LOCUS       NM_001106552            2121 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus Sp5 transcription factor (Sp5), mRNA.
ACCESSION   NM_001106552 XM_001059614 XM_231003
VERSION     NM_001106552.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2121)
  AUTHORS   Li W, Wu J, Yang J, Sun S, Chai R, Chen ZY and Li H.
  TITLE     Notch inhibition induces mitotically generated hair cells in
            mammalian cochleae via activating the Wnt pathway
  JOURNAL   Proc Natl Acad Sci U S A 112 (1), 166-171 (2015)
   PUBMED   25535395
REFERENCE   2  (bases 1 to 2121)
  AUTHORS   Fujimura N, Vacik T, Machon O, Vlcek C, Scalabrin S, Speth M, Diep
            D, Krauss S and Kozmik Z.
  TITLE     Wnt-mediated down-regulation of Sp1 target genes by a
            transcriptional repressor Sp5
  JOURNAL   J Biol Chem 282 (2), 1225-1237 (2007)
   PUBMED   17090534
REFERENCE   3  (bases 1 to 2121)
  AUTHORS   Harrison SM, Houzelstein D, Dunwoodie SL and Beddington RS.
  TITLE     Sp5, a new member of the Sp1 family, is dynamically expressed
            during development and genetically interacts with Brachyury
  JOURNAL   Dev Biol 227 (2), 358-372 (2000)
   PUBMED   11071760
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473949.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001059614.1, XM_231003.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760433,
                              SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2121
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q22"
     gene            1..2121
                     /gene="Sp5"
                     /note="Sp5 transcription factor"
                     /db_xref="GeneID:296510"
                     /db_xref="RGD:1308499"
     exon            1..388
                     /gene="Sp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..1534
                     /gene="Sp5"
                     /note="trans-acting transcription factor 5"
                     /codon_start=1
                     /product="transcription factor Sp5"
                     /protein_id="NP_001100022.1"
                     /db_xref="GeneID:296510"
                     /db_xref="RGD:1308499"
                     /translation="MAAVAVLRNDSLQAFLQDRTPSASPDLGKHSPLALLAATCSRIG
                     QPGAAAAPDFLQVPYDPALGSPSRLFHPWTADMPAHSPGALPPPHPSLGLTPQKTHLQ
                     PSFGAAHELPLTPPADPSYPYEFSPVKMLPSSMAALPASCAPAYVPYAAQAALPPGYS
                     NLLPPPPPPPPPPTCRQLSPAPAPDDLPWWSIPQSGAGPGSSGVPGTSLSSACAGPPH
                     APRFPASAAAAAAAAAALQRGLVLGPSDFAQYQSQIAALLQTKAPLAATARRCRRCRC
                     PNCQAAGGAPEAEPGKKKQHVCHVPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCG
                     KSFTRSDELQRHLRTHTGEKRFACPECGKRFMRSDHLAKHVKTHQNKKLKVAEAGVKR
                     ENPRDL"
     exon            389..2121
                     /gene="Sp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatcagttct tttatccaga ccaacaaaca caccatagga gctttgtgga ttcaaaggat
       61 ttgctttcgc ttctgaaaga gccgctattc tttgatgatt gggtagcggc aaacttcaaa
      121 gccataaatc tttcctctga ctggctggcg gcccagcaaa gcccttatca aattcttgga
      181 ggtgatcctg aagcgctcag accgcgagcg gggcgagcaa gcggggcgcg ggtggggagg
      241 actcggaggc acgctgggcg gccgttcgtc ctcgggtgtc catgcctcgg cggcggccgc
      301 gtcccgctcc acagcgagcg gccttcaagc agtagccatg gccgctgtgg ctgtcctccg
      361 gaacgactca ctgcaggcct tcctccagga ccgcaccccc agcgcctccc cggacctggg
      421 caagcactcg cccctggcac tgctggccgc cacctgtagc cggatcggcc agccgggcgc
      481 tgcggcggca cccgacttcc ttcaggtgcc ctatgaccca gctctgggtt caccctccag
      541 gcttttccac ccgtggactg ccgacatgcc cgcgcactcg ccaggagccc tgccgccccc
      601 acaccccagc ctggggctga cgccacagaa aacacacctg cagccatcct tcggggcagc
      661 tcacgagctc ccgctcactc cccccgcgga tccgtcctac ccttacgagt tctcgcccgt
      721 caagatgctg ccctcgagca tggcggctct gccagccagc tgcgcgccgg catacgtgcc
      781 ctacgctgcc caagccgcgt tgcccccggg ctactccaac ctgctacccc cgccgccacc
      841 accgcctcca ccgcccacct gccgccagtt gtcccccgcc ccggccccgg acgacctccc
      901 ctggtggagc atcccgcaat cgggtgctgg gccggggagc tccggggttc cagggaccag
      961 cctctccagc gcctgtgccg ggcctcccca cgctccccgc tttcccgcct cggctgcggc
     1021 tgctgcagca gcggctgctg ccctgcaacg gggcctagtg ttgggcccgt cggactttgc
     1081 acagtaccag agccagatcg ccgcgctgct gcagaccaag gcccccctgg cggccacggc
     1141 caggaggtgc cgccgctgcc gctgccccaa ctgccaggca gctggcggtg cccccgaggc
     1201 ggagccgggc aaaaagaagc aacacgtgtg ccacgtgcca ggctgcggca aggtgtacgg
     1261 caagacgtcg cacctgaagg cgcacctgcg ctggcacacg ggcgagcgtc ccttcgtgtg
     1321 caattggctc ttctgcggca agagcttcac gcgctccgac gagctgcagc ggcacctccg
     1381 gactcacacg ggcgagaagc gcttcgcctg tcccgagtgc ggcaaacgct tcatgcgaag
     1441 cgaccacctc gccaagcacg tgaagacgca ccaaaataag aagctcaaag tcgccgaggc
     1501 cggggtgaag cgggagaacc cgcgggacct atgagcgcac cggggcactt ccgaggccac
     1561 tcccacccaa gacatccgtc ccagcaccat tgcaggcacg ctcgggtact tgccatcgag
     1621 gtagctgaca gagaggaaac tttaaaaatg aactttttat tgtcctcctc ccgaagcgaa
     1681 gtcctgccgc ccggccctag agcggagggc agggcaggca gggctggaaa ctaggtcata
     1741 gttgagaacc ccgacttacc ccaggaggat tccaaagtcg gagccatccc tgcctgggag
     1801 acttacatta ggggattcta cccagggctg gctttgcttg tgggagccgc tgctgaaatt
     1861 aaaaacaaaa caaacaaaaa ccagaaggac cttcagagat ttaaaaacag ggcttaagtt
     1921 ttcgctaggc ccgattcgga ctttgtacag gttatttaat aatagctttg tcaaagagta
     1981 attataatta taacgttaat aaatgtttct gttctcagct ccacgcagag ctacagcatg
     2041 gtcatggtac gtttctgtaa agcgatcagc agttgcagcg tgaaaataaa tacgtcaggg
     2101 tctcctcggg aagacccccg c
//
