LOCUS       NM_019193               2741 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus SRY-box transcription factor 10 (Sox10), mRNA.
ACCESSION   NM_019193
VERSION     NM_019193.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2741)
  AUTHORS   Aberle,T., Walter,A., Piefke,S., Hillgartner,S., Wust,H.M.,
            Wegner,M. and Kuspert,M.
  TITLE     Sox10 Activity and the Timing of Schwann Cell Differentiation Are
            Controlled by a Tle4-Dependent Negative Feedback Loop
  JOURNAL   Int J Mol Sci 25 (10), 5234 (2024)
   PUBMED   38791273
  REMARK    GeneRIF: Sox10 Activity and the Timing of Schwann Cell
            Differentiation Are Controlled by a Tle4-Dependent Negative
            Feedback Loop.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2741)
  AUTHORS   Deng,J., Ding,H.H., Long,J.L., Lin,S.Y., Liu,M., Zhang,X.Q.,
            Xin,W.J. and Ruan,X.
  TITLE     Oxaliplatin-induced neuropathic pain involves HOXA6 via a
            TET1-dependent demethylation of the SOX10 promoter
  JOURNAL   Int J Cancer 147 (9), 2503-2514 (2020)
   PUBMED   32428246
  REMARK    GeneRIF: Oxaliplatin-induced neuropathic pain involves HOXA6 via a
            TET1-dependent demethylation of the SOX10 promoter.
            Erratum:[Int J Cancer. 2021 Sep 15;149(6):E10. doi:
            10.1002/ijc.33718.. PMID: 34196406]
REFERENCE   3  (bases 1 to 2741)
  AUTHORS   Stuepp,R.T., Modolo,F., Trentin,A.G., Garcez,R.C. and Biz,M.T.
  TITLE     HNK1 and Sox10 are present during repair of mandibular bone defects
  JOURNAL   Biotech Histochem 95 (8), 619-625 (2020)
   PUBMED   32362205
  REMARK    GeneRIF: HNK1 and Sox10 are present during repair of mandibular
            bone defects.
REFERENCE   4  (bases 1 to 2741)
  AUTHORS   Yang,L.N., Huang,W.K., Li,X.L., Bai,Y.Z. and Zhang,S.C.
  TITLE     Sox10 Is a Specific Biomarker for Neural Crest Stem Cells in
            Immunohistochemical Staining in Wistar Rats
  JOURNAL   Dis Markers 2020, 8893703 (2020)
   PUBMED   32908618
  REMARK    GeneRIF: Sox10 Is a Specific Biomarker for Neural Crest Stem Cells
            in Immunohistochemical Staining in Wistar Rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2741)
  AUTHORS   Ueharu,H., Yoshida,S., Kanno,N., Horiguchi,K., Nishimura,N.,
            Kato,T. and Kato,Y.
  TITLE     SOX10-positive cells emerge in the rat pituitary gland during late
            embryogenesis and start to express S100beta
  JOURNAL   Cell Tissue Res 372 (1), 77-90 (2018)
   PUBMED   29130118
  REMARK    GeneRIF: the present study identified that one of the lineages of
            S100beta-positive cells is a SOX10-positive one and that
            SOX10-positive cells express pituitary stem/progenitor cell marker
            genes.
            Erratum:[Cell Tissue Res. 2018 Apr;372(1):161-162. doi:
            10.1007/s00441-018-2816-z.. PMID: 29480457]
REFERENCE   6  (bases 1 to 2741)
  AUTHORS   Liu,Q., Melnikova,I.N., Hu,M. and Gardner,P.D.
  TITLE     Cell type-specific activation of neuronal nicotinic acetylcholine
            receptor subunit genes by Sox10
  JOURNAL   J Neurosci 19 (22), 9747-9755 (1999)
   PUBMED   10559384
REFERENCE   7  (bases 1 to 2741)
  AUTHORS   Herbarth,B., Pingault,V., Bondurand,N., Kuhlbrodt,K.,
            Hermans-Borgmeyer,I., Puliti,A., Lemort,N., Goossens,M. and
            Wegner,M.
