LOCUS       NM_001401192            2080 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus SRY-box transcription factor 3 (Sox3), mRNA.
ACCESSION   NM_001401192 XM_008773577
VERSION     NM_001401192.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2080)
  AUTHORS   Araujo,F.C., Milsted,A., Watanabe,I.K., Del Puerto,H.L.,
            Santos,R.A., Lazar,J., Reis,F.M. and Prokop,J.W.
  TITLE     Similarities and differences of X and Y chromosome homologous
            genes, SRY and SOX3, in regulating the renin-angiotensin system
            promoters
  JOURNAL   Physiol Genomics 47 (5), 177-186 (2015)
   PUBMED   25759379
  REMARK    GeneRIF: These results suggest that SRY regulation of the
            renin-angiotensin system is partially shared with its X-chromosome
            homolog SOX3.
REFERENCE   2  (bases 1 to 2080)
  AUTHORS   Sutton,E., Hughes,J., White,S., Sekido,R., Tan,J., Arboleda,V.,
            Rogers,N., Knower,K., Rowley,L., Eyre,H., Rizzoti,K., McAninch,D.,
            Goncalves,J., Slee,J., Turbitt,E., Bruno,D., Bengtsson,H.,
            Harley,V., Vilain,E., Sinclair,A., Lovell-Badge,R. and Thomas,P.
  TITLE     Identification of SOX3 as an XX male sex reversal gene in mice and
            humans
  JOURNAL   J Clin Invest 121 (1), 328-341 (2011)
   PUBMED   21183788
REFERENCE   3  (bases 1 to 2080)
  AUTHORS   Rizzoti,K. and Lovell-Badge,R.
  TITLE     SOX3 activity during pharyngeal segmentation is required for
            craniofacial morphogenesis
  JOURNAL   Development 134 (19), 3437-3448 (2007)
   PUBMED   17728342
REFERENCE   4  (bases 1 to 2080)
  AUTHORS   Raverot,G., Weiss,J., Park,S.Y., Hurley,L. and Jameson,J.L.
  TITLE     Sox3 expression in undifferentiated spermatogonia is required for
            the progression of spermatogenesis
  JOURNAL   Dev Biol 283 (1), 215-225 (2005)
   PUBMED   15893302
REFERENCE   5  (bases 1 to 2080)
  AUTHORS   Rizzoti,K., Brunelli,S., Carmignac,D., Thomas,P.Q., Robinson,I.C.
            and Lovell-Badge,R.
  TITLE     SOX3 is required during the formation of the hypothalamo-pituitary
            axis
  JOURNAL   Nat Genet 36 (3), 247-255 (2004)
   PUBMED   14981518
REFERENCE   6  (bases 1 to 2080)
  AUTHORS   Laumonnier,F., Ronce,N., Hamel,B.C., Thomas,P., Lespinasse,J.,
            Raynaud,M., Paringaux,C., Van Bokhoven,H., Kalscheuer,V.,
            Fryns,J.P., Chelly,J., Moraine,C. and Briault,S.
  TITLE     Transcription factor SOX3 is involved in X-linked mental
            retardation with growth hormone deficiency
  JOURNAL   Am J Hum Genet 71 (6), 1450-1455 (2002)
   PUBMED   12428212
REFERENCE   7  (bases 1 to 2080)
  AUTHORS   Shen,J.H. and Ingraham,H.A.
  TITLE     Regulation of the orphan nuclear receptor steroidogenic factor 1 by
            Sox proteins
  JOURNAL   Mol Endocrinol 16 (3), 529-540 (2002)
   PUBMED   11875113
REFERENCE   8  (bases 1 to 2080)
  AUTHORS   Collignon,J., Sockanathan,S., Hacker,A., Cohen-Tannoudji,M.,
            Norris,D., Rastan,S., Stevanovic,M., Goodfellow,P.N. and
            Lovell-Badge,R.
  TITLE     A comparison of the properties of Sox-3 with Sry and two related
            genes, Sox-1 and Sox-2
  JOURNAL   Development 122 (2), 509-520 (1996)
   PUBMED   8625802
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000021.1.
