LOCUS       NM_001107902            2326 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus SRY-box transcription factor 17 (Sox17), mRNA.
ACCESSION   NM_001107902 XM_001068621 XM_232640
VERSION     NM_001107902.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2326)
  AUTHORS   Walters,R., Vasilaki,E., Aman,J., Chen,C.N., Wu,Y., Liang,O.D.,
            Ashek,A., Dubois,O., Zhao,L., Sabrin,F., Cebola,I., Ferrer,J.,
            Morrell,N.W., Klinger,J.R., Wilkins,M.R., Zhao,L. and Rhodes,C.J.
  TITLE     SOX17 Enhancer Variants Disrupt Transcription Factor Binding And
            Enhancer Inactivity Drives Pulmonary Hypertension
  JOURNAL   Circulation 147 (21), 1606-1621 (2023)
   PUBMED   37066790
REFERENCE   2  (bases 1 to 2326)
  AUTHORS   Zou,X., Liu,T., Huang,Z., Zhou,W., Yuan,M., Zhao,H., Pan,Z.,
            Chen,P., Shao,Y., Hu,X., Zhang,S., Zheng,S., Zhang,Y. and Huang,P.
  TITLE     SOX17 is a Critical Factor in Maintaining Endothelial Function in
            Pulmonary Hypertension by an Exosome-Mediated Autocrine Manner
  JOURNAL   Adv Sci (Weinh) 10 (14), e2206139 (2023)
   PUBMED   36919784
REFERENCE   3  (bases 1 to 2326)
  AUTHORS   Sangam,S., Sun,X., Schwantes-An,T.H., Yegambaram,M., Lu,Q., Shi,Y.,
            Cook,T., Fisher,A., Frump,A.L., Coleman,A., Sun,Y., Liang,S.,
            Crawford,H., Lutz,K.A., Maun,A.D., Pauciulo,M.W., Karnes,J.H.,
            Chaudhary,K.R., Stewart,D.J., Langlais,P.R., Jain,M., Alotaibi,M.,
            Lahm,T., Jin,Y., Gu,H., Tang,H., Nichols,W.C., Black,S.M. and
            Desai,A.A.
  TITLE     SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads
            of Sex, Metabolism, and Genetics
  JOURNAL   Am J Respir Crit Care Med 207 (8), 1055-1069 (2023)
   PUBMED   36913491
  REMARK    GeneRIF: SOX17 Deficiency Mediates Pulmonary Hypertension: At the
            Crossroads of Sex, Metabolism, and Genetics.
REFERENCE   4  (bases 1 to 2326)
  AUTHORS   Wan,Q., Liu,H., Xu,Y., Zhang,Q. and Tao,L.
  TITLE     Upregulated miR-194-5p suppresses retinal microvascular endothelial
            cell dysfunction and mitigates the symptoms of hypertensive
            retinopathy in mice by targeting SOX17 and VEGF signaling
  JOURNAL   Cell Cycle 22 (3), 331-346 (2023)
   PUBMED   36200131
REFERENCE   5  (bases 1 to 2326)
  AUTHORS   Park,C.S., Kim,S.H., Yang,H.Y., Kim,J.H., Schermuly,R.T., Cho,Y.S.,
            Kang,H., Park,J.H., Lee,E., Park,H., Yang,J.M., Noh,T.W., Lee,S.P.,
            Bae,S.S., Han,J., Ju,Y.S., Park,J.B. and Kim,I.
  TITLE     Sox17 Deficiency Promotes Pulmonary Arterial Hypertension via
            HGF/c-Met Signaling
  JOURNAL   Circ Res 131 (10), 792-806 (2022)
   PUBMED   36205124
REFERENCE   6  (bases 1 to 2326)
  AUTHORS   Park,K.S., Wells,J.M., Zorn,A.M., Wert,S.E. and Whitsett,J.A.
