LOCUS       NM_001024781            1643 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus SRY-box transcription factor 18 (Sox18), mRNA.
ACCESSION   NM_001024781 XM_230968
VERSION     NM_001024781.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1643)
  AUTHORS   Ng CK, Li NX, Chee S, Prabhakar S, Kolatkar PR and Jauch R.
  TITLE     Deciphering the Sox-Oct partner code by quantitative cooperativity
            measurements
  JOURNAL   Nucleic Acids Res 40 (11), 4933-4941 (2012)
   PUBMED   22344693
REFERENCE   2  (bases 1 to 1643)
  AUTHORS   Hoeth M, Niederleithner H, Hofer-Warbinek R, Bilban M, Mayer H,
            Resch U, Lemberger C, Wagner O, Hofer E, Petzelbauer P and de
            Martin R.
  TITLE     The transcription factor SOX18 regulates the expression of matrix
            metalloproteinase 7 and guidance molecules in human endothelial
            cells
  JOURNAL   PLoS One 7 (1), e30982 (2012)
   PUBMED   22292085
REFERENCE   3  (bases 1 to 1643)
  AUTHORS   Serrano AG, Gandillet A, Pearson S, Lacaud G and Kouskoff V.
  TITLE     Contrasting effects of Sox17- and Sox18-sustained expression at the
            onset of blood specification
  JOURNAL   Blood 115 (19), 3895-3898 (2010)
   PUBMED   20228271
REFERENCE   4  (bases 1 to 1643)
  AUTHORS   Downes M, Francois M, Ferguson C, Parton RG and Koopman P.
  TITLE     Vascular defects in a mouse model of
            hypotrichosis-lymphedema-telangiectasia syndrome indicate a role
            for SOX18 in blood vessel maturation
  JOURNAL   Hum Mol Genet 18 (15), 2839-2850 (2009)
   PUBMED   19429912
REFERENCE   5  (bases 1 to 1643)
  AUTHORS   Hosking B, Francois M, Wilhelm D, Orsenigo F, Caprini A, Svingen T,
            Tutt D, Davidson T, Browne C, Dejana E and Koopman P.
  TITLE     Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic
            defects caused by Sox18 dysfunction in mice
  JOURNAL   Development 136 (14), 2385-2391 (2009)
   PUBMED   19515696
REFERENCE   6  (bases 1 to 1643)
  AUTHORS   Hosking BM, Wyeth JR, Pennisi DJ, Wang SC, Koopman P and Muscat GE.
  TITLE     Cloning and functional analysis of the Sry-related HMG box gene,
            Sox18
  JOURNAL   Gene 262 (1-2), 239-247 (2001)
   PUBMED   11179689
REFERENCE   7  (bases 1 to 1643)
  AUTHORS   Pennisi D, Bowles J, Nagy A, Muscat G and Koopman P.
  TITLE     Mice null for sox18 are viable and display a mild coat defect
  JOURNAL   Mol Cell Biol 20 (24), 9331-9336 (2000)
   PUBMED   11094083
REFERENCE   8  (bases 1 to 1643)
  AUTHORS   Pennisi D, Gardner J, Chambers D, Hosking B, Peters J, Muscat G,
            Abbott C and Koopman P.
  TITLE     Mutations in Sox18 underlie cardiovascular and hair follicle
            defects in ragged mice
  JOURNAL   Nat Genet 24 (4), 434-437 (2000)
   PUBMED   10742113
REFERENCE   9  (bases 1 to 1643)
  AUTHORS   Hosking BM, Muscat GE, Koopman PA, Dowhan DH and Dunn TL.
  TITLE     Trans-activation and DNA-binding properties of the transcription
            factor, Sox-18
  JOURNAL   Nucleic Acids Res 23 (14), 2626-2628 (1995)
   PUBMED   7651823
REFERENCE   10 (bases 1 to 1643)
  AUTHORS   Wallace,M.E.
  TITLE     Analysis of genetic control of chylous ascites in ragged mice
  JOURNAL   Heredity (Edinb) 43 (1), 9-18 (1979)
   PUBMED   291594
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097973.1.
