LOCUS       NM_001039455            4287 bp    mRNA    linear   ROD 08-APR-2024
DEFINITION  Rattus norvegicus sperm antigen with calponin homology and
            coiled-coil domains 1-like (Specc1l), mRNA.
ACCESSION   NM_001039455 XM_342122
VERSION     NM_001039455.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4287)
  AUTHORS   Wilson,N.R., Olm-Shipman,A.J., Acevedo,D.S., Palaniyandi,K.,
            Hall,E.G., Kosa,E., Stumpff,K.M., Smith,G.J., Pitstick,L.,
            Liao,E.C., Bjork,B.C., Czirok,A. and Saadi,I.
  TITLE     SPECC1L deficiency results in increased adherens junction stability
            and reduced cranial neural crest cell delamination
  JOURNAL   Sci Rep 6, 17735 (2016)
   PUBMED   26787558
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4287)
  AUTHORS   Saadi,I., Alkuraya,F.S., Gisselbrecht,S.S., Goessling,W.,
            Cavallesco,R., Turbe-Doan,A., Petrin,A.L., Harris,J., Siddiqui,U.,
            Grix,A.W. Jr., Hove,H.D., Leboulch,P., Glover,T.W., Morton,C.C.,
            Richieri-Costa,A., Murray,J.C., Erickson,R.P. and Maas,R.L.
  TITLE     Deficiency of the cytoskeletal protein SPECC1L leads to oblique
            facial clefting
  JOURNAL   Am J Hum Genet 89 (1), 44-55 (2011)
   PUBMED   21703590
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY884296.1.
            
            On Mar 18, 2021 this sequence version replaced NM_001039455.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY884296.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4287              AY884296.1         1-4287
FEATURES             Location/Qualifiers
     source          1..4287
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..4287
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /note="sperm antigen with calponin homology and
                     coiled-coil domains 1-like"
                     /db_xref="GeneID:361828"
                     /db_xref="RGD:1309570"
     exon            1..147
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /inference="alignment:Splign:2.1.0"
     exon            148..337
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..3541
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /note="SPECC1-like protein; 28S ribosomal protein S7,
                     mitochondrial-like"
                     /codon_start=1
                     /product="cytospin-A"
                     /protein_id="NP_001034544.1"
                     /db_xref="GeneID:361828"
                     /db_xref="RGD:1309570"
                     /translation="MKKANRSAGSVPKVSGISKPQTVEKSKSENSSSAPTGGKPVKPG
                     AAAALSKTKSNDDLLAGMAGGVNVTNGVKAKKSNCSSAAPSAPAPAMTISESKSKSST
                     GTSSSAKRSTSAGNKESSSTRERLRERTRLNQSKKLPSVSQGANDVALAKRSRSRTAT
                     EGDIRMSKSKSDNQISDKAALEAKVKDLLTLAKTKDVEILHLRNELRDMRAQLGISED
                     HCEGEDRSEEKETIIAHQPTDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNALG
                     FSLEQRLDNSEKLFGYQSLSPEITPGNQSDGGGTLTSSVEGSAPGSVEDLLSQDENTL
                     MAHQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGVPSIERSRKGSSGNASEV
                     SVACLTERIHQMEENQHSTSEELQATLQELADLQQITQELNSENERLGEEKVILMESL
                     CQQSDKLEHFGRQIEYFRSLLDEHHISYVIDEDVKSGRYMELEQRYMDLAENARFERE
                     QLLGVQQHLSNTLKMAEQDNKEAQEMIGALKERSHHMERIIESEQKGKAALAATLEEY
                     KATVASDQIEMNRLKAQLEKEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLA
                     SSLQEDLAHTRNDANRLQDTIAKVEDEYRAFQEEAKKQIEDLNMTLEKLRSELEEKET
                     ERSDMKETIFELEDEVEQHRAVKLHDNLIISDLENTVKKLQDQKHDLERENKTLHRRL
