LOCUS       NM_001271205            4707 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus SRY-box transcription factor 4 (Sox4), mRNA.
ACCESSION   NM_001271205 XM_001068302 XM_344594
VERSION     NM_001271205.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4707)
  AUTHORS   Bin,S., Xinyi,F., Huan,P., Xiaoqin,Z., Jiming,W., Yi,H., Ziyue,L.,
            Xiaochun,Z., Zhouqi,L., Bangwei,Z., Jing,J., Shihui,L. and
            Jinlai,G.
  TITLE     SOX4 as a potential therapeutic target for pathological cardiac
            hypertrophy
  JOURNAL   Eur J Pharmacol 958, 176071 (2023)
   PUBMED   37741429
  REMARK    GeneRIF: SOX4 as a potential therapeutic target for pathological
            cardiac hypertrophy.
REFERENCE   2  (bases 1 to 4707)
  AUTHORS   Zawerton,A., Yao,B., Yeager,J.P., Pippucci,T., Haseeb,A.,
            Smith,J.D., Wischmann,L., Kuhl,S.J., Dean,J.C.S., Pilz,D.T.,
            Holder,S.E., McNeill,A., Graziano,C. and Lefebvre,V.
  CONSRTM   Deciphering Developmental Disorders Study; University of Washington
            Center for Mendelian Genomics
  TITLE     De Novo SOX4 Variants Cause a Neurodevelopmental Disease Associated
            with Mild Dysmorphism
  JOURNAL   Am J Hum Genet 104 (2), 246-259 (2019)
   PUBMED   30661772
  REMARK    Erratum:[Am J Hum Genet. 2019 Apr 4;104(4):777. PMID: 30951678]
REFERENCE   3  (bases 1 to 4707)
  AUTHORS   Sasaki,A., Abe,H., Mochizuki,S., Shimoda,M. and Okada,Y.
  TITLE     SOX4, an epithelial-mesenchymal transition inducer, transactivates
            ADAM28 gene expression and co-localizes with ADAM28 at the invasive
            front of human breast and lung carcinomas
  JOURNAL   Pathol Int (2018) In press
   PUBMED   29882245
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 4707)
  AUTHORS   Pan,B., Xue,X., Zhang,D., Li,M. and Fu,J.
  TITLE     SOX4 arrests lung development in rats with hyperoxia-induced
            bronchopulmonary dysplasia by controlling EZH2 expression
  JOURNAL   Int J Mol Med 40 (6), 1691-1698 (2017)
   PUBMED   29039454
  REMARK    GeneRIF: Studied role of SOX4 in the occurrence of bronchopulmonary
            dysplasia (BPD). Found in total lung tissues, SOX4 and EZH2
            expression greatly decreased early and increased late following
            exposure to hyperoxia; the expression of the EZH2 protein was
            positively correlated with that of the SOX4 protein.
REFERENCE   5  (bases 1 to 4707)
  AUTHORS   Ling,K.H., Brautigan,P.J., Moore,S., Fraser,R., Cheah,P.S.,
            Raison,J.M., Babic,M., Lee,Y.K., Daish,T., Mattiske,D.M.,
            Mann,J.R., Adelson,D.L., Thomas,P.Q., Hahn,C.N. and Scott,H.S.
  TITLE     Derivation of an endogenous small RNA from double-stranded Sox4
            sense and natural antisense transcripts in the mouse brain
  JOURNAL   Genomics 107 (2-3), 88-99 (2016)
   PUBMED   26802803
REFERENCE   6  (bases 1 to 4707)
  AUTHORS   Lubec,B., Labudova,O., Hoeger,H., Kirchner,L. and Lubec,G.
  TITLE     Expression of transcription factors in the brain of rats with
            perinatal asphyxia
  JOURNAL   Biol Neonate 81 (4), 266-278 (2002)
   PUBMED   12011571
REFERENCE   7  (bases 1 to 4707)
  AUTHORS   Ya,J., Schilham,M.W., de Boer,P.A., Moorman,A.F., Clevers,H. and
            Lamers,W.H.