  TITLE     Mutation of the Sry-related Sox10 gene in Dominant megacolon, a
            mouse model for human Hirschsprung disease
  JOURNAL   Proc Natl Acad Sci U S A 95 (9), 5161-5165 (1998)
   PUBMED   9560246
REFERENCE   8  (bases 1 to 2741)
  AUTHORS   Pingault,V., Bondurand,N., Kuhlbrodt,K., Goerich,D.E., Prehu,M.O.,
            Puliti,A., Herbarth,B., Hermans-Borgmeyer,I., Legius,E.,
            Matthijs,G., Amiel,J., Lyonnet,S., Ceccherini,I., Romeo,G.,
            Smith,J.C., Read,A.P., Wegner,M. and Goossens,M.
  TITLE     SOX10 mutations in patients with Waardenburg-Hirschsprung disease
  JOURNAL   Nat Genet 18 (2), 171-173 (1998)
   PUBMED   9462749
REFERENCE   9  (bases 1 to 2741)
  AUTHORS   Kuhlbrodt,K., Herbarth,B., Sock,E., Hermans-Borgmeyer,I. and
            Wegner,M.
  TITLE     Sox10, a novel transcriptional modulator in glial cells
  JOURNAL   J Neurosci 18 (1), 237-250 (1998)
   PUBMED   9412504
REFERENCE   10 (bases 1 to 2741)
  AUTHORS   Lane,P.W. and Liu,H.M.
  TITLE     Association of megacolon with a new dominant spotting gene (Dom) in
            the mouse
  JOURNAL   J Hered 75 (6), 435-439 (1984)
   PUBMED   6512238
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jul 19, 2021 this sequence version replaced NM_019193.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062067.1, SRR26360194.904736.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000007.1  112614883-112615097 c
            216-721             JAXUCZ010000007.1  112613885-112614390 c
            722-990             JAXUCZ010000007.1  112609594-112609862 c
            991-2741            JAXUCZ010000007.1  112605721-112607471 c
FEATURES             Location/Qualifiers
     source          1..2741
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2741
                     /gene="Sox10"
                     /note="SRY-box transcription factor 10"
                     /db_xref="GeneID:29361"
                     /db_xref="RGD:3735"
     exon            1..215
                     /gene="Sox10"
                     /inference="alignment:Splign:2.1.0"
     exon            216..721
                     /gene="Sox10"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..1694
                     /gene="Sox10"
                     /function="transcriptional modulator"
                     /note="SRY-box containing gene 10; SRY (sex determining
                     region Y)-box 10; SRY box 10"
                     /codon_start=1
                     /product="transcription factor SOX-10"
                     /protein_id="NP_062066.1"
                     /db_xref="GeneID:29361"
                     /db_xref="RGD:3735"
                     /translation="MAEEQDLSEVELSPVGSEEPRCLSPSSAPSLGPDGGGGGSGLRA
                     SPGPGELGKVKKEQQDGEADDDKFPVCIREAVSQVLSGYDWTLVPMPVRVNGASKSKP
                     HVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERL
                     RMQHKKDHPDYKYQPRRRKNGKAAQGEAECPGGETDQGGAAAIQAHYKSAHLDHRHPE
                     EGSPMSDGNPEHPSGQSHGPPTPPTTPKTELQSGKADPKRDGRSLGEGGKPHIDFGNV
                     DIGEISHEVMSNMETFDVTELDQYLPPNGHPGHVGSYSAAGYGLSSALAVASGHSAWI
                     SKPPGVALPTVSPPAVDAKAQVKTETTGPQGPPHYTDQPSTSQIAYTSLSLPHYGSAF
                     PSISRPQFDYSDHQPSGPYYGHAGQASGLYSAFSYMGPSQRPLYTAISDPSPSGPQSH
                     SPTHWEQPVYTTLSRP"
     exon            722..990
                     /gene="Sox10"
                     /inference="alignment:Splign:2.1.0"
     exon            991..2741
