LOCUS       NM_138855               1868 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus speedy/RINGO cell cycle regulator family member A
            (Spdya), mRNA.
ACCESSION   NM_138855
VERSION     NM_138855.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1868)
  AUTHORS   McGrath,D.A., Fifield,B.A., Marceau,A.H., Tripathi,S., Porter,L.A.
            and Rubin,S.M.
  TITLE     Structural basis of divergent cyclin-dependent kinase activation by
            Spy1/RINGO proteins
  JOURNAL   EMBO J 36 (15), 2251-2262 (2017)
   PUBMED   28666995
REFERENCE   2  (bases 1 to 1868)
  AUTHORS   Liu,Q., Song,Y.J., Meng,L.J., Hu,F., Gou,L.X., Jia,C.H., Tang,H.M.,
            Wang,W.J., Li,M., Zhang,X.J. and Jia,M.C.
  TITLE     Role of LM23 in cell proliferation and apoptosis and its expression
            during the testis development
  JOURNAL   Asian J Androl 15 (4), 539-544 (2013)
   PUBMED   23685908
  REMARK    GeneRIF: LM23 played a protective role in H2O2-induced apoptosis of
            293T cells, mediated at least in part through the Akt/PI3K signal
            pathway; these results provide new insights into the role of LM23
            in the development of the testes and spermatogenesis.
REFERENCE   3  (bases 1 to 1868)
  AUTHORS   Cao,J., Yang,J., Wang,Y., Xu,J., Zhou,Z., Cheng,C., Liu,X.,
            Cheng,X., Long,L. and Gu,X.
  TITLE     Temporal-spatial expressions of Spy1 in rat sciatic nerve after
            crush
  JOURNAL   Cell Mol Neurobiol 33 (2), 213-221 (2013)
   PUBMED   23129232
  REMARK    GeneRIF: Spy1 participated in the pathological process response to
            sciatic nerve injury and may be associated with Schwann cells
            proliferation and axons regeneration.
REFERENCE   4  (bases 1 to 1868)
  AUTHORS   Yildiz-Unal,A., Korulu,S. and Karabay,A.
  TITLE     SpeedyRINGO inhibits calpain-directed apoptosis in neurons
  JOURNAL   J Alzheimers Dis 31 (4), 779-791 (2012)
   PUBMED   22751172
  REMARK    GeneRIF: In the hippocampus, SpeedyRINGO acts as a savior for
            neurons that are under apoptosis.
            Erratum:[J Alzheimers Dis. 2016 Jul 13;53(2):743. doi:
            10.3233/JAD-169003.. PMID: 27434285]
REFERENCE   5  (bases 1 to 1868)
  AUTHORS   Kogo,H., Kowa-Sugiyama,H., Yamada,K., Bolor,H., Tsutsumi,M.,
            Ohye,T., Inagaki,H., Taniguchi,M., Toda,T. and Kurahashi,H.
  TITLE     Screening of genes involved in chromosome segregation during
            meiosis I: toward the identification of genes responsible for
            infertility in humans
  JOURNAL   J Hum Genet 55 (5), 293-299 (2010)
   PUBMED   20339383
REFERENCE   6  (bases 1 to 1868)
  AUTHORS   Huang,Y., Liu,Y., Chen,Y., Yu,X., Yang,J., Lu,M., Lu,Q., Ke,Q.,
            Shen,A. and Yan,M.
  TITLE     Peripheral nerve lesion induces an up-regulation of Spy1 in rat
            spinal cord
  JOURNAL   Cell Mol Neurobiol 29 (3), 403-411 (2009)
   PUBMED   19082704
  REMARK    GeneRIF: Peripheral nerve injury induced an up-regulation of Spy1
            in lumbar spinal cord, which was associated with glial
            proliferation.
REFERENCE   7  (bases 1 to 1868)
  AUTHORS   Liu,M.L., Pei,K.Y., Shi,X.Q., Liu,D.Y. and Jia,M.C.
