.1  84360956-84362915
            7768-7899           JAXUCZ010000009.1  84363223-84363354
            7900-8016           JAXUCZ010000009.1  84366287-84366403
            8017-8184           JAXUCZ010000009.1  84366566-84366733
            8185-8307           JAXUCZ010000009.1  84366848-84366970
            8308-8475           JAXUCZ010000009.1  84367159-84367326
            8476-9055           JAXUCZ010000009.1  84367443-84368022
            9056-9295           JAXUCZ010000009.1  84368449-84368688
            9296-9519           JAXUCZ010000009.1  84368775-84368998
            9520-9595           JAXUCZ010000009.1  84369810-84369885
            9596-9745           JAXUCZ010000009.1  84370164-84370313
            9746-10978          JAXUCZ010000009.1  84370581-84371813
FEATURES             Location/Qualifiers
     source          1..10978
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..10978
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /note="striated muscle enriched protein kinase"
                     /db_xref="GeneID:363256"
                     /db_xref="RGD:2124"
     exon            1..552
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..9938
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     striated muscle-specific serine/threonine-protein kinase;
                     aortic preferentially expressed gene 1; aortic
                     preferentially expressed protein 1; SPEG complex locus"
                     /codon_start=1
                     /product="striated muscle-specific
                     serine/threonine-protein kinase isoform 1"
                     /protein_id="NP_001102272.1"
                     /db_xref="GeneID:363256"
                     /db_xref="RGD:2124"
                     /translation="MQKARGTRGEDAGTRAPPSPGVPPKRAKVGAGRGVLVTGAGAGA
                     PVFLRPLKNAAVCAGSDVRLRVVVSGTPEPSLSWFRDGQLLPTPVPEPSCLWLRNCGA
                     QDAGVYSCSAQNERGKASCEAVLTVLEVRDSETAEDDISDVPGTQRLELRDDRAFSTP
                     TGGSDTLVGTSLDTPPTSVTGTSEEQVSWWGSGQTVLEQEAGSGGGTRPLPGSPRQAQ
                     TTGAGPRHLGVEPLVRASRANLVGASWGSEDSLSVASDLYGSAFSLYRGRALSIHVSI
                     PPSGLRREEPDLQPQPASDALRPRPALPPPSKSALLPPPSPRVGKRALPGSSAQPPAT
                     PTSPHRCTQEPSLPEDITTTEEKRGKKPKSSGPSLAGTVESRPQTPLSEASGRLSALG
                     RSPRLVRAGSRILDKLQFFEERRRSLERSDSPPAPLRPWVPLRKARSLEQPKSEGGAA
                     WDTPGASQEELRSPRGSVAERRRLFQQKAASLDERTRQRSATSDLELRFAQELGRIRR
                     STSREELVRSHESLRATLQRAPSPREPGEPPLFSRPSIPKTSRAVSPAATQPPPPSGA
                     GKSGDETGRPRSRGPVGRTEPGEGPQQEIKRRDQFPLTRSRAIQECRSPVPPFTADPP
                     ESRTKAPSARKREPPAQAVRFLPWATPGVEDSVLPQTLEKNRAGPEAEKRLRRGPEED
                     GPWGAWDRRGTRSQGKGRRARPTSPELESSDDSYVSAGEEPLEAPVFEIPLQNMVVAP
                     GADVLLKCIITANPPPQVSWKKDGSVLHSEGRLLIRAEGERHTLLLREAQAADAGSYT