            
            On Feb 3, 2022 this sequence version replaced XM_008773577.3.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2080              JAXUCZ010000021.1  144344892-144346971 c
FEATURES             Location/Qualifiers
     source          1..2080
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq36"
     gene            1..2080
                     /gene="Sox3"
                     /note="SRY-box transcription factor 3"
                     /db_xref="GeneID:679158"
                     /db_xref="RGD:1591839"
     exon            1..2080
                     /gene="Sox3"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1359
                     /gene="Sox3"
                     /note="SRY-box containing gene 3; SRY-box 3"
                     /codon_start=1
                     /product="transcription factor SOX-3"
                     /protein_id="NP_001388121.1"
                     /db_xref="GeneID:679158"
                     /db_xref="RGD:1591839"
                     /translation="MRPARENASGERSPRVPADFARSPSASLPFPPELPARRPPSATP
                     TESPGLFTVAAPAPGAPSPPATLAHLLPAPAMYSLLETELKNPVGPPTPAAATGGPPA
                     PGAAGKSSANPAGGANAGSGGSGGANGGGGGGGGGSDQDRVKRPMNAFMVWSRGQRRK
                     MALENPKMHNSEISKRLGADWKLLTDAEKRPFIDEAKRLRAVHMKEYPDYKYRPRRKT
                     KTLLKKDKYSLPGGLLPPGAAAAAAAAAAAAAASSPVGVGQRLDTYTHVNGWANGAYS
                     LVQEQLGYAQPPSMSSPPPPPALPQMHRYDMAGLQYSPMMPPGAQSYMNAAAAAAAAS
                     GYGGMAPSAAAAAAAAYGQQPATAAAAAAAAAAMSLGPMGSVVKSEPSSPPPAIASHS
                     QRACLGDLRDMISMYLPPGGDAADAASPLPGGRLHGVHQHYQGAGTAVNGTVPLTHI"
ORIGIN      
        1 aggctgcgaa tgcgaccagc tcgagagaac gcatcaggtg agagaagccc gcgcgttccc
       61 gccgacttcg cgcggagccc ttctgcaagc ctgcccttcc cgcctgagct gccggcccgc
      121 cggcccccga gcgccactcc gacggagtcc ccgggccttt tcaccgtggc cgctccagcc
      181 cccggagcgc catctcctcc cgccacgctg gcgcacctcc ttcccgcccc ggcgatgtac
      241 agcctgctgg agactgaact caagaacccc gtggggccgc ctaccccagc cgcggccacc
      301 ggcggccccc cagctcctgg cgctgcgggc aagagtagcg cgaacccagc cggcggcgcg
      361 aacgcaggca gcgggggcag cgggggcgcg aacggcggcg gcggcggcgg cggcgggggc
      421 agcgaccagg accgcgtcaa gagacccatg aacgctttca tggtgtggtc ccgcgggcag
      481 cggcgcaaga tggccctgga gaaccccaag atgcacaact ccgagatcag caagcgcctg
      541 ggcgccgact ggaaactgct gaccgacgcg gagaagcggc cgttcatcga cgaggccaag
      601 cgactgcgcg ccgtgcacat gaaggagtac ccggactaca agtaccggcc ccgccgcaag
      661 accaagacgc tgctcaagaa ggacaagtac tcgctgcccg gcggcctcct gcccccgggc
      721 gctgccgccg ccgccgccgc cgctgccgct gccgccgccg ccagcagccc ggtgggcgtg
      781 ggccagcgcc tggacacgta cacgcacgtg aacggctggg ccaacggcgc ctactcgctg
      841 gtgcaggagc agctgggcta cgcgcagccc ccgagcatga gcagcccgcc gccgccgccc
      901 gcgctgccgc agatgcaccg ctacgacatg gccggcctgc agtacagccc catgatgcca
      961 cccggcgccc agagctacat gaacgccgcc gccgccgccg ccgccgcctc cggctacggg
     1021 ggcatggcgc cctccgccgc cgctgcggcg gccgccgcct atggccagca gcccgccacc
     1081 gccgccgccg cggccgccgc cgccgccgcc atgagcctgg gccccatggg ctccgtggtg
     1141 aagtcggagc ccagctctcc gccgcccgcc atcgcttcgc actcgcagcg cgcgtgcctc
     1201 ggcgacctgc gcgacatgat cagcatgtac ctgccacctg gcggggacgc ggccgacgcc
     1261 gcctctccgc tcccgggcgg ccggctgcac ggcgtgcacc agcactacca gggcgccggg
     1321 actgcggtca atggaacggt gccgctgacc cacatctgag ctcccgcgcg cgctcccagc
     1381 tcttcgcccc caccccgccc cacaccccca cgttgggacg ccttgctgtt tagctttgct
     1441 cgcctgggac cgttgccttg taccgaagat gaggaggacc gaaagttttg ccgtagctgt
     1501 cggagtttgt acaaaagcaa gaagtccgga gcagcggaaa tgggacttgc ttgagctgcc
     1561 cgcttctgac cgccgcccct ccctcccccg ctggctggga atcgctgtgg tgtttgcgga
     1621 gaaaccgcgc gcggcccctt cctcctcttc ccaggtccct aggttcttct gtcgcatttg
     1681 aaaatgttgt cttgttagtt tgctattaat cgaggactga gtgaagttga ccccccccaa
     1741 gaactgcaat gcctccaccc ccagtcgtat tgcttctatt ttcctctggc tttttttttg
     1801 ggggggggtg ctggccgcgc caattggcgc gacagcgaaa gccaatgtta atttatagcc
     1861 aggtgtgcgt gtgtttcccg cctcgccgcc cctggccgcg ggacagcctc tgtccagtgc
     1921 gcgtttaggc tgttgagttt gtgatttctg cagtgatcta tttgctattt cgtgtacgca
     1981 tttcgttcgg gtggtgggga aggggttatt ttgttccagg ttttttcaag gttttactct
     2041 taattcctaa gtgagagatc aataaatttt ataaccaaca
//
