LOCUS       NM_053675               2422 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus spermatogenesis associated 2 (Spata2), mRNA.
ACCESSION   NM_053675
VERSION     NM_053675.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2422)
  AUTHORS   Ren,Y., Jiang,J., Jiang,W., Zhou,X., Lu,W., Wang,J. and Luo,Y.
  TITLE     Spata2 Knockdown Exacerbates Brain Inflammation via
            NF-kappaB/P38MAPK Signaling and NLRP3 Inflammasome Activation in
            Cerebral Ischemia/Reperfusion Rats
  JOURNAL   Neurochem Res 46 (9), 2262-2275 (2021)
   PUBMED   34075523
  REMARK    GeneRIF: Spata2 Knockdown Exacerbates Brain Inflammation via
            NF-kappaB/P38MAPK Signaling and NLRP3 Inflammasome Activation in
            Cerebral Ischemia/Reperfusion Rats.
REFERENCE   2  (bases 1 to 2422)
  AUTHORS   Zhao,J., Zhao,J., Xu,G., Wang,Z., Gao,J., Cui,S. and Liu,J.
  TITLE     Deletion of Spata2 by CRISPR/Cas9n causes increased inhibin alpha
            expression and attenuated fertility in male mice
  JOURNAL   Biol Reprod 97 (3), 497-513 (2017)
   PUBMED   29025062
REFERENCE   3  (bases 1 to 2422)
  AUTHORS   Wei,R., Xu,L.W., Liu,J., Li,Y., Zhang,P., Shan,B., Lu,X., Qian,L.,
            Wu,Z., Dong,K., Zhu,H., Pan,L., Yuan,J. and Pan,H.
  TITLE     SPATA2 regulates the activation of RIPK1 by modulating linear
            ubiquitination
  JOURNAL   Genes Dev 31 (11), 1162-1176 (2017)
   PUBMED   28701375
  REMARK    Erratum:[Genes Dev. 2018 Dec 1;32(23-24):1591. PMID: 30509949]
REFERENCE   4  (bases 1 to 2422)
  AUTHORS   Schlicher,L., Wissler,M., Preiss,F., Brauns-Schubert,P., Jakob,C.,
            Dumit,V., Borner,C., Dengjel,J. and Maurer,U.
  TITLE     SPATA2 promotes CYLD activity and regulates TNF-induced NF-kappaB
            signaling and cell death
  JOURNAL   EMBO Rep 17 (10), 1485-1497 (2016)
   PUBMED   27458237
REFERENCE   5  (bases 1 to 2422)
  AUTHORS   Elliott,P.R., Leske,D., Hrdinka,M., Bagola,K., Fiil,B.K.,
            McLaughlin,S.H., Wagstaff,J., Volkmar,N., Christianson,J.C.,
            Kessler,B.M., Freund,S.M., Komander,D. and Gyrd-Hansen,M.
  TITLE     SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC
            Signaling
  JOURNAL   Mol Cell 63 (6), 990-1005 (2016)
   PUBMED   27591049
REFERENCE   6  (bases 1 to 2422)
  AUTHORS   Wagner,S.A., Satpathy,S., Beli,P. and Choudhary,C.
  TITLE     SPATA2 links CYLD to the TNF-alpha receptor signaling complex and
            modulates the receptor signaling outcomes
  JOURNAL   EMBO J 35 (17), 1868-1884 (2016)
   PUBMED   27307491
REFERENCE   7  (bases 1 to 2422)
  AUTHORS   Kupka,S., De Miguel,D., Draber,P., Martino,L., Surinova,S.,
            Rittinger,K. and Walczak,H.
  TITLE     SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to
            Signaling Complexes
  JOURNAL   Cell Rep 16 (9), 2271-2280 (2016)
   PUBMED   27545878
REFERENCE   8  (bases 1 to 2422)
  AUTHORS   Onisto,M., Slongo,L.M., Graziotto,R., Zotti,L., Negro,A.,
            Merico,M., Moro,E. and Foresta,C.