            
            On Jun 10, 2005 this sequence version replaced XM_230968.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097973.1, CO554216.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1643
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..1643
                     /gene="Sox18"
                     /note="SRY-box transcription factor 18"
                     /db_xref="GeneID:311723"
                     /db_xref="RGD:1311718"
     exon            1..446
                     /gene="Sox18"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1240
                     /gene="Sox18"
                     /note="SRY-box containing gene 18; SRY (sex determining
                     region Y)-box 18; SRY box 18"
                     /codon_start=1
                     /product="transcription factor SOX-18"
                     /protein_id="NP_001019952.1"
                     /db_xref="GeneID:311723"
                     /db_xref="RGD:1311718"
                     /translation="MQRSPPGYGAQDDPPSRRDCAWAPGLGAAAEPRGLPVTNVSPTS
                     PASPSSLPRSPPRSPESGRYGFGRGERQTADELRIRRPMNAFMVWAKDERKRLAQQNP
                     DLHNAVLSKMLGKAWKELNTAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQARKVR
                     RLEPGLLLPGLVQPSAPPEPFAAASGSARSFRELPTLGAEFDGLGLPTPERSPLDGLE
                     SGEASFFPPPLAPEDCALRAFRAPYAPELARDPSFCYGSSLAEALRTAPPAAPLAGLY
                     YGTLGTPGPFPNPLSPPPEAPSLEGTEQLEPTADLWADVDLTEFDQYLNCSRTRPDAT
                     ALPYHVALAKLGPRAMSCPEESSLISALSDASSAVYYSACISG"
     exon            447..1619
                     /gene="Sox18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtctccac ccgacgtccg tcagacctcc gtacttggct tcgcagtgcc cgccactgtc
       61 tcctgcgctc ccgcgctgcg ttctgcccag gccttgccca gctggaatgc agagatcgcc
      121 gcccggctac ggcgcacagg acgacccgcc ctcccgccgc gactgtgcat gggcccccgg
      181 actcggggcc gctgctgagc cgcgcggcct cccggtcacc aacgtctcgc ctacctcgcc
      241 tgcctcgccg tccagccttc cgcggagccc accgcgcagc cccgaatcag ggcgctatgg
      301 ctttggccgc ggagagcgcc aaacggccga cgagttgcgc atccggcggc ccatgaacgc
      361 ctttatggtg tgggcgaagg acgagcgcaa gcgactggcg caacaaaatc cggatctcca
      421 caacgcagtg ctgagcaaga tgctgggcaa agcgtggaag gagctgaaca cggcggagaa
      481 gaggcccttc gtggaagagg ccgaacggct gcgtgtgcag cacttgcgcg accatcccaa
      541 ctacaagtac cggcctcgcc gcaaaaaaca ggcgcgcaag gtccggaggc tggagcctgg
      601 cctcttgctc ccgggcctcg tgcagccgtc tgcgccgccg gaacccttcg ctgcagcatc
      661 aggctcagct cgctccttcc gcgagctacc cactctgggt gcggagttcg acggcttggg
      721 gctacccacg cccgagcgct cgcctctgga cggcctggag tctggcgagg cctccttctt
      781 cccaccgcct ttggcgcccg aggactgcgc tctgcgggct ttccgggcgc cctatgcccc
      841 ggagctggca cgggacccga gcttctgcta cgggtcatcc ctggctgagg cgctcaggac
      901 agcgccgcct gccgcgccgc tcgcgggcct ctactatggc accctgggca ctccgggccc
      961 gtttcccaat cctctgtcac caccacctga ggccccgtct cttgagggca cagagcaatt
     1021 ggagcctacc gccgaccttt gggccgatgt ggacctcacc gaattcgatc agtatctcaa
     1081 ttgcagccgg actcgaccgg atgccactgc actcccctac catgtggcac tggccaaact
     1141 aggtccgcgt gccatgtcct gtccagagga aagcagcctc atttctgcac tgtctgacgc
     1201 cagcagcgcg gtctattaca gcgcttgcat ctcaggctag acactgtcct ccttgccctc
     1261 cactgcttct gcatgtggcc aagtggcagg gccttgcctg cttccttcct ttcgcatatg
     1321 tatgttagag tatgcagcag catttagagc tggtggccta agggtgccac ttctgtcgcc
     1381 tcctcattta cacacctcct tctgggggct cctgtgagtt gggccttccc taggaacctc
     1441 aggccctgga cttgctagca gcctctgtca gggttgtttt tgaatcatct aattctttcc
     1501 tgctatgtat tttctagaac gagactgtat tttttacttt gcctttatat atatatatat
     1561 atatatatat atatatatat atatatatac atatataata caatatattt aatttttaaa
     1621 aaaaaaaaaa aaaaaaaaaa aaa
//
