LOCUS       NM_001024751            2724 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus SRY-box transcription factor 6 (Sox6), mRNA.
ACCESSION   NM_001024751 XM_215016
VERSION     NM_001024751.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2724)
  AUTHORS   Ying,D., Zhou,X., Ruan,Y., Wang,L. and Wu,X.
  TITLE     LncRNA Gm4419 induces cell apoptosis in hepatic
            ischemia-reperfusion injury via regulating the miR-455-SOX6 axis
  JOURNAL   Biochem Cell Biol 98 (4), 474-483 (2020)
   PUBMED   32114773
  REMARK    GeneRIF: LncRNA Gm4419 induces cell apoptosis in hepatic
            ischemia-reperfusion injury via regulating the miR-455-SOX6 axis.
REFERENCE   2  (bases 1 to 2724)
  AUTHORS   Shi,Y., Han,Y., Niu,L., Li,J. and Chen,Y.
  TITLE     MiR-499 inhibited hypoxia/reoxygenation induced cardiomyocytes
            injury by targeting SOX6
  JOURNAL   Biotechnol Lett 41 (6-7), 837-847 (2019)
   PUBMED   31076992
  REMARK    GeneRIF: The authors proved that miR-499-5p inhibited
            hypoxia/reoxygenation-induced cardiomyocytes injury by targeting
            SOX6.
REFERENCE   3  (bases 1 to 2724)
  AUTHORS   Jia,Z., Wang,J., Shi,Q., Liu,S., Wang,W., Tian,Y., Lu,Q., Chen,P.,
            Ma,K. and Zhou,C.
  TITLE     SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced
            miR-499 inhibition
  JOURNAL   Apoptosis 21 (2), 174-183 (2016)
   PUBMED   26659076
  REMARK    GeneRIF: The apoptosis process enhanced by overexpression of SOX6
            or PDCD4, was rescued by the cardiac-abundant miR-499 in rat
            cardiomyocytes.
REFERENCE   4  (bases 1 to 2724)
  AUTHORS   Baroti,T., Schillinger,A., Wegner,M. and Stolt,C.C.
  TITLE     Sox13 functionally complements the related Sox5 and Sox6 as
            important developmental modulators in mouse spinal cord
            oligodendrocytes
  JOURNAL   J Neurochem 136 (2), 316-328 (2016)
   PUBMED   26525805
REFERENCE   5  (bases 1 to 2724)
  AUTHORS   Tony,H., Meng,K., Wu,B., Yu,A., Zeng,Q., Yu,K. and Zhong,Y.
  TITLE     MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes
            Cardiomyocyte Apoptosis during Ischemia and Its Silencing Improves
            Cardiac Function after Myocardial Infarction
  JOURNAL   Mediators Inflamm 2015, 479123 (2015)
   PUBMED   26688617
REFERENCE   6  (bases 1 to 2724)
  AUTHORS   Cohen-Barak,O., Yi,Z., Hagiwara,N., Monzen,K., Komuro,I. and
            Brilliant,M.H.
  TITLE     Sox6 regulation of cardiac myocyte development
  JOURNAL   Nucleic Acids Res 31 (20), 5941-5948 (2003)
   PUBMED   14530442
REFERENCE   7  (bases 1 to 2724)
  AUTHORS   Hwang,C.K., Wu,X., Wang,G., Kim,C.S. and Loh,H.H.
  TITLE     Mouse mu opioid receptor distal promoter transcriptional regulation
            by SOX proteins
  JOURNAL   J Biol Chem 278 (6), 3742-3750 (2003)
   PUBMED   12446692
REFERENCE   8  (bases 1 to 2724)
  AUTHORS   Narahara,M., Yamada,A., Hamada-Kanazawa,M., Kawai,Y. and Miyake,M.
  TITLE     cDNA cloning of the Sry-related gene Sox6 from rat with
            tissue-specific expression
  JOURNAL   Biol Pharm Bull 25 (6), 705-709 (2002)
   PUBMED   12081133
  REMARK    GeneRIF: Sox6 was specifically expressed in the neonatal brain and
            adult testis with Northern blotting.