                     ATATNELGQASCASSLAVRPGASTSPFSSPITSDEEYLSPPEEFPEPGETWSRTPTMK
                     PSPSQDRDSSDSSSKAPPTFKVSLMDQSVREGQDVIMSIRVQGEPKPVVSWLRNRQPV
                     RPDQRRFAEEAEGGLCRLRILAAERGDAGFYTCKAVNEYGARQCEARLEVRAHPESRS
                     LAVLAPLQDVDVGAGEMALFECLVAGPADVEVDWLCRGRLLQPALLKCKMHFDGRKCK
                     LLLTSVHEDDSGVYTCKLSTVKDELTCSARLTVRPSLAPLFTRLLEDVEVLEGRAARL
                     DCKISGTPPPSVTWTHFGHPVNESENLRLRQDGGLHSLHIARVGSEDEGLYEVSATNT
                     HGQAHCSAQLYVEEPRTAASGPSSKLEKMPSIPEEPEHGDLERLSIPDFLRPLQDLEV
                     GLAKEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDIHRLVFPAVGPQHAGV
                     YKSVIANKLGKAACYAHLYVTDVVPGPPDGAPQVVAVTGRMVTLSWNPPRSLDMAIDP
                     DSLTYTVQHQVLGSDQWTALVTGLREPEWAATGLKKGLHHIFRVLSSSGKSSSKPSAP
                     SEPVQLLEHGPPLEEAPAVLDKQDIVYVVEGQPACVTVTFNHVEAQVVWRSCRGALLE
                     PRTGVYELSQPDDDQYCLRICRVSRRDLGPLTCSARNRHGTKACSITLELAEAPRFES
                     IMEDVEVGPGETARFAVVVEGKPLPDIMWYKDEVLLAESNHVSFVYEENECSLVVLSA
                     GSQDGGVYTCTARNLAGEVSCKAELSVHSAQTAMEVEGVGEDEEHRGRRLSDYYDIHQ
                     EIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHDCVLYFHEA
                     FERRRGLVIVTELCTEELLERMARKPTVCESETRTYMRQVLEGIGYLHQSHVLHLDVK
                     PENLLVWDGAGGEEQVRICDFGNAQELTPGEPQYCQFGTPEFVAPEIVNQSPVSGVTD
                     IWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLV
                     QDRLRPTAEETLEHPWFKTEAKGAEVSTDHLKLFLSRRRWQRSQISYKCHLVLRPIPE
                     LLRAPPERVWVAMPRRQPPSGGLSSSSDSEEEELEELPSVPRPLQPEFSGSRVSLTDI
                     PTEDEALGTPEAGAATPMDWQEQGRAPSKDQEAPSPEALPSPGQESPDGPSPRRPELR
                     RGSSAESALPRVGSREPGRSLHKAASVELPQRRSPSPGATRLTRGGLGEGEYAQRLQA
                     LRQRLLRGGPEDGKVSGLRGPLLESLGGRARDPRMARAASSEAAPHHQPPPESRGLQK
                     SSSFSQGEAEPRGRHRRAGAPLEIPVARLGARRLQESPSLSALSETQPPSPALPSAPK
                     PSITKSPEPSAATSRDSPQPPAPQPVPEKIPEPKPEPVRAAKPAQPPLALQMPAQSLT
                     PYAQIMQSLQLSSPTLSPQVPPSEPKPHAAVFARVASPPPGASEKRVPSARIPPVLAE
                     KVRVPTVPPRPGSSLSGSIENLESEAVFEAKFKRSRESPLSRGLRLLSRSRSEERGPF
                     RGAEDDGIYRPSPAGTPLELVRRPERSRSVQDLRVAGEPGLVRRLSLSLSQKLRRTPP
                     GQRHPAWESRSGDGESSEGGSSARGSPVLAVRRRLSSTLERLSSRLQRSGSSEDSGGA
                     SGRSTPLFGRLRRATSEGESLRRLGVPHNQLASQTGATTPSAESLGSEASGTSGSSAP
                     GESRSRHRWGLSRLRKDKGLSQPNLSASVQEDLGHQYVPSESDFPPVFHIKLKDQVLL
                     EGEAATLLCLPAACPTPRISWMKDKQSLRSEPSVVIVSCKDGRQLLSIPRASKRHAGL
                     YECSATNVLGSITSSCTVAVARTPGKLAPPEVPQTYCDTALVLWKPGDSRAPCTYTLE
                     RRVDGESVWHPVSSGIPDCYYNVTQLPVGVTVRFRVACSNRAGQGPFSNPSEKVFIRG
                     TQDSPAQSAAAPRDAPVTSGPTRAPPPDSPTSLVPTPPLAPQVSQASTLSPSTSSMSA
                     NQALSSLKAVGPPPATPPRKHRGLLATQQAEPSPPSILVTPSEHKSFVPDTGTLTPTS
