LOCUS       NM_012655               7718 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Rattus norvegicus Sp1 transcription factor (Sp1), mRNA.
ACCESSION   NM_012655
VERSION     NM_012655.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7718)
  AUTHORS   Vaghf,A., Sadegh,M., Khansarinejad,B. and Mondanizadeh,M.
  TITLE     MicroRNA-124-3p targets Sp1 transcription factor to regulate glioma
            progression in rats
  JOURNAL   Gene 930, 148858 (2024)
   PUBMED   39153708
  REMARK    GeneRIF: MicroRNA-124-3p targets Sp1 transcription factor to
            regulate glioma progression in rats.
REFERENCE   2  (bases 1 to 7718)
  AUTHORS   Shen,C., Peng,C., Zhang,S., Li,R., Liu,S., Kuang,Y., Su,F., Liu,Y.,
            Liang,L., Xiao,Y. and Xu,H.
  TITLE     Eukaryotic translation initiation factor 6-mediated ribosome
            biogenesis promotes synovial aggression and inflammation by
            increasing the translation of SP1 in rheumatoid arthritis
  JOURNAL   Int Immunopharmacol 142 (Pt B), 113164 (2024)
   PUBMED   39288622
  REMARK    GeneRIF: Eukaryotic translation initiation factor 6-mediated
            ribosome biogenesis promotes synovial aggression and inflammation
            by increasing the translation of SP1 in rheumatoid arthritis.
REFERENCE   3  (bases 1 to 7718)
  AUTHORS   Li,Y., Cheng,M., Jin,J., Zhang,D., Zhang,S., Bai,Y. and Xu,J.
  TITLE     Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells
            apoptosis by activating Mark4 in vascular calcification
  JOURNAL   Aging (Albany NY) 16 (3), 2438-2456 (2024)
   PUBMED   38301049
  REMARK    GeneRIF: Interaction of Sp1 and Setd8 promotes vascular smooth
            muscle cells apoptosis by activating Mark4 in vascular
            calcification.
REFERENCE   4  (bases 1 to 7718)
  AUTHORS   Xu,L.J., Yang,Y., Yuan,L.F., Liu,H., Xu,N.P., Yang,Y. and Huang,L.
  TITLE     SP1-stimulated miR-208a-5p aggravates sepsis-induced myocardial
            injury via targeting XIAP
  JOURNAL   Exp Cell Res 435 (1), 113905 (2024)
   PUBMED   38163563
  REMARK    GeneRIF: SP1-stimulated miR-208a-5p aggravates sepsis-induced
            myocardial injury via targeting XIAP.
REFERENCE   5  (bases 1 to 7718)
  AUTHORS   Li,X.H., Fu,J.J., Shi,X.J., Zhang,Y.N., Shao,M., Yue,S.J., Li,C.
            and Luo,Z.Q.
  TITLE     Sp1 mediated the inhibitory effect of glutamate on pulmonary
            surfactant synthesis
  JOURNAL   PLoS One 18 (8), e0289530 (2023)
   PUBMED   37556489
  REMARK    GeneRIF: Sp1 mediated the inhibitory effect of glutamate on
            pulmonary surfactant synthesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7718)
  AUTHORS   Kovacs,P., Voigt,B. and Kloting,I.
  TITLE     Novel quantitative trait loci for blood pressure and related traits
            on rat chromosomes 1, 10, and 18
  JOURNAL   Biochem Biophys Res Commun 235 (2), 343-348 (1997)
   PUBMED   9199194
REFERENCE   7  (bases 1 to 7718)
  AUTHORS   Rajput,B., Shaper,N.L. and Shaper,J.H.
  TITLE     Transcriptional regulation of murine beta1,4-galactosyltransferase
            in somatic cells. Analysis of a gene that serves both a
            housekeeping and a mammary gland-specific function
  JOURNAL   J Biol Chem 271 (9), 5131-5142 (1996)
   PUBMED   8617793
REFERENCE   8  (bases 1 to 7718)
  AUTHORS   Imataka,H., Sogawa,K., Yasumoto,K., Kikuchi,Y., Sasano,K.,
            Kobayashi,A., Hayami,M. and Fujii-Kuriyama,Y.
  TITLE     Two regulatory proteins that bind to the basic transcription
            element (BTE), a GC box sequence in the promoter region of the rat
            P-4501A1 gene
  JOURNAL   EMBO J 11 (10), 3663-3671 (1992)
   PUBMED   1356762
REFERENCE   9  (bases 1 to 7718)
  AUTHORS   Nehls,M.C., Grapilon,M.L. and Brenner,D.A.