  TITLE     Sox17 influences the differentiation of respiratory epithelial
            cells
  JOURNAL   Dev Biol 294 (1), 192-202 (2006)
   PUBMED   16574095
REFERENCE   7  (bases 1 to 2326)
  AUTHORS   Niimi,T., Hayashi,Y., Futaki,S. and Sekiguchi,K.
  TITLE     SOX7 and SOX17 regulate the parietal endoderm-specific enhancer
            activity of mouse laminin alpha1 gene
  JOURNAL   J Biol Chem 279 (36), 38055-38061 (2004)
   PUBMED   15220343
REFERENCE   8  (bases 1 to 2326)
  AUTHORS   Murakami,A., Shen,H., Ishida,S. and Dickson,C.
  TITLE     SOX7 and GATA-4 are competitive activators of Fgf-3 transcription
  JOURNAL   J Biol Chem 279 (27), 28564-28573 (2004)
   PUBMED   15082719
REFERENCE   9  (bases 1 to 2326)
  AUTHORS   Kanai-Azuma,M., Kanai,Y., Gad,J.M., Tajima,Y., Taya,C.,
            Kurohmaru,M., Sanai,Y., Yonekawa,H., Yazaki,K., Tam,P.P. and
            Hayashi,Y.
  TITLE     Depletion of definitive gut endoderm in Sox17-null mutant mice
  JOURNAL   Development 129 (10), 2367-2379 (2002)
   PUBMED   11973269
REFERENCE   10 (bases 1 to 2326)
  AUTHORS   Kanai,Y., Kanai-Azuma,M., Noce,T., Saido,T.C., Shiroishi,T.,
            Hayashi,Y. and Yazaki,K.
  TITLE     Identification of two Sox17 messenger RNA isoforms, with and
            without the high mobility group box region, and their differential
            expression in mouse spermatogenesis
  JOURNAL   J Cell Biol 133 (3), 667-681 (1996)
   PUBMED   8636240
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473984.1.
            
            [WARNING] On Mar 20, 2025 this sequence was replaced by
            NM_001107902.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_232640.4, XM_001068621.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..2326
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..2326
                     /gene="Sox17"
                     /note="SRY-box transcription factor 17"
                     /db_xref="GeneID:312936"
                     /db_xref="RGD:1305371"
     exon            1..125
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
     exon            126..220
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
     exon            221..606
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..1571
                     /gene="Sox17"
                     /note="SRY-box containing gene 17; SRY (sex determining
                     region Y)-box 17; SRY box 17"
                     /codon_start=1
                     /product="transcription factor SOX-17"
                     /protein_id="NP_001101372.1"
                     /db_xref="GeneID:312936"
                     /db_xref="RGD:1305371"
                     /translation="MSSPDAGYASDDQSQPRSAQPAVMAGLGPCPWAESLSSLGDVKV
                     KGEVVASSGAPAGTSSRAKAESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKML
                     GKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRMKRVEGGFLHALA
                     EPQAGALGPEGGRVAMDGLGLPFPEPGYPAGPPLMSPHMGAHYRDCQGLGAPALDGYP
                     LPTPDTSPLDGVEQDPAFFAAPLPGDCPAAGAYTYAQVSDYAVPAEPSAGPMRVGPDP
                     SGSAMPGILAPPSALHLYYGAMGSPAASAGRGFHAQPQQPLQPQPPPPPPPPPPPQQH
