LOCUS       NM_001106989            3244 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus SRY-box transcription factor 8 (Sox8), mRNA.
ACCESSION   NM_001106989 XM_001060343 XM_220283
VERSION     NM_001106989.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3244)
  AUTHORS   Ng CK, Li NX, Chee S, Prabhakar S, Kolatkar PR and Jauch R.
  TITLE     Deciphering the Sox-Oct partner code by quantitative cooperativity
            measurements
  JOURNAL   Nucleic Acids Res 40 (11), 4933-4941 (2012)
   PUBMED   22344693
REFERENCE   2  (bases 1 to 3244)
  AUTHORS   Rajan S, Chu Pham Dang H, Djambazian H, Zuzan H, Fedyshyn Y, Ketela
            T, Moffat J, Hudson TJ and Sladek R.
  TITLE     Analysis of early C2C12 myogenesis identifies stably and
            differentially expressed transcriptional regulators whose
            knock-down inhibits myoblast differentiation
  JOURNAL   Physiol Genomics 44 (2), 183-197 (2012)
   PUBMED   22147266
REFERENCE   3  (bases 1 to 3244)
  AUTHORS   Reginensi A, Clarkson M, Neirijnck Y, Lu B, Ohyama T, Groves AK,
            Sock E, Wegner M, Costantini F, Chaboissier MC and Schedl A.
  TITLE     SOX9 controls epithelial branching by activating RET effector genes
            during kidney development
  JOURNAL   Hum Mol Genet 20 (6), 1143-1153 (2011)
   PUBMED   21212101
REFERENCE   4  (bases 1 to 3244)
  AUTHORS   Muto A, Iida A, Satoh S and Watanabe S.
  TITLE     The group E Sox genes Sox8 and Sox9 are regulated by Notch
            signaling and are required for Muller glial cell development in
            mouse retina
  JOURNAL   Exp Eye Res 89 (4), 549-558 (2009)
   PUBMED   19490914
REFERENCE   5  (bases 1 to 3244)
  AUTHORS   Guth SI, Schmidt K, Hess A and Wegner M.
  TITLE     Adult-onset degeneration of adipose tissue in mice deficient for
            the Sox8 transcription factor
  JOURNAL   J Lipid Res 50 (7), 1269-1280 (2009)
   PUBMED   19286648
REFERENCE   6  (bases 1 to 3244)
  AUTHORS   Schepers G, Wilson M, Wilhelm D and Koopman P.
  TITLE     SOX8 is expressed during testis differentiation in mice and
            synergizes with SF1 to activate the Amh promoter in vitro
  JOURNAL   J Biol Chem 278 (30), 28101-28108 (2003)
   PUBMED   12732652
REFERENCE   7  (bases 1 to 3244)
  AUTHORS   Shen JH and Ingraham HA.
  TITLE     Regulation of the orphan nuclear receptor steroidogenic factor 1 by
            Sox proteins
  JOURNAL   Mol Endocrinol 16 (3), 529-540 (2002)
   PUBMED   11875113
REFERENCE   8  (bases 1 to 3244)
  AUTHORS   Sock E, Schmidt K, Hermanns-Borgmeyer I, Bosl MR and Wegner M.
  TITLE     Idiopathic weight reduction in mice deficient in the
            high-mobility-group transcription factor Sox8
  JOURNAL   Mol Cell Biol 21 (20), 6951-6959 (2001)
   PUBMED   11564878
REFERENCE   9  (bases 1 to 3244)
  AUTHORS   Schepers GE, Bullejos M, Hosking BM and Koopman P.
  TITLE     Cloning and characterisation of the Sry-related transcription
            factor gene Sox8
  JOURNAL   Nucleic Acids Res 28 (6), 1473-1480 (2000)
   PUBMED   10684944
REFERENCE   10 (bases 1 to 3244)
  AUTHORS   Pfeifer D, Poulat F, Holinski-Feder E, Kooy F and Scherer G.
