LOCUS       NM_001108833            1995 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus Sp6 transcription factor (Sp6), mRNA.
ACCESSION   NM_001108833 XM_001081357 XM_343961
VERSION     NM_001108833.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1995)
  AUTHORS   Yanuaryska RD, Miyoshi K, Adiningrat A, Horiguchi T, Tanimura A,
            Hagita H and Noma T.
  TITLE     Sp6 regulation of Rock1 promoter activity in dental epithelial
            cells
  JOURNAL   J Med Invest 61 (3-4), 306-317 (2014)
   PUBMED   25264049
  REMARK    GeneRIF: Sp6 positively regulates Rock1 transcription by direct
            binding to the Rock1 promoter region from -206 to -150, which
            functionally distinct from Sp1
REFERENCE   2  (bases 1 to 1995)
  AUTHORS   Muto T, Miyoshi K, Horiguchi T, Hagita H and Noma T.
  TITLE     Novel genetic linkage of rat Sp6 mutation to Amelogenesis
            imperfecta
  JOURNAL   Orphanet J Rare Dis 7, 34 (2012)
   PUBMED   22676574
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1995)
  AUTHORS   Muto T, Miyoshi K, Horiguchi T and Noma T.
  TITLE     Dissection of morphological and metabolic differentiation of
            ameloblasts via ectopic SP6 expression
  JOURNAL   J Med Invest 59 (1-2), 59-68 (2012)
   PUBMED   22449994
  REMARK    GeneRIF: Morphological differentiation and metabolism of the
            iron-containing pigment in ameloblasts are independently regulated
            during amelogenesis by means of ectopic SP6 expression.
REFERENCE   4  (bases 1 to 1995)
  AUTHORS   Utami TW, Miyoshi K, Hagita H, Yanuaryska RD, Horiguchi T and Noma
            T.
  TITLE     Possible linkage of SP6 transcriptional activity with amelogenesis
            by protein stabilization
  JOURNAL   J Biomed Biotechnol 2011, 320987 (2011)
   PUBMED   22046099
  REMARK    GeneRIF: Findings suggest that the regulation of SP6 protein
            stability is one of the crucial steps in amelogenesis.
REFERENCE   5  (bases 1 to 1995)
  AUTHORS   Nakamura T, de Vega S, Fukumoto S, Jimenez L, Unda F and Yamada Y.
  TITLE     Transcription factor epiprofin is essential for tooth morphogenesis
            by regulating epithelial cell fate and tooth number
  JOURNAL   J Biol Chem 283 (8), 4825-4833 (2008)
   PUBMED   18156176
REFERENCE   6  (bases 1 to 1995)
  AUTHORS   Ruspita I, Miyoshi K, Muto T, Abe K, Horiguchi T and Noma T.
  TITLE     Sp6 downregulation of follistatin gene expression in ameloblasts
  JOURNAL   J Med Invest 55 (1-2), 87-98 (2008)
   PUBMED   18319550
  REMARK    GeneRIF: Sp6 promotes amelogenesis through inhibition of
            follistatin gene expression.
            Erratum:[J Med Invest. 2008 Aug;55(3-4):303]
REFERENCE   7  (bases 1 to 1995)
  AUTHORS   Nakamura T, Unda F, de-Vega S, Vilaxa A, Fukumoto S, Yamada KM and
            Yamada Y.