REFERENCE   9  (bases 1 to 2724)
  AUTHORS   Hagiwara,N., Klewer,S.E., Samson,R.A., Erickson,D.T., Lyon,M.F. and
            Brilliant,M.H.
  TITLE     Sox6 is a candidate gene for p100H myopathy, heart block, and
            sudden neonatal death
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4180-4185 (2000)
   PUBMED   10760285
REFERENCE   10 (bases 1 to 2724)
  AUTHORS   Lefebvre,V., Li,P. and de Crombrugghe,B.
  TITLE     A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in
            chondrogenesis and cooperatively activate the type II collagen gene
  JOURNAL   EMBO J 17 (19), 5718-5733 (1998)
   PUBMED   9755172
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097403.1.
            
            On Jun 10, 2005 this sequence version replaced XM_215016.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097403.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2724
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q35"
     gene            1..2724
                     /gene="Sox6"
                     /note="SRY-box transcription factor 6"
                     /db_xref="GeneID:293165"
                     /db_xref="RGD:1309000"
     exon            1..61
                     /gene="Sox6"
                     /inference="alignment:Splign:2.1.0"
     exon            62..131
                     /gene="Sox6"
                     /inference="alignment:Splign:2.1.0"
     exon            132..372
                     /gene="Sox6"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..2499
                     /gene="Sox6"
                     /note="SRY-box containing gene 6; SRY (sex determining
                     region Y)-box 6; SRY box 6"
                     /codon_start=1
                     /product="transcription factor SOX-6"
                     /protein_id="NP_001019922.1"
                     /db_xref="GeneID:293165"
                     /db_xref="RGD:1309000"
                     /translation="MSSKQATSPFACTVDGEETMTQDLTSREKEEGSDQHPASHLPLH
                     PIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKP
                     DEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKD
                     WKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAAS
                     QIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQQVQGHMPPLMIPIFPHD
                     QRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQQLYAAQL
                     ASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPK
                     TAEPVKSPTSPTQSLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALF
                     GDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNSMGLSNCRNEKERTRFENL
                     GPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARV
                     YRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQ
                     EKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQ
                     FFTVGQQPQIPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYG
                     MKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN"
     exon            373..580
                     /gene="Sox6"
                     /inference="alignment:Splign:2.1.0"
     exon            581..670
                     /gene="Sox6"
                     /inference="alignment:Splign:2.1.0"
     exon            671..843
                     /gene="Sox6"
                     /inference="alignment:Splign:2.1.0"
     exon            844..912
                     /gene="Sox6"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1036
                     /gene="Sox6"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1116
                     /gene="Sox6"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1266
                     /gene="Sox6"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1450
                     /gene="Sox6"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1635
