LOCUS       NM_012761               8194 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus Sp4 transcription factor (Sp4), mRNA.
ACCESSION   NM_012761 XM_346784
VERSION     NM_012761.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8194)
  AUTHORS   Nair,B., Johar,K., Priya,A. and Wong-Riley,M.T.
  TITLE     Specificity protein 4 (Sp4) transcriptionally regulates inhibitory
            GABAergic receptors in neurons
  JOURNAL   Biochim Biophys Acta 1863 (1), 1-9 (2016)
   PUBMED   26469128
  REMARK    GeneRIF: Sp4 is in a position to transcriptionally regulate the
            balance between excitatory and inhibitory neurochemical expressions
            in neurons.
REFERENCE   2  (bases 1 to 8194)
  AUTHORS   Higa,K.K., Ji,B., Buell,M.R., Risbrough,V.B., Powell,S.B.,
            Young,J.W., Geyer,M.A. and Zhou,X.
  TITLE     Restoration of Sp4 in Forebrain GABAergic Neurons Rescues
            Hypersensitivity to Ketamine in Sp4 Hypomorphic Mice
  JOURNAL   Int J Neuropsychopharmacol 18 (11), pyv063 (2015)
   PUBMED   26037489
  REMARK    GeneRIF: Results suggest that the Sp4 gene in forebrain GABAergic
            neurons regulates ketamine-induced hyperlocomotion
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8194)
  AUTHORS   Lalonde,J., Saia,G. and Gill,G.
  TITLE     Store-operated calcium entry promotes the degradation of the
            transcription factor Sp4 in resting neurons
  JOURNAL   Sci Signal 7 (328), ra51 (2014)
   PUBMED   24894994
  REMARK    GeneRIF: Store-operated calcium entry promotes the degradation of
            the transcription factor Sp4 in resting neurons.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8194)
  AUTHORS   Saia,G., Lalonde,J., Sun,X., Ramos,B. and Gill,G.
  TITLE     Phosphorylation of the transcription factor Sp4 is reduced by NMDA
            receptor signaling
  JOURNAL   J Neurochem 129 (4), 743-752 (2014)
   PUBMED   24475768
  REMARK    GeneRIF: Sp4 is regulated by NMDA-receptor-dependent activation of
            a protein phosphatase 1/2A signaling pathway.  Reuglated control of
            SP4 activity is an important mechanism governing the developmental
            patterning of dendrites.
REFERENCE   5  (bases 1 to 8194)
  AUTHORS   Jolma,A., Yan,J., Whitington,T., Toivonen,J., Nitta,K.R.,
            Rastas,P., Morgunova,E., Enge,M., Taipale,M., Wei,G., Palin,K.,
            Vaquerizas,J.M., Vincentelli,R., Luscombe,N.M., Hughes,T.R.,
            Lemaire,P., Ukkonen,E., Kivioja,T. and Taipale,J.
  TITLE     DNA-binding specificities of human transcription factors
  JOURNAL   Cell 152 (1-2), 327-339 (2013)
   PUBMED   23332764
REFERENCE   6  (bases 1 to 8194)
  AUTHORS   Hammer,F., Compagnone,N.A., Vigne,J.L., Bair,S.R. and Mellon,S.H.
  TITLE     Transcriptional regulation of P450scc gene expression in the
            embryonic rodent nervous system
  JOURNAL   Endocrinology 145 (2), 901-912 (2004)
   PUBMED   14576192
  REMARK    GeneRIF: Sp1, Sp2 and Sp4 transcription factors play a role in
            activating cholesterol desmolase gene transcription in the nervous
            system, and Ku antigen may further augment this activation
REFERENCE   7  (bases 1 to 8194)
  AUTHORS   Liu,A., Zhuang,Z., Hoffman,P.W. and Bai,G.
  TITLE     Functional analysis of the rat N-methyl-D-aspartate receptor 2A
            promoter: multiple transcription starts points, positive regulation
            by Sp factors, and translational regulation
  JOURNAL   J Biol Chem 278 (29), 26423-26434 (2003)
   PUBMED   12746457
REFERENCE   8  (bases 1 to 8194)
  AUTHORS   Davis,W. Jr., Chen,Z.J., Ile,K.E. and Tew,K.D.