  TITLE     NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene
            expression
  JOURNAL   DNA Cell Biol 11 (6), 443-452 (1992)
   PUBMED   1524678
REFERENCE   10 (bases 1 to 7718)
  AUTHORS   Mermod,N., Williams,T.J. and Tjian,R.
  TITLE     Enhancer binding factors AP-4 and AP-1 act in concert to activate
            SV40 late transcription in vitro
  JOURNAL   Nature 332 (6164), 557-561 (1988)
   PUBMED   2833704
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jan 1, 2008 this sequence version replaced NM_012655.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.219836.1,
                                           SRR26360176.172451.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000007.1  135420050-135420094
            46-203              JAXUCZ010000007.1  135421437-135421594
            204-1716            JAXUCZ010000007.1  135421876-135423388
            1717-1885           JAXUCZ010000007.1  135438391-135438559
            1886-2085           JAXUCZ010000007.1  135444415-135444614
            2086-7718           JAXUCZ010000007.1  135444881-135450513
FEATURES             Location/Qualifiers
     source          1..7718
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..7718
                     /gene="Sp1"
                     /note="Sp1 transcription factor"
                     /db_xref="GeneID:24790"
                     /db_xref="RGD:3738"
     exon            1..45
                     /gene="Sp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..2399
                     /gene="Sp1"
                     /note="trans-acting transcription factor 1"
                     /codon_start=1
                     /product="transcription factor Sp1"
                     /protein_id="NP_036787.2"
                     /db_xref="GeneID:24790"
                     /db_xref="RGD:3738"
                     /translation="MSDQDHSMDEVTAVKIEKGVGGNNGGSGNGGGAAFSQTRSSSTG
                     SSSSSGGGGGQESQPSPLALLAATCSRIESPNENSNNSQGPSQSGGTGELDLTATQLS
                     QGANGWQIISSSSGATPTSKEQSGNSTNGSNGSESSKNRTVSGGQYVVAATPNLQNQQ
                     VLTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITN
                     RGSGGNIIAAMPNLLQQAVPLQGLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAA
                     TLTPSSQAGTISSSGSQESGSQPVTSGTAISSASLVSSQASSSSFFTNANSYSTTTTT
                     SNMGIMNFTSSGSSGTSSQGQTSQRVGGLQGSDSLNIQQNQTSGGSLQGSQQKEGEQS
                     QQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVQNSGPI
                     IIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIAS
                     AASIPAGTVTVNAAQLSSMPGLQTINLSALGTSGIQVHQLPGLPLAIANTPGDHGAQL
                     GLHGPGGDGIHDETAGGEEGENSPDPQPQAGRRTRREACTCPYCKDSEGRGSGDPGKK
                     KQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCNWSYCGKRFTRSDELQRHKRTHT
                     GEKKFACPECPKRFMRSDHLSKHIKTHQNKKGGPGVALSVGTLPLDSGAGSEGSGTAT
                     PSALITTNMVAMEAICPEGIARLANSGINVMQVTELQSINISGNGF"
     exon            46..203
                     /gene="Sp1"
                     /inference="alignment:Splign:2.1.0"
     exon            204..1716
                     /gene="Sp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1885
                     /gene="Sp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2085
