LOCUS       NM_001401802            3729 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus SP100 nuclear antigen (Sp100), transcript variant
            1, mRNA.
ACCESSION   NM_001401802 XM_039083904
VERSION     NM_001401802.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3729)
  AUTHORS   Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk
            SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni
            N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider
            J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA,
            Pelletier L, Aloy P, Hill DE, Vidal M and Roth FP.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3729)
  AUTHORS   Dejardin J and Kingston RE.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
REFERENCE   3  (bases 1 to 3729)
  AUTHORS   Takahashi K, Yoshida N, Murakami N, Kawata K, Ishizaki H,
            Tanaka-Okamoto M, Miyoshi J, Zinn AR, Shime H and Inoue N.
  TITLE     Dynamic regulation of p53 subnuclear localization and senescence by
            MORC3
  JOURNAL   Mol Biol Cell 18 (5), 1701-1709 (2007)
   PUBMED   17332504
REFERENCE   4  (bases 1 to 3729)
  AUTHORS   Milovic-Holm K, Krieghoff E, Jensen K, Will H and Hofmann TG.
  TITLE     FLASH links the CD95 signaling pathway to the cell nucleus and
            nuclear bodies
  JOURNAL   EMBO J 26 (2), 391-401 (2007)
   PUBMED   17245429
REFERENCE   5  (bases 1 to 3729)
  AUTHORS   Negorev DG, Vladimirova OV, Ivanov A, Rauscher F 3rd and Maul GG.
  TITLE     Differential role of Sp100 isoforms in interferon-mediated
            repression of herpes simplex virus type 1 immediate-early protein
            expression
  JOURNAL   J Virol 80 (16), 8019-8029 (2006)
   PUBMED   16873258
REFERENCE   6  (bases 1 to 3729)
  AUTHORS   Seeler JS, Marchio A, Sitterlin D, Transy C and Dejean A.
  TITLE     Interaction of SP100 with HP1 proteins: a link between the
            promyelocytic leukemia-associated nuclear bodies and the chromatin
            compartment
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7316-7321 (1998)
   PUBMED   9636146
REFERENCE   7  (bases 1 to 3729)
  AUTHORS   Sternsdorf T, Jensen K and Will H.
  TITLE     Evidence for covalent modification of the nuclear dot-associated
            proteins PML and Sp100 by PIC1/SUMO-1
  JOURNAL   J Cell Biol 139 (7), 1621-1634 (1997)
   PUBMED   9412458
REFERENCE   8  (bases 1 to 3729)
  AUTHORS   Sternsdorf T, Jensen K, Zuchner D and Will H.
  TITLE     Cellular localization, expression, and structure of the nuclear dot
            protein 52
  JOURNAL   J Cell Biol 138 (2), 435-448 (1997)
   PUBMED   9230084
REFERENCE   9  (bases 1 to 3729)
  AUTHORS   Grotzinger T, Jensen K and Will H.
  TITLE     The interferon (IFN)-stimulated gene Sp100 promoter contains an
            IFN-gamma activation site and an imperfect IFN-stimulated response
            element which mediate type I IFN inducibility
  JOURNAL   J Biol Chem 271 (41), 25253-25260 (1996)
   PUBMED   8810287
REFERENCE   10 (bases 1 to 3729)
  AUTHORS   Szostecki C, Guldner HH, Netter HJ and Will H.
  TITLE     Isolation and characterization of cDNA encoding a human nuclear
            antigen predominantly recognized by autoantibodies from patients
            with primary biliary cirrhosis
  JOURNAL   J Immunol 145 (12), 4338-4347 (1990)
   PUBMED   2258622
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000215.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001401802.2.