  TITLE     Reciprocal regulation of expression of the human adenosine
            5'-triphosphate binding cassette, sub-family A, transporter 2
            (ABCA2) promoter by the early growth response-1 (EGR-1) and
            Sp-family transcription factors
  JOURNAL   Nucleic Acids Res 31 (3), 1097-1107 (2003)
   PUBMED   12560508
REFERENCE   9  (bases 1 to 8194)
  AUTHORS   Nguyen-Tran,V.T., Kubalak,S.W., Minamisawa,S., Fiset,C.,
            Wollert,K.C., Brown,A.B., Ruiz-Lozano,P., Barrere-Lemaire,S.,
            Kondo,R., Norman,L.W., Gourdie,R.G., Rahme,M.M., Feld,G.K.,
            Clark,R.B., Giles,W.R. and Chien,K.R.
  TITLE     A novel genetic pathway for sudden cardiac death via defects in the
            transition between ventricular and conduction system cell lineages
  JOURNAL   Cell 102 (5), 671-682 (2000)
   PUBMED   11007485
REFERENCE   10 (bases 1 to 8194)
  AUTHORS   Zhu,H., Nguyen,V.T., Brown,A.B., Pourhosseini,A., Garcia,A.V., van
            Bilsen,M. and Chien,K.R.
  TITLE     A novel, tissue-restricted zinc finger protein (HF-1b) binds to the
            cardiac regulatory element (HF-1b/MEF-2) in the rat myosin
            light-chain 2 gene
  JOURNAL   Mol Cell Biol 13 (7), 4432-4444 (1993)
   PUBMED   8321243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Feb 26, 2021 this sequence version replaced NM_012761.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.37479.1, U07610.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               JAXUCZ010000006.1  145394941-145395114 c
            175-284             JAXUCZ010000006.1  145394416-145394525 c
            285-1842            JAXUCZ010000006.1  145392348-145393905 c
            1843-2071           JAXUCZ010000006.1  145351981-145352209 c
            2072-2271           JAXUCZ010000006.1  145345086-145345285 c
            2272-8194           JAXUCZ010000006.1  145330416-145336338 c
FEATURES             Location/Qualifiers
     source          1..8194
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q33"
     gene            1..8194
                     /gene="Sp4"
                     /gene_synonym="HF-1b"
                     /note="Sp4 transcription factor"
                     /db_xref="GeneID:25162"
                     /db_xref="RGD:3741"
     exon            1..174
                     /gene="Sp4"
                     /gene_synonym="HF-1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..2519
                     /gene="Sp4"
                     /gene_synonym="HF-1b"
                     /function="transcription factor"
                     /note="trans-acting transcription factor 4; HF-1b zinc
                     finger protein"
                     /codon_start=1
                     /product="transcription factor Sp4"
                     /protein_id="NP_036893.1"
                     /db_xref="GeneID:25162"
                     /db_xref="RGD:3741"
                     /translation="MSDQKKEEEEEAAAAMATEGGKTSEPENNNKKPKTSGSQDSQPS
