LOCUS       NP_001401883             613 aa            linear   ROD 01-APR-2024
DEFINITION  spastin isoform 1 [Rattus norvegicus].
ACCESSION   NP_001401883 XP_008762709
VERSION     NP_001401883.1
DBSOURCE    REFSEQ: accession NM_001414954.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 613)
  AUTHORS   Yang,Y., Yang,J., Liang,Y., Zhang,G., Cai,Z., Zhang,Y., Lin,H. and
            Tan,M.
  TITLE     Rab3A interacts with spastin to regulate neurite outgrowth in
            hippocampal neurons
  JOURNAL   Biochem Biophys Res Commun 643, 77-87 (2023)
   PUBMED   36587525
  REMARK    GeneRIF: Rab3A interacts with spastin to regulate neurite outgrowth
            in hippocampal neurons.
REFERENCE   2  (residues 1 to 613)
  AUTHORS   Tan,D., Zhang,H., Deng,J., Liu,J., Wen,J., Li,L., Wang,X., Pan,M.,
            Hu,X. and Guo,J.
  TITLE     RhoA-GTPase Modulates Neurite Outgrowth by Regulating the
            Expression of Spastin and p60-Katanin
  JOURNAL   Cells 9 (1), 230 (2020)
   PUBMED   31963385
  REMARK    GeneRIF: RhoA-GTPase Modulates Neurite Outgrowth by Regulating the
            Expression of Spastin and p60-Katanin.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 613)
  AUTHORS   Valenstein,M.L. and Roll-Mecak,A.
  TITLE     Graded Control of Microtubule Severing by Tubulin Glutamylation
  JOURNAL   Cell 164 (5), 911-921 (2016)
   PUBMED   26875866
REFERENCE   4  (residues 1 to 613)
  AUTHORS   Vietri,M., Schink,K.O., Campsteijn,C., Wegner,C.S., Schultz,S.W.,
            Christ,L., Thoresen,S.B., Brech,A., Raiborg,C. and Stenmark,H.
  TITLE     Spastin and ESCRT-III coordinate mitotic spindle disassembly and
            nuclear envelope sealing
  JOURNAL   Nature 522 (7555), 231-235 (2015)
   PUBMED   26040712
REFERENCE   5  (residues 1 to 613)
  AUTHORS   Goyal,U., Renvoise,B., Chang,J. and Blackstone,C.
  TITLE     Spastin-interacting protein NA14/SSNA1 functions in cytokinesis and
            axon development
  JOURNAL   PLoS One 9 (11), e112428 (2014)
   PUBMED   25390646
  REMARK    GeneRIF: NA14 may act as an adaptor protein regulating SPG4
            localization to centrosomes, temporally and spatially regulating
            the microtubule-severing activity of SPG4 that is particularly
            critical during the cell cycle and neuronal development.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 613)
  AUTHORS   Salinas,S., Carazo-Salas,R.E., Proukakis,C., Cooper,J.M.,
            Weston,A.E., Schiavo,G. and Warner,T.T.
  TITLE     Human spastin has multiple microtubule-related functions
  JOURNAL   J Neurochem 95 (5), 1411-1420 (2005)
   PUBMED   16219033
REFERENCE   7  (residues 1 to 613)
  AUTHORS   Claudiani,P., Riano,E., Errico,A., Andolfi,G. and Rugarli,E.I.
  TITLE     Spastin subcellular localization is regulated through usage of
            different translation start sites and active export from the
            nucleus
  JOURNAL   Exp Cell Res 309 (2), 358-369 (2005)
   PUBMED   16026783
REFERENCE   8  (residues 1 to 613)
  AUTHORS   Evans,K.J., Gomes,E.R., Reisenweber,S.M., Gundersen,G.G. and
            Lauring,B.P.