                     REESAEWRQFQADLQTAVVIANDIKSEAQEEIGDLKRRLHEAQEKNEKLTKELEEIKS
                     RKQEEERGRVYNYMNAVERDLAALRQGMGLSRRSSTSSEPTPTVKTLIKSFDSASQVP
                     NAAAAAIPRTPLSPSPMKTPPAAAVSPMQRHSISGPVSTSKPLTALSDKRSNYGEIPG
                     QEHLLRTSSTSRPASLPRVPAMESAKTISVSRRSSEEMKRDISASEGASPASLMAMGT
                     TSPQLSLSSSPTASVTPSTRSRIREERKDPLSALAREYGGSKRNALLKWCQKKTEGYQ
                     NIDITNFSSSWNDGLAFCALLHTYLPAHIPYQELNSQEKKRNFTLAFQAAESVGIKST
                     LDINEMARTERPDWQNVMLYVTAIYKYFET"
     exon            338..491
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /inference="alignment:Splign:2.1.0"
     exon            492..2125
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2333
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2407
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2583
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2747
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2839
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..2930
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..3014
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3171
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /inference="alignment:Splign:2.1.0"
     exon            3172..3274
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /inference="alignment:Splign:2.1.0"
     exon            3275..3391
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /inference="alignment:Splign:2.1.0"
     exon            3392..3451
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /inference="alignment:Splign:2.1.0"
     exon            3452..4287
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagggagaca gggcgggccg aaggagtggc gctgtggggt tggctgttgc cctgaggccg
       61 gactcaacgg accgggccgc gccaccgggc gagctcgccg cccggcccca gcccggagcc
      121 agcgagtgag cgaggcggtg ccgcgcggtt tggttgtaaa tgcatcacca agaggcagcc
      181 cagaatgaag aaagcaaaca ggagtgctgg ctcagtgcct aaggtgtctg ggataagcaa
      241 accacaaacg gtagaaaaaa gcaagtctga aaacagctct tcagcaccca caggaggcaa
      301 acctgtaaag cctggggcag cagcggcctt gtcaaagacc aagagcaatg atgacctttt
      361 agctggaatg gctggaggag tgaacgtgac taatggtgtt aaagccaaga aaagcaactg
      421 ttcatctgca gcgccttcag cccctgcccc tgccatgacc atctcggaga gcaagtccaa
      481 gagtagcaca ggcactagtt cctcagccaa acggagtact tcggctggta ataaagagtc
      541 cagttctact agagaaagat tacgtgaacg cacccggcta aaccagagca aaaaactgcc
      601 ctccgtaagt cagggagcta acgatgtggc actggctaag cgctcacgca gccgcactgc
      661 tacagagggt gatattcgca tgagcaagtc taagtcggac aatcagatca gtgacaaagc
      721 tgctttggaa gccaaggtga aagatctcct cacactggcg aaaaccaagg atgtggaaat
      781 tttacatttg agaaatgaac tccgagacat gcgtgctcag ctgggcatta gtgaggacca
      841 ttgtgaaggt gaggacaggt ctgaggagaa ggaaaccatt attgcccacc agccaactga
      901 tgtggagtct accctcctgc agctgcagga acagaataca gccatccgcg aggagctcaa
      961 ccagctcaag aatgaaaaca gaatgctaaa ggacaggctg aatgctttgg gcttttccct
     1021 agagcaaagg ctggacaatt ctgaaaaact gtttggctat cagtccctga gcccagaaat
     1081 cacccctggt aaccagagtg atggaggagg aacgctgaca tcctcagtag aaggctctgc
     1141 tccggggtca gtggaagatc tcctgagcca ggatgaaaac acactcatgg cccatcagca
     1201 cagtaactcc atggacaacc tggacagtga gtgcagcgag gtctaccagc ccctcacttc
     1261 cagcgatgat gctctggacg ccccttcctc ttcagagtca gagggcgtcc caagcattga
     1321 gcgctctcgg aaggggagca gtggcaacgc cagcgaggtg tccgtcgctt gcctgacaga
     1381 acggattcac cagatggaag agaaccagca cagtaccagt gaggagcttc aggcaactct
     1441 gcaagagcta gcggatctcc agcagattac ccaggagctc aacagcgaga acgaaaggct