                     PLALLAATCSKIGTPGENQATGQQQIIIDPSQGLVQLQNQPQQLELVTTQLAGNAWQL
                     VASTPPASKENNVSQPASSSSSSSSSNNGSSSPTKTKSGNPSTPNQFQVIQVQNPSGS
                     VQYQVIPQLQTVEGQQIQINPTSSSSLQDLQGQIQLISAGNNQAILTAANRTASGNIL
                     AQNLANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTTLPINIGGVTLALPVINNVTAGG
                     GTGQVGQPTTTTTDSGTSNGNQLVSTPTTSTAPASTMPESPSSSTTCTTTASTSLTSS
                     DTLVSSADTGQYASTSASSSERTIEEPQTPAATESEAQSSSQLQSNGIQNAQDQSNSL
                     QQVQIVGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQLQAVNP
                     TQVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGGTTLAQ
                     IAPVAVAGAPITLNTAQLASVPNLQTVSVANLGAAGVQVQGVPVTITSVAGQQQGQDG
                     VKVQQATIAPVTVAVGGIANATIGAVSPDQLTQVHLQQGQQTSDAEVQPGKRLRRVAC
                     SCPNCREGEGRGSSEPGKKKQHVCHIEGCGKVYGKTSHLRAHLRWHTGERPFICNWMF
                     CGKRFTRSDELQRHRRTHTGEKRFECPECSKRFMRSDHLSKHVKTHQNKKGGGTALAI
                     VTSGELDSSVTEVLGSPRIVTVAAISQDSNPATPNVSTNMEEF"
     exon            175..284
                     /gene="Sp4"
                     /gene_synonym="HF-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            285..1842
                     /gene="Sp4"
                     /gene_synonym="HF-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2071
                     /gene="Sp4"
                     /gene_synonym="HF-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2271
                     /gene="Sp4"
                     /gene_synonym="HF-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..8194
                     /gene="Sp4"
                     /gene_synonym="HF-1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagcccagc ggcggccatt cgcggaaaaa gaggcagagc ctgtgccagc tacagcctcc
       61 tccgagccac cgcgggcggg cgggaccggc ctctcctccc gcctcgcccc cacccccacc
      121 cacctctatc ccagtgtctc tgagagggtt tgtcctgtta atgcgggatg agcgatcaga
      181 agaaggagga ggaggaggag gcggcagcgg caatggctac agaaggaggg aaaacctctg
      241 agccagagaa taacaataaa aaacccaaaa cctcaggctc ccaggactct cagccctctc
      301 ctctggcttt actggcagct acttgcagca aaatagggac tcctggtgaa aatcaagcaa
      361 ctggacaaca gcagattatt atagatccaa gccaaggatt ggtgcaactt cagaatcaac
      421 cacagcagct agaactggtg acaacgcagc ttgctggaaa cgcttggcaa cttgttgcct
      481 ccactcctcc tgcttcaaaa gaaaataacg tttctcagcc agcttctagt tcatctagtt
      541 cttccagcag taataacggg agttcctctc ctacaaaaac taaatcaggt aatccttcca
      601 cccctaatca atttcaagtc atacaagtac agaatccaag tggtagtgta cagtaccaag
      661 tgatccccca acttcagacg gtggaaggtc agcaaattca aatcaatcca actagtagtt
      721 catctctaca ggatttgcag ggtcaaattc aactcatttc tgcaggtaat aatcaagcta
      781 tcctcacggc tgctaacagg acagcttctg ggaatatcct tgctcaaaac ctggcaaatc
      841 agacagttcc ggtacaaatt agacctggtg tttcaatacc attgcaattg cagacccttc
      901 ctggtactca ggctcaagtt gtaacaaccc taccaattaa cattggagga gtgactttag
      961 ctttgccagt aataaataac gtgactgctg gaggagggac tggacaagtt ggccagccta