  TITLE     Sox4-deficiency syndrome in mice is an animal model for common
            trunk
  JOURNAL   Circ Res 83 (10), 986-994 (1998)
   PUBMED   9815146
REFERENCE   8  (bases 1 to 4707)
  AUTHORS   Schilham,M.W., Moerer,P., Cumano,A. and Clevers,H.C.
  TITLE     Sox-4 facilitates thymocyte differentiation
  JOURNAL   Eur J Immunol 27 (5), 1292-1295 (1997)
   PUBMED   9174623
REFERENCE   9  (bases 1 to 4707)
  AUTHORS   Schilham,M.W., Oosterwegel,M.A., Moerer,P., Ya,J., de Boer,P.A.,
            van de Wetering,M., Verbeek,S., Lamers,W.H., Kruisbeek,A.M.,
            Cumano,A. and Clevers,H.
  TITLE     Defects in cardiac outflow tract formation and pro-B-lymphocyte
            expansion in mice lacking Sox-4
  JOURNAL   Nature 380 (6576), 711-714 (1996)
   PUBMED   8614465
REFERENCE   10 (bases 1 to 4707)
  AUTHORS   Wotton,D., Lake,R.A., Farr,C.J. and Owen,M.J.
  TITLE     The high mobility group transcription factor, SOX4, transactivates
            the human CD2 enhancer
  JOURNAL   J Biol Chem 270 (13), 7515-7522 (1995)
   PUBMED   7706298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On or before Sep 8, 2012 this sequence version replaced
            XM_344594.5, XM_001068302.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR21887620.248731.1,
                                        SRR21887620.248732.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4707              JAXUCZ010000017.1  35876298-35881004
FEATURES             Location/Qualifiers
     source          1..4707
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..4707
                     /gene="Sox4"
                     /note="SRY-box transcription factor 4"
                     /db_xref="GeneID:364712"
                     /db_xref="RGD:1309488"
     exon            1..4707
                     /gene="Sox4"
                     /inference="alignment:Splign:2.1.0"
     CDS             657..1979
                     /gene="Sox4"
                     /note="SRY-box containing gene 4; SRY (sex determining
                     region Y)-box 4; SRY box 4"
                     /codon_start=1
                     /product="transcription factor SOX-4"
                     /protein_id="NP_001258134.1"
                     /db_xref="GeneID:364712"
                     /db_xref="RGD:1309488"
                     /translation="MVQQTNNAENTEALLAGESSDSGAGLELGIASSPTPGSTASTGG
                     KADDPSWCKTPSGHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKD
                     SDKIPFIQEAERLRLKHMADYPDYKYRPRKKVKSGNTGAGSAATAKPGEKGDKVAGGS
                     GHAGSGHAGGGAGGSSKPAPKKSCGPKVAGSSVGKPHAKFVPAGGGKAAASFSPEQAA
                     LLPLGEPAAVYKVRTPSAATPAASSSPSSALATPAKHPADKKVKRVYLFGSLGASASP
                     VGGLGASADPSDPLGLYEDGGPGCSPDGRSLSGRSSAASSPAASRSPADHRGYASLRA
                     ASPAPSSAPSHASSSLSSSSSSSSGSSSSDDEFEDDLLDLNPSSNFESMSLGSFSSSS
                     ALDRDLDFNFEPGSGSHFEFPDYCTPEVSEMISGDWLESSISNLVFTY"
ORIGIN      