                     /gene="Sp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..7718
                     /gene="Sp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacaggacc cccttgagct cgcccctcag ctgccaccat gagcgaccaa gatcactcaa
       61 tggatgaagt gacagctgtg aagattgaaa aaggtgttgg tggcaataac gggggtagcg
      121 ggaacggtgg tggtgccgcc ttttctcaga ctcgaagcag cagcacaggc agtagcagca
      181 gcagtggtgg cggaggaggg caggaatccc agccatctcc tttggctctg ctggcagcaa
      241 cctgcagcag aattgagtca cccaatgaga acagcaacaa ctcccagggt ccgagtcagt
      301 cagggggcac aggtgaactt gacctcacag ccacacaact ttcacagggt gccaatggct
      361 ggcagatcat ctcttcctcc tctggggcta cccctacctc aaaggaacag agtggcaaca
      421 gtaccaatgg cagcaatggc agtgagtctt ccaagaaccg cacagtctct ggtgggcagt
      481 atgttgtggc tgctaccccc aacttacaga accagcaagt tctgacaggt ctacctggag
      541 taatgcctaa tattcagtat caagtaatcc cacagttcca gactgttgat gggcaacagc
      601 tgcagtttgc tgccactggg gcccaagtgc agcaggatgg ttctggtcaa atacagatca
      661 taccaggtgc aaatcaacag atcatcacaa atagaggaag tgggggcaac attattgctg
      721 ctatgccaaa tctactccag caagctgtcc ccctccaagg ccttgctaat aatgtgctct
      781 caggacagac tcagtatgtg accaatgtac cagtggccct gaatgggaac atcaccttgc
      841 tacctgtcaa cagcgtttct gcagctaccc tgactcccag ctctcaggca ggcacgatca
      901 gcagctctgg atcccaggag agtggctcac agcctgtcac ctcagggact gccatcagtt
      961 ctgccagctt ggtgtcatca caagccagtt ccagctcctt tttcaccaat gccaacagct
     1021 attcaacaac taccaccacc agcaacatgg gaattatgaa ctttaccagc agcggatcat
     1081 cagggactag ttctcaaggc cagacatccc agagagttgg tgggctgcaa gggtctgatt
     1141 ctctaaacat ccagcagaac cagacatcag gaggatcact gcaaggaagt cagcaaaaag
     1201 agggagagca aagtcagcag acacagcaac aacaaattct tattcagcct cagctagttc
     1261 aaggtggaca agctcttcag gccctccaag cagcaccatt gtcaggacag accttcacaa
     1321 ctcaagctat ttcccaggaa accctccaga acctccagct tcaggctgtt caaaactctg
     1381 gccccatcat cattcggaca ccaaccgtgg ggcccaatgg acaggtcagt tggcagaccc
     1441 ttcagctgca gaaccttcaa gttcagaacc cacaagccca gacaatcacc ttggccccta
     1501 tgcagggtgt ttccttgggg cagactagca gcagcaatac cacccttaca cccattgcct
     1561 cagctgcctc cattcctgct ggcacagtca ctgtgaatgc tgctcaactg tcctccatgc
     1621 caggcctcca gaccattaac ctcagtgcat tgggtacttc agggatccag gtgcaccagc
     1681 ttccaggcct gcctttggct atagcaaaca ccccaggtga tcatggagct caacttggcc
     1741 ttcatggacc tggcggtgat ggaatacatg atgagacagc aggtggagaa gaaggagaga
     1801 acagccctga tccccaaccc caagctggtc gcaggactcg gcgggaagca tgtacatgcc
     1861 cctattgtaa agacagtgag gggaggggct ctggagatcc tggcaaaaag aaacagcaca
     1921 tttgtcatat ccaaggatgc ggcaaagtat atggcaaaac ctcacatctc cgtgcacact
     1981 tgcgctggca tacaggggag aggccattca tgtgtaattg gtcatactgt gggaagcgct
     2041 ttactcgttc ggatgagctt cagagacata aacgtacaca tacaggagag aagaaatttg
     2101 cctgccctga gtgccctaag cgtttcatga ggagcgatca tctgtcaaag catatcaaga
     2161 cccaccagaa caaaaaggga ggcccaggtg tagccttgag cgtgggcaca ttgcccctgg
     2221 acagtggggc aggttcagaa ggcagtggca ctgccactcc ttcagccctt attaccacca
     2281 atatggtagc catggaggcc atctgtccag agggtattgc ccgtcttgcc aacagtggca
     2341 tcaacgtcat gcaggtgaca gagctgcagt ccattaatat cagtggcaat ggtttctgag
     2401 attagacgcc cagggccaga gacatatggg ccaataccca ccaagcctgg gatgcaaggt