  TITLE     The Kruppel-like factor epiprofin is expressed by epithelium of
            developing teeth, hair follicles, and limb buds and promotes cell
            proliferation
  JOURNAL   J Biol Chem 279 (1), 626-634 (2004)
   PUBMED   14551215
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001081357.1, XM_343961.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM041822.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1995
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..1995
                     /gene="Sp6"
                     /note="Sp6 transcription factor"
                     /db_xref="GeneID:363672"
                     /db_xref="RGD:1306768"
     exon            1..25
                     /gene="Sp6"
                     /inference="alignment:Splign:2.1.0"
     exon            26..1995
                     /gene="Sp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1213
                     /gene="Sp6"
                     /note="trans-acting transcription factor 6"
                     /codon_start=1
                     /product="transcription factor Sp6"
                     /protein_id="NP_001102303.1"
                     /db_xref="GeneID:363672"
                     /db_xref="RGD:1306768"
                     /translation="MLTAVCGSLGSQHTDAPHSSPPRLDLQPLQTYQGHTSPEAGDYP
                     SPLQPGELQSLPLGPEVDFSQGYELPGASSRVTCEDLESDSPLAPGPFSKLLQPDMSH
                     HYESWFRPTHPGTEDGSWWDLHPGTSWMDLPHTQGALTSPGHPGALQPALGGYVGDHQ
                     LCAPPPHPHPHHLLPAAGGQHLLGPPDGAKVLEAAAPESQGLDSSLDAAARPKGSRRS
                     VPRSSGQTVCRCPNCLEAERLGAPCGPDGGKKKHLHNCHIPGCGKAYAKTSHLKAHLR
                     WHSGDRPFVCNWLFCGKRFTRSDELQRHLQTHTGTKKFPCAVCSRVFMRSDHLAKHMK
                     THEGAKEEAAAAAQGEGKAGGVVESPGGKGKREAEGSSASSN"
ORIGIN      
        1 cctcaagccc gagcgcagcc gccaggtccc acctgaggta cccttgaccg tccctgccct
       61 cattccaccc cggaacccgg caatgctaac cgctgtctgt ggctctctgg gcagccagca
      121 caccgacgcg cctcactcat caccgccgcg cctcgacctg cagcctcttc agacatatca
      181 gggtcacacg agcccggagg ccggggacta cccctccccg ctgcagcctg gagagctgca
      241 gagcctcccg ctgggcccgg aggtagactt ctcacagggc tatgagttgc caggggcctc
      301 ctcgcgggta acctgcgagg acctggaaag tgacagtccc ttggctccgg gacccttttc
      361 caagctcctg cagccggaca tgtcacacca ctacgaatcg tggttccggc cgacgcaccc
      421 aggcacggag gatggctctt ggtgggacct tcatcccggc accagctgga tggacctccc
      481 ccatactcag ggagcgctga cctcacctgg ccacccgggg gcgcttcagc ctgctttggg
      541 aggatacgtc ggagaccacc agctctgtgc tccgccaccc cacccgcacc cgcaccacct
      601 cctcccagcc gctggtgggc agcacctctt ggggccaccc gacggggcta aggtcttgga
      661 agcagcagca ccagagtccc aagggctgga ttccagtctg gatgccgctg cccgacccaa
      721 aggctcccgg cgatctgtgc cccgcagctc agggcagacc gtgtgtcgct gtcccaactg
      781 cctggaggcg gagcgactcg gggctccgtg cgggcccgat gggggcaaga agaagcattt
      841 gcataactgc cacatcccag gctgcggcaa ggcatacgct aagacgtcgc atctgaaggc
      901 gcacctgcgg tggcacagcg gcgaccgacc cttcgtgtgc aattggcttt tctgcggcaa
      961 gcgcttcacg cgctccgacg agctgcagcg ccatcttcag acccacaccg ggaccaagaa
     1021 gttcccctgt gcggtctgca gccgtgtctt catgcgcagc gaccacctgg ccaagcacat
     1081 gaaaacccac gaaggcgcca aagaagaggc tgcggctgcg gcccagggcg agggcaaggc
     1141 cggtggcgtg gtggagtcac ccgggggcaa aggcaaacgc gaagccgaag gcagctcggc
     1201 gtcctccaac tgagccccat ggatgtcaca ttcctgcctt tctttatagg ggggcggcct
     1261 gagtaagagg ggaagacggt tatttattgg tggtgagggg acagggaaag gggcactagg
     1321 ggttttttag tctctggggc tgcacgggag gctgcttgaa tattatttag gctgccagga
     1381 gctgaacacg cccctcgctt cttccctttc tatttcaccc tcccctgagt ttctgaagag
     1441 gttcggactg tagagatggc atgacctagg agttgaggga aatggagatt gggtcggggc
     1501 gttggggtag ctgtctggac atgtttttaa ctcctgggaa tccggacata aaagcacctc
     1561 ggaaccgccc atcggcctag gtctctttca tcccctcttc tagtgctgct ccctctaaaa
     1621 tttccggaga gaaagcagag atgaggtggt ggtggtggtg gaggagcttg gggtagttcc
     1681 ccatagggac cgtctatcta gcttggaggg ttattacttt atgaagaatc cccttcagtg
     1741 aatttcttct aaacccttcc agattccgtt tgataaagcc aggaagagca gctcagctct
     1801 gcagccagag ctgtgagcta gaggtccgag ctggatggag tcgagggatc cggcagggaa
     1861 atcctcttgc gaagtggaag gactaacccc ttcttctgtc aagattcttt ctttcgaatt
     1921 caatccttaa ctcttagacc cttaaaaaaa aaatcgaact cagtagtcca cgttccccat
     1981 ccatctaggt agttt
//