                     /gene="Sox6"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1744
                     /gene="Sox6"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1978
                     /gene="Sox6"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2195
                     /gene="Sox6"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2698
                     /gene="Sox6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttaggtctga aaaaggagca attcttgtgc tacatgagac aggaaagatt tccatggctt
       61 tgtcactttc atgaattcaa aggcgattta ccagtgactt ctgggtgctg gggtgatcct
      121 cgtgtataat taagaatgtc ttccaagcaa gccacctctc catttgcctg tacagtggat
      181 ggagaggaaa caatgaccca ggatttgacc tcaagggaaa aggaagaggg cagtgatcaa
      241 cacccggcct cccatctgcc tctgcacccc ataatgcaca acaaacctca ctctgaggag
      301 ctgccgacgc ttgtcagtac cattcaacaa gatgctgact gggacagcgt tctgtcatct
      361 cagcaaagaa tggagtcaga gaataataag ttatgttccc tatattcctt ccgaaatacg
      421 tctacctcac cacataagcc tgacgaaggg agtcgggagc gggaaataat gaacagtgtt
      481 acttttggaa ccccggaacg ccgcaaaggg agccttgccg atgtggtgga tacgctgaag
      541 cagaagaagc tggaggagat gactcggacg gaacaagagg attcctcctg catggaaaaa
      601 ctactttcaa aagattggaa ggaaaaaatg gaaagactaa atacgagtga acttcttgga
      661 gaaatcaaag gtacacctga gagccttgca gagaaagaac ggcaactctc caccatgatt
      721 acccagctga tcagcttgcg ggagcagctc ctggcagcgc acgatgaaca gaaaaagctg
      781 gcagcctcgc agatcgagaa acagcggcag caaatggacc ttgctcgcca acagcaagaa
      841 cagatcgcaa gacaacagca gcaacttcta cagcagcagc acaagattaa tctcctgcag
      901 caacagatcc agcaggttca ggggcacatg cctccgctca tgatcccaat ttttccacat
      961 gaccagcgga ccttggcagc agctgctgcc gcccaacagg gattcctctt cccccctgga
     1021 ataacataca agccaggtga taactacccc gtacagttca ttccgtcaac aatggcagct
     1081 gctgctgctt ctggactcag ccctttacag cttcagcagc tctatgccgc tcagctggcc
     1141 agcatgcagg tgtcacctgg agcaaagatg ccatcaactc cgcagccacc aaactcagca
     1201 ggggcggtct cacctactgg gataaaaaat gaaaagagag ggaccagccc tgtaactcaa
     1261 gttaaggatg aaacaacagc ccagccactg aatctctcat cccggccgaa gacagcagag
     1321 cctgtgaagt ccccaacatc tcccacccag agcctcttcc cagccagcaa aaccagccct
     1381 gtcaacctgc caaacaagag cagcatcccc agccccatcg ggggaagcct ggggagagga
     1441 tcctctttag atatactatc cagtctcaac tctcctgccc tgtttgggga ccaggacaca
     1501 gtgatgaaag ctatccagga ggctcggaag atgcgagaac agatccagcg ggagcagcaa
     1561 cagcagccgc acggagttga tgggaagctg tcctccatga acagcatggg gctgagcaac
     1621 tgcaggaatg agaaggaaag aacacgcttt gagaacctgg gtccccaatt aacaggaaag
     1681 tcaagtgaag atggaaagct gggccctggt gtcatcgatc tgactcggcc agaggacgca
     1741 gaaggaagca aagcaatgaa tggctctgca gctaaactac agcagtatta ttgttggcca
     1801 acaggaggcg ccactgtggc tgaagcacgc gtctacaggg atgcccgagg ccgtgccagc
     1861 agcgagcccc acatcaagcg accaatgaat gcgttcatgg tttgggcaaa ggacgaaagg
     1921 aggaaaattc ttcaggcctt ccctgacatg cataactcca acattagcaa aatcttagga
     1981 tctcgctgga aatccatgtc caaccaggag aagcaacctt actatgaaga gcaggcccgg
     2041 ctaagcaaaa tccacctaga gaagtaccca aactacaagt acaaaccccg gccgaagcgc
     2101 acgtgcattg tggacggcaa gaagctccgg atcggggagt acaagcagct gatgcgctca
     2161 cgaaggcagg agatgcgaca gttcttcact gtggggcaac agcctcagat tcccatcacc
     2221 acaggaacag gtgttgtgta tcctggtgct attactatgg caacgaccac accatcacct
     2281 cagatgacat ctgactgctc tagcacctct gccagcccag agcccagcct ccctgtcatc
     2341 cagagcacgt atggtatgaa gatggacggc gcgagcctgg ctgggaacga catgattaat
     2401 ggcgaggatg aaatggaagc ctatgacgac tacgaagatg atcccaaatc agactatagc
     2461 agcgaaaacg aggccccaga gcctgtcagt gccaactgag gagcttttgt ttgctgaatt
     2521 aaaacactct gacatttcgc tccctttccc caacaacaac aacaaagttc ttaaagagcc
     2581 cgcatgcatt tgtggctcca caatacatca gcagaatggt cttaattgct tcgtaacgtg
     2641 tgagacagat gacgttttcc tgatttttca taaacttgag tttttgtcgt taccgttaaa
     2701 aaaaaaaaaa aaaaaaaaaa aaaa
//