  TITLE     The SOX8 gene is located within 700 kb of the tip of chromosome 16p
            and is deleted in a patient with ATR-16 syndrome
  JOURNAL   Genomics 63 (1), 108-116 (2000)
   PUBMED   10662550
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473948.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_220283.4, XM_001060343.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760386,
                              SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3244
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..3244
                     /gene="Sox8"
                     /note="SRY-box transcription factor 8"
                     /db_xref="GeneID:302993"
                     /db_xref="RGD:1309072"
     exon            1..771
                     /gene="Sox8"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..1750
                     /gene="Sox8"
                     /note="SRY-box containing gene 8; SRY (sex determining
                     region Y)-box 8; SRY box 8"
                     /codon_start=1
                     /product="transcription factor SOX-8"
                     /protein_id="NP_001100459.1"
                     /db_xref="GeneID:302993"
                     /db_xref="RGD:1309072"
                     /translation="MLDMSEARAQPPCSPSGTASSMSHVEDSDSDAPPSPAGSEGLGR
                     AGGGGRGDTAEAADERFPACIRDAVSQVLKGYDWSLVPMPVRGGGGGTLKAKPHVKRP
                     MNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEEAERLRVQHK
                     KDHPDYKYQPRRRKSVKTGRSDSDSGTELGHHPGGPMYKTDTVLGDAHRHSDHTGQTH
                     GPPTPPTTPKTDLHQASNGSKQELRLEGRRLVDSGRQNIDFSNVDISELSSEVISNMD
                     TFDVHEFDQYLPLNGHSALATEPSQATASGSYGGASYSHSGATGIGASPVWAHKGAPS
                     ASASPTEAGPLRPHIKTEQLSPSHYNDQSHGSPGRADYGSYSAQASVTTAASATAASS
                     FASAQCDYTDLQASNYYSPYPGYPPSLYQYPYFHSSRRPYASSLLNGLSMPPAHSPSS
                     NWDQPVYTTLTRP"
     exon            772..1001
                     /gene="Sox8"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..3244
                     /gene="Sox8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctcagttg aggaatcagg ctgcggggcg cctggcccac gtggtgcgga gggtggggcg
       61 gggtccgcag tcttctttgg attaggggcg gggcaaacaa actccgcctc ggggaggacg
      121 cgcctgccaa cccggacccg gaggggcggg gtttcggccg cgttttaaag aaacttgttg
      181 cgggtcccag aactgagact gagctgcagc ggcagaggag cggttgctgg gctcctgcgg
      241 tgaggacaaa gattgggccc tgcgtggcaa ccttggattc cagagtgtcc gtccacagag
      301 tgaccgggcg cgacccctgc gtccatcccc actgagcgct tctccgcgcg tggccccgat
      361 gctggacatg agtgaggccc gcgcccagcc gccctgcagc ccgtctggca ctgctagctc
      421 catgtcacac gtggaggatt cagactccga cgcgccaccg tcgcccgcgg gatcagaggg
      481 cttgggccgc gcggggggcg gcggccgagg ggataccgct gaggcagcag acgaacgctt
      541 cccagcctgc atccgtgatg ccgtgtcgca ggtgcttaag ggctatgact ggagtctggt
      601 gcctatgccg gtgcgcggcg gcggtggcgg cacactcaag gccaagccac acgtgaagcg
      661 gcccatgaat gccttcatgg tgtgggcaca ggcggcgcgc cgcaagctgg cggaccagta
      721 cccgcatctc cataacgcag agctcagcaa gaccctgggc aagctgtggc gcttgctgag
