LOCUS       NM_181374               1385 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus Sp7 transcription factor (Sp7), transcript
            variant 2, mRNA.
ACCESSION   NM_181374
VERSION     NM_181374.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1385)
  AUTHORS   da Silva Sasso GR, Florencio-Silva R, Sasso-Cerri E, Gil CD, de
            Jesus Simoes M and Cerri PS.
  TITLE     Spatio-temporal immunolocalization of VEGF-A, Runx2, and osterix
            during the early steps of intramembranous ossification of the
            alveolar process in rat embryos
  JOURNAL   Dev Biol 478, 133-143 (2021)
   PUBMED   34245724
  REMARK    GeneRIF: Spatio-temporal immunolocalization of VEGF-A, Runx2, and
            osterix during the early steps of intramembranous ossification of
            the alveolar process in rat embryos.
REFERENCE   2  (bases 1 to 1385)
  AUTHORS   Pokrovskaya LA, Nadezhdin SV, Zubareva EV, Burda YE and Gnezdyukova
            ES.
  TITLE     Expression of RUNX2 and Osterix in Rat Mesenchymal Stem Cells
            during Culturing in Osteogenic-Conditioned Medium
  JOURNAL   Bull Exp Biol Med 169 (4), 571-575 (2020)
   PUBMED   32910396
  REMARK    GeneRIF: Expression of RUNX2 and Osterix in Rat Mesenchymal Stem
            Cells during Culturing in Osteogenic-Conditioned Medium.
REFERENCE   3  (bases 1 to 1385)
  AUTHORS   Qin,G., Li,Y., Wang,H., Yang,J., Chen,Q., Tang,H., Wang,Y.,
            Zhang,M., Jiang,T., Lin,S. and Huo,S.
  TITLE     Lysine-Specific Demethylase 4A Regulates Osteogenic Differentiation
            via Regulating the Binding Ability of H3K9me3 with the Promoters of
            Runx2, Osterix and Osteocalcin
  JOURNAL   J Biomed Nanotechnol 16 (6), 899-909 (2020)
   PUBMED   33187585
  REMARK    GeneRIF: Lysine-Specific Demethylase 4A Regulates Osteogenic
            Differentiation via Regulating the Binding Ability of H3K9me3 with
            the Promoters of Runx2, Osterix and Osteocalcin.
REFERENCE   4  (bases 1 to 1385)
  AUTHORS   Xi Y, Miao X, Li Y, Lai K, Du X, Jiang Z, Wang Y and Yang G.
  TITLE     BMP2-mimicking peptide modified with E7 coupling to calcined bovine
            bone enhanced bone regeneration associating with activation of the
            Runx2/SP7 signaling axis
  JOURNAL   J Biomed Mater Res B Appl Biomater 108 (1), 80-93 (2020)
   PUBMED   30912295
  REMARK    GeneRIF: BMP2-mimicking peptide modified with E7 coupling to
            calcined bovine bone enhanced bone regeneration associating with
            activation of the Runx2/SP7 signaling axis.
REFERENCE   5  (bases 1 to 1385)
  AUTHORS   Fukuda M, Yoshizawa T, Karim MF, Sobuz SU, Korogi W, Kobayasi D,
            Okanishi H, Tasaki M, Ono K, Sawa T, Sato Y, Chirifu M, Masuda T,
            Nakamura T, Tanoue H, Nakashima K, Kobashigawa Y, Morioka H, Bober
            E, Ohtsuki S, Yamagata Y, Ando Y, Oike Y, Araki N, Takeda S, Mizuta
            H and Yamagata K.
  TITLE     SIRT7 has a critical role in bone formation by regulating lysine
            acylation of SP7/Osterix
  JOURNAL   Nat Commun 9 (1), 2833 (2018)
   PUBMED   30026585
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1385)
  AUTHORS   Amorim BR, Okamura H, Yoshida K, Qiu L, Morimoto H and Haneji T.
  TITLE     The transcriptional factor Osterix directly interacts with RNA
            helicase A
  JOURNAL   Biochem Biophys Res Commun 355 (2), 347-351 (2007)
   PUBMED   17303075
REFERENCE   7  (bases 1 to 1385)
  AUTHORS   Wang BL, Dai CL, Quan JX, Zhu ZF, Zheng F, Zhang HX, Guo SY, Guo G,
            Zhang JY and Qiu MC.
  TITLE     Parathyroid hormone regulates osterix and Runx2 mRNA expression
            predominantly through protein kinase A signaling in osteoblast-like
            cells
  JOURNAL   J Endocrinol Invest 29 (2), 101-108 (2006)
   PUBMED   16610234
  REMARK    GeneRIF: Parathyroid hormone (1-34) regulates osterix mRNA
            expression, in rat osteoblast-like cell line UMR 106, in a dose-
            and time-dependent manner.
REFERENCE   8  (bases 1 to 1385)
  AUTHORS   Koga T, Matsui Y, Asagiri M, Kodama T, de Crombrugghe B, Nakashima
            K and Takayanagi H.