        1 aacagagtga gggaaagagg gccgtctccc tcccggtttc cagttcttgc acgctgtttc
       61 ttagagagtc tgcagtgggg gaactctgcc ggtaaccagc tctccttctt gcaggaggga
      121 gggagaaaca tacatttatt catgccggtc tgttgcatgc aagcttcttg gcttcctacc
      181 ttgcaacaaa ataattgcac caactcctca gcaccgattc cgcccacaga gagtcccgga
      241 gccagagtcg ctttggcttt gctctgcagg aaagggactt aggcgctaga gacgatgtcg
      301 ctttcctgag ctaccgcgag ctctcgtgaa ctgcaatcga ctgcttcagg ggaaaggggt
      361 gggggaaaga cttgccccgg aggcggcgag aaacttgcgt ttggaagata ctccggctac
      421 caacgtttgg agaaactcct cgccgcggcc gactccagcc tcggtgcccg cagggagaac
      481 ttcagcggtg agggaggacg gagggcctcg gagactctag gttggcggcg ggaggcggcc
      541 gcccctggcc cgcgcgctgc tcaggggacc ctggtctccg ccccggggag cccgcagggc
      601 ccggcgaccg cgccgcgagc gtgtgagcgc gcgtgggcgc ccggcaagcc ggggccatgg
      661 tacaacagac caacaacgcg gagaacacgg aggctttgct ggctggggag agctcagact
      721 cgggcgccgg cctggagctg ggcatcgcgt cctccccgac gcccggctcc acggcgtcca
      781 cgggtggcaa ggcggacgac cctagctggt gcaagacgcc cagtggccac atcaagcggc
      841 ccatgaacgc ctttatggtg tggtcgcaga tcgagcggcg caagatcatg gagcagtcgc
      901 ccgacatgca caacgccgag atctccaagc ggctgggcaa acgctggaag ctgctcaagg
      961 acagcgacaa gatcccgttc atccaggagg cggagcggct gcgcctcaag cacatggctg
     1021 actaccctga ctacaagtac cggccgcgaa agaaggtgaa gtcgggcaac acgggcgcgg
     1081 gatcggcggc cacagccaaa cctggggaga agggcgacaa ggtcgccggc ggcagcggcc
     1141 acgcgggaag cggccacgcg gggggtggcg cgggcggcag ctccaagccc gcgcccaaga
     1201 agagctgcgg ccccaaggtg gcgggcagct cggtcggcaa gccccacgcc aagttcgtcc
     1261 cggcgggcgg cggtaaggcg gctgcatcgt tctctccgga gcaggccgcc ctgctgcccc
     1321 tgggggagcc cgcggccgtc tacaaggtgc ggactcccag cgcggccacc ccggccgcct
     1381 cctcctcgcc gtccagcgcg ctggccaccc ccgccaaaca ccctgccgac aagaaggtga
     1441 agcgcgttta cctgttcgga agcctgggcg cttcggcatc cccggtcggg ggcctgggag
     1501 cgagcgccga ccccagcgat ccactggggt tatacgaaga tgggggcccg ggatgctcgc
     1561 ccgatggccg gagtctgagc ggccgtagca gcgcagcatc atcgcccgcc gccagccgat
     1621 cgcccgctga ccaccgcggc tacgccagcc tacgtgcagc ctcgcccgcc ccgtccagcg
     1681 cgccctcgca cgcgtcctcg tcgctctcct catcctcctc ctcttcctcg ggctcttcgt
     1741 cgtccgatga tgagttcgaa gatgacctgc tcgacctgaa ccccagctca aactttgaga
     1801 gcatgtccct gggcagtttc agctcctcat ccgcgcttga tcgggacctg gattttaact
     1861 tcgaacccgg ctcaggctcc cacttcgagt tcccggacta ttgcacgccc gaggtgagcg
     1921 agatgatctc gggagattgg ctggagtcca gcatctctaa cctggtcttc acctactgaa
     1981 gggagcgcgg gccggggaga aggagggcca agaggcagga gaggagagag gaagacaaaa
     2041 aacaaaacaa aacaaaaatt aaaaaaaaaa aaaagaagaa agaagcagga aaaaaaagag
     2101 gaaaaaagaa tagatggaga gtggaaggag aaaggagaaa agaaaaggaa ggaaaaaaag
     2161 tgcatagggc tggcctgaac catgtcccgc cgttggagaa ggagcgcggg ggcgtagtgg
     2221 acccgtgctc ccatccccca ctctcagggc tggggactcg aggaggcgga gagtagacag
     2281 gggcgacctt tttttgttgt tattgatgtt ggtggtggct aaaaaagcta catcgagttt