                     SPQGVKPAPSSSSLYMVTSFVSAPPDPQPPAPEPPPEPTKVTVRSLSPAKEVVSSPTP
                     ESTTLRQGPPQKPYTFLEEKARGRFGVVRSCRENATGRTFVAKIVPYAAEGKRRVLQE
                     YEVLRTLHHERLMSLHEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYVVQ
                     LLQGLDYLHGRHVLHLDIKPDNLLLAADNALKIVDFGSAQPYNPQALKPLGHRTGTLE
                     FMAPEMVRGDPIGSATDIWGAGVLTYIMLSGYSPFYEPDPQETEARIVGGRFDAFQLY
                     PNTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWLQDAYLMKLRRQTLTFTTNRLKEFL
                     GEQRRRRAEAATRHKVLLRSYPGSP"
     exon            553..642
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..979
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            980..2286
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2430
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2613
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2789
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2878
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..3054
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..3315
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3474
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3664
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..3888
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            3889..4008
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            4009..4113
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            4114..4320
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            4321..4444
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            4445..4620
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            4621..4733
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            4734..4902
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            4903..4999
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            5000..5200
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            5201..5258
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            5259..5336
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            5337..5515
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            5516..5542
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            5543..5695
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            5696..5738
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            5739..5807
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            5808..7767
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            7768..7899
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            7900..8016
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            8017..8184
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            8185..8307
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            8308..8475
