LOCUS       NP_001034544            1118 aa            linear   ROD 30-APR-2025
DEFINITION  cytospin-A [Rattus norvegicus].
ACCESSION   NP_001034544 XP_342123
VERSION     NP_001034544.1
DBSOURCE    REFSEQ: accession NM_001039455.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1118)
  AUTHORS   Wilson,N.R., Olm-Shipman,A.J., Acevedo,D.S., Palaniyandi,K.,
            Hall,E.G., Kosa,E., Stumpff,K.M., Smith,G.J., Pitstick,L.,
            Liao,E.C., Bjork,B.C., Czirok,A. and Saadi,I.
  TITLE     SPECC1L deficiency results in increased adherens junction stability
            and reduced cranial neural crest cell delamination
  JOURNAL   Sci Rep 6, 17735 (2016)
   PUBMED   26787558
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1118)
  AUTHORS   Saadi,I., Alkuraya,F.S., Gisselbrecht,S.S., Goessling,W.,
            Cavallesco,R., Turbe-Doan,A., Petrin,A.L., Harris,J., Siddiqui,U.,
            Grix,A.W. Jr., Hove,H.D., Leboulch,P., Glover,T.W., Morton,C.C.,
            Richieri-Costa,A., Murray,J.C., Erickson,R.P. and Maas,R.L.
  TITLE     Deficiency of the cytoskeletal protein SPECC1L leads to oblique
            facial clefting
  JOURNAL   Am J Hum Genet 89 (1), 44-55 (2011)
   PUBMED   21703590
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY884296.1.
            
            On Feb 7, 2006 this sequence version replaced XP_342123.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY884296.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1118
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     Protein         1..1118
                     /product="cytospin-A"
                     /note="SPECC1-like protein; 28S ribosomal protein S7,
                     mitochondrial-like"
                     /calculated_mol_wt=124208
     Region          1..50
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2KN99.1)"
     Region          75..175
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2KN99.1)"
     Region          178..>826
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          294..324
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2KN99.1)"
     Region          359..391
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2KN99.1)"
     Site            385
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q2KN98; propagated from
                     UniProtKB/Swiss-Prot (Q2KN99.1)"
     Site            386
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q2KN98; propagated from
                     UniProtKB/Swiss-Prot (Q2KN99.1)"
     Site            390
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q2KN98; propagated from
                     UniProtKB/Swiss-Prot (Q2KN99.1)"
     Region          <500..816
                     /region_name="SMC_N"
                     /note="RecF/RecN/SMC N terminal domain; cl47134"
                     /db_xref="CDD:481474"
     Site            869
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q69YQ0; propagated from
                     UniProtKB/Swiss-Prot (Q2KN99.1)"
     Site            882
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q69YQ0; propagated from
                     UniProtKB/Swiss-Prot (Q2KN99.1)"
     Site            888
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q2KN99.1)"
     Region          916..999
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2KN99.1)"
     Region          1006..1117
                     /region_name="CH_CYTS"
                     /note="calponin homology (CH) domain found in the cytospin
                     family; cd21199"
                     /db_xref="CDD:409048"
     Site            order(1014,1018,1068,1070..1071,1074..1075,1077,
                     1085..1093,1101,1103..1104,1106..1107,1110..1111,1114)
                     /site_type="other"
                     /note="putative actin binding site [polypeptide binding]"
                     /db_xref="CDD:409048"
     CDS             1..1118
                     /gene="Specc1l"
                     /gene_synonym="Cytsa; RGD1309570"
                     /coded_by="NM_001039455.2:185..3541"
                     /db_xref="GeneID:361828"
                     /db_xref="RGD:1309570"
ORIGIN      
        1 mkkanrsags vpkvsgiskp qtveksksen sssaptggkp vkpgaaaals ktksnddlla
       61 gmaggvnvtn gvkakksncs saapsapapa mtisesksks stgtsssakr stsagnkess
      121 strerlrert rlnqskklps vsqgandval akrsrsrtat egdirmsksk sdnqisdkaa
      181 leakvkdllt laktkdveil hlrnelrdmr aqlgisedhc egedrseeke tiiahqptdv
      241 estllqlqeq ntaireelnq lknenrmlkd rlnalgfsle qrldnseklf gyqslspeit
      301 pgnqsdgggt ltssvegsap gsvedllsqd entlmahqhs nsmdnldsec sevyqpltss
      361 ddaldapsss esegvpsier srkgssgnas evsvaclter ihqmeenqhs tseelqatlq
      421 eladlqqitq elnsenerlg eekvilmesl cqqsdklehf grqieyfrsl ldehhisyvi
      481 dedvksgrym eleqrymdla enarfereql lgvqqhlsnt lkmaeqdnke aqemigalke
      541 rshhmeriie seqkgkaala atleeykatv asdqiemnrl kaqlekekqk vaelysihns
      601 gdksdiqdll esvrldkeka etlasslqed lahtrndanr lqdtiakved eyrafqeeak
      661 kqiedlnmtl eklrseleek etersdmket ifeledeveq hravklhdnl iisdlentvk
      721 klqdqkhdle renktlhrrl reesaewrqf qadlqtavvi andikseaqe eigdlkrrlh
      781 eaqekneklt keleeiksrk qeeergrvyn ymnaverdla alrqgmglsr rsstsseptp
      841 tvktliksfd sasqvpnaaa aaiprtplsp spmktppaaa vspmqrhsis gpvstskplt
      901 alsdkrsnyg eipgqehllr tsstsrpasl prvpamesak tisvsrrsse emkrdisase
      961 gaspaslmam gttspqlsls ssptasvtps trsrireerk dplsalarey ggskrnallk
     1021 wcqkktegyq niditnfsss wndglafcal lhtylpahip yqelnsqekk rnftlafqaa
     1081 esvgikstld inemarterp dwqnvmlyvt aiykyfet
//