      781 tgaaagcgag aagcggccat tcgtggagga ggccgagagg ctccgtgtgc agcacaagaa
      841 ggaccaccca gattacaaat accagccgag gagaaggaag agtgtgaaaa ccggccggag
      901 cgactcggac tctggtactg aactgggcca ccaccctggt ggtcccatgt acaaaacgga
      961 cacagtgcta ggtgatgcac accgccacag cgaccacaca ggccagaccc atgggccacc
     1021 caccccaccc accaccccca agacggacct gcaccaggcc agcaatggaa gcaagcaaga
     1081 gctaaggctg gaagggcgcc gcctggtgga cagcgggcgc cagaacatcg acttcagcaa
     1141 tgtggacatc tccgagctca gcagcgaggt tatcagtaac atggatacct tcgatgtcca
     1201 cgagtttgac cagtacttac ccctcaatgg ccactcagcc ctggccactg agcccagcca
     1261 ggccactgcc tctggctcct atggaggcgc ttcctactcc cactccggtg caactggcat
     1321 aggcgcatcc cctgtgtggg cccacaaggg agctccctcg gcctcagcct cgcccacaga
     1381 ggcaggaccc cttcggccac atatcaagac ggagcagctg agtcccagcc attacaacga
     1441 ccagtcacac ggctcacccg gccgtgccga ctatggctcc tacagcgccc aggccagtgt
     1501 caccacggct gcctcggcca cagctgccag ctctttcgcc agcgcacagt gtgactacac
     1561 tgacctgcag gcttccaact actacagccc ctaccctggc taccctccca gcctctatca
     1621 atacccttac ttccattcat cccgccggcc ctatgcctcg tcactgctca atgggctctc
     1681 catgcccccc gcacacagcc ccagcagcaa ctgggaccag cctgtgtaca ccaccctgac
     1741 ccggccctga ggctgctgca ccctggagga cgcagcgtcc acgaagtata gccaggtctt
     1801 tgagttcttc cagaagtgta cttggtggag ggtagaggca gccggcacgg cctcactccg
     1861 tcaagtgcct gctgaatgtg caggaaacca ggctctgtca ccttgtatcc ctttgcctct
     1921 ggatatccaa acttctgcca ggggacagag ttctctttcc cccctcttct ctctctgagg
     1981 tgactggtga tttctgaaac agccattctg ttgctctcgg tttggataag tgtgcaccag
     2041 ctcctgagtt ttgcatctcg gtagataaga agatcgctac acctaaggac aaagagagaa
     2101 ggggcttcag gtccttacca gcccagccga gaactccctg gaaccaaggg atgctgttcc
     2161 catggtgaaa gcatgaaagc acatctgtgg atgctccagg atacatccac ccagggatcc
     2221 cttgggaccg atgtgcgatg gaggctttct cattaccaca ggtctttccc agcaaggttt
     2281 ggctgagacg aacactttcc gtgtttattt ttattttttt tttgttattt ttattttaag
     2341 gcttaaacat gtttgttttt gaaaggtgtt gaagacgtat ttatgttctg ttattatttt
     2401 atctttaatt aatgaagtaa tttgtgcaga gagtagagtt taagacaaaa cgaacgtcgg
     2461 gaagcttgtt tttgtaaagg gcaggaggga ggtggccagg caccccctgc agcatctcct
     2521 ggctctgcct ttggatgtcc ctggaggcct ccaccaggca caggagaaag tgatcgacct
     2581 cttggggtct ggttagaaca aaaagcccag caccagcatc ggggttgggc attggaaggc
     2641 agggacagca tctctgccct cggtggtgcc aagcggcaga agacagaatc tcctgcaggc
     2701 tggcagctgc agaaccacga taatcttggc tctttggcac caggcgctgc ttaccgagct
     2761 gcggaaggag agcctccccc actaacctgc ctaggttcct agttagagag taacatccac
     2821 ccgcttcgcc gcccgcttcg cagtgtgctg agtgtgtaac cagcgacttc acggaaactt
     2881 gtgccttgga gactttgtat atttactcac tcttgagaag ttttgcttct ttttaatttt
     2941 tctacttttc ctaccttttt ctagagggga aaaaaatctt cctttttttt ttttttcttt
     3001 cagcatctct ccttccgggg gtgggggtgg gagccacagc aaactcattt ttaatgcagt
     3061 catttttttt tttttttttt ggcgttgaat tcagaaagac attcgctgtc ctttacctac
     3121 tgtgtttcgt tactttctga ccaggcaatg ctaacttttg tacagatcga tttgataaaa
     3181 tttaaaaaaa gaaaaacaaa gaacaaaaca aaacaaaaaa gcccaatgcc ttttatctac
     3241 ttgg
//
