LOCUS       NM_001109530            1783 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus SAM pointed domain containing ets transcription
            factor (Spdef), mRNA.
ACCESSION   NM_001109530 XM_001069981 XM_006256229
VERSION     NM_001109530.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1783)
  AUTHORS   Jolma,A., Yan,J., Whitington,T., Toivonen,J., Nitta,K.R.,
            Rastas,P., Morgunova,E., Enge,M., Taipale,M., Wei,G., Palin,K.,
            Vaquerizas,J.M., Vincentelli,R., Luscombe,N.M., Hughes,T.R.,
            Lemaire,P., Ukkonen,E., Kivioja,T. and Taipale,J.
  TITLE     DNA-binding specificities of human transcription factors
  JOURNAL   Cell 152 (1-2), 327-339 (2013)
   PUBMED   23332764
REFERENCE   2  (bases 1 to 1783)
  AUTHORS   Ghadersohi,A., Sharma,S., Zhang,S., Azrak,R.G., Wilding,G.E.,
            Manjili,M.H. and Li,F.
  TITLE     Prostate-derived Ets transcription factor (PDEF) is a potential
            prognostic marker in patients with prostate cancer
  JOURNAL   Prostate 71 (11), 1178-1188 (2011)
   PUBMED   21656828
REFERENCE   3  (bases 1 to 1783)
  AUTHORS   Chen,G., Korfhagen,T.R., Xu,Y., Kitzmiller,J., Wert,S.E., Maeda,Y.,
            Gregorieff,A., Clevers,H. and Whitsett,J.A.
  TITLE     SPDEF is required for mouse pulmonary goblet cell differentiation
            and regulates a network of genes associated with mucus production
  JOURNAL   J Clin Invest 119 (10), 2914-2924 (2009)
   PUBMED   19759516
REFERENCE   4  (bases 1 to 1783)
  AUTHORS   Gregorieff,A., Stange,D.E., Kujala,P., Begthel,H., van den Born,M.,
            Korving,J., Peters,P.J. and Clevers,H.
  TITLE     The ets-domain transcription factor Spdef promotes maturation of
            goblet and paneth cells in the intestinal epithelium
  JOURNAL   Gastroenterology 137 (4), 1333-45 (2009)
   PUBMED   19549527
REFERENCE   5  (bases 1 to 1783)
  AUTHORS   Ghadersohi,A., Odunsi,K., Zhang,S., Azrak,R.G., Bundy,B.N.,
            Manjili,M.H. and Li,F.
  TITLE     Prostate-derived Ets transcription factor as a favorable prognostic
            marker in ovarian cancer patients
  JOURNAL   Int J Cancer 123 (6), 1376-1384 (2008)
   PUBMED   18567002
REFERENCE   6  (bases 1 to 1783)
  AUTHORS   Park,K.S., Korfhagen,T.R., Bruno,M.D., Kitzmiller,J.A., Wan,H.,
            Wert,S.E., Khurana Hershey,G.K., Chen,G. and Whitsett,J.A.
  TITLE     SPDEF regulates goblet cell hyperplasia in the airway epithelium
  JOURNAL   J Clin Invest 117 (4), 978-988 (2007)
   PUBMED   17347682
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On or before Apr 8, 2021 this sequence version replaced
            XM_006256229.4, NM_001109530.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166744.1, SRR22582419.2064075.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN16676784
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               JAXUCZ010000020.1  5787345-5787685     c
            342-776             JAXUCZ010000020.1  5779229-5779663     c
            777-974             JAXUCZ010000020.1  5776807-5777004     c
            975-1022            JAXUCZ010000020.1  5775729-5775776     c
            1023-1169           JAXUCZ010000020.1  5775476-5775622     c
            1170-1783           JAXUCZ010000020.1  5773236-5773849     c
FEATURES             Location/Qualifiers
     source          1..1783
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1783
                     /gene="Spdef"
                     /note="SAM pointed domain containing ets transcription
                     factor"
                     /db_xref="GeneID:689210"
                     /db_xref="RGD:1594842"
     exon            1..341
