LOCUS       NM_145087                382 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus sperm associated antigen 11A (Spag11a), mRNA.
ACCESSION   NM_145087
VERSION     NM_145087.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 382)
  AUTHORS   Sangeeta,K. and Yenugu,S.
  TITLE     Ablation of the sperm-associated antigen 11A (SPAG11A) protein by
            active immunization promotes epididymal oncogenesis in the rat
  JOURNAL   Cell Tissue Res 389 (1), 115-128 (2022)
   PUBMED   35438340
  REMARK    GeneRIF: Ablation of the sperm-associated antigen 11A (SPAG11A)
            protein by active immunization promotes epididymal oncogenesis in
            the rat.
REFERENCE   2  (bases 1 to 382)
  AUTHORS   Sangeeta,K. and Yenugu,S.
  TITLE     siRNA-mediated knockdown of sperm-associated antigen 11a (Spag11a)
            mRNA in epididymal primary epithelial cells affects proliferation:
            a transcriptome analyses
  JOURNAL   Cell Tissue Res 379 (3), 601-612 (2020)
   PUBMED   31691005
  REMARK    GeneRIF: siRNA-mediated knockdown of sperm-associated antigen 11a
            (Spag11a) mRNA in epididymal primary epithelial cells affects
            proliferation: a transcriptome analyses.
REFERENCE   3  (bases 1 to 382)
  AUTHORS   Biswas,B. and Yenugu,S.
  TITLE     Transcriptional regulation of the rat sperm-associated antigen 11e
            (Spag 11e) gene during endotoxin challenge
  JOURNAL   Mol Genet Genomics 289 (5), 837-845 (2014)
   PUBMED   24777385
  REMARK    GeneRIF: Androgen receptor and NF-kappaB proteins bind to the
            upstream regulatory sequences of the rat Spag11e gene to regulate
            expression.
REFERENCE   4  (bases 1 to 382)
  AUTHORS   Cao,D., Li,Y., Yang,R., Wang,Y., Zhou,Y., Diao,H., Zhao,Y.,
            Zhang,Y. and Lu,J.
  TITLE     Lipopolysaccharide-induced epididymitis disrupts epididymal
            beta-defensin expression and inhibits sperm motility in rats
  JOURNAL   Biol Reprod 83 (6), 1064-1070 (2010)
   PUBMED   20826730
  REMARK    GeneRIF: evidence suggests SPAG11E expression in epididymis has a
            role in sperm motility: SPAG11E expression is down-regulated in
            epididymitis (associated with decreased sperm motility); exogenous
            SPAG11E corrects sperm motility
REFERENCE   5  (bases 1 to 382)
  AUTHORS   Zhou,C.X., Zhang,Y.L., Xiao,L., Zheng,M., Leung,K.M., Chan,M.Y.,
            Lo,P.S., Tsang,L.L., Wong,H.Y., Ho,L.S., Chung,Y.W. and Chan,H.C.
  TITLE     An epididymis-specific beta-defensin is important for the
            initiation of sperm maturation
  JOURNAL   Nat Cell Biol 6 (5), 458-464 (2004)
   PUBMED   15122269
  REMARK    GeneRIF: Data show that Bin1b can bind to the sperm head in
            different regions of the epididymis with varied binding patterns,
            and can induce progressive sperm motility in immotile immature
            sperm.
REFERENCE   6  (bases 1 to 382)
  AUTHORS   Li,P., Chan,H.C., He,B., So,S.C., Chung,Y.W., Shang,Q., Zhang,Y.D.
            and Zhang,Y.L.
  TITLE     An antimicrobial peptide gene found in the male reproductive system
            of rats
  JOURNAL   Science 291 (5509), 1783-1785 (2001)
   PUBMED   11230693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Jan 23, 2015 this sequence version replaced NM_145087.1.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no single transcript from the reference strain was
            available for the full length of the gene. The extent of this
            transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF217088.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               JAXUCZ010000016.1  77386389-77386496   c
            109-382             JAXUCZ010000016.1  77384755-77385028   c
FEATURES             Location/Qualifiers
     source          1..382
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..382
                     /gene="Spag11a"
                     /gene_synonym="Bin1b; Spag11; Spag11b"
                     /note="sperm associated antigen 11A"
                     /db_xref="GeneID:246305"
                     /db_xref="RGD:628905"
     exon            1..108
                     /gene="Spag11a"
                     /gene_synonym="Bin1b; Spag11; Spag11b"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..260
                     /gene="Spag11a"
                     /gene_synonym="Bin1b; Spag11; Spag11b"
                     /note="antimicrobial-like protein Bin-1b;
                     anti-microbial-like protein BIN-1B; sperm associated
                     antigen 11B; sperm-associated antigen 11; EP2 protein"
                     /codon_start=1
                     /product="sperm-associated antigen 11A precursor"
                     /protein_id="NP_659555.1"
                     /db_xref="GeneID:246305"
                     /db_xref="RGD:628905"
                     /translation="MKVLLLFAVFFCLVQRNSGDIPPGIRNTVCFMQRGHCRLFMCRS
                     GERKGDICSDPWNRCCVSSSIKNR"
     exon            109..382
                     /gene="Spag11a"
                     /gene_synonym="Bin1b; Spag11; Spag11b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacccagtca tcagtcacat ctgctttcct gcacagagag agcgccataa aacatgaagg
       61 ttttgttact ctttgctgtt ttcttctgct tggtccaaag aaactcaggg gacataccac
      121 ctggaatcag aaacaccgtg tgcttcatgc agcggggcca ctgtaggctc ttcatgtgcc
      181 gttctgggga gagaaagggg gatatttgct ctgacccctg gaacagatgc tgcgtatcca
      241 gttccattaa aaacagatga tagaagactc attggaagat ctgagatgtg gggtgcaagc
      301 tcttggaagc tggagacctg gaagcacccc aaaggctttg agtatgtgtg gctgatggtg
      361 cgtgctcaat aaacacttgc tg
//