  TITLE     Identification and characterization of a novel spermatogenesis
            related gene LM23 in rat testis
  JOURNAL   Biochem Biophys Res Commun 356 (3), 576-581 (2007)
   PUBMED   17376406
  REMARK    GeneRIF: testis-specific gene LM23 identified & characterized from
            rat type A spermatogonia, pachytene spermatocytes, & round
            spermatids.
REFERENCE   8  (bases 1 to 1868)
  AUTHORS   Cheng,A., Xiong,W., Ferrell,J.E. Jr. and Solomon,M.J.
  TITLE     Identification and comparative analysis of multiple mammalian
            Speedy/Ringo proteins
  JOURNAL   Cell Cycle 4 (1), 155-165 (2005)
   PUBMED   15611625
REFERENCE   9  (bases 1 to 1868)
  AUTHORS   Barnes,E.A., Porter,L.A., Lenormand,J.L., Dellinger,R.W. and
            Donoghue,D.J.
  TITLE     Human Spy1 promotes survival of mammalian cells following DNA
            damage
  JOURNAL   Cancer Res 63 (13), 3701-3707 (2003)
   PUBMED   12839962
REFERENCE   10 (bases 1 to 1868)
  AUTHORS   Porter,L.A., Dellinger,R.W., Tynan,J.A., Barnes,E.A., Kong,M.,
            Lenormand,J.L. and Donoghue,D.J.
  TITLE     Human Speedy: a novel cell cycle regulator that enhances
            proliferation through activation of Cdk2
  JOURNAL   J Cell Biol 157 (3), 357-366 (2002)
   PUBMED   11980914
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138855.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF492385.1, SRR26360186.2881886.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                JAXUCZ010000006.1  29674891-29674951   c
            62-311              JAXUCZ010000006.1  29670804-29671053   c
            312-370             JAXUCZ010000006.1  29668443-29668501   c
            371-456             JAXUCZ010000006.1  29665197-29665282   c
            457-628             JAXUCZ010000006.1  29658962-29659133   c
            629-926             JAXUCZ010000006.1  29642031-29642328   c
            927-1868            JAXUCZ010000006.1  29630298-29631239   c
FEATURES             Location/Qualifiers
     source          1..1868
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..1868
                     /gene="Spdya"
                     /gene_synonym="Gs4; Lm23; Spdy1; Spy1"
                     /note="speedy/RINGO cell cycle regulator family member A"
                     /db_xref="GeneID:192209"
                     /db_xref="RGD:621730"
     exon            1..61
                     /gene="Spdya"
                     /gene_synonym="Gs4; Lm23; Spdy1; Spy1"
                     /inference="alignment:Splign:2.1.0"
     exon            62..311
                     /gene="Spdya"
                     /gene_synonym="Gs4; Lm23; Spdy1; Spy1"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1018
                     /gene="Spdya"
                     /gene_synonym="Gs4; Lm23; Spdy1; Spy1"
                     /note="RINGO A; speedy-1; rapid inducer of G2/M
                     progression in oocytes A; speedy homolog 1;
                     spermatogenesis related protein Gs4; speedy homolog A"
                     /codon_start=1
                     /product="speedy protein A"
                     /protein_id="NP_620210.1"
                     /db_xref="GeneID:192209"
                     /db_xref="RGD:621730"
                     /translation="MRHNQMCCETPPTVTVHVKSGSNRSHQTRKPVSLKRPILKDSWQ
                     ASEKNAHNNKPKRPRGPCLIIQRQEMTAFFKLFDDDLIQDFLWMDCCCKIADKYLLAM
