LOCUS       NM_001402540            4016 bp    mRNA    linear   ROD 17-JUL-2023
DEFINITION  Rattus norvegicus SRY-box transcription factor 1 (Sox1), mRNA.
ACCESSION   NM_001402540 XM_003752252
VERSION     NM_001402540.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4016)
  AUTHORS   Rubio-Osornio C, Eguiluz-Melendez A, Trejo-Solis C, Custodio V,
            Rubio-Osornio M, Rosiles-Abonce A, Martinez-Lazcano JC, Gonzalez E
            and Paz C.
  TITLE     Decreased Expression of Sox-1 in Cerebellum of Rat with Generalized
            Seizures Induced by Kindling Model
  JOURNAL   CNS Neurol Disord Drug Targets 15 (6), 723-729 (2016)
   PUBMED   26996170
  REMARK    GeneRIF: Results show that Sox-1 expression decreases as the number
            of seizures increases, and this is probably due to an altered
            glutamate regulation by a dysfunctional Bergmann s glia, and
            suggest this mechanism as a one possible explanation of how the
            cerebellum participates in the pathophysiology of epilepsy.
REFERENCE   2  (bases 1 to 4016)
  AUTHORS   Panayi H, Panayiotou E, Orford M, Genethliou N, Mean R, Lapathitis
            G, Li S, Xiang M, Kessaris N, Richardson WD and Malas S.
  TITLE     Sox1 is required for the specification of a novel p2-derived
            interneuron subtype in the mouse ventral spinal cord
  JOURNAL   J Neurosci 30 (37), 12274-12280 (2010)
   PUBMED   20844123
REFERENCE   3  (bases 1 to 4016)
  AUTHORS   Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, Parisi S
            and Russo T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   4  (bases 1 to 4016)
  AUTHORS   Iqbal MS, Otsuyama K, Shamsasenjan K, Asaoku H and Kawano MM.
  TITLE     CD56 expression in human myeloma cells derived from the neurogenic
            gene expression: possible role of the SRY-HMG box gene, SOX4
  JOURNAL   Int J Hematol 91 (2), 267-275 (2010)
   PUBMED   20049565
REFERENCE   5  (bases 1 to 4016)
  AUTHORS   Ekonomou A, Kazanis I, Malas S, Wood H, Alifragis P, Denaxa M,
            Karagogeos D, Constanti A, Lovell-Badge R and Episkopou V.
  TITLE     Neuronal migration and ventral subtype identity in the
            telencephalon depend on SOX1
  JOURNAL   PLoS Biol 3 (6), e186 (2005)
   PUBMED   15882093
REFERENCE   6  (bases 1 to 4016)
  AUTHORS   Nishiguchi S, Wood H, Kondoh H, Lovell-Badge R and Episkopou V.
  TITLE     Sox1 directly regulates the gamma-crystallin genes and is essential
            for lens development in mice
  JOURNAL   Genes Dev 12 (6), 776-781 (1998)
   PUBMED   9512512
REFERENCE   7  (bases 1 to 4016)
  AUTHORS   Collignon J, Sockanathan S, Hacker A, Cohen-Tannoudji M, Norris D,
            Rastan S, Stevanovic M, Goodfellow PN and Lovell-Badge R.
  TITLE     A comparison of the properties of Sox-3 with Sry and two related
            genes, Sox-1 and Sox-2
  JOURNAL   Development 122 (2), 509-520 (1996)
   PUBMED   8625802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000283.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001402540.2.
