LOCUS       NM_001109181            2412 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Rattus norvegicus SRY-box transcription factor 2 (Sox2), mRNA.
ACCESSION   NM_001109181 XM_001067354 XM_574919
VERSION     NM_001109181.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2412)
  AUTHORS   Li,D., Qu,Y., Wang,B., Zhang,H. and Qin,L.
  TITLE     Spatio-temporal expression of Sox2+ progenitor cells regulates the
            regeneration of rat submandibular gland
  JOURNAL   Arch Oral Biol 168, 106080 (2024)
   PUBMED   39217919
  REMARK    GeneRIF: Spatio-temporal expression of Sox2[+] progenitor cells
            regulates the regeneration of rat submandibular gland.
REFERENCE   2  (bases 1 to 2412)
  AUTHORS   Horiguchi,K., Tsutsui,Y., Fujiwara,K., Tsukada,T., Nakakura,T.,
            Yoshida,S., Hasegawa,R. and Takigami,S.
  TITLE     Fluctuation of CD9/SOX2-positive cell populations during the
            turnover of GH- and TSH-producing cells in the adult anterior
            pituitary gland
  JOURNAL   J Reprod Dev 69 (6), 308-316 (2023)
   PUBMED   37778977
  REMARK    GeneRIF: Fluctuation of CD9/SOX2-positive cell populations during
            the turnover of GH- and TSH-producing cells in the adult anterior
            pituitary gland.
REFERENCE   3  (bases 1 to 2412)
  AUTHORS   Li,Z., Liu,G. and Huang,H.
  TITLE     Silencing of long non-coding RNA SOX2-overlapping transcript
            relieves myocardial ischemia/reperfusion injury through
            up-regulating miRNA-146a-5p
  JOURNAL   Gen Physiol Biophys 42 (2), 191-199 (2023)
   PUBMED   36896948
  REMARK    GeneRIF: Silencing of long non-coding RNA SOX2-overlapping
            transcript relieves myocardial ischemia/reperfusion injury through
            up-regulating miRNA-146a-5p.
REFERENCE   4  (bases 1 to 2412)
  AUTHORS   Cicek,B., Hacimuftuoglu,A., Kuzucu,M., Cetin,A., Yeni,Y., Genc,S.,
            Yildirim,S., Bolat,I., Kantarci,M., Gul,M., Hayme,S., Matthaios,D.,
            Vageli,D.P., Doukas,S.G., Tsatsakis,A. and
            Taghizadehghalehjoughi,A.
  TITLE     Sorafenib Alleviates Inflammatory Signaling of Tumor
            Microenvironment in Precancerous Lung Injuries
  JOURNAL   Pharmaceuticals (Basel) 16 (2), 221 (2023)
   PUBMED   37259369
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2412)
  AUTHORS   Chen,Z., Fan,T., Zhao,X. and Zhang,Z.
  TITLE     Depleting SOX2 improves ischemic stroke via lncRNA
            PVT1/microRNA-24-3p/STAT3 axis
  JOURNAL   Mol Med 27 (1), 107 (2021)
   PUBMED   34521353
  REMARK    GeneRIF: Depleting SOX2 improves ischemic stroke via lncRNA
            PVT1/microRNA-24-3p/STAT3 axis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2412)
  AUTHORS   Botquin,V., Hess,H., Fuhrmann,G., Anastassiadis,C., Gross,M.K.,
            Vriend,G. and Scholer,H.R.
  TITLE     New POU dimer configuration mediates antagonistic control of an
            osteopontin preimplantation enhancer by Oct-4 and Sox-2
  JOURNAL   Genes Dev 12 (13), 2073-2090 (1998)
   PUBMED   9649510
REFERENCE   7  (bases 1 to 2412)
  AUTHORS   Nishiguchi,S., Wood,H., Kondoh,H., Lovell-Badge,R. and Episkopou,V.
  TITLE     Sox1 directly regulates the gamma-crystallin genes and is essential
            for lens development in mice
  JOURNAL   Genes Dev 12 (6), 776-781 (1998)
   PUBMED   9512512
REFERENCE   8  (bases 1 to 2412)
  AUTHORS   Collignon,J., Sockanathan,S., Hacker,A., Cohen-Tannoudji,M.,
            Norris,D., Rastan,S., Stevanovic,M., Goodfellow,P.N. and
            Lovell-Badge,R.
  TITLE     A comparison of the properties of Sox-3 with Sry and two related
            genes, Sox-1 and Sox-2
  JOURNAL   Development 122 (2), 509-520 (1996)
   PUBMED   8625802
REFERENCE   9  (bases 1 to 2412)
  AUTHORS   Yuan,H., Corbi,N., Basilico,C. and Dailey,L.
  TITLE     Developmental-specific activity of the FGF-4 enhancer requires the
            synergistic action of Sox2 and Oct-3
  JOURNAL   Genes Dev 9 (21), 2635-2645 (1995)
   PUBMED   7590241
REFERENCE   10 (bases 1 to 2412)
  AUTHORS   Kamachi,Y., Sockanathan,S., Liu,Q., Breitman,M., Lovell-Badge,R.
            and Kondoh,H.