            
            On Feb 25, 2022 this sequence version replaced XM_039083904.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               JACYVU010000215.1  19380723-19380837
            116-275             JACYVU010000215.1  19388821-19388980
            276-444             JACYVU010000215.1  19390868-19391036
            445-516             JACYVU010000215.1  19391910-19391981
            517-582             JACYVU010000215.1  19393603-19393668
            583-672             JACYVU010000215.1  19396026-19396115
            673-816             JACYVU010000215.1  19397781-19397924
            817-897             JACYVU010000215.1  19398305-19398385
            898-1044            JACYVU010000215.1  19403936-19404082
            1045-1119           JACYVU010000215.1  19404915-19404989
            1120-1170           JACYVU010000215.1  19412031-19412081
            1171-1224           JACYVU010000215.1  19414095-19414148
            1225-1278           JACYVU010000215.1  19421629-19421682
            1279-1353           JACYVU010000215.1  19425629-19425703
            1354-1404           JACYVU010000215.1  19428098-19428148
            1405-1509           JACYVU010000215.1  19430726-19430830
            1510-1652           JACYVU010000215.1  19433430-19433572
            1653-1691           JACYVU010000215.1  19435114-19435152
            1692-1736           JACYVU010000215.1  19435402-19435446
            1737-1852           JACYVU010000215.1  19439067-19439182
            1853-1970           JACYVU010000215.1  19441180-19441297
            1971-2042           JACYVU010000215.1  19441561-19441632
            2043-2186           JACYVU010000215.1  19442321-19442464
            2187-3729           JACYVU010000215.1  19445185-19446727
FEATURES             Location/Qualifiers
     source          1..3729
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..3729
                     /gene="Sp100"
                     /note="SP100 nuclear antigen"
                     /db_xref="GeneID:363269"
                     /db_xref="RGD:1359550"
     exon            1..115
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..2312
                     /gene="Sp100"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear antigen Sp100; nuclear autoantigen Sp-100; nuclear
                     autoantigen Sp-100-like"
                     /codon_start=1
                     /product="nuclear autoantigen Sp-100 isoform 1"
                     /protein_id="NP_001388731.1"
                     /db_xref="GeneID:363269"
                     /db_xref="RGD:1359550"
                     /translation="MEGNSFSSRMSSEHENTETFPFELIFQHFKRQKVAISNAIKNPF
                     PFLEGLRDHELITAKMYEDLQDSYRALVRVQEVIYRALDKLEKIFSMKVLYEVFSNVN
                     MEKYPDLQLIYQSFERVLPNGLCFQRSDGGDPNSQLSLEQGPNGSCSQATLTLSPFNH
                     SFSDGWGSNDRLNSSLTHGNQSENHQLPGSPNHLVSSLEDGLSETVQTSRVRREATTS
                     TTNNTNESARKCSTLLRSPGSVLEDACEFQVQLNNRDASPEPYSLQPSNEERAVQLNH
                     DLQINPCSVRLVDIKKENISYSLDDNQQTQARTNENQGSEIIELSSDEDSNDEINLSE
                     ASTLILSKPETAHSRQPPTPRTYRRGDTSDTSSSSLDRRRKRTGHTIAVGNNPVLGRD
                     GGRRRKKRERHGNYLIRNIKIPMNASWKTAFGTRHSNPSSQQGRKRGPRIHKDVNADF
                     SSNELLVTCGKVVGTLYKEKLNQGIHVKSIQSTEGKWFTPLEFEIEGGYEKCKNWRQS
                     IRCSGWPLKELIKRGELQDPPRKTEMKETPPNSQQRKRKRKLKNLKACKVCGQRRRVR
                     PCATCRKCYHKNCHIPPVEVQSGPWHCAFCKTRNQLRCQENQACHKESEVLKRKMSPE
                     EQLKCELLLLTIYCCPKSGFFIRKPKKRKEDFPDLQEHMWLNKIKHRLNKKAYHSVQH
                     FVGDMRLIFQNHSKFYKSRFKNLGVIVGNKFEKTFKSVFSIEDTSKQLQPSQHTVLLT
                     "
     exon            116..275
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            276..444
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            445..516
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            517..582
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            583..672
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            673..816
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            817..897
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1044
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1119
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1170
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1224
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1278
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1353
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1404
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1509
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1652
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1691
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1736
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1852
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1970
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2042