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            8476..9055
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            9056..9295
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            9296..9519
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            9520..9595
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            9596..9745
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
     exon            9746..10978
                     /gene="Speg"
                     /gene_synonym="APEG-1; Apeg1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccttctgg gtagcacagg ccgaaagcgg gcgggcagca ggaaggccgg ccgccggccc
       61 cataggactc atctcttaag gcaccataac ccctggggcg tccccctggc ctcccaattc
      121 taacgtccct tgcctcccta gtccagctca tagaggccat gcaaaaagcc cggggtacgc
      181 gaggcgagga cgccggcacg agggcacctc ctagccccgg ggtgcccccg aagagagcca
      241 aggtgggggc cggcagaggg gtcctcgtca ccggggcagg ggccggggcg ccggtcttcc
      301 tgcggcccct gaagaacgcg gcggtgtgtg cgggcagtga tgtgcggctg cgggtggttg
      361 tgagcgggac acccgagcct agcctcagtt ggttccggga tgggcagctc ctgcctacac
      421 cggtcccaga gcccagctgc ctatggctgc ggaactgcgg ggcacaggac gccggcgtgt
      481 acagctgcag cgcccagaat gagcggggca aggcctcctg tgaggctgtg ctcacagtgc
      541 tggaggtcag agactcggag actgctgagg atgacatcag cgatgtgccg gggacccagc
      601 gcctggagct tcgggatgac agggccttca gcacccccac ggggggctct gacaccctgg
      661 tgggcacctc cctggacaca cccccgacct ccgtgacagg cacctcagag gagcaagtga
      721 gctggtgggg cagcgggcag acggtcctgg agcaggaagc gggcagcggg ggtggcaccc
      781 gccccctccc aggcagccca aggcaagcac agacaaccgg ggccgggcca cggcacctgg
      841 gggtggagcc gctggtgcgg gcatcgcgag ctaatctggt gggcgcaagc tgggggtcag
      901 aggatagcct ttcggtggcc agtgacctgt atggcagcgc gttcagtctg tacagaggac
      961 gggcgctctc gatccacgtc agcattcctc cgagtggatt gcgcagagag gagcctgacc
     1021 ttcagcctca accggccagt gatgcccttc gtccacgtcc tgcccttcca cctccctcca
     1081 agtccgctct gcttccgcca ccatctcctc gggtgggtaa gagggctctg ccaggatcta
     1141 gtgcccagcc cccagctact cccacttcgc cccatcggtg tactcaggag ccctcgctgc
     1201 ctgaggacat caccaccacc gaagagaagc gagggaaaaa gcctaagtca tcggggccgt
     1261 cgctggcggg cacagtggag tcccggcccc agacgccatt gagcgaagct tcaggtcgcc
     1321 tgtcagcact gggccgttcg ccccggctgg tgcgcgccgg ctcccgcatc ctggacaagc
     1381 tgcagttctt cgaggagcgg cgccgcagcc tggagcgcag cgactcgccg ccagcgcccc
     1441 tgcggccctg ggtgcccctg cgcaaggctc gctcgctgga gcagccgaag tccgagggtg
     1501 gcgcggcgtg ggacacaccc ggggcctctc aggaggagct gcggtcacct aggggcagtg
     1561 tggcagagcg gcgtcgcctg ttccaacaaa aggcggcctc tctggacgag cgcacgcgac
     1621 aacgcagtgc aacctcggac ctcgagctcc gcttcgccca ggagctgggt cgcatccgcc
     1681 gatctacgtc ccgggaggag ctggtgcgtt cgcacgagtc cctgcgtgcc acgctgcagc
     1741 gcgccccatc ccctcgagag cccggcgagc ccccactctt ctcccggccc tccataccca
