LOCUS       NM_012946               2666 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus SPARC like 1 (Sparcl1), mRNA.
ACCESSION   NM_012946
VERSION     NM_012946.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2666)
  AUTHORS   Jiang,D., Cheng,S., Kang,P., Li,T., Li,X., Xiao,J. and Ren,L.
  TITLE     microRNA-105-5p protects against chondrocyte injury, extracellular
            matrix degradation, and osteoarthritis progression by targeting
            SPARCL1
  JOURNAL   Histol Histopathol 39 (4), 483-496 (2024)
   PUBMED   37534667
  REMARK    GeneRIF: microRNA-105-5p protects against chondrocyte injury,
            extracellular matrix degradation, and osteoarthritis progression by
            targeting SPARCL1.
REFERENCE   2  (bases 1 to 2666)
  AUTHORS   Kang,Y., Xue,J., Zheng,J., Liang,J., Cai,C. and Wang,Y.
  TITLE     Upregulation of Hevin contributes to postoperative pain
            hypersensitivity by inducing neurexin1beta/neuroligin1-mediated
            synaptic targeting of GluA1-containing AMPA receptors in rat dorsal
            horn
  JOURNAL   Brain Res 1792, 148004 (2022)
   PUBMED   35820448
  REMARK    GeneRIF: Upregulation of Hevin contributes to postoperative pain
            hypersensitivity by inducing neurexin1beta/neuroligin1-mediated
            synaptic targeting of GluA1-containing AMPA receptors in rat dorsal
            horn.
REFERENCE   3  (bases 1 to 2666)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   4  (bases 1 to 2666)
  AUTHORS   Singh,S.K., Stogsdill,J.A., Pulimood,N.S., Dingsdale,H., Kim,Y.H.,
            Pilaz,L.J., Kim,I.H., Manhaes,A.C., Rodrigues,W.S. Jr., Pamukcu,A.,
            Enustun,E., Ertuz,Z., Scheiffele,P., Soderling,S.H., Silver,D.L.,
            Ji,R.R., Medina,A.E. and Eroglu,C.
  TITLE     Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1alpha
            and NL1 via Hevin
  JOURNAL   Cell 164 (1-2), 183-196 (2016)
   PUBMED   26771491
REFERENCE   5  (bases 1 to 2666)
  AUTHORS   Lively,S. and Schlichter,L.C.
  TITLE     SC1/hevin identifies early white matter injury after ischemia and
            intracerebral hemorrhage in young and aged rats
  JOURNAL   J Neuropathol Exp Neurol 71 (6), 480-493 (2012)
   PUBMED   22588386
  REMARK    GeneRIF: SC1 appears to characterize damaged striatal white matter
            damage after multiple types of injury
REFERENCE   6  (bases 1 to 2666)
  AUTHORS   Kucukdereli,H., Allen,N.J., Lee,A.T., Feng,A., Ozlu,M.I.,
            Conatser,L.M., Chakraborty,C., Workman,G., Weaver,M., Sage,E.H.,
            Barres,B.A. and Eroglu,C.
  TITLE     Control of excitatory CNS synaptogenesis by astrocyte-secreted
            proteins Hevin and SPARC
  JOURNAL   Proc Natl Acad Sci U S A 108 (32), E440-E449 (2011)
   PUBMED   21788491
REFERENCE   7  (bases 1 to 2666)
  AUTHORS   Lively,S. and Brown,I.R.
  TITLE     Localization of the extracellular matrix protein SC1 coincides with
            synaptogenesis during rat postnatal development
  JOURNAL   Neurochem Res 33 (9), 1692-1700 (2008)
   PUBMED   18335312
  REMARK    GeneRIF: These findings indicate that the pattern of SC1
            localization coincides with synaptogenesis during rat postnatal
            development.
REFERENCE   8  (bases 1 to 2666)
  AUTHORS   Lively,S., Ringuette,M.J. and Brown,I.R.
  TITLE     Localization of the extracellular matrix protein SC1 to synapses in
            the adult rat brain
  JOURNAL   Neurochem Res 32 (1), 65-71 (2007)
   PUBMED   17151913
REFERENCE   9  (bases 1 to 2666)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   10 (bases 1 to 2666)
  AUTHORS   Johnston,I.G., Paladino,T., Gurd,J.W. and Brown,I.R.
