LOCUS       NM_001106045            3282 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus SRY-box transcription factor 7 (Sox7), mRNA.
ACCESSION   NM_001106045 XM_001065660 XM_224283
VERSION     NM_001106045.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3282)
  AUTHORS   Li X, Giri V, Cui Y, Yin M, Xian Z and Li J.
  TITLE     LncRNA FTX inhibits hippocampal neuron apoptosis by regulating
            miR-21-5p/SOX7 axis in a rat model of temporal lobe epilepsy
  JOURNAL   Biochem Biophys Res Commun 512 (1), 79-86 (2019)
   PUBMED   30871773
  REMARK    GeneRIF: demonstrated the anti-apoptosis ability of FTX during
            epileptogenesis and uncovered a novel FTX-mediated mechanism in
            status epilepticus-induced neural apoptosis by targeting
            miR-21-5p/SOX7 axis, which provides a new target in developing
            lncRNA-based strategies to reduce SE-induced hippocampal neuron
            apoptosis
REFERENCE   2  (bases 1 to 3282)
  AUTHORS   Wang C, Qin L, Min Z, Zhao Y, Zhu L, Zhu J and Yu S.
  TITLE     SOX7 interferes with beta-catenin activity to promote neuronal
            apoptosis
  JOURNAL   Eur J Neurosci 41 (11), 1430-1437 (2015)
   PUBMED   25847511
  REMARK    GeneRIF: Findings demonstrated that SOX7 interfered with
            beta-catenin activity to promote neuronal apoptosis, which acted as
            a novel signaling mechanism in neuronal cell death.
REFERENCE   3  (bases 1 to 3282)
  AUTHORS   Artus J, Piliszek A and Hadjantonakis AK.
  TITLE     The primitive endoderm lineage of the mouse blastocyst: sequential
            transcription factor activation and regulation of differentiation
            by Sox17
  JOURNAL   Dev Biol 350 (2), 393-404 (2011)
   PUBMED   21146513
REFERENCE   4  (bases 1 to 3282)
  AUTHORS   Hosking B, Francois M, Wilhelm D, Orsenigo F, Caprini A, Svingen T,
            Tutt D, Davidson T, Browne C, Dejana E and Koopman P.
  TITLE     Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic
            defects caused by Sox18 dysfunction in mice
  JOURNAL   Development 136 (14), 2385-2391 (2009)
   PUBMED   19515696
REFERENCE   5  (bases 1 to 3282)
  AUTHORS   Palasingam P, Jauch R, Ng CK and Kolatkar PR.
  TITLE     The structure of Sox17 bound to DNA reveals a conserved bending
            topology but selective protein interaction platforms
  JOURNAL   J Mol Biol 388 (3), 619-630 (2009)
   PUBMED   19328208
REFERENCE   6  (bases 1 to 3282)
  AUTHORS   Guo L, Zhong D, Lau S, Liu X, Dong XY, Sun X, Yang VW, Vertino PM,
            Moreno CS, Varma V, Dong JT and Zhou W.
  TITLE     Sox7 Is an independent checkpoint for beta-catenin function in
            prostate and colon epithelial cells
  JOURNAL   Mol Cancer Res 6 (9), 1421-1430 (2008)
   PUBMED   18819930
REFERENCE   7  (bases 1 to 3282)
  AUTHORS   Seguin CA, Draper JS, Nagy A and Rossant J.
  TITLE     Establishment of endoderm progenitors by SOX transcription factor
            expression in human embryonic stem cells
  JOURNAL   Cell Stem Cell 3 (2), 182-195 (2008)
   PUBMED   18682240
REFERENCE   8  (bases 1 to 3282)
  AUTHORS   Niimi T, Hayashi Y, Futaki S and Sekiguchi K.
  TITLE     SOX7 and SOX17 regulate the parietal endoderm-specific enhancer
            activity of mouse laminin alpha1 gene
  JOURNAL   J Biol Chem 279 (36), 38055-38061 (2004)
   PUBMED   15220343
REFERENCE   9  (bases 1 to 3282)
  AUTHORS   Murakami A, Shen H, Ishida S and Dickson C.