     1021 ctactactac tactgatagt gggacttcca atggaaatca gttagtgtct acgcccacca
     1081 ccagcactgc tcccgccagt actatgcctg aatcaccctc ttcctctact acctgcacaa
     1141 ctactgcatc aacatctctg acgagcagtg acacattagt gagctcagca gatacgggcc
     1201 agtatgcaag cacatcagcc agtagttctg aacgcaccat tgaagaacca cagacacctg
     1261 ctgctactga gtctgaggcc cagagctcca gtcagcttca gtccaatggg atacagaatg
     1321 cacaggatca gtcaaattct cttcagcaag tacagattgt aggccagcct atcctgcagc
     1381 aaatccagat ccagcagcct cagcagcaga ttattcaagc tatcccgcca cagtcatttc
     1441 aactccagtc agggcagaca attcagacca tccagcagca gcctttgcag aacgttcaac
     1501 ttcaagcagt aaacccgact caggtgctta tcagggctcc aactttaaca ccttcagggc
     1561 aaatcagctg gcaaactgtc caggtccaga atattcagag tctttcaaat ttgcaagttc
     1621 agaacgctgg gttatcccag cagttaacca tcaccccagt gtcttcaagc ggtggcacaa
     1681 ctcttgctca gattgctcct gtggctgttg ctggtgcccc aataacattg aatactgccc
     1741 agcttgcatc agtgcctaac cttcagacag tgagcgttgc caacctgggt gctgcgggtg
     1801 ttcaagttca gggagttcca gtaacaatca ctagtgttgc aggtcagcag caaggacagg
     1861 atggagtgaa agtccagcaa gctactatag ctcctgtaac ggtggcagtt ggagggatcg
     1921 ctaatgcgac aataggtgct gttagtcctg accaactcac acaagtgcat ttgcagcaag
     1981 gccagcagac ctctgatgcc gaggtgcaac ctggcaagag gcttcgaaga gttgcctgct
     2041 cgtgtcctaa ctgtagggaa ggagaaggaa ggggcagcag tgaaccagga aagaaaaagc
     2101 agcatgtttg ccacattgaa gggtgtggga aagtgtatgg caagacttct cacctacgag
     2161 cacatctccg ctggcacact ggagaacggc ctttcatatg caactggatg ttttgtggca
     2221 aaagattcac caggagtgat gagcttcaga ggcacagaag gacccacaca ggtgaaaaga
     2281 gatttgaatg tccagaatgt tctaaaaggt ttatgcggag tgatcacctt tccaagcatg
     2341 tcaaaactca ccagaataag aaaggaggtg ggacagctct tgccattgtc acctccggag
     2401 aactggactc atccgttaca gaggtgcttg gctctccacg gattgtcaca gttgccgcca
     2461 tttctcaaga ttcgaatcca gcaactccca atgtttcaac aaacatggaa gaattctgaa
     2521 acgctattta taacaaagac ctctagtgct gcactaagtt tacacctttg aaaatctgga
     2581 aatgggctgg tcaagtgagt tacagagtag gaaatcacgt ttgcatcctt ggcatcttta
     2641 agtattccat ggattatggt tcaacacata aagtgttgaa tttttaaaaa atagaaaagg
     2701 aaaaccaata tactggaaac agaaaagtat ttcttccatg gtataagttg ctgtagtttt
     2761 ttggaaatac atcacataac ctttaaacag aatcttccct cctttaacat cctgtgttgt
     2821 tgacgcgtct aaagagacag accacactaa tttgcaggct gggccttaat tggactttct
     2881 ctgtttggaa gaactttgtt aaaattttag tcagtaataa cttacataca tttcttctac
     2941 tgtctagcac agaaaacaga ttgttatctg acaataggga taatactgtg tttctttagc
     3001 ttggtttttt ggaaaaacct attcaaaata gttttggccg tcttttctaa atatcaaaaa
     3061 ttctttaaaa gttgaattag aatatgttcc aaaatagtaa tctgagctgt gtctcagatc
     3121 tttattacac tacattgtag tagtgtgtgt gcagacaatc agtgaaaccc gattattttc
     3181 tccatcttgg agacacaaga ggaccttaga gctaaatctt aggttaaact ttagattgaa
     3241 accttaggaa aacgctgggg aaaatttgct agcacagaat ggatggaagc ctcagaaagg
     3301 caagacaaag cagtttaaca atatttttaa gttagggttg actgtgtgcc taaccctgtg
     3361 ttcaatagca aaatttcatt ttaaatgttc atattggaaa tgcttgcata gatgatagat