  TITLE     Molecular cloning of SC1: a putative brain extracellular matrix
            glycoprotein showing partial similarity to osteonectin/BM40/SPARC
  JOURNAL   Neuron 4 (1), 165-176 (1990)
   PUBMED   1690015
  REMARK    Erratum:[Neuron 1990 Mar;4(3):477]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012946.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U27562.1, BC061755.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               JAXUCZ010000014.1  5937484-5937820
            338-402             JAXUCZ010000014.1  5951909-5951973
            403-525             JAXUCZ010000014.1  5954860-5954982
            526-1479            JAXUCZ010000014.1  5955361-5956314
            1480-1549           JAXUCZ010000014.1  5957840-5957909
            1550-1668           JAXUCZ010000014.1  5958626-5958744
            1669-1789           JAXUCZ010000014.1  5959615-5959735
            1790-1926           JAXUCZ010000014.1  5960758-5960894
            1927-2075           JAXUCZ010000014.1  5962160-5962308
            2076-2224           JAXUCZ010000014.1  5962849-5962997
            2225-2666           JAXUCZ010000014.1  5968091-5968532
FEATURES             Location/Qualifiers
     source          1..2666
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2666
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; Sc1"
                     /note="SPARC like 1"
                     /db_xref="GeneID:25434"
                     /db_xref="RGD:2531"
     exon            1..337
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; Sc1"
                     /inference="alignment:Splign:2.1.0"
     exon            338..402
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; Sc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..2253
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; Sc1"
                     /note="SPARC-like protein 1; matrix glycoprotein Sc1;
                     SPARC-like 1 (mast9, hevin); Extracellular matrix protein
                     2; SPARC-like 1 (hevin)"
                     /codon_start=1
                     /product="SPARC-like protein 1 precursor"
                     /protein_id="NP_037078.2"
                     /db_xref="GeneID:25434"
                     /db_xref="RGD:2531"
                     /translation="MKAVLLLLYALGIAAAVPTTFLSDHSNPTSATLPTLEDATVPTV
                     PAEAAADIEKHPNDKAEKPSALNSEEEAHEQSTEQDKTYSFEVDLKDEEDGDGDLSVD
                     PTERTLDLQEGTSEPQQKRLPENAGFPATVSTPFVDSDQPANITKGEESQEQPVSDSH
                     QQQDESGKQTQDSMTEESHKQDPGIPNEEKEEEEDPEDVGAPSDNQEEEKEPPEEQPT
                     SKWEGNGDQSEDILQESSQPTQISKTKNDFEQGSQGQEGDSNAEGEDKAAGSKEHLPH
                     TEWQGQEGRAGLDAIGNRKDTDEEKAVSTEPTDAAVVPRNHGASDNGGGDDSKHGASD
                     DYFIPSQEFLEAERMHSLSYYLKYGEETPDESENRSEAGDNQGAKKAESSPNAEPSDE
                     GNSRGHSADSCMNFQCKRGHTCKTDQHGKPHCVCQDPETCPPAKILDQACGTDNQTYA
                     SSCHLFATKCMLEGTKKGHQLQLDYFGACKSIPACTDFEVAQFPLRMRDWLKNILMQL
                     YEPNPKHGGYLNEKQRSKVKKIYLDEKRLLAGDHPIELLLRDFKKNYHMYVYPVHWQF
                     NELDQHPADRILTHSELAPLRASLVPMEHCITRFFEECDPNKDKHITLKEWGHCFGIK
                     EEDIDENLLF"
     exon            403..525
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; Sc1"
                     /inference="alignment:Splign:2.1.0"
     exon            526..1479
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; Sc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1549
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; Sc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1668
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; Sc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1789
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; Sc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1926