  TITLE     Evidence for FSH-dependent upregulation of SPATA2
            (spermatogenesis-associated protein 2)
  JOURNAL   Biochem Biophys Res Commun 283 (1), 86-92 (2001)
   PUBMED   11322771
  REMARK    Erratum:[Biochem Biophys Res Commun 2001 Jul 13;285(2):570.
            Maurizio, O [corrected to Onisto, M]; Liliana, SM [corrected to
            Slongo, LM]; Romina, G [corrected to Graziotto, R], Lorenza, Z
            [corrected to Zotti, L]; Alessandro, N [corrected to Negro, A],
            Maurizio, M [corrected to Merico, M]; Enrico, M [corrected to Mor]
REFERENCE   9  (bases 1 to 2422)
  AUTHORS   Graziotto,R., Foresta,C., Scannapieco,P., Zeilante,P., Russo,A.,
            Negro,A., Salmaso,R. and Onisto,M.
  TITLE     cDNA cloning and characterization of PD1: a novel human testicular
            protein with different expressions in various testiculopathies
  JOURNAL   Exp Cell Res 248 (2), 620-626 (1999)
   PUBMED   10222154
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081752.1.
            
            [WARNING] On Apr 24, 2024 this sequence was replaced by
            NM_053675.3.
            
            On Sep 16, 2004 this sequence version replaced NM_053675.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081752.1, CK603515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2422
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2422
                     /gene="Spata2"
                     /note="spermatogenesis associated 2"
                     /db_xref="GeneID:114210"
                     /db_xref="RGD:620754"
     exon            1..202
                     /gene="Spata2"
                     /inference="alignment:Splign:2.1.0"
     exon            203..635
                     /gene="Spata2"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..1856
                     /gene="Spata2"
                     /codon_start=1
                     /product="spermatogenesis-associated protein 2"
                     /protein_id="NP_446127.3"
                     /db_xref="GeneID:114210"
                     /db_xref="RGD:620754"
                     /translation="MDTKYKDDLFRKYVQFHEGKVDTTPGKQSGSDEYLRVAAATLLS
                     LHKVDPLYRFRLIQFYEVVESSLRSLSSSSLSALHCAFSMLETMAINLFLFPWKKEFR
                     SIKTYTGPFVYYVKSTLLEKDIRAILKFMGYEPELGTAYKLKELVESLQVKMVSFELF
                     LAKVECEQMLGIHSQVKDKGYSELDVVTERKSSTEDARGCSDALRRRAESREHLTTSM
                     ARVALQKSASERAAKDYYKPRVTKPSRSVDAYDSYWESRKPPSKASLSLRKEPLAMDV
                     GEDLKDEIIRPSPSLLTMSSSPHGSPDDLPSISPINGLGLLRSTYFPTQDDVDLYTDS
                     EPRATYRRQDALRSDIWLVKNDAHSIYHKRSPPTKESALSKCQNCGLSCSSSLCQRCD
                     SVCPSASKPSGFPSKASAHDSLVHGAPMREKYVGQTQGLDRLATVHSKPKPSTTATSR
                     CGFCNRAGATNTCTQCSKVSCDPCLGAYHYDPCCRKSELHKFMPNNQLNYKSTQFSHP
                     VYR"
     exon            636..2389
                     /gene="Spata2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgggggca ggcaccgcgc tgtggctctc agccgggagg ggaggctgac ctggttttgg