  TITLE     NFAT and Osterix cooperatively regulate bone formation
  JOURNAL   Nat Med 11 (8), 880-885 (2005)
   PUBMED   16041384
REFERENCE   9  (bases 1 to 1385)
  AUTHORS   Milona MA, Gough JE and Edgar AJ.
  TITLE     Expression of alternatively spliced isoforms of human Sp7 in
            osteoblast-like cells
  JOURNAL   BMC Genomics 4, 43 (2003)
   PUBMED   14604442
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1385)
  AUTHORS   Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR and
            de Crombrugghe B.
  TITLE     The novel zinc finger-containing transcription factor osterix is
            required for osteoblast differentiation and bone formation
  JOURNAL   Cell 108 (1), 17-29 (2002)
   PUBMED   11792318
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BK001412.1.
            
            On Dec 23, 2004 this sequence version replaced NM_181374.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK001412.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1385
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..1385
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="Sp7 transcription factor"
                     /db_xref="GeneID:300260"
                     /db_xref="RGD:631377"
     exon            1..119
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1385
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /note="isoform 2 is encoded by transcript variant 2;
                     osterix; Transcription factor Sp7"
                     /codon_start=1
                     /product="transcription factor Sp7 isoform 2"
                     /protein_id="NP_852039.2"
                     /db_xref="GeneID:300260"
                     /db_xref="RGD:631377"
                     /translation="MASSLLEEEAHYGSSPLAMLTAACSKFGGSSPLRDSTALGKGGT
                     KKPYTDLSAPKTMGDAYPAPFSSTNGLLSPAGSPPAPASGYANDYPPFPHSFPGPTGA
                     QDPGLLVPKGHSSSDCLPSVYTSLDMSHPYGSWYKAGIHAGISPGPGNTPTPWWDMHP
                     GGNWLGGGQGQGDGLQGTLSTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQ
                     HVLPQDVYKPKAVGNSGQLEGSGAGKPPRGAGTGGSGGYAGSGAGRSTCDCPNCQELE
                     RLGAAAAGLRKKPIHSCHIPGCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTR
                     SDELERHVRTHTREKKFTCLLCSKRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGR
                     SVGEEEANQPPRSSTSPAPPEKAPGGSPEQSNLLEI"
     exon            120..1385
                     /gene="Sp7"
                     /gene_synonym="Osx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attctcccat tctccctccc tctccctttc ccctctccca ctggctcctg gttctctcca
       61 tctgcctgac tccttgggac ccggtcccca gcctgaggat ggcgtcctct ctgcttgagg
      121 aagaagctca ctatggctcc agtcccctgg ccatgctgac agcagcctgc agcaagtttg
      181 gtggctccag ccctctgcga gactcaacag ccctgggaaa aggaggcaca aagaagccat
      241 acactgacct ttcagccccc aaaaccatgg gggacgccta cccagctccc ttctcaagca
      301 ccaatggact cctctcccct gcaggcagtc ccccggcccc ggcctctggc tatgccaatg
      361 actacccacc ctttccccac tcatttcctg ggcccactgg tgcccaagac ccggggctgc
      421 tggtgccgaa ggggcacagc tcttctgact gcctgcctag tgtctacacg tccttggata
      481 tgtcccatcc ctacggctcc tggtacaagg cgggcatcca tgcaggcatc tcaccaggtc
      541 ctggcaacac tcctacccct tggtgggaca tgcaccctgg gggcaattgg ttaggtggtg
      601 ggcagggcca gggtgatggg ctgcaaggga cactgtccac aggccctgcc cagcctccac
      661 tgaaccccca gctgcctact tacccgtctg actttgcccc ccttaaccca gctccctatc
      721 cagcacccca cctcttgcaa ccaggtcccc agcatgtcct accccaagat gtctataagc
      781 ccaaggcagt tggcaatagt gggcaactgg aggggagtgg tgcaggcaaa cctccccggg
      841 gtgcaggcac agggggcagt ggtggatatg caggcagtgg ggcagggcgt tctacctgcg
      901 actgccccaa ctgtcaggag ctagagcggc tgggggcagc agcggctggg ctgaggaaga
      961 agcccattca cagctgccac atccccggct gcggcaaggt gtacggcaag gcttcgcatc
     1021 tgaaagccca cttgcgctgg cacactggcg agaggccttt cgtctgcaac tggcttttct
     1081 gtggcaagag gttcacccgc tctgacgagc tggagcgcca cgtgcgcact cacacccggg
     1141 agaagaagtt cacctgtctg ctctgctcca agcgctttac ccgaagcgac cacttgagca
     1201 aacatcagcg cacccacggg gagccaggtc ccgggccgcc cccaagtggc cctaaggagc
     1261 tgggggaggg tcgcagcgtc ggggaagaag aagccaatca gccgccccga tcttccacct
     1321 cgcctgcacc cccagaaaaa gcccctggag gcagcccaga gcagagcaac ctgctagaga
     1381 tctga
//