     1801 agacctcacg ggctgtgagc ccggctgcca cccagccgcc tcctcccagt ggcgcgggca
     1861 aatctgggga cgagactggg agaccccgaa gcagagggcc ggtgggcagg actgaaccgg
     1921 gggaaggccc acagcaggag atcaagcgtc gggaccaatt cccactcacc cggagcagag
     1981 ccatccagga gtgcaggagc cctgtgccgc ccttcaccgc ggatcctcca gagagcagga
     2041 caaaagcccc ctctgctcgc aagcgggaac cccctgccca agccgtgcgc tttctgccct
     2101 gggccactcc gggagtggag gactctgttc tgccccaaac cttggagaag aacagagcgg
     2161 gacctgaggc tgagaaaagg cttcgtagag gacctgagga ggatggtccc tggggggcct
     2221 gggaccgtag agggacccgc agccaaggca aaggtcgccg tgctcggcct acttcccctg
     2281 agctcgagtc ctcggacgac tcctatgtgt ccgctgggga agagcccctg gaggcaccag
     2341 tgtttgagat acccctgcag aacatggtgg tggcgccagg agctgatgta ctacttaagt
     2401 gtatcatcac cgccaacccc ccaccccaag tgtcctggaa aaaggatggg tccgtgttac
     2461 acagtgaggg tcgtcttctc atccgggctg aaggtgaacg gcacacactg ctacttagag
     2521 aggcccaggc tgctgatgct gggagctaca cagccactgc caccaacgaa ctgggccagg
     2581 ctagctgtgc ttcttctctg gccgtgagac ctggcgcgtc cacatccccc ttcagcagcc
     2641 caatcacctc tgatgaggag tacctgagcc ccccagagga gttcccagaa cctggggaga
     2701 cctggtcccg aacccctacc atgaagccca gtcccagcca ggatcgagat tcctctgact
     2761 cttcctccaa ggcaccccca accttcaagg tctcactcat ggaccaatca gtgagagaag
     2821 gtcaagatgt cattatgagc atccgcgtgc agggggagcc caagcctgtg gtctcctggc
     2881 tgaggaatcg gcagcctgtg cgcccagacc agcggcgctt tgcagaggag gccgagggtg
     2941 ggctctgccg gttgaggatc ctggctgctg agaggggaga tgctggtttc tacacttgca
     3001 aggcggtcaa cgaatatggc gctcggcagt gtgaggcccg cctggaggtc cgagcacacc
     3061 ctgaaagccg gtccctggcc gtgctggccc ccctgcagga cgtggacgtg ggggccgggg
     3121 agatggcgct gtttgagtgc ctggtggcag gtccagctga cgtcgaggtg gactggctgt
     3181 gccgtggccg cctgctgcag cctgcgctgc tcaaatgcaa gatgcatttt gatggccgca
     3241 agtgcaagct gctgctgacc tctgtgcatg aggacgacag cggtgtctac acttgcaagc
     3301 tgagcacagt caaagatgaa ctgacctgca gtgcccggct gacggtccgg ccatcgctgg
     3361 cgcctctgtt cacccggtta ctggaagatg tggaggtgct agaaggccgt gctgcccgcc
     3421 tggattgcaa gatcagcggc accccgcctc cctctgttac ctggactcat tttggccacc
     3481 ctgtaaatga gagtgaaaac ttgcggctgc ggcaggatgg ggggctacac tcactgcaca
     3541 ttgcccgggt gggcagcgag gacgagggac tctatgaagt cagtgccacc aacactcatg
     3601 gccaggccca ctgctctgcc cagctgtatg tggaggagcc tcggacagcg gcctctggcc
     3661 ccagctcgaa gctggagaag atgccatcta tccctgagga gccggagcat ggagatctag
     3721 agaggctgtc tattcctgac ttcctgcggc cactgcaaga tctggaagtg ggactagcta
     3781 aggaagccat gctggagtgc caagtgaccg gcctgcccta tcccaccatc agctggttcc
     3841 acaatggcca ccgcattcaa agcagtgacg accgacgcat gacacagtac agggatatac
     3901 atcgcctggt gttcccagct gtggggcctc agcacgctgg tgtctacaag agtgtcatcg
     3961 ccaacaagct gggcaaagca gcctgctatg cccatctcta tgtcacagat gtggttccag
     4021 gccctccaga tggcgctccg caagtagtgg ctgtgaccgg aaggatggtc acactctcat
     4081 ggaacccacc caggagtctg gacatggcta ttgacccaga ttccctgaca tacacagtgc