     2341 cctccccaat tttgcttgaa gagactcccc ctccccttcc aacgagcttc cggacttggt
     2401 tgcaccccca gcaagaaaag aagccaagct aagcttctaa agaccgaagg aatcttgccc
     2461 ccccccctcg ccttggtgat ttcttttttg attttatttt gcctcttggt caagaaagga
     2521 ggggggaaat ccagcgcgcc ccatctccta cccaccctct ctttgtattc tctttgcatt
     2581 ttcccccttt ttaaattttc tttttctgca atgaagacag aaggctctgg ggtgatgcgt
     2641 tttggccatg gcgtttgtgt tgggcttagg ggagcattgg catggagaaa ctccacgctg
     2701 gcgagatccc gggctgggct ttcttctccc ccccctcccc ccattccttg tccctgcagc
     2761 tggaggagat gtgcagggag cagcaggcca gcctcggaaa tggacatggg gacctcgtgg
     2821 aagccacagc agcctagttg gggacgcaga aggacccgga gcacagagag cgttggggtc
     2881 ccccgggcct ccgcaaaatt aaagaattta aaaaaaaaaa tcagagaggt gaggctaccc
     2941 agagccggcg ggaggacagg agactgtggg atgtggtcca ggggccgcgg agtggttttg
     3001 gggggtaaag agattttttt cttctcttaa tgggaatcgt gatggtgttg agttatttca
     3061 ctggtggggt taatatagca tgttatcctg tctatctttt gaagatttct gtataagact
     3121 gttgagcagt ttttaaaata gtgtagggta atataaaagg cggatagatg gcgctatgtt
     3181 tgattcctac aacgaaccga tcaccagctc cttttcattc ttaactcttt aaaaggattc
     3241 aaacgcaact caaatctgtg ctggactttt gaaaaaaaac acaattcagg accaaatttt
     3301 ttctccgtgt gtgtttattc cttataggtg taattgagaa gacccgttta tttttacccc
     3361 ctcacggacg ctccatcttt ctattttttt tcccttgtaa atgtaatcag atgccatttt
     3421 atatgtggac gtatttatac tggccaaaca gttttcttat tttgtccccc cttttccccc
     3481 ttttcttttg ctttcttgtc ttttgacctt gtttctttat cttccttttt attttctttc
     3541 tttttcttcg ctttttttct ttctagtgtt gttacccacg ccattttacg tctccttcac
     3601 tgaagggcta gagttttaac ttttaatttt ttatatttaa atgtagactt ttgacacttt
     3661 taaaaaacaa aaaaagacaa gagagatgaa aacgtttgat tattttctca gtgtattttt
     3721 gtaaaaaata tataaagggg gtgttaatcg gtgtaaatcg ctgtttggat ttcctgattt
     3781 tataataggg tggctggtta atatctcaca cagtttgaaa aatcagcccc tggtttctcc
     3841 atgtttacac ttcaatctgc aggcttctta aagtgacagt atcccttaac ctgccaccag
     3901 tttccacctt tcaacccctg ggcttaaaag gggatgagag ttcagcccag caccataatg
     3961 ctttaaagaa aacagatttt ttttttttta aacgaattgc tgttctgtct agaggtttta
     4021 aaactggtgc attcacagca aaaagggatt ctgtagcttt aactcgtaaa ccacatcttt
     4081 tttgcacttt ttttataagc aaaaacgtgc cgtttaaacc actggatcta tctaaatgcc
     4141 gatttgagtt cgcgacacta tgtactgcgt tttcattctt gtatttgact atttaatcct
     4201 ttctacttgt cgctaaatat aattgtttta gtcttatggc atggtgatag catatgtgtt
     4261 caggtttata gctgttgtgt ttaaagattg aaaaaaaagt ggaaaacatc tttgtacatt
     4321 taagtctgta ttataataag caaaaagatt gtgtgtatgt atgtttaata taacatgaca
     4381 ggcacgagga cccctgcctt ttaagaggca gttccgttaa gggtttttgg tttttaaact
     4441 ttaatttttt ttcctttttt ttctctctct tttttttttt accatccatc ctgtgcaata
     4501 tgccgtgtag aatatttgtc ttaaaattca aggccacaaa aaagaaaaaa aaaaaaaagc
     4561 aatgtttggg ggaagagaaa aagaaaaaag aaaaaaaaaa ataccagcta atcctgtccg
     4621 tcactgcctg tcaggttgtt gctatatacc ttctgtaaat aacttttttt gagaaggaaa
     4681 taaaatcagc tggaactgaa ccctaaa
//