  TITLE     Linking axonal degeneration to microtubule remodeling by
            Spastin-mediated microtubule severing
  JOURNAL   J Cell Biol 168 (4), 599-606 (2005)
   PUBMED   15716377
REFERENCE   9  (residues 1 to 613)
  AUTHORS   Charvin,D., Cifuentes-Diaz,C., Fonknechten,N., Joshi,V., Hazan,J.,
            Melki,J. and Betuing,S.
  TITLE     Mutations of SPG4 are responsible for a loss of function of
            spastin, an abundant neuronal protein localized in the nucleus
  JOURNAL   Hum Mol Genet 12 (1), 71-78 (2003)
   PUBMED   12490534
REFERENCE   10 (residues 1 to 613)
  AUTHORS   Mead,S.H., Proukakis,C., Wood,N., Crosby,A.H., Plant,G.T. and
            Warner,T.T.
  TITLE     A large family with hereditary spastic paraparesis due to a frame
            shift mutation of the spastin (SPG4) gene: association with
            multiple sclerosis in two affected siblings and epilepsy in other
            affected family members
  JOURNAL   J Neurol Neurosurg Psychiatry 71 (6), 788-791 (2001)
   PUBMED   11723204
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Dec 16, 2022 this sequence version replaced XP_008762709.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.576399.1,
                                           SRR26643298.34314.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..613
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q13"
     Protein         1..613
                     /product="spastin isoform 1"
                     /EC_number="5.6.1.1"
                     /note="spastic paraplegia 4 (autosomal dominant; spastin)"
                     /calculated_mol_wt=66539
     Region          114..192
                     /region_name="MIT_spastin"
                     /note="MIT: domain contained within Microtubule
                     Interacting and Trafficking molecules. This MIT domain
                     sub-family is found in the AAA protein spastin, a probable
                     ATPase involved in the assembly or function of nuclear
                     protein complexes; spastins might also be...; cd02679"
                     /db_xref="CDD:239142"
     Region          340..503
                     /region_name="RecA-like_spastin"
                     /note="ATPase domain of spastin; cd19524"
                     /db_xref="CDD:410932"
     Site            order(341..344,381..387)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:410932"
     Region          530..584
                     /region_name="AAA_lid_3"
                     /note="AAA+ lid domain; pfam17862"
                     /db_xref="CDD:465537"
     Region          <577..609
                     /region_name="Vps4_C"
                     /note="Vps4 C terminal oligomerization domain; pfam09336"
                     /db_xref="CDD:462762"
     CDS             1..613
                     /gene="Spast"
                     /gene_synonym="Spg4"
                     /coded_by="NM_001414954.1:272..2113"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:362700"
                     /db_xref="RGD:1308494"
ORIGIN      
        1 msspagrrkk kgsggaspap arppppaavp apaagpapap gsphkrnlyy fsyplvvgfa
       61 llrllachlg llfvwlcqrf sralmaakrs sgtapapasp stpapgpgge aesvrvfhkq
      121 afeyisialr ideeekgqke qavewykkgi eelekgiavi vtgqgeqyer arrlqakmmt
      181 nlvmakdrlq lleklqpvlq fsksqtdvyn estnltcrng hlqsesgavp kkkdplthas
      241 nslprsktvm ksgstglsgh hrapscsgls mvsgarpgsg paatthkgts kpnrtnkpst
      301 pttavrkkkd lknfrnvdsn lanlimneiv dngtavkfdd iagqelakqa lqeivilpsl
      361 rpelftglra parglllfgp pgngktmlak avaaesnatf fnisaaslts kyvgegeklv
      421 ralfavarel qpsiifidev dsllcerreg ehdasrrlkt efliefdgvq sagddrvlvm
      481 gatnrpqeld eavlrrfikr vyvslpneet rllllknllc kqgspltqke laqlarmtdg
      541 ysgsdltala kdaalgpire lkpeqvknms asemrnirls dfteslkkik rsvspqtlea
      601 yirwnkdfgd ttv
//