  TITLE     SOX7 and GATA-4 are competitive activators of Fgf-3 transcription
  JOURNAL   J Biol Chem 279 (27), 28564-28573 (2004)
   PUBMED   15082719
REFERENCE   10 (bases 1 to 3282)
  AUTHORS   Taniguchi K, Hiraoka Y, Ogawa M, Sakai Y, Kido S and Aiso S.
  TITLE     Isolation and characterization of a mouse SRY-related cDNA, mSox7
  JOURNAL   Biochim Biophys Acta 1445 (2), 225-231 (1999)
   PUBMED   10320775
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474023.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_224283.3, XM_001065660.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB733444.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132299, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3282
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..3282
                     /gene="Sox7"
                     /note="SRY-box transcription factor 7"
                     /db_xref="GeneID:290317"
                     /db_xref="RGD:1310038"
     exon            1..319
                     /gene="Sox7"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1233
                     /gene="Sox7"
                     /note="SRY-box containing gene 7; SRY (sex determining
                     region Y)-box 7; SRY box 7"
                     /codon_start=1
                     /product="transcription factor SOX-7"
                     /protein_id="NP_001099515.1"
                     /db_xref="GeneID:290317"
                     /db_xref="RGD:1310038"
                     /translation="MASLLGAYPWTEGLECPALEAELSDGLSPPAVPRPSGDKGSESR
                     IRRPMNAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKALTLSQKRPYVDEAERLR
                     LQHMQDYPNYKYRPRRKKQGKRLCKRVDPGFLLSSLSRDQNTLPEKNSIGRGPLGEKE
                     DRGEYAPGATLPGLHSCYREGAAAAPGSVDTYPYGLPTPPEMSPLDALEPEQTFFSSS
                     CQEEHGHPHHLPHLPGPPYSPEFTPSPLHCSHPLGSLALGQSPGVSMMSSVPGCPPSP
                     AYYSHATYHPLHPNLQAHLGQLSPPPEHPGFDTLDQLSQVELLGDMDRNEFDQYLNTP
                     GHPDSASGVGTLTGHAPLSQGTPTGPTETSLISVLADATATYYNSYSVS"
     exon            320..3282
                     /gene="Sox7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaagttgga cgtcgcgacc cgagtgaggg ccaggtcaac gccggcccca cgaggcgaag
       61 ccaagtgacc cgcgttcggc catggcctcg ttgctgggcg cttacccgtg gaccgaggga
      121 ctggagtgtc ctgccctgga agccgagctg tcggatgggc tgtcgccgcc cgccgtcccc
      181 cgaccttcag gggacaaggg ttcagagagc cggatccggc ggcccatgaa tgccttcatg
      241 gtgtgggcca aggatgagag gaaacgtctg gcagtgcaga acccggacct gcacaacgcg
      301 gagcttagca agatgctggg aaagtcatgg aaggcgctga cactgtcaca gaagaggccc
      361 tatgtggatg aggcagagcg gctgcgcctg cagcacatgc aggattaccc taactacaag
      421 taccgacccc gcaggaagaa acaaggcaag cgtctctgca agcgcgtgga ccctggcttc
      481 ctcctgagct ccctctctcg tgaccagaac acgctgcctg agaaaaacag cattggcagg
      541 gggcccctgg gggagaagga ggacaggggt gagtacgccc caggtgccac cttgcctgga
      601 ctgcacagct gctaccggga aggtgcagct gctgcccctg gcagtgtgga cacatatccc
      661 tacgggctgc ccacaccccc agagatgtcg cccctggatg cgctggagcc ggagcagacc
      721 ttcttctcgt cctcatgtca ggaggagcat ggccaccccc atcaccttcc ccatctacca