     4141 agcaccaggt gttgggctcg gaccagtgga cagcactggt cacgggcctg cgggagcctg
     4201 agtgggcagc cacggggctg aagaaggggc tccatcacat cttccgggtc ctcagctcca
     4261 gcggcaagag cagcagcaaa ccctcagcac catcggaacc tgtacagctg ttagagcacg
     4321 gcccacccct ggaagaggca cctgccgtgc tggacaagca ggacattgtg tatgtggtag
     4381 agggccagcc tgcctgtgtc accgtcactt ttaaccatgt ggaggcccag gttgtctgga
     4441 ggagctgccg gggagccctc ctggagccgc gcacgggtgt gtatgaactg agtcagccag
     4501 atgacgacca atattgcctt cggatctgcc gggtgagccg acgagacctg ggacccctta
     4561 cttgcagtgc ccgaaaccgc catggcacaa aggcctgctc gatcacccta gagctggcag
     4621 aggcacctcg gtttgagtct atcatggaag atgtggaggt ggggcctgga gaaaccgctc
     4681 gctttgctgt ggtggttgag gggaaaccac tgccggacat catgtggtac aaggatgagg
     4741 tgctgctggc cgagagcaat catgtgagct tcgtgtacga agagaacgag tgctccctgg
     4801 tggtgctcag tgcaggaagc caggatggag gcgtctatac ctgtacggcc cggaacctgg
     4861 caggcgaagt ctcctgcaag gcagagctgt ctgtgcactc agctcagaca gccatggagg
     4921 tcgaaggggt cggagaggat gaggagcacc gaggaagaag acttagcgac tactatgaca
     4981 tccaccaaga gatcggcaga ggtgccttct cctacctgcg gcgggtagtg gagcggagct
     5041 ctggcctgga gtttgcagcc aagttcatcc ctagtcaggc caagcctaaa gcatcagcga
     5101 gacgcgaggc ccggttgctg gcccgactcc agcatgactg tgtgctctac ttccacgaag
     5161 ccttcgaaag gcgcagggga cttgtcatag tcaccgagct ctgcacagaa gagcttctag
     5221 agcgcatggc caggaagccc accgtgtgtg agtctgagac tcggacttat atgcgccaag
     5281 tgctagaggg gataggctat ctgcatcaga gccatgtgct gcacctggat gtcaagccgg
     5341 agaacctgct ggtgtgggat ggtgccgggg gtgaggagca ggtgcgcatc tgtgacttcg
     5401 ggaacgccca ggaactcact ccgggagaac cccagtactg ccagtttggc acgccagagt
     5461 ttgttgcgcc tgagattgtc aaccagagcc ctgtgtctgg agtcactgac atctggcccg
     5521 tgggcgtcgt tgccttcctc tgtttgacgg gtatctcccc atttgttgga gagaacgacc
     5581 ggacaacact catgaatatc cgaaattaca acgtggcatt tgaagagact acgttcctga
     5641 gtctgagcag ggaggcccgg ggcttcctta tcaaagtgct ggtgcaggat cgactgagac
     5701 ctactgcaga agagactctg gaacatcctt ggttcaaaac agaagcaaag ggtgcagagg
     5761 tgagcacaga ccacctgaag ctctttctgt cacggaggag gtggcagcgc tctcaaatca
     5821 gctacaagtg ccacctggtg ctgcgaccca ttccggaact gctacgggca cccccggagc
     5881 gggtgtgggt ggccatgcct agaagacaac ccccgagtgg gggactttca tcctcttcag
     5941 actcagaaga ggaagaattg gaggaacttc cctcagtacc ccgccccctg cagcctgagt
     6001 tctcaggttc tcgggtatcc ctcaccgaca tccccaccga agatgaggct ctggggaccc
     6061 cggaagctgg ggctgccacc cccatggact ggcaagagca gggaagggct ccctctaagg
     6121 accaggaggc ccccagccct gaggcactcc cctctccagg ccaggagtcc cctgatgggc
     6181 ctagccccag gcggccagaa ctccgtaggg gcagctctgc tgagagcgcc ctgccccggg
     6241 tcgggtcgcg ggagccgggc cggagcctgc acaaagcagc atcggtggag ctgccgcagc
     6301 gcaggagccc cagcccgggt gccactcgcc tgactcgggg aggcctgggt gagggcgagt
     6361 atgcccagag gctgcaggcc ctgcgtcagc ggctgctgag gggaggcccg gaggatggca