     2461 agcatgggtc caagagacat gtggaagaga gagccatgag gcattcatgt gcttggtgat
     2521 aggaagaatt gggagatggt acaaaagaag agatgggatc gtggcaccca tctatgtcac
     2581 tggtgactcc ttgaaaatgg agaatattag tgaaaattct gttggtgcca ctttttgatc
     2641 agcatttatc tcatcccagg ttcttcttac ccttcttacc cagcctcctc ttcctgtttt
     2701 tccctcttag ctctcccatg atggatcccc ccctttccta aagccatcat gccttgataa
     2761 atatatatga tcattgaaat actttttaac aaaaacagat tctatattat atatatatat
     2821 attaaaaaat atatagagat gctttcacag gggctggctg ggaggaggaa aaagaccatt
     2881 ctgtgaccaa aataccttgg tctttttttc tttttctttt tttttatatt gccttatttc
     2941 tcaatggctg agccttatca tgacacatca agctttccta taaatgttgt cctggcatcc
     3001 caccagagta agcattcata cgctctgctt cagttcatat atacatatat aatgtgtctt
     3061 cttccttaat tttgttactt tatttgggat cagctccttg cactctttcc tgactcagtc
     3121 ctttttgtct cacacccttt tcttacatga tcatttcctg tgttgttttt gacagtgatc
     3181 cctggattag gcacttctgt taatatttta aagacgttag ttccagcaac ggagtggaaa
     3241 agccttgaag tgtagctatg gagggagtgt tcaaatacta ctgacgcagg cacattagtg
     3301 ctggagagtc aaagccatct ccctttatta gttgttctac acatcaaaag tcagaagtat
     3361 ttctgtggaa ttgtgtaaga ggccctttga aggagataca ctgtcaaaat gctcaaatat
     3421 aggcagcagc tttcagtatg aaaaagatgt tctcagaaaa ggaaataact caatagtctt
     3481 gggttcagaa gttagtggaa ttattcggat ttcagtatca ttgtcttcca gataactctc
     3541 agcctcacag aatggccttc tgagttcaca ctctgaaagg aagtacactt cctcttttga
     3601 acatttctgt agttccttcg tattaatgtt ttaatgttta ggagcatcag ccagggaatc
     3661 tgtttggact ttccattctg tagagtgcaa aacttgtgcc agtggcaaaa gtggttcttt
     3721 taaaaaaaaa aaaaaagtcc cccttaactc ttccttacat gtacttgggt ggttcctaag
     3781 ggaaagggaa gcacacaatc atgggaacga tagcccagaa caaaaagaaa tcttgtctta
     3841 ccactgtgga ttttaggaga aattgggaga aattatcctg ctttctctat ggcctgattc
     3901 cagaagagac tgatccaaaa attatatcgg cagggaaact cagtgcattt tacactgaga
     3961 cttaaatgca accagaattg tcctcaaggc ccagccatta aagcattgtc tctcttgact
     4021 ttctgctatc ttgtcagaga gcttttcact gtgaggaagt atgaaagtgg ttgagtgtat
     4081 gtgtggaatc tattaggttg gggataggtt ttctgttagc caatatttaa agagacctgc
     4141 aataaaaaat taccctgatc tgatagagaa tctaaaatgt ttgtgtatga ctgcgtgtga
     4201 atgtgtttgt gcctgtatat atctacatgc agatgagaac ttatatttga aattgttgga
     4261 aaataaattc agatcgaaat gcctttcagg tccattatct agaaattggt cataaaactt
     4321 gggtatgttc ctaaggtcag ttctctgctt gtgttaaatt ggttaacaat tatggggtgg
     4381 ggggatatcc tagtgcactt tctaaaaaaa gaaactattt ttgtgtttga aaatgaaatc
     4441 aacatccaaa tctatagtgg attccttatt ctaacttctt tatcttggct acaaatagct
     4501 tatagtgtta ttatacatgt tacgtaaatt ccatctaaac taggttcttg ttaagtttac
     4561 ggtgttgtta gcctgaaata ctaacattag tttattccat ttggtccttt ctgtgcagac
     4621 ttaatactgt tatcaagact caggaaatat ttcaagggac tttccccaaa tcacatgtta
     4681 ttaatgttga agtaaacgtt acctgtcctt agccatcatc acaccttttg ttcctaacga
     4741 aaagcagaac tcaaacttat tttacactca taatcatgtg ctttggcatc tctgggggaa
     4801 gagggcagga taactcactg gagtgtgcag tattttgcta gaaaattgaa ggagtagaat
     4861 cttgtttagt tcgaggtgat tagatataag ctggcctggt gttgctgatg accgtaaaag
     4921 ccttatataa gttaaggatc ggaaggtgtt ttctcttggt gagaagttga tgatttaccc
     4981 tcaaggtctg ctacattaac attaacatga attaatttac atcagattct ttctgctttt
     5041 tgagtttcct tctccagtgt cttattgccc ataaaatgga atcagtttct gctcttatct