      781 gggccccctt actcacccga gttcacacct agtccccttc actgcagtca ccctctaggt
      841 tctttggccc ttggccaatc cccaggagtt tctatgatgt cctctgttcc tggatgtccc
      901 ccatctccag cctactactc ccatgccacc taccaccctc tccaccccaa cctccaggcc
      961 cacctgggcc agctgtcccc accccccgag caccctggct ttgacacctt ggatcagcta
     1021 agccaggtgg aacttctggg ggacatggac cgcaatgagt ttgaccagta tttgaacact
     1081 cctggtcacc ctgactctgc ttcaggggtt ggaaccctca ctgggcatgc ccctctctcc
     1141 caggggactc caacaggccc tacagagacc agcctcatct ccgtcctggc tgatgccaca
     1201 gccacgtatt acaacagcta cagtgtgtca tagagctaga ggaatggagg ctggcccagc
     1261 ctttccaccc tctcctccct atgaagcact gagcagagca gaaactgtag cgttaccact
     1321 ctttggtggc aggaggtcag aactgctgtc ccagagtctt cagtccaaag ccaggatcca
     1381 gcgccccttc tgtcccttca aatgtgttgg cttcacccag gaagtacagc cttggggctg
     1441 tctgcagtag ggtttcctag acactttata ccatcagtgt agctggtagg gagaagccca
     1501 atgcaatgga gctcctgctt ttggtgtagc tgcttctgat ctgtggtgct cccagtgaga
     1561 gggaccctgg gcctggggtc catcttttgt tcagtctcta atgggcaaaa cctcattctg
     1621 gcttgactgg cccaggctgt tctctcccat acagtgagga ctggcctcat agccaagccc
     1681 ttgctctatg ggtctccaag ttacatcctg ctcaaggcca aggaaagtgt gacctcagta
     1741 atgggcagcc tcacagggac ctcatgtgaa ccaactgccc aaggacccag gttttctgct
     1801 ttcccataac cccgtccaca gccactctag aattccaaag gaactcctcc agttgagaaa
     1861 aggattcacc tttgggctgg caagatgacg tgggatggct cagtgggtaa aagtgcctgc
     1921 tgcctagcct gatggcctac gctctgtccc tggaaccgac gtggtggaag aagagaactg
     1981 actcctgcaa gttgtattct cacctctgaa cgcacgtgtg cccctacatt atatgtgtga
     2041 ttgaacctac atacacacac acacacacac acacacacac acacacacac taaatgtaat
     2101 tttttttcaa aggaaaacat ggtccctggt tcaggaaatt aattagtatg ttcagctgca
     2161 tcactgaaag caaattagat tcaaacttgt tgttttgctt tcttttgtcc tgagacaggg
     2221 tttctctgtg tagccctggc tgtcctagaa ctcactgtgt agatcaggct gacctcaaac
     2281 tcaaagttta agcctgctcc tgcctcctga gcactgggat taaaggcaag ggccaccact
     2341 gcccagtatg ggattatttt ttaaatatat actttagata cattattttt gttacatctc
     2401 aggagattac agtgtgggag aaatgtcctt atgcaggcat gcccctgctc ccacgcccca
     2461 aggtgggtag cctgatttag agtcttctca actgtagcga tgtctcacca cctccctgca
     2521 gaatgaacta aagagctagg aacctaaaaa gtctgtccac aaagcagcat ctttggggtg
     2581 tgctgatttc tctgtagcac acccttatct acagatgcaa aggatgactc ccttcccgct
     2641 gtctgctgcc cctccgtcca aactggcccc taattcaaag ggccctacac tcggaatccc
     2701 agacatgatt cccctggcca tgaagggaac ttggttcttg ttcctcaagt ggatgcagca
     2761 gaacaattca cctaccccac tgtcctttgg ctgtcccaaa caaacatact gtgacaccca
     2821 aagatgtctc tgagctttgg tcccacccca gacatttcca tcccctacag ctcctttgaa
     2881 ggaacatgcc taacgctgag ctaacaggct cttgcctgtc cttggacacg tgtgtattat
     2941 tgcctctatg aaatgtgttt ttatattctg ccattatgtc caccttatat tttgtattgt
     3001 tgacagattc cccacccaag aagtcttatt ataaaatcac gtataagata tacttaatct
     3061 ttatgctatt gctgtatata ccatttggtg ataaatagtg aattgttgat atgattgact
     3121 ggtgcccagt cccggatgta tattaataat ctcgtgaaac agtatcacag acattaagct
     3181 actctgttcc attttttttc aagaaaacgt catatgcatg gaacagttat gaatatcaat
     3241 ttgttgaaaa tgtttaattt aaataaattt ttttgtacct tg
//