                     /gene="Sox10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctcagtca gtctcgggct gtccagccag ggtgtttggt ggtgaggatt caggctccgt
       61 ccagacaagg cagtggcctg aggctcaggg ccccccagcc cctccctccc agtccatcag
      121 cgtcactccc cagccccgag ctggaccgca caccttggga cacggttttc cacttcctca
      181 ggacgagccc cagactggag gagaggtcgg aggaggtggg cgttgggctc ttcacgagga
      241 ccccggcggc gggcccgggg gaggcggccg aagcggcggc ggccgggagc gacatggccg
      301 aggagcaaga cctatcagag gtggagctga gccccgtggg ctcggaggaa cctcgctgcc
      361 tgtccccaag cagcgcgccg tcgctgggac ccgacggcgg cggcggtggc tcaggcctgc
      421 gagccagccc agggcccggc gaattgggca aggtcaagaa ggaacagcag gacggcgagg
      481 cagacgatga caagttcccg gtgtgcatcc gcgaagcggt cagccaggtg ctcagcggct
      541 acgactggac gctggtgccc atgcccgtgc gggtcaacgg tgccagcaag agcaagccgc
      601 acgtcaaacg gcccatgaac gcctttatgg tgtgggcaca ggcggcacgc agaaagttag
      661 ccgaccagta cccgcacctc cacaatgctg agctcagcaa gacgctgggc aagctctgga
      721 ggttgctgaa cgagagtgac aagcgcccct tcattgagga ggctgagcgg ctccggatgc
      781 agcacaaaaa agaccatccg gactacaagt accaacctcg gcggcggaag aatgggaagg
      841 cagcccaggg ggaggcagag tgcccaggcg gggagaccga ccaaggaggg gctgctgcta
      901 tccaggctca ctacaagagt gcccacctgg accaccggca cccagaagaa ggctccccca
      961 tgtcagatgg gaacccagag cacccctcag gccagagcca tggccctcct acccctccaa
     1021 ccaccccaaa gacagagctg cagtccggca aggcagatcc caaaagggat gggcgctcct
     1081 tgggggaggg cgggaagccc cacatcgact tcggcaatgt ggacatcggg gagatcagcc
     1141 atgaggtaat gtccaacatg gagacctttg atgtgactga gctggaccaa tacctgccgc
     1201 ccaatgggca cccaggccac gtgggcagct actcggcagc tggctacggg ctgagcagtg
     1261 ccctggctgt ggccagtgga cactctgcct ggatctccaa gccaccaggt gtggctctgc
     1321 ccacggtctc gccccctgct gtggatgcca aagcccaggt gaagacagag accacagggc
     1381 cccagggacc cccacactac accgaccagc cgtccacttc ccagatcgcc tacacctccc
     1441 tcagtctgcc ccactacggc tccgccttcc cctccatctc acgcccccag tttgactact
     1501 ctgaccatca gccctcagga ccctattatg gccacgcagg ccaggcctct ggcctctact
     1561 cagctttttc ctacatgggc ccctctcagc ggcccctcta cacggccatc tctgacccca
     1621 gcccctcagg gccccagtcc cacagtccca cacactggga acagccagta tatacgactc
     1681 tatcccgacc ttagaggggc cctgtcacca ttggtgccca cgtggcccag ggccccttcc
     1741 cccagcctgt gtgccctgct cctcatcagc ctcatgccca gcagtggcag tggaggaggc
     1801 tgcagaggct gacagcagca ggcaggcttc tgccagctcc tgccctgatg acctccaccc
     1861 accctggctc aggaggccaa gccctgactg agctggcaaa ggaggagttt ggtggccatc
     1921 ccagactgag ggtgaggggc cacccatccc cagaaataac cctctatccc aggacctgag
     1981 aagtcgttct caagtccttc agggaggcag aaaagggtag ggtgggaaac ctcactgctc
     2041 ctgttctctc ctgggagagc aaggggctca agggcctgtg tgccactgtg tcactgtgcc
     2101 taaaagctag gctgcctagg gacctgcttc aaagcctgga gctggctctg tcctgtcact
     2161 aaggactcac tgaggacagc tttgaacagc tttgtgaaga gcagggtggg acactcaatg
     2221 gacactctga tcctttcacc cccctcctca cctgaatggg aactggccga ggtccccaga
     2281 tccagttctg cattagtaac ctcatccctc acctaactga ggagagtcct catgttcttc
     2341 cccacgacct ccactcctca aggcccaccc caggtgagga ggcaggggct ccaggaaaga
     2401 atcagaggtg tccagccttc ctctcgcctt ctgtcagcct cagttagcac tgcacgggcc
     2461 ctagccccag agcccagtac ctgggttgct ggcagcaggc tggacactaa accccttcca
     2521 tgtacagtct acctttgcct cgcacccttt gctccagcga taccttaata aagtacgtag
     2581 ctctgtctcc ccatctcctg tctgcagccc agtccacacg taacacatcg ctgccccttt
     2641 atctccacag tcaccatgtt cccatccctc tagctactcc agccccaatt aacttgcatt
     2701 aagcactcca agtaataaaa tcaaagcttc tggttgcctg c
//