     3421 ctatgtaatt tcatattctg taaatatgag ttttgttgac aataagcaag attctttatg
     3481 ctttggtagc caaagaaaga attgtcatac ttttcaaggc cagcagaaaa ttatttttaa
     3541 ttacattatc accttttttc ctttactaaa aattggcaaa tcccatatta tttctagtac
     3601 tgtgttaggc taattaggaa catatatcat acagtgatat ctttatgtta cgtcaataac
     3661 agaattttcc ctaaaggtct agacagctta acaaatgtat aataaataaa atattatgaa
     3721 gcaaaaatta tttttggaaa accagaatac ttttcagtca aatactgact gaaaatatat
     3781 ttcattgttc gtgcaagggt cttagagagc ggtgtcttat taggaaagat ggccaaacgt
     3841 ttcatgtgaa aagcaattgg attattctaa tagattagac attagtaaga cacctcatgt
     3901 ttttagaacg tatttacaca gaatcataac tattgaaaca gaccatttgg aaactaaagt
     3961 ttttacctac ttcctttttt accttcattg gttcgaatat aggtatatgt tttcttgtgc
     4021 attctttatt atttcaggaa aagtactact catgagaatt ctcttccaaa attgtgatgt
     4081 ttcatgtact tttgatgaag gagaaatact gtaatgatca ctgtttacac tatgtacact
     4141 ttaggccagc cctttgtagc gttatataaa actgaaggcc ttttgtgctt tcggtttgta
     4201 taaaaaagct ttgagattaa aggaaaaaat ttttacactg tggttataaa tttcaagttt
     4261 cttaaagctt ttgtagactt gtaacaaagt ctttaaattt tagttggatt ttgtaaattg
     4321 ttttgtatat tttatttaat gtactcttaa cagctgatgg atctggcttt aaaacatcag
     4381 aatcagtttg ttgttttgtc tggtacagag aagcatttgg taatgttgat tttaatttta
     4441 ttatatagga gctgaaacat caaatatatt ttatctatca tgctacacaa tcagtgctat
     4501 caattttttt atgcaaagag actttctcaa tgttttaatc gtgttttctt cgagtgatac
     4561 tttttgttgt ttgcaccaag tatgagcgct ctgcatcact gttccacgag ccagttttat
     4621 gcaacccacg tacgctcatc agaagtgcaa gttgtcctca tcagcaatga ggtctactgt
     4681 acatgtatca gactgaatct ggataacctt ctatcatata aaacaacctg tcagcaggca
     4741 catttcacca ctggaatcag acctattttg gcagtctgtt ctgcatacca ttctgaatcc
     4801 accttccttt ctgtctgaca gcagtcgtag gtttcggtgt cctgtgtttg actcagtggg
     4861 gtgtagccgt ggtaggccgc agatgcgcag tacagtctcg cgaagggcat ttcgctgctc
     4921 actcccctgg ccaccattat aaagcttttc tttgtaaaat tatcagtgtg aagctctgta
     4981 tttaccatgg tagaactcca gtgttagaat agttttctct tacagtatac tttctttggt
     5041 taggtttgtg tatgtgttgc tgattacatt agaagctgat gttaagtcat tatttatcac
     5101 actcatgaga gcagtaataa acgtgtgtaa tctaggagaa aaagttaatt tgtcaaactt
     5161 agataagcat gatgtttagg tcctattttt caattttata actgttttat tgcaacaata
     5221 tttgtactta agtctccatt ttaatgcctt gtggtgtttt tttatgcatg tcactaagtt
     5281 gtcaccccac ataaattgat gtacagcata gggtattaaa tctacataat gattttaaaa
     5341 cagaaatagt tgatggtaaa ttgtaaatgt tttgcaaaaa ttccttataa aaagtttcgt
     5401 agtaacattt cacttgtaaa ttttttgtaa aaaagaaaat ggatttaaaa aaagatgaat
     5461 ccagaaaaaa aaaaaaaaca tgttttccca tattctagaa tttagacaat tattctgcca
     5521 gcaaagcctc tggggctgta attgacattt ttacagtgct gatttgtata aaatttgttt
     5581 tttgtggatt tggaaataaa atcatgtaca agttgttgcc tgcagtaaca attgcaagta
     5641 acctattaaa gtccccttgg gttgaacatg cctcatttaa ttatgtatac tatagagcaa
     5701 taaagtgttt aaactaccaa ccttctcatc acagtgaaca ctgaaaattt aaatacctct
     5761 cactagaacg tttattggca acccttctta atcccggttt taagatctga tcaacttgcc