     5101 ccctgtctat gaaccactca gcctttttca cagttaagag attacattac tccagtcagg
     5161 gtattgttac tgaaagggaa cctttcccag aacttttggc catcagaatt taacataatt
     5221 ggcttgcata aggtttctaa aattctcttc attacatttg ttgtttggaa tttttttgtt
     5281 tgttttcttt catcgagata gggttttact ctgtatccca ggctagcctg gaattcacta
     5341 tgtaactcag actggccttg aactttgaat aatctttttt gcctcctaag tgttgggatt
     5401 acaagtatat gccactgtgt ccagccttca tgatttttta cctaattttt aaaagaaaaa
     5461 tgactatacc ttgcaaagtg ataggtgacc accaatgtaa tagtcttctt ttgttttgaa
     5521 ataggtcttt caaagtatcc ttggctggtc tgaatttata tgtagtcccg gctgcagaga
     5581 tctgtccacc ttggcctttc aagtgttggg gctacaaatg tatgccacca cacgcagcag
     5641 aaatagtaat cttaaacatt catttccttg tcctaggctg ccctttatat tcatctacaa
     5701 attgtttgac tgtgtcatct ttttccacca tcttccttca gggacctccc ataggcactc
     5761 tttttggggg tgctattcaa aatgcagtat agtggttctt tcatagcctg gtctcagtaa
     5821 atagaccctt taatcacaga aggtatagac tgaagtatgg gatgacggtg ttataatttg
     5881 gggagggcgg gagactaaag ctgtaattac tatggctgat ttatctctac tatatacata
     5941 tattttttgc ttttgtatat ccgatataga aaactaagca ttgtattttt ttaacaaatc
     6001 tgagaaagca ctatgaactg caggtgttga ctttcagaat atattttgta ttgttaatac
     6061 ttcacattat gtgaatactg gaagctgcag atctttgtaa gccgcaataa aattggatac
     6121 tttttgaggg gttcttttgg aggtgctaat caggcctctg ttatactttg aaggagccct
     6181 ggtgctacaa gattaaagtt ttcattcaat tttaagtgcc ctaatgtctt tttggacctt
     6241 gggatcagat gagaagtgat tcggaggtca ggtactgagg aagtgacgat cgtgtcccgc
     6301 ctcagctgag ggcctctttg catggtttta ctttccatag ccaaagttgg gtaacctctt
     6361 cgggctgcca ggagaaatat tagaaatctc agtttggtct tctctcagat gagccagtaa
     6421 cttagaagga taaaggcagc agcagttgct ttgggagagg aggggatggc atttttccaa
     6481 cccggaaaac attgcttcga tcgctgctga taaaacatgg gcaggttatt actttggttt
     6541 agaaaggctg tgtgcctctc ttggctctgc tccgggggta cagatcttca tctaggagga
     6601 tgagtagacc agctttgagg ttgagctgtt tcttttcttt gtctgccttc cctaaatacc
     6661 atcccccaga aaagacatta agcagccttt attttaagtt cctactccct cttccagact
     6721 tggctcatgt gttgtagatt gaagactggg aagagaaaag agggggaagt atttggctcc
     6781 attccttccc taagtcatct cacttcccaa actcagaagg atttctccac agcactcatt
     6841 tgagagagtg aagctttttt tttttttttt ttccctttca atttgctcct ttatcaaaca
     6901 gcctaacctt ccttgtcttg gctgagagag tacagggact cctcatctgt ccttctgctc
     6961 caaatcccag ctcgtggaga ttgaggagca caacaggtta ggctggggct gcagatggaa
     7021 gagacttcgg ttcatctgct tggttgtgtg ctttcctata tcttgccttc aggaatcaca
     7081 ctgtgccttc tctaccaggg aactgattct gtctacacag cttttccagt aactgctctt
     7141 gaaaattgtg gatatggcag ttcttcctat ttctgatgac acttttctcc cagtaacatc
     7201 ctaatacccc ttaccttgct aaagactagg cacaaagtca gaatatgttg ataatgatct
     7261 gaggaagcca aaggcagctg ccctagggcc tgcttccctc tcccaagtct gtcatcccag
     7321 ggcagaggag tagtgctcca ctctggtgcc taaaaccagt ttatctttct tgatactggg
     7381 aataaccagt ctctgtacca ctgttgcctt taagccttta atctcacgat gtttgttgtg
     7441 ggttccaatc cagttgtcac cagggctgtg agggtaaata cttctcaagt cactcacttt
     7501 ctccaccctc actcttgagt atgtatgatg ttaatctctc gtcttcctgc tccttttgta
     7561 tcttcctcgt ctctcccccc acatttttcc ctgggtgttt tggggtctca gtatctcttt
     7621 ctctatatct ctatctccgt ctccaccttt tgtacaaaga ttagttccaa tgtagtctgt
     7681 agctcctttg taaaacaatt aaaaactttt ttaataaa
//