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; Sc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2075
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; Sc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2224
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; Sc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2666
                     /gene="Sparcl1"
                     /gene_synonym="Ecm2; Sc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgcgctgc ctgcgaagct ctgcagcacg gagccagcga gggagggaga tccaggaatc
       61 cgcagcagaa accatgacat cctgagacac cctgtggtgc caaccttcaa actctcatct
      121 gtcactctag accctgacgg gctggcagag cggcagaatt tcaaccccag tacacttgaa
      181 tgggcttcca ggcaaagcag tcaagctaac gaggaagggg ggtggaagag ctcctcttgg
      241 gcgtttgtca aacttttacc tcctggctgt gtgcaaagag gggattcaac ttcagcttca
      301 agctacccag gctctggatc cagccacctc tcagcaggtc tagccagcat gaaggccgtg
      361 cttctcctcc tgtatgcctt ggggatcgct gctgcagtcc cgacaacgtt tctctctgat
      421 cattccaacc caacttccgc aacactgccg acactggaag atgctacagt ccccactgtc
      481 ccagctgaag ctgcagcaga catagaaaag caccccaacg ataaggctga aaaaccttca
      541 gcactgaact cagaagagga agcccatgaa cagtcgacag agcaggacaa aacctacagc
      601 ttcgaggtgg acctgaagga tgaggaggat ggggatgggg atttaagtgt agatccgacg
      661 gaaagaacgc tagatctaca ggaagggaca agcgaaccgc agcagaaaag gctcccggag
      721 aacgccggtt tccctgctac tgtgtccact ccctttgtgg attctgacca acctgcaaat
      781 atcacaaagg gagaggagag tcaggagcaa cctgtaagtg actcgcacca gcaacaggac
      841 gagagcggca agcagaccca agactcgatg actgaagaaa gccacaaaca agatccgggt
      901 attcccaatg aagaaaagga agaagaggaa gatccagaag acgttggtgc acccagtgat
      961 aaccaagagg aagaaaaaga accacccgag gagcagccta ccagcaagtg ggaaggaaac
     1021 ggagaccaat ctgaagacat cttacaagag tccagtcagc caactcagat aagcaagaca
     1081 aagaatgatt tcgagcaagg aagccaaggg caagagggtg actctaatgc agaaggggag
     1141 gacaaggcag caggcagcaa ggaacacctt ccgcatacgg agtggcaggg ccaagaaggg
     1201 agagctggcc ttgacgctat tggcaaccgg aaggacacag atgaagaaaa ggctgtttcc
     1261 acggaaccta ccgatgctgc cgtcgtgcct aggaaccacg gagccagtga taacgggggc
     1321 ggggatgact ctaagcatgg tgcaagcgat gactacttca tccccagcca ggaattccta
     1381 gaggctgaaa gaatgcattc cctctcctat tacctcaaat acggagagga gacgccggac
     1441 gagagcgaga accgaagtga ggctggagac aaccaagggg ccaagaaagc tgagagctca
     1501 ccaaatgctg aaccgtccga tgagggcaac tcaagggggc acagtgctga ttcttgcatg
     1561 aacttccagt gtaaaagggg acacacttgc aaaacggatc aacacggaaa accccactgt
     1621 gtttgccaag atccagagac gtgtccccct gcaaaaatcc tcgaccaagc ttgtggcact
     1681 gacaaccaga cctacgccag ctcctgtcac ctgtttgcta ccaagtgcat gctggaaggg
     1741 accaaaaagg gacaccagct gcagttggat tactttggag cttgcaaatc tattcctgct
     1801 tgtacggact tcgaagtggc tcagtttccg ctgcggatga gagactggct caaaaacatc
     1861 ctcatgcagc tttacgaacc aaaccccaaa catggcggct acctaaatga aaagcaaaga
     1921 agcaaagtca agaaaattta cctggatgaa aagagactct tggctggaga ccaccccatt
     1981 gaacttctct taagggactt caagaaaaac taccacatgt atgtgtatcc tgtgcactgg
     2041 cagtttaacg aattggatca gcatcctgcg gacaggatct tgacacattc tgaacttgcg
     2101 cctctgcgag cttccctggt gcccatggag cactgcataa cgcgcttctt tgaggagtgt
     2161 gaccccaaca aggacaagca tatcaccttg aaggaatggg gccactgctt tggaattaaa
     2221 gaagaagaca tagatgaaaa cctcctcttt tgaattaaga ctcgagagaa tcgaaacttt
     2281 ccatcagccc tgcttgcttt aaccacttcc gcgtaggagc cgccatgaca ctctacattc
     2341 ctatgtagca aaacgtgttt gcatgtaaga gaagacaatg atagtaattg cttcttagaa
     2401 atatatatat attaacttag taaataaaac tttaaaatta agtagagtcg atgtctaaaa
     2461 gactgtcctg cctggggaca gttacccatg gtaatgtcac cctgtgcatc tgcgtttgta
     2521 attgataatt acaaactatt aaaaacagcg tttgtactgt ccatgacacc tgatgcatgc
     2581 taaggaagtg ggatattgtt ctttcgagat taatatacct tattgtcagt atcctgatgt
     2641 cctaataaaa agtctatgaa acctca
//