     5821 tctgaaaata ccgccaaaga acaccagttt aaattgcatg ttaatttgtg accaattgct
     5881 gtagacgtct gtggaaatta aattttgatt tagagacacc ttatttaaat aattttaata
     5941 aatgttagga gatagtcaaa aaatgagaga caaaatttaa ataatattta agttcacagc
     6001 gaatatttag gttcacttag aagcagtgta ggcctcctag gtgtggaaga attgtcttcc
     6061 ttctgggaga gatttgcatg tctctgagaa acccttactg ccgtgagaat ccactccagt
     6121 atgacttgaa tggacacatt tctaggtgtg catggacagc agagctgtag ggagagctgc
     6181 aggatgtcag gcacagagga aagtgagctg cccacacgct tccaactagt gtttaaacat
     6241 ggagtaggta gggtagtgta ctgtctggat acatagcttg tatgacatag tgtaagggca
     6301 tggttctaat tcgttgtaca tacatacata gcataacagt gatcaaaaac aagaggcagt
     6361 taaatttatg ctcctctatc aagtaacatc tttgtcaaaa gctttcatgt caaaagtaaa
     6421 ggtacccatt gtgaccagga ctgcttaatt atgcctgatt catattcccc tgagttcttt
     6481 acttaagccc aaagctcatg ttgctacccc aaagataaac ttggggtggg gaggggggat
     6541 ccttgacctc tttatctgtt cctcctacca gtgaccacca attaaatttc tactttttaa
     6601 tccttcccaa aacacatacc tgttccaatt tccttaaaga ttgacatatg tgcttatcag
     6661 gatgacactg catgaaaaga taatgaaatt taaaacctga aactttcact tttaactccg
     6721 tgatgctctg gtttctaagc tagggattga accacatgaa taagactgag acataaagta
     6781 ggatcgctga catgaaaccg ttcagtgtgg agtgaaagca ggggttagag ccactgttgt
     6841 catagccgtg gttcaccatg tcttgttaaa gacaaccccg aagtcagaaa actcatgttt
     6901 gatacaactt ttctctgttt aaagttcagg tgtaagatat aggggtactg ggacttcaga
     6961 tgccagtaag caatgtgggg ttctttgatt cctcagtgat tgattgattg tctgtgctgt
     7021 gatgtgcata gtgtatgatt gtgttgcagg attttaaagg cattgtctaa gattctctgg
     7081 ttggtatagc cttgggttct gcttctctta gttgcaatga aataatttat ttttttggat
     7141 gcctgagcaa gaagatctca agtggaaggg agcaaggaga gaagggggaa aggaaagagc
     7201 acaaagggct gttggtaatg cggagttatc tctccatggt gatagcactt gggaaaaagg
     7261 agccggtgtt cgagctgggc tcctgattta gttgttgctg agctatttag tctcactgca
     7321 ctgtgtgctt atttgcacaa ttataattga cactgtagta agtacaccca gcatctggta
     7381 agcagtagca tacacagtag ctaacccaga ggggattact tcattcatga gactgtgcca
     7441 aaacagcata agctggatgg cttgtagaca ataggactaa gtccaaagtc acagttcagt
     7501 gtcccctgac aacacatgtt ccctcacatc atagaaggat gaggtggctt tctgagggcc
     7561 tttttgtttt tcttggatca ttaataccat ttcaggagga tgccatattt atgatcttac
     7621 tgcttcttag aggccccacc tcctctgctg tgttggtaat tggatttcaa catgatggat
     7681 ctggagagac aaaccatcag acccagcagg aggcattgaa tagttcccaa caagattact
     7741 ggtgaaatgc ttgggaaagg agcttggaaa agctggctct ctaaattaca tcaaaggaac
     7801 ttctgtgaga atttcccatt tcaagcgtgt ttttttctca agccgagcta gtttgaggta
     7861 ctgtacctca aaaactacac gatggcatga ctcactggga acaagactga agataatgaa
     7921 cgcacatcaa gattgtgcag ggcaaggaag gaagcccagg tttcgagaca gctgagaagg
     7981 ctcaccctgt tgcggtgatc agacaccagc aagggatggg agacaggtgc ctcaagcaac
     8041 agttcatctt tgcatcctac ctttctaggt agttggcttg gtttaaagtg tgttatttat
     8101 ggtcctgctg tgaaacgcag tctaataaat attttattta tagtattttt gtgatgtgga
     8161 agctataata aagttatatt ttctgctgat aaaa
//