                     PTHGPGQPSPPPEALPCRDGTEPNQPTELLGEVDRTEFEQYLHFVYKPEMGLPYQGHD
                     CGVNLSDSHGAISSVVSDASSAVYYCNYPDI"
     exon            607..2326
                     /gene="Sox17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccatttag tgaagaaact gaaacatggt ccactcacaa ctgctggcgg gtctgaagtg
       61 cggttgcccc caacacttct cccaaagtat ctatcaagag aatggtcagc agaaattaga
      121 tctagtgagc aatatctcca gacatttgaa tttcagccgt cctatttccc cgagaggact
      181 tggcgccaga gcccggctcc agccagtttt cccctggcag cttcccatcc ccgcctcagg
      241 gtccggggaa gcggcgtgtc ccgtggccgt agcagagcgc ggggtcggtc tggagcgcca
      301 tgagcagccc ggatgcggga tacgccagtg acgaccagag ccagcctcgg agcgcgcagc
      361 ccgcggtgat ggccgggttg ggcccctgtc cctgggccga gtccctgagc tctctcgggg
      421 acgtaaaggt gaaaggagag gtggtggcga gtagcggggc gccagccggg acctcgagtc
      481 gagccaaagc cgagtctcgc atccggcggc cgatgaatgc ctttatggtg tgggccaaag
      541 acgaacgcaa gcggctggca cagcagaacc cggatctgca caacgcagag ctgagcaaga
      601 tgctaggcaa atcctggaag gcgttgacct tggcggagaa gcggcccttc gtggaagagg
      661 ccgagcggct gcgtgtgcag cacatgcagg accatcccaa ctacaagtac cggccgcggc
      721 ggcgcaagca ggtgaagcgc atgaaacggg tggagggagg cttcctgcac gctctcgccg
      781 agcctcaggc cggcgcgctt ggtcccgagg gcggccgcgt ggccatggat ggcctgggtc
      841 tgcctttccc ggagccaggc tatccggccg gcccgccgct gatgtccccg cacatgggcg
      901 cccactaccg tgactgccag ggactgggcg cacccgcgct cgacggctac cctctgccca
      961 ctccggacac atccccgttg gatggcgtgg agcaggaccc ggctttcttt gctgccccgc
     1021 tgccagggga ctgcccggcg gccggagcct acacgtatgc tcaggtctcg gactatgcgg
     1081 tgcccgcaga gccgtccgct ggccccatgc gagtgggacc cgacccctcc ggctctgcga
     1141 tgccggggat cctggcgccc cccagtgctc tgcacctgta ctacggcgcg atgggctcgc
     1201 ccgcggcaag cgccgggcgc ggtttccacg ctcagcccca gcagccactg caaccgcagc
     1261 caccgccgcc accaccaccg cctccaccgc cgcagcagca cccgacgcac ggtccggggc
     1321 agccttctcc acctcccgag gctctgccct gccgggatgg cacggaaccc aaccagccca
     1381 ctgagctact aggggaggtg gaccgcacgg aattcgaaca gtatttgcac tttgtgtata
     1441 agccggagat gggtcttccc taccagggac acgactgcgg tgtgaacctc tcggacagcc
     1501 acggagccat ttcctccgtg gtgtccgacg ctagctcagc ggtctactac tgcaactacc
     1561 ctgacatctg acggttgccg atttgacctg cgggccagaa gcagtgttac acacttcctg
     1621 gaagcgctaa ggaaatcctt agcgtcacgc tgttttgttt ttaagttgcc ttggcatata
     1681 atttatggta atttattttg tctgccactt gaacagttga agggctacat gagattctca
     1741 tttcaaatgc ctcgaggggt ttgctcccca ccatcactgt ccagttttag ccagttttta
     1801 atatctcacc aacttgatcc aaagaaattt tgtcacgatc ttaaaaaaat cctggaatct
     1861 tttttaaaaa aatctctatc acattggttt tatcaaagta atttaaagat caacagtaaa
     1921 tattacacaa ttagaagtgt atagttaatt gtaaactttc tattttctta caaaatttaa
     1981 gaaaccctaa atacaaacag tggggtgttc agatgtgata tcgttgttct cctacgaaaa
     2041 aaattctcac agaatgaact tgctatgtac attccaaaat attggtttct aaaaataata
     2101 ctgtaaatgt ttttaattct gtatacttta ataaggctgt tcaaaaattc tggttttttt
     2161 ttttgtcatc ttgatatctg ccaaaagagc ttttcagata tatctgtttt cgtttgtgtt
     2221 ttcttccaaa tgtctttatc cctttcccca caaaatttgc ctttaatccc cacattttta
     2281 gagtcagaga aactaatcaa aataaaattt gttgtgactg ttaatc
//