     1501 cggagaggag aaggtcattc tcatggagtc gctgtgtcag cagagtgata agctggaaca
     1561 ctttggccga cagattgaat atttccgttc ccttctcgat gagcatcaca tttcttacgt
     1621 catagatgaa gacgtaaaga gcgggcgcta catggagcta gagcagcgct acatggactt
     1681 ggctgagaat gcccgttttg agcgagagca gcttctaggc gttcagcagc atctaagcaa
     1741 cactctgaag atggccgaac aagataacaa ggaagctcaa gaaatgatcg gtgccctcaa
     1801 agagcgcagc caccacatgg agcggataat tgagtctgag cagaagggca aggcggccct
     1861 ggcagccacg ttggaggagt acaaagctac tgtggccagt gaccagatag agatgaatcg
     1921 cttgaaggcc cagctggaga aggagaagca gaaggtggct gagctgtact ctatccataa
     1981 ctctggagac aagtccgata tccaggacct cctggagagc gtcaggctgg acaaggaaaa
     2041 ggccgagact ctggccagca gcctgcagga ggacctggct catacccgca atgacgccaa
     2101 tcgcttacag gacaccatcg ctaaggtaga agatgagtac cgagctttcc aggaagaagc
     2161 caagaagcag attgaagatt tgaatatgac gttagaaaag ctaagatcag agctggagga
     2221 aaaagaaaca gagcggagcg acatgaagga aaccatcttt gagcttgaag atgaggtgga
     2281 gcagcaccgg gctgtgaagc tgcacgacaa cctcattatc tctgacttag agaatacagt
     2341 taaaaaactc caagaccaaa agcatgactt ggaaagagaa aacaagaccc ttcacaggag
     2401 acttcgggaa gagtccgcag aatggcggca gtttcaggct gatctccaga ctgcggtggt
     2461 cattgcaaat gacatcaagt ctgaagccca agaggagatc ggtgatctaa agcggcggct
     2521 acatgaggcc caagagaaaa atgagaaact caccaaagaa ttggaggaaa taaagtcacg
     2581 caagcaagag gaggagcgtg gccgggtgta taactacatg aatgctgttg aaagagatct
     2641 ggcagccttg aggcaaggga tgggactgag tagaaggtcc tcgacttcct cagagccaac
     2701 tcccacagta aaaaccctca tcaagtcttt cgacagtgcg tctcaagtac caaatgctgc
     2761 tgctgctgca atccctcgga cacctctgag tccaagtccc atgaagaccc cccctgcagc
     2821 tgccgtttcc cccatgcaga gacattctat aagtgggcca gtctcgacct ccaagcctct
     2881 gacagcctta tcggataaga ggtcaaacta tggagaaatt cccggacaag agcatctact
     2941 aagaacgtct tcaactagcc gacccgcctc tctcccaaga gtccctgcta tggaaagtgc
     3001 taagaccatc tcagtgtctc gacggagtag tgaagaaatg aagcgggaca tatctgcatc
     3061 tgagggggca tcaccagcct ctctcatggc tatgggcacc acatccccac agctctccct
     3121 gtcttcctct cccaccgcat cagtcactcc aagcacccgg agccgaataa gggaagaaag
     3181 gaaagacccc ctctcagcat tggcgagaga atacggagga tctaagagga atgccttgtt
     3241 gaagtggtgt cagaagaaaa cagaaggcta tcagaatatc gacatcacaa acttcagcag
     3301 cagctggaac gatgggctgg ctttctgcgc acttcttcac acctatctcc cagcccacat
     3361 accatatcaa gagctgaaca gccaagagaa gaaaaggaac ttcaccttgg ctttccaggc
     3421 agctgaaagt gttggaatca aatccactct ggacatcaat gaaatggcac gcactgaacg
     3481 gccggactgg cagaacgtaa tgctgtatgt cacagccatc tacaagtact ttgaaacctg
     3541 agcacaccgg atggctgcta ccagctaggg acctctgcag tcaccaagtg acaacaccat
     3601 tagctagaac ccctaaagct ttcagcgact ctgggcctcc ctgcagggag tgtgcccagc
     3661 tctaggcctc tgcattggaa ctggaactgc agaccagggc tcttcgacgt ggctgtcctc
     3721 gggatcagaa cacagcacac cgccggcctt cttccagaga ccgtctagct ctaactagcc
     3781 ctggagtgta aaaacacaaa ggcttgtgcc tggctcatcc tgggaaatgg gattaagttg
     3841 tgggagccac gggtcagtga aagctaaagc tatcgaactt cttgactgtc atccgtggga
     3901 ttcccagtgc tgggacagag ctggccttgg tcccttcatg tgggcctggg ttctaggagt
     3961 gaatcagaga agagggtcag taccccttcc gtgcgaggac cgtcctaacc actgcggtaa
     4021 cttagcagtg ttaaaggcca gcgcagaggc ccacagccag ttgagtctac acggccacca
     4081 agcagatttt tgtcagtctc aagaagcagg tggcacaccc agtaggtgct cagcctctag
     4141 cctgtagcac caaggaaaag actggtcaca cggagtctct cattaaagtt gttgttttat
     4201 tataagcaat attggtgaaa tagctcctat tctgttagta ccaaagttaa ttgctttagt
     4261 aagcatagaa ataaaaacat aatgtgg
//