                     TFVYFKRAKFTISEHTRINFFIALYLANTVEEDEEEAKYEIFPWALGKNWRKLFPNFL
                     KLRDQLWDRIDYRAIVSRRCCEEVMAIAPSHYIWQRERSVHHSGAARNYNRDEVHLPR
                     GPSATPVDCSLCGKKGRYVRLGLSSSSSSSSDIVELTGKRSQELHNSLSMDMIGDPSQ
                     ANTYSQVANDHQSKKENETNFVKKTKSMGWFAESEE"
     exon            312..370
                     /gene="Spdya"
                     /gene_synonym="Gs4; Lm23; Spdy1; Spy1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..456
                     /gene="Spdya"
                     /gene_synonym="Gs4; Lm23; Spdy1; Spy1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..628
                     /gene="Spdya"
                     /gene_synonym="Gs4; Lm23; Spdy1; Spy1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..926
                     /gene="Spdya"
                     /gene_synonym="Gs4; Lm23; Spdy1; Spy1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1868
                     /gene="Spdya"
                     /gene_synonym="Gs4; Lm23; Spdy1; Spy1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctgaggta gatcgctgag gcggaggctg cgggccgctc gcgcttcgct gacctgcaca
       61 ggaatcttgg gaagctaaaa tgcggcataa tcagatgtgt tgtgagacac cacctactgt
      121 cactgttcat gtaaaatcag gttcaaatag gtcacatcaa actagaaagc ctgttagtct
      181 gaagcgtcct attcttaaag atagttggca agcatctgaa aaaaatgcac ataataacaa
      241 acctaagcgg cccagagggc cttgtctaat tatacagcgt caggaaatga ctgctttctt
      301 taaattattt gatgatgatt taattcaaga tttcttgtgg atggactgct gctgcaaaat
      361 cgcagacaag tatcttttgg ctatgacctt tgtttatttc aagagagcta aatttactat
      421 aagtgaacat accaggataa atttctttat tgctctatat ctggctaata cagttgaaga
      481 agatgaagaa gaagccaagt acgaaatttt tccatgggct ttagggaaaa actggagaaa
      541 attgttccct aatttcttaa agttacggga ccagctgtgg gacagaattg actatagggc
      601 tattgtaagc cggcgctgct gtgaagaggt tatggccatt gcaccaagcc attacatctg
      661 gcaacgcgag cggtctgtgc accacagtgg agctgctagg aactacaaca gagatgaggt
      721 tcatctgccc cggggaccta gtgccacacc agtggattgc tcactgtgtg gtaaaaaagg
      781 aagatacgtg agactgggac tgtcttcatc atcatcttca tccagtgaca tagtagagct
      841 aacgggaaaa cgttctcagg aattacacaa ttctttatca atggacatga taggtgatcc
      901 ttctcaagct aatacctatt ctcaagtagc caatgaccat caatcaaaaa aagaaaatga
      961 aactaatttt gtgaagaaaa ccaaatctat gggatggttt gcagagagcg aagaatgaca
     1021 aggctcaact aaagcacgct ggagtcacag ctacaaaatg gcaaactaaa ttcgagatgg
     1081 tcagatggga cagttaccca gttgttcaat ggtctttagc ctctgttatt tttcaaacaa
     1141 atgtaaaagt cacacaaatc atagtaataa ctaaacatac caaaaaaact aaacatacca
     1201 aaataaggta aaaacacttt gcaaggtagg gactgataat acacagttct aattagatac
     1261 ttctttgtct tcaagttcac tgcagtcatc tcaggggcca gttcagttgt ggtctgaacc
     1321 agaagacaag aagagtgagc ttaaaagaga aaacaattaa gggcataaca ctgaattaat
     1381 tagaagaaac atttaattag tatactctga aaacagtact gacatgtgtg accacttgac
     1441 gagtgaaaaa gtctagcaat aggcacatgg tctgtacatg actcctcctg tcacagaaga
     1501 ggcacactgc actgtagaaa tgctttagag tctgttcaca gagtgtgaaa tgttaaacac
     1561 tgtccttctc ctgtaagaac tttttttttt ttttgagcat tcgtttgggg gctatttggc
     1621 tagttagtaa gaaacatttg tcagtcatcc cacagcaact ttacagataa gcttataccc
     1681 aaaagaataa gcctgtttca taaatcaatg tatctgaaac ccatttcttg gcctaaatat
     1741 tgtgtaccta tgagtaccta aacttgcagc aacattttag gagctccatt ttgcaactga
     1801 ctcagcaaaa tagaaaaata catttcattt tctgtactaa taaaaaataa aaaataaaaa
     1861 tccctgaa
//