                     /gene="Spdef"
                     /inference="alignment:Splign:2.1.0"
     exon            342..776
                     /gene="Spdef"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..1348
                     /gene="Spdef"
                     /codon_start=1
                     /product="SAM pointed domain-containing Ets transcription
                     factor"
                     /protein_id="NP_001103000.1"
                     /db_xref="GeneID:689210"
                     /db_xref="RGD:1594842"
                     /translation="MGSASPGLSNVSPGCLLLSPDVALRTGVEKAASGAMGLEKQEWS
                     PSPPATPEQGLSAFYLSYFNMYPEDGSWVAKVPEASAREDHPEEPEQCPVIDSQASGN
                     TLDEHSLEQVQSMVVGEVLKDIETACKLLNITADPGDWSPGNVQKWLLWTEHQYRLPP
                     AGKAFQELGGKELCAMSEEQFRQRAPLGGDVLHAHLDIWKSAAWMKERTSPGALHYCA
                     STSEEGWTDGEVDSSCSGQPIHLWQFLKELLLKPHSYGRFIRWLNKEKGIFKIEDSAQ
                     VARLWGVRKNRPAMNYDKLSRSIRQYYKKGIIRKPDISQRLVYQFVHPV"
     exon            777..974
                     /gene="Spdef"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1022
                     /gene="Spdef"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1169
                     /gene="Spdef"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1783
                     /gene="Spdef"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cattcctgca ctccgtccgt ccgcactgcc tcccacacct aacaccccag ctcgctgccc
       61 tgcgcccggt gagaaccccc aggttgggcc ttgtcatggt gccagcaggt gaccctgagc
      121 ctctgacagg ggcctgcctc tagacctgca ggcctgaggc ctcagactca cgctcaaggg
      181 tggagaggct ctggcagccc acccaagagc cacctctgcc ctccagccct gctggctcta
      241 ctgatgtctg actgagaccc agcagtggcc ctgagctgcc cactgcctcc ccgacgatag
      301 ctctaaagag gccgactcct cggacagcag gcagctaacg gaagcagccc caagccgccg
      361 ttgctgcagc atgggcagcg ccagccctgg cctgagcaac gtgtcccccg gttgcctgct
      421 gctgtcccca gatgtggcac tgcggacagg ggtggagaag gcagcgtcag gggcaatggg
      481 cctcgagaag caggaatgga gtcctagtcc acccgccacc cctgagcagg gcctgtctgc
      541 cttctacctc tcctacttta acatgtaccc tgaggatggc agctgggtcg ccaaagtccc
      601 cgaggccagc gccagggagg accacccgga ggagcctgag cagtgcccag tcatcgacag
      661 ccaggcctct gggaacacgc tggatgaaca ctccctagag caggtgcagt ccatggtggt
      721 gggcgaggtc ctgaaagata tcgagactgc atgcaagctg ctgaatatca cagccgaccc
      781 tggggactgg agccctggta acgtgcagaa gtggcttctg tggacagaac accagtaccg
      841 gctgcctcca gcgggcaagg ccttccagga gctgggtggc aaagagctat gcgccatgtc
      901 cgaggagcag ttccgccagc gggcaccctt gggcggggac gtgctgcatg ctcacctgga
      961 catctggaag tcagcggcct ggatgaagga aaggacctcg cctggggccc ttcactactg
     1021 cgcctccacc agcgaggagg gctggacgga tggtgaggtg gattcgtcgt gctccgggca
     1081 acccatccac ctgtggcagt tcctcaaaga actgctgctc aagccccaca gctatggccg
     1141 cttcatccgc tggctcaaca aggagaaagg catcttcaaa attgaagatt ccgcacaggt
     1201 ggcccggctg tggggtgtgc gcaagaaccg gccggccatg aactacgata aactaagccg
     1261 ctccatccgc cagtattaca agaaggggat cattcgcaaa cccgacatct ctcagcgcct
     1321 cgtctaccag tttgtgcatc cggtctgaga gccgcagaga ccagaggcct acaacctgcc
     1381 ccaggcagcc actctctgga tcacctgggc ctctctggcc aatctgaatc cagaggctgc
     1441 tggtacccca gaatccgagg tcccagacag acagccactg atctggggat acacctgagc
     1501 tctctgggcc cctcttcagg tcgtacacgg gtcccaggag gacggaggga gctagctagg
     1561 actgttcaca atggagaact ccctgagcca ggcctagact gtagaaatcc ctatagcaca
     1621 cagggacccg accgagtcag ctcacgggac agcgatgtca gtggtctctt ctcctgtcac
     1681 tcgtcttgta ccatacctgg catgatgcta agagatgatt gcaccctgag ttggggagcc
     1741 aagggtgccc taggaatgga taataaaggt gtaagataac tga
//