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2186
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..3729
                     /gene="Sp100"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtgggcc acagcaaata gtccggaagc ctgtgcagac accaaggcgt ccgagctcac
       61 tgtcccagac cccaggcagg tgttggaaaa tggaagggaa cagcttcagc tccaggatgt
      121 ccagtgaaca tgagaataca gagacgtttc cctttgaact tatatttcaa cacttcaaga
      181 gacagaaagt ggcaatttct aatgcaataa aaaatccatt tccttttctt gagggcctcc
      241 gagatcatga attaatcact gctaaaatgt atgaagatct tcaagattcg tatagagccc
      301 tggtccgtgt acaggaagtg atctacagag ccctggataa actggagaag atattcagca
      361 tgaaggtcct ctatgaagta ttcagtaatg tcaacatgga gaaatatcca gatttgcaac
      421 tcatttatca aagctttgaa cgtgtgttac caaatggatt gtgtttccaa aggagtgatg
      481 gaggagaccc aaactcccag ctgagtcttg aacaaggacc taatggcagc tgttctcaag
      541 caaccctgac cttgtcaccc ttcaatcact ccttttctga cggctgggga agtaatgata
      601 gactaaattc cagcctcacc catggaaacc aaagtgagaa tcatcaactc cccggatcac
      661 caaatcacct tgtttcgagt cttgaagatg gactctcaga aactgtacag actagcagag
      721 tgagaagaga ggccaccacc agcactacga acaatactaa tgaatcagca aggaaatgct
      781 cgaccctgct tagaagccca ggttctgtgc tagaggatgc ctgtgaattc caagtccaac
      841 tgaacaacag agatgctagc ccagagcctt acagcctaca gcccagcaat gaagagagag
      901 ctgtgcaact caaccatgac ctccaaatta atccctgttc tgtgcggctg gtagatataa
      961 agaaggaaaa tatatcatat tctttggatg ataaccaaca gacccaagca aggactaacg
     1021 aaaatcaggg ctctgagata atagagctca gcagtgatga ggattctaat gatgaaatca
     1081 acttgtcaga agcctctacc ttaatcctct ccaagccaga gactgcacat tccagacaac
     1141 ctcccacacc aagaacatac agaagaggag atacttctga taccagcagc tcaagcctcg
     1201 atagaagacg gaaaaggaca ggacatacca tagctgttgg aaacaatcct gttctgggga
     1261 gagacggagg aagaagaagg aaaaagagag agagacatgg aaactactta atacggaaca
     1321 tcaaaatccc aatgaatgca agctggaaaa cagctttcgg aacaagacat agcaatcctt
     1381 cttcacaaca aggcagaaaa cgaggtccga gaattcacaa agatgtaaat gcggatttta
     1441 gcagtaatga gcttctggtg acatgtggca aagttgtggg gactctgtat aaggagaaat
     1501 taaatcaagg catccatgtg aagagcatac agagtacgga aggaaagtgg ttcactcccc
     1561 tggaatttga aattgaagga ggctacgaga aatgcaagaa ctggaggcaa agcatccgct
     1621 gcagtgggtg gcccctgaaa gaactgataa agagaggaga actacaagac ccaccaagga
     1681 agacagaaat gaaggaaaca ccaccaaact cacaacaaag aaagagaaag agaaagctga
     1741 aaaatctaaa agcatgtaaa gtgtgcggcc aacgacggag agtgcgccct tgtgctactt
     1801 gtagaaaatg ctaccataag aattgccaca tcccacctgt ggaagttcag agtggcccgt
     1861 ggcattgtgc cttctgcaag acaaggaatc aattaaggtg ccaagaaaac caagcatgtc
     1921 ataaggaatc tgaggtcttg aagaggaaga tgtcacccga ggaacagctg aaatgtgagc
     1981 tgcttctatt gactatctat tgctgtccaa aaagtggctt ttttatccga aaaccaaaga
     2041 aaaggaaaga ggactttcca gacctccagg agcacatgtg gttaaacaaa atcaagcata
     2101 ggctgaataa gaaggcatac cattcggtac aacactttgt tggggacatg cgtctcatct
     2161 ttcagaacca cagcaaattt tataaaagca ggttcaaaaa tcttggagtc atagtgggaa
     2221 acaaatttga gaagactttc aaaagcgttt tttcaatcga ggatacaagc aaacaacttc
     2281 aaccgtctca gcacaccgtt ttgttaacct agtcctttct gttccctcca ctacccatcc
     2341 ctccagcagc caacagcatt acactcagag aacctacctt tcttcgtaga ccgcctgcca
     2401 cactctgtct ctaactttct atatcgtcct tcctgtttga tcatctttct aaagagaact
     2461 tagggcatac aatgtacatc actggtgaac tctcaggtgc tgagcccact gagaggatga
     2521 ctctggagac tgctccctcc cccatttcaa acccaagtct cataaaatgc cctccgaggt
     2581 atcttgtcta ggggtggcct tgcctgtcta actctgacag ggaggaggaa ccagcaaaac
     2641 cagtctaaga atgaaaatac tatgtccttg aaaacagcta gaaggtgacc attgctaaca
     2701 gatattatta caattgttta tcctgggatg taaaatgaga aagagaaacc agaaattcag
     2761 ctataagagc tcagtcatgg agagaaagct caactggaaa ctgtgatgct gactgtcgag
     2821 tttccacaaa cagttcctgc tgcctattgt gagcatccag tttgatgata tgctctctct
     2881 ctctctctct ctctctctct ctctctctct ctctctctct ctctcaatat gtagtctttt
     2941 atctggaagc cccacaagag attaactctt ctctgacctg aactctactg gaaactccag
     3001 ctgactgtct ccgcaggact tcctctggat tccagtccat tccccctaga tatatgaagc
     3061 acatgattaa aatcatcttt tgttggtttt ttttttctat ttactctttt actttagctt
     3121 gttatatact taatgaactc gatcacttga aactgaaagt ggctaacatt gtctgctctt
     3181 aggactgtgc agaacagaat agagtgggtg agcgatcaca agatgctctt gctatttgaa
     3241 ggtggtgagg cctataaaaa gtgtgtgtgt gaggccagac aatggacacc aagacagaca
     3301 cctggcctct gctcagacta ctagaataaa ggaacaaatg ccttctatgt ctaaaactgc
     3361 agtttacagg atgaacatgt aaagattttg gctctctgtg catttttttc ttctgcattt
     3421 tagccagaca gactctcact aaatgcaaaa ctttctctaa ctctcaaact ctgtgagacc
     3481 tcaggaaaaa taaagtataa aaatccaagc tgtaaggagg attgcctgag acttgtaaca
     3541 ataaccaaag gcttgttagt cggacatcat gtacagacag taaatctcag tttgttacat
     3601 cgtgccatgt atgtaatttg gattcaactc ttgctttgaa agttattaaa attcctaaaa
     3661 atactaatct gcttatagta gcacgtgtaa tgactggctt aaaaaataaa aatgcacgtt
     3721 taatcaaga
//