     6421 aggtcagcgg tctcagggga cccctgctgg agagcctggg gggccgagca cgggatccca
     6481 ggatggcgcg ggctgcctcc agtgaggctg caccccacca ccagccccct cccgagtccc
     6541 gcggcctgca aaagagcagc agcttctctc agggtgaggc agagccccgg ggtcggcacc
     6601 gccgagcggg ggcacccctc gaaatccccg tagctaggct tggggcccgt aggctgcagg
     6661 agtctccctc cttatctgcc cttagtgaga cccagccacc gagtcctgcg ttgcccagcg
     6721 cccccaaacc cagtatcacc aagtctccgg aaccttccgc tgccacatcc agagactctc
     6781 cccagccccc agcacctcag cctgtcccag aaaagatccc agagcccaaa ccagaaccag
     6841 tccgagctgc caaaccagca caaccccctt tggctctgca aatgccagcg cagtctctca
     6901 ccccctatgc ccagatcatg cagtcgctcc agctgtccag tcccaccctg tccccacagg
     6961 tgcctccatc agagcccaag ccccacgcgg ctgtgtttgc cagggtggct tctccgccgc
     7021 ccggagcctc tgagaagcgc gtgccttcgg ccagaattcc cccagtgcta gccgagaaag
     7081 tccgagtccc cacggtgccc cccaggccag gcagcagcct cagcggtagc atcgagaacc
     7141 tcgagtcaga ggccgtgttc gaggctaagt ttaagcgtag ccgcgaatcg ccactgtcgc
     7201 ggggcctgag gctactaagc cgctcgcgct cagaggagcg cggtcccttc cgtggggcgg
     7261 aggacgatgg catataccgg cccagcccgg cgggaacgcc gctagagctg gtgcgacggc
     7321 cggagcgctc gcgctcggtg caggacctca gggtagccgg agagccaggc cttgtgcgtc
     7381 gcctttcgct gtccctgtcg cagaagctgc ggcggacacc gcccgggcag cgacaccctg
     7441 cgtgggagtc ccgcagtgga gatggagaga gctccgaggg cggcagctca gctcggggtt
     7501 ccccggtgct ggcggtgcgc aggagactca gctccacgct ggagcgtctg tccagccgtt
     7561 tgcagcgcag cggcagcagc gaggactccg ggggcgcctc gggtcgcagc acgccgctgt
     7621 ttggacggct acgcagggct acttccgaag gggagagcct gcgacgcctc ggtgttccgc
     7681 acaatcagct ggcttcgcag actggtgcca ccacaccgtc cgctgagtct ctgggctcag
     7741 aggccagcgg cacatcgggt tcctcagctc caggggaaag ccgaagccgg caccggtggg
     7801 gcctttccag gctgcgcaag gacaagggct tatcgcagcc aaacctctcc gccagtgtcc
     7861 aagaggactt gggtcaccag tatgtgccca gtgagtcaga tttcccccca gtcttccaca
     7921 tcaaactcaa ggaccaggtg ctgttggagg gggaagcagc taccctgctc tgcctaccag
     7981 cagcctgccc aacaccccgc atctcctgga tgaaagataa gcagtccctg cggtcagagc
     8041 cctcggtggt cattgtgtcc tgcaaagatg gtcggcagct gctgagcata ccccgggcta
     8101 gcaagcggca tgctgggctc tatgagtgct cagcgaccaa cgtcctaggc agcattacca
     8161 gctcctgtac tgtggcagtg gcccgcaccc caggaaagct ggctcctcca gaggtgcccc
     8221 agacctactg tgacacggcg ctggtgctgt ggaagccggg agacagtcgg gcaccttgca
     8281 cgtatactct ggagcggcgg gtagatgggg aatccgtctg gcaccctgtg agctcaggca
     8341 tccccgactg ttactacaat gtgactcagc tgcctgttgg tgtgactgtg aggttccggg
     8401 tggcctgttc caatcgtgct gggcaggggc ccttcagcaa cccttctgag aaggtcttca
     8461 tccgaggcac tcaagattct ccagctcagt cagctgctgc tccccgagat gcccctgtta
     8521 cctcagggcc aactagggcc ccaccgcctg actctcctac ctcactggtc cctaccccgc
     8581 ctcttgctcc ccaagtctcc caggcatcca cactcagccc ttcaacctcc tccatgtctg
     8641 ccaaccaggc cttgtcctct ctcaaggctg tgggtccacc acccgcaacc cctccacgaa