  TITLE     Involvement of SOX proteins in lens-specific activation of
            crystallin genes
  JOURNAL   EMBO J 14 (14), 3510-3519 (1995)
   PUBMED   7628452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jun 4, 2021 this sequence version replaced NM_001109181.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR22399484.454192.1,
                                        SRR22399484.293410.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2412              JAXUCZ010000002.1  119465131-119467542
FEATURES             Location/Qualifiers
     source          1..2412
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..2412
                     /gene="Sox2"
                     /gene_synonym="RGD1565646"
                     /note="SRY-box transcription factor 2"
                     /db_xref="GeneID:499593"
                     /db_xref="RGD:1565646"
     exon            1..2412
                     /gene="Sox2"
                     /gene_synonym="RGD1565646"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..1323
                     /gene="Sox2"
                     /gene_synonym="RGD1565646"
                     /note="SRY-box containing gene 2; SRY (sex determining
                     region Y)-box 2; SRY box 2"
                     /codon_start=1
                     /product="transcription factor SOX-2"
                     /protein_id="NP_001102651.1"
                     /db_xref="GeneID:499593"
                     /db_xref="RGD:1565646"
                     /translation="MYNMMETELKPPGPQQASGGGGGGGNATAAATGGNQKNSPDRVK
                     RPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRAL
                     HMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMD
                     SYAHMNGWSNGSYSMMQEQLGYPQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTY
                     MNGSPTYSMSYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMI
                     SMYLPGAEVPEPAAPSRLHMAQHYQSGPVPGTAINGTLPLSHM"
ORIGIN      
        1 gtgtttgcaa aaagggaaaa gtactttgct gcctctttaa gactagggct gggagaaaga
       61 agaggagaga aaaagaaagg agagaagttt ggagcccgag gcttaagcct ttccaaaaac
      121 taatcacaac aatcgcggcg gcccgaggag gagagcgact gttttttcat cccaattgca
      181 cttcgcccgt ctcgagctcc gcttcccccc aactattctc cgccagatct ccgcgcaagg
      241 ccgtgcacgc cgacgacccc gcccgcggcc cctgcatccc ggcccccgcg cgcggccccc
      301 gcagtcccgg ccgggccgag ggtcggcggc cgccggcggg ccgcgcccgc gcccagcgcc
      361 cgcatgtata acatgatgga gacggagctg aagccgccgg gccctcagca agcttcgggg
      421 ggcggcggcg gaggaggcaa cgccacggcg gcggcgaccg gcggcaacca gaagaacagc
      481 ccggaccgcg tcaagaggcc catgaatgcc ttcatggtgt ggtcccgggg gcagcggcgt
      541 aagatggccc aggagaaccc caagatgcac aactcggaga tcagcaagcg cctgggcgcc
      601 gagtggaaac ttttgtcgga gaccgagaag cggccgttca tcgacgaggc caagcggctg
      661 cgcgctctgc acatgaagga gcacccggat tataaatacc ggccgcggcg gaaaaccaag
      721 acgctcatga agaaggataa gtacacgctt cccggaggct tgctggcccc cggcgggaac
      781 agcatggcga gcggggttgg ggtgggcgcc ggcctgggtg cgggcgtgaa ccagcgcatg
      841 gacagctacg cgcacatgaa cggctggagc aacggcagct acagcatgat gcaggagcag
      901 ctgggctacc cgcagcaccc gggcctcaac gctcacggcg cggcacagat gcagccgatg
      961 caccgctacg acgtcagcgc cctgcagtac aactccatga ccagctcgca gacctacatg
     1021 aacggctcgc ccacctacag catgtcctac tcgcagcagg gcacccccgg tatggcgctg
     1081 ggctccatgg gctctgtggt caagtccgag gccagttcca gcccccccgt ggttacctct
     1141 tcctcccact ccagggcgcc ctgccaggcc ggggacctcc gggacatgat cagcatgtac
     1201 ctccccggcg ccgaggtgcc ggagcccgct gcgcccagta gactgcacat ggcccagcac
     1261 taccagagcg gcccggtgcc cggcacggcc attaacggca cactgcccct gtcgcacatg
     1321 tgagggccgg accgcgaact ggagaagggg agagattttt caaaaagata caagggaatt
     1381 gggaggggtg caaaagagga gagtaagaaa aatctgaatg ctcaaaagga aaaaaaaaat
     1441 ctcattaccc gcagcaaaat gacagctgcg gaaaaaaacc accaatccca tccaaattaa
     1501 cgcaaaaacc gtgatgccga ctagaaaact tttatgagag atcttgggac ttctttttgg
     1561 gggactattt ttgtacagag aaaacctgag ggcggcgggg agggcggggg aattggacca
     1621 tgtatagatc tggaggaaaa aaactacgca aaactttttt ttaaagttct agtggtacgt
     1681 taggcgcttc gcagggagtt ctcaaaagtc tttaccagta atatttagaa ctagactccg
     1741 ggcgatgaaa aaagttttaa tatttgcaag caacttttgt acagtattta tcgagataaa
     1801 catggcaatc aaatgtccat tgtttataag ctgagaattt gccaatattt ttcgaggaaa
     1861 gggttcttgc tgggttttga ttctgcagct taaattaagg accgttacag acaaggaagg
     1921 aatttattcg gatttgaacg ttttagtttt aaaattgtac aaaaggaaaa catgagagca
     1981 agtactggca agaccatttt cgtggtcttg tttagggcaa acgttctaga ttgtactaaa
     2041 tttttaactt actgttaaag gcaaaaaaaa aatgtccatg caggttgata tcgttggtaa
     2101 tttataatag cttttgttca atcccaccct tttcattttg ttcacataaa aatatggaaa
     2161 ttactgtgtt tgaaatattt tcttatggtt tgtaatattt ctgtaaattg tgatatttta
     2221 aggttttttc ccccttttat tttccgtagt tgtattttaa aagattcggc tgttattgga
     2281 accaggctgc cgagaatcca tgtatatatt tgaactaata ccatccttat aacagttacg
     2341 tttccaactt aagtttttac tccattatgc acagtttgag ataaataaat ttttgaaata
     2401 tggacactga aa
//