            
            On Mar 17, 2022 this sequence version replaced XM_003752252.4.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4016              JACYVU010000283.1  26311599-26315614   c
FEATURES             Location/Qualifiers
     source          1..4016
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..4016
                     /gene="Sox1"
                     /note="SRY-box transcription factor 1"
                     /db_xref="GeneID:100912302"
                     /db_xref="RGD:6487636"
     exon            1..4016
                     /gene="Sox1"
                     /inference="alignment:Splign:2.1.0"
     CDS             831..2009
                     /gene="Sox1"
                     /note="transcription factor SOX-1-like; SRY (sex
                     determining region Y)-box 1; SRY box 1"
                     /codon_start=1
                     /product="transcription factor SOX-1"
                     /protein_id="NP_001389469.1"
                     /db_xref="GeneID:100912302"
                     /db_xref="RGD:6487636"
                     /translation="MYSMMMETDLHSPGGAQAPTNLSGPAGAGGGGGGGGGGGGGGGG
                     TKANQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAEKRPFI
                     DEAKRLRALHMKEHPDYKYRPRRKTKTLLKKDKYSLAGGLLAAGAGGGGAAVAMGVGV
                     GVGAAAVGQRLESPGGAAGGGYAHVNGWANGAYPGSVAAAAAAAAMMQEAQLAYGQHP
                     GAGGAHPHAHPAHPHPHHPHAHPHNPQPMHRYDMGALQYSPISNSQGYMSASPSGYGG
                     IPYGAAAAAAAAAGGAHQNSAVAAAAAAAAASSGALGALGSLVKSEPSGSPPAPAHSR
                     APCPGDLREMISMYLPAGEGGDPAAAAAAAAQSRLHSLPQHYQGAGAGVNGTVPLTHI
                     "
ORIGIN      
        1 gtcactcgcc agcgcgccat gcaaatcacc gccgccgcca gctcccattg gccgcggcgc
       61 gctcatttaa tggcagcccg ggcccggcgt atggctgctg ggccccccgc gccaccggcc
      121 ccgcgtgcgc ctccgctccg agcgcacggc cccgggcagg cagcggacag cttgtcctgg
      181 gcacagcggc cccgctctct ggctctctgc tcgcgttggc actcccaccg ctgtccctaa
      241 ccccctcact ggctgcacag cgatcgcccc ctccgaaccc ccctccgagt ccccctcagc
      301 gcctggctcc ccccaggcac ctgggaccag cacatgccca gcgcacgcgg cgcaccgcct
      361 tgctagaagt tgcggcccca gagttggaag ccgccaagga agccagcaca ggaaggagtc
      421 ttccagtcgc caagaggagg cagcgaaccc cgcgtcgggc ccagcggcac cgcttcagac
      481 ccagaaagtg aagccttaac ttggccacga ctgcacctgt ttgcacagct cagccttgag
      541 cgaccggact gcggcagcgg cgacggcaat catcctggcc atcggcctct ttggcaagtg
      601 gtttgtgcac ccggagaaac tttccacctg cgagctggac ccgcgctaag tgcgtgtgct
      661 tttgcctctt ttttgttgtg gcctccaccc aacccccttc tctctgctag gcacccaccc
      721 caccccccag tctctctggg ctgatcctct ccccacccac ccacccccac ccggccgtct
      781 atgctccagg ccctctcttt gcggtaccgg tgaacccgct agccgcccag atgtacagca
      841 tgatgatgga gaccgacctg cactcgcccg gcggcgccca ggcgcccacg aacctctcgg
      901 gcccggccgg ggcgggcggg ggcggcggcg ggggcggggg cggcggcggc ggcggcgggg
      961 gcaccaaggc caaccaggat cgggtcaagc ggcccatgaa cgccttcatg gtgtggtccc
     1021 gcggacagcg gcgcaagatg gcccaggaaa accccaagat gcacaactca gaaatcagca
     1081 agcgcctggg ggccgagtgg aaggtcatgt ccgaggccga gaagcggccg ttcatcgacg
     1141 aggccaagag actgcgcgcg ctgcacatga aggagcaccc ggattacaag taccggccgc
     1201 gccgcaagac caagacgctg ctcaagaagg acaagtactc gctggccggc gggctgctgg
     1261 cggccggagc aggtggcggc ggcgcggcgg tggccatggg cgtgggcgtg ggcgtcgggg