     8701 agcacagggg gcttctggcc acccagcaag cagagccatc cccacccagt atcctggtca
     8761 ccccaagtga acacaagtct tttgtccctg acactggaac cctgacccca acctctagtc
     8821 ctcaaggggt caaaccagca ccttcctcaa gttccttgta tatggtgact tccttcgtgt
     8881 ctgcacctcc agacccccag cccccagccc ctgagccccc tcccgagccc accaaggtga
     8941 ctgttcgaag cctcagccca gccaaggagg tggtcagctc cccaacacct gagagcacca
     9001 ctcttcgaca gggccctcct cagaaaccct acaccttcct tgaggagaag gccaggggcc
     9061 gctttggcgt tgtgcggtca tgccgggaga atgctacagg ccgaacgttc gttgctaaga
     9121 tcgtgccgta tgctgccgag ggcaagcgac gagtgctgca ggaatatgag gtgcttcgga
     9181 cactgcacca cgagaggctc atgtccctgc acgaggccta catcacccct cggtaccttg
     9241 tgcttatcgc cgagagctgt ggcaaccggg aacttctctg tgggctcagc gacagattcc
     9301 ggtattcaga agatgatgtg gccacctatg tggtgcagct gctacaaggc ctggactacc
     9361 tccatggccg ccatgtgctg cacctggaca tcaagccgga caatctactc ttggccgctg
     9421 ataatgccct taagattgtg gacttcggca gtgctcagcc ctataaccct caggccctga
     9481 agccgcttgg ccaccgcaca ggcactctag agttcatggc tcctgagatg gtaaggggag
     9541 accccatcgg ctctgccacg gatatctggg gagcgggtgt gctcacctac atcatgctta
     9601 gtgggtactc cccattctat gagccagatc cccaggaaac agaggctcgg attgttgggg
     9661 gtcgctttga tgccttccag ctgtacccta acacctccca gagtgccacc ctcttcttga
     9721 gaaaggtcct ctcagtacat ccctggagcc ggccctccct gcaggactgc ttggcccacc
     9781 catggctgca ggatgcctac ttgatgaagc tgcgccgcca gacactcacc ttcaccacca
     9841 accggctcaa ggaattcctg ggcgagcagc gtcgacgtcg ggctgaggct gctacccgtc
     9901 acaaggtgct gctccgctcc taccctggca gcccctaggt ggcatggacc acagcccggc
     9961 cacgggcttc aaccttgggt tctcactcaa cgctgccaag ggacattcca gaacccgtgc
    10021 cgagctggac gggcgggggc ttcagatacc agcagcggca acatctggct gggctattac
    10081 ctcatggacc taagaggaca aggccctggg gcttcagccg gatgtcaccc ggccacaacc
    10141 agagcaggag acccactggc caggctgggc aagggtgaga gcagaaagag gcaaggaagg
    10201 agttgggacg tgaagaagga agggagttgg ggagtacagg aagggaggag cttgaggaag
    10261 gttctgggct ggagttggag tgctatatct cagggagaac ccagaggagg acatggctaa
    10321 agaggaagca gggtcctgtg atgtgggagt atgttggaga ggaggacaag acaggagcca
    10381 gagcagagac atgagggaga gcagacaggt ggaaggcaac aggagtgggc tcaggggtgg
    10441 cagggcaggc cagcggctgc atcttcagat agagcaagga ggggctggag agatggctca
    10501 gtggataaga gcacagactg ctcttccaga ggtcctgagt tcaatttaca acaaccacat
    10561 ggtggctcat aaccatctgt aattagatct catgccctct tctggtgtgt ctgaagagag
    10621 caacagtgta ctcacataca aaataaataa attaatcaat taaaattaaa aaagaaaaag
    10681 aaaagaaaga gcaaggagaa aggcaaagag acatgtgcct gaggccactg cggctggtct
    10741 cctgtcccag ccgacgcagt tctgggcatt ctacactggc ccagggctgt tctcactgct
    10801 tctccatggc ctttgccctc cttcccgttt gtatttattt atttattgcc ttttgtggag
    10861 tttcctttct atccaatccc tattgcctat gttgtcccga ccatcccctc agccatccag
    10921 ccgtctgtgc agctctctgt ctgtctgtca caaggaaaat aaaaaacagc aagtggca
//