       61 actcaccgag tgaccttggc tgagtcgctc tgcctcagaa tccttggtct ccaggtctgt
      121 gaggagggac gaggcggcct tccggggccg cggtgggcgt ggaaagagga cacggttgtt
      181 gcacggtgtc ggggtgcagc agagcatgcg ctggtccatg ggcaccatgc cagttcttca
      241 tgtgatgtgc cagcctccag ccccagagcc atgggggaga tgaggtagcc cttgggtttg
      301 atttggggaa gcccagttca atggatacga agtacaagga tgacttattc cggaagtacg
      361 tgcagttcca tgagggcaaa gtggacacca cccccggcaa acagtctggc agcgatgagt
      421 acctgcgcgt ggcagctgcc accctgctca gcctgcacaa ggtggaccct ttatatcgat
      481 ttcggctgat ccagttttat gaggtggtgg agagctccct ccgctcgctg agtagctcca
      541 gcctgagcgc tctgcactgc gccttcagca tgctggagac aatggccatc aacctcttcc
      601 tgttcccctg gaagaaggag ttccgcagca tcaagaccta cacgggccct tttgtttact
      661 atgtcaagtc cacgttgctg gagaaggaca tccgagccat tctaaagttc atgggctacg
      721 aacctgagtt ggggactgca tacaaactca aagagcttgt ggagtccctc caggtgaaga
      781 tggtctcctt tgagctcttc ctggccaagg tcgagtgtga gcagatgctg ggaatacact
      841 cacaggtaaa ggacaagggc tattcagagc tggatgtggt gactgagcgc aagagcagca
      901 cagaggatgc acgtgggtgc tcagatgccc tgcggaggcg ggctgagagt cgagagcacc
      961 tgaccacttc catggctcgt gtggcactcc agaagtcagc cagtgagcgc gcagccaagg
     1021 actactacaa gccccgagtg accaaaccct ccaggtcggt ggatgcctac gacagctact
     1081 gggaaagcag gaagcccccc tcaaaggcct cactgagtct gcgcaaggag cccctggcta
     1141 tggatgtagg ggaagacttg aaggatgaga tcatccgccc atccccctca ttgctgacca
     1201 tgtccagctc cccccatggt agccctgatg accttccctc catctccccc atcaatggcc
     1261 tgggccttct tcgtagcacg tacttcccca ctcaggatga cgtggacctg tacacggatt
     1321 ccgaacccag ggccacctac cggaggcaag atgctctgcg gtcagatata tggctggtca
     1381 aaaatgatgc ccactccatc taccacaagc gttcaccccc caccaaagag tctgccctct
     1441 ccaagtgcca aaactgcggc ctgtcctgca gctcctccct ctgtcagcgc tgtgacagtg
     1501 tctgtccttc ggcctccaag cccagcggtt ttcccagcaa ggcctctgca cacgacagcc
     1561 tggtccatgg ggcacctatg cgggagaaat atgtgggaca gactcagggc cttgaccggc
     1621 tggcaactgt ccactcaaag cccaagccct ctaccacagc cacctcccgc tgtggcttct
     1681 gtaaccgtgc aggtgccacc aacacctgca cccagtgttc aaaagtttcc tgtgacccct
     1741 gcctcggcgc ctaccactac gacccctgct gcagaaagag tgagctgcac aaattcatgc
     1801 ccaacaatca gctgaattac aaatccaccc agttctccca tcccgtgtac agataggccc
     1861 cgccccccat cttctgctac aagggctata caccactgac ctggcttggc agcagagctg
     1921 tgctggaagg gaacagagac ttgagcttga ccatggaagc gccagggcta actgctctgt
     1981 cacacagctc acttggcaca ccacatccca gccggcagct gctgtgtgat ctgaaggaca
     2041 ggatggcact tccagtcact ttgctgacct ctccactccc tgctcagccg gtttgggttt
     2101 gggttctggt tctggttccc ttgaaataag gtctctgtct cgggactctt gctacacctg
     2161 ccccccactg caaagccagc ttggactggg aaggagcctt tggggtcact ttcaaatcct
     2221 catcaggagt ggtgagctag aggcctgctg gcttgtgaaa tgagccctcc tgccacaccc
     2281 ggcctctgat ggctcgcctc tctttctgct cccttgatac aaggatccct aggcagatgt
     2341 ccccaccctt tgtctccctc caactggtat taaaggggag ccaagtccaa aaaaaaaaaa
     2401 aaaaaaaaaa aaaaaaaaaa aa
//