     1321 cggcggccgt gggccagcgc ctggagagcc cgggcggcgc ggcgggagga ggctacgcgc
     1381 atgtcaacgg ctgggctaac ggcgcctacc ccggctcggt ggccgcggcg gctgcggccg
     1441 cggccatgat gcaggaggca cagctggcct acgggcagca cccaggcgcg ggcggcgcgc
     1501 acccgcacgc gcacccggcg cacccgcacc cgcaccatcc gcacgcgcat cctcacaacc
     1561 cgcagcccat gcaccgctac gacatgggcg cgctgcagta cagccccatc tccaactctc
     1621 agggctacat gagcgcgtcg ccttcgggct acggcggcat cccttacggt gccgcggcag
     1681 ccgccgccgc cgctgcgggc ggcgcgcacc agaactcggc ggtggcggcc gcggcggctg
     1741 cggcggccgc gtcgtcgggt gccctgggcg ccctcggttc tctggtcaag tccgagccga
     1801 gcggcagtcc gccggctccg gctcactcgc gggcgccgtg ccccggggac ctgcgcgaga
     1861 tgatcagcat gtacctgccg gccggcgagg gtggcgaccc ggcggcggct gcggctgccg
     1921 cggcccaaag ccggctgcac tcgctgccac agcactacca gggcgcgggc gcgggcgtca
     1981 acggcacggt gcccctgacg cacatctagc gccgcgggga cgccggggac actgcggctc
     2041 aaggccggcg ccccggcgac gaagagcgtg aggcctgttc cccagcctcc agagccccag
     2101 tttgtacaga tgtctccgcg ctctagtgaa aaagaccgct ctggagagcc gagcgccagg
     2161 tgacatctgc ccccctcacc tttcccggga ctctgaggcg ctgacaccag actggcctct
     2221 tagactgaac ttccgtgttt tcacgagacc ttttgtacag tatttatcgt ccgcagagga
     2281 ggcacacagc gttttctcgg ctcgggagga caaaagacaa aaacccagcg aggcgatgcc
     2341 aacttttgta tgaccgccgg ctctgtaact ttttccgggg tttgcttccc gccggctctt
     2401 ctgcctgagg ctgagggacg gacctcgagc ccttctcact tgttataaat ctagtaaggc
     2461 agatccaacc acttacgagt tttttgtagc tattacggct cttttgggtt ggttggttaa
     2521 tttataccgc aatgccctct cagacggtgg ggttatattc tgggttttgt aaaactctgt
     2581 atccgagcat ttgcaatttt tttgttttgt tttgtattat ttcttgtaaa ggagttgtga
     2641 catttttatt ttaggcgttg cgatatggga cgggagagga gtcggatgta catagcctac
     2701 aagtctttca tctaaaaacg aaaaacaaag agagatcccc cccccaaaat gcatcaaatt
     2761 tgaatcaata cattgaagag agaatagccg gtttccctac gaaatcgaaa cgtgctaatt
     2821 ttatatgcat gtttgttttt ttttttagtt caaaatacaa ttagaaatct gttggaggag
     2881 aaattatcag gatggtccaa gagtaaggaa gtccccgcca agcagagggc agcgtttccg
     2941 tggctttagt ctgtggggaa agagaaatct aaactccata gattattttg tagaattgaa
     3001 gttgacacag aagggaagta gttacaaaat acttcctaat ggtttagcat tttaactgcc
     3061 ccccctgcat atttttgcat ttctttccag tgtctctgcc cttcactcac tgtagcagtt
     3121 ttgaggcagt ttggtcttgg aaggagaaag gacagtgctc agtagtgaga caaggccaag
     3181 gatagggaca accaccgacg ccaagacagc gtgcctttga tttctttgta attgaaattg
     3241 taagtgaaat gatcttcctg cggttcaaaa aagcaatcct aacccagccg gcaccgccag
     3301 agtctctcac ccaggtctta tcccagccct cccgctcttc ctctctggga aaataatttt
     3361 accgattttc ttacgtacac ccaccacccc ctctcctgtg tgaaccgaga tgcaggtcgc
     3421 tggggatgta aacacaaagt gcccgtgttt atcattcctg accagacctt gaggttgttt
     3481 gatgctttaa atatttttaa ttatattttt tctaggtgtt tattggtata ttgcaggccc
     3541 cccccccccc cggaatttaa agtttcctgt aaaactttgt cttcaagtaa cctgacagca
     3601 ttaaatattg catttaaaag ttacactgta gcaaatatgt tttaaaatca atcacaacat
     3661 tagaatgaca ttctattttt gaaggaaatt ttctttacgt ccagatgggg aaccatacta
     3721 tattttcagc atcctttccc ctcattttcc ccccaatttc ttttcttgga atgaatgtgg
     3781 actggccgtt aaaagtggac ttaatctatc aattcagtaa aacctgggct cagcctacat
     3841 tggagactat ctttcagtat aaatgctaac attacaagtg acacgtgtga tttttttaaa
     3901 gtcctttttt tatgattttg cttaaaccca tcattcctta aagtgattga aagagattca
     3961 agaatgacgc ccactgcttt ctgatgaggt agtaaaagaa caaccccccc tttttt
//
