LOCUS       NM_001191073             763 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus signal peptidase complex subunit 3 (Spcs3), mRNA.
ACCESSION   NM_001191073 XM_001058844
VERSION     NM_001191073.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 763)
  AUTHORS   Chen,Q., Denard,B., Lee,C.E., Han,S., Ye,J.S. and Ye,J.
  TITLE     Inverting the Topology of a Transmembrane Protein by Regulating the
            Translocation of the First Transmembrane Helix
  JOURNAL   Mol Cell 63 (4), 567-578 (2016)
   PUBMED   27499293
REFERENCE   2  (bases 1 to 763)
  AUTHORS   Zhang,R., Miner,J.J., Gorman,M.J., Rausch,K., Ramage,H.,
            White,J.P., Zuiani,A., Zhang,P., Fernandez,E., Zhang,Q., Dowd,K.A.,
            Pierson,T.C., Cherry,S. and Diamond,M.S.
  TITLE     A CRISPR screen defines a signal peptide processing pathway
            required by flaviviruses
  JOURNAL   Nature 535 (7610), 164-168 (2016)
   PUBMED   27383988
REFERENCE   3  (bases 1 to 763)
  AUTHORS   Kalies,K.U. and Hartmann,E.
  TITLE     Membrane topology of the 12- and the 25-kDa subunits of the
            mammalian signal peptidase complex
  JOURNAL   J Biol Chem 271 (7), 3925-3929 (1996)
   PUBMED   8632014
REFERENCE   4  (bases 1 to 763)
  AUTHORS   Shelness,G.S., Lin,L. and Nicchitta,C.V.
  TITLE     Membrane topology and biogenesis of eukaryotic signal peptidase
  JOURNAL   J Biol Chem 268 (7), 5201-5208 (1993)
   PUBMED   8444896
REFERENCE   5  (bases 1 to 763)
  AUTHORS   Evans,E.A., Gilmore,R. and Blobel,G.
  TITLE     Purification of microsomal signal peptidase as a complex
  JOURNAL   Proc Natl Acad Sci U S A 83 (3), 581-585 (1986)
   PUBMED   3511473
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Jul 17, 2010 this sequence version replaced XM_001058844.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM037640.1, FQ206714.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JAXUCZ010000016.1  44038421-44038563
            144-217             JAXUCZ010000016.1  44039939-44040012
            218-294             JAXUCZ010000016.1  44040466-44040542
            295-410             JAXUCZ010000016.1  44042018-44042133
            411-763             JAXUCZ010000016.1  44043503-44043855
FEATURES             Location/Qualifiers
     source          1..763
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p11"
     gene            1..763
                     /gene="Spcs3"
                     /note="signal peptidase complex subunit 3"
                     /db_xref="GeneID:680782"
                     /db_xref="RGD:1588184"
     CDS             1..543
                     /gene="Spcs3"
                     /note="signal peptidase complex subunit 3 homolog"
                     /codon_start=1
                     /product="signal peptidase complex subunit 3"
                     /protein_id="NP_001178002.1"
                     /db_xref="GeneID:680782"
                     /db_xref="RGD:1588184"
                     /translation="MNTVLSRANSLFAFSLSVMAALTFGCFITTAFKDRSVPVRLHVS
                     RIMLKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQ
                     VVLWDKIVLRGDNPKLLLKDMKTKYFFFDDGNGLKGNRNVTLTLSWNVVPNAGILPLV
                     TGSGHISVPFPDTYEITKSY"
     exon            1..143
                     /gene="Spcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            144..217
                     /gene="Spcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            218..294
                     /gene="Spcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            295..410
                     /gene="Spcs3"
                     /inference="alignment:Splign:2.1.0"
     exon            411..763
                     /gene="Spcs3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaacaccg tgctgtcgcg cgcgaattcc ctgttcgcct tctcgctgag tgtgatggcg
       61 gcgctcacct tcggctgttt catcaccacc gccttcaaag acaggagcgt cccggtgcgg
      121 ctgcacgtct cgcggatcat gctaaaaaat gtagaagact tcactggccc tagagaaaga
      181 agtgaccttg gattcatcac atttgatata acagctgatc tagagaatat atttgattgg
      241 aatgttaagc aattatttct ttatttatca gcagaatatt caacaaaaaa taatgctctg
      301 aaccaagttg tcctttggga caagattgtt ttgagaggtg ataatccaaa gctgcttttg
      361 aaagatatga agacaaagta tttcttcttt gacgatggaa atggcctcaa gggaaacagg
      421 aatgtcactt tgacgctctc ctggaatgtt gtaccaaacg ctggaattct acctcttgtg
      481 acaggatcgg gacatatatc tgtcccattt ccagatacat acgaaatcac caagagttac
      541 taaattatta tgaatttgaa acatattttt atacatgttg aattgcatct catctcttcc
      601 cagtttcttc attgatcttt cttgcttgtt tgcttgcttt cttttatttt gttttatttt
      661 gttttgatgt aagaaagact cagatcagaa gacacagttg aagtgaaagg ttctgaggtg
      721 cttaagctga gctttgtaaa cagaaagata aaaaaaagcc tac
//
