LOCUS       NM_153737               1618 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus sclerostin domain containing 1 (Sostdc1), mRNA.
ACCESSION   NM_153737
VERSION     NM_153737.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1618)
  AUTHORS   Wang,C., Wang,X., Cheng,H. and Fang,J.
  TITLE     MiR-22-3p facilitates bone marrow mesenchymal stem cell
            osteogenesis and fracture healing through the SOSTDC1-PI3K/AKT
            pathway
  JOURNAL   Int J Exp Pathol 105 (2), 52-63 (2024)
   PUBMED   38152045
  REMARK    GeneRIF: MiR-22-3p facilitates bone marrow mesenchymal stem cell
            osteogenesis and fracture healing through the SOSTDC1-PI3K/AKT
            pathway.
REFERENCE   2  (bases 1 to 1618)
  AUTHORS   Sun,L., Li,Z., Xue,H., Ma,T., Ren,C., Li,M., Lu,Y., Sun,H. and
            Zhang,K.
  TITLE     MiR-26a promotes fracture healing of nonunion rats possibly by
            targeting SOSTDC1 and further activating Wnt/beta-catenin signaling
            pathway
  JOURNAL   Mol Cell Biochem 460 (1-2), 165-173 (2019)
   PUBMED   31313025
  REMARK    GeneRIF: miR-26a promoted fracture healing of rats with nonunion in
            vivo and osteogenic differentiation of mesenchymal stem cells in
            vitro, possibly by targeting SOSTDC1.
REFERENCE   3  (bases 1 to 1618)
  AUTHORS   Pradhan,B.S., Bhattacharya,I., Sarkar,R. and Majumdar,S.S.
  TITLE     Downregulation of Sostdc1 in Testicular Sertoli Cells is
            Prerequisite for Onset of Robust Spermatogenesis at Puberty
  JOURNAL   Sci Rep 9 (1), 11458 (2019)
   PUBMED   31391487
  REMARK    GeneRIF: Downregulation of Sostdc1 in Testicular Sertoli Cells is
            Prerequisite for Onset of Robust Spermatogenesis at Puberty.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1618)
  AUTHORS   Cao,J., Wang,W., Li,Y., Xia,J., Peng,Y., Zhang,Y. and Xia,A.
  TITLE     Artesunate attenuates unilateral ureteral obstruction-induced renal
            fibrosis by regulating the expressions of bone morphogenetic
            protein-7 and uterine sensitization-associated gene-1 in rats
  JOURNAL   Int Urol Nephrol 48 (4), 619-629 (2016)
   PUBMED   26865179
  REMARK    GeneRIF: Art is able to improve the renal function decline and
            renal fibrosis induced by UUO, which may be associated with the
            up-regulation of BMP-7 and down-regulation of USAG-1.
REFERENCE   5  (bases 1 to 1618)
  AUTHORS   Qian,X., Yuan,X., Vonderfecht,S., Ge,X., Lee,J., Jurisch,A.,
            Zhang,L., You,A., Fitzpatrick,V.D., Williams,A., Valente,E.G.,
            Pretorius,J., Stevens,J.L., Tipton,B., Winters,A.G., Graham,K.,
            Harriss,L., Baker,D.M., Damore,M., Salimi-Moosavi,H., Gao,Y.,
            Elkhal,A., Paszty,C., Simonet,W.S., Richards,W.G. and Tullius,S.G.
  TITLE     Inhibition of WISE preserves renal allograft function
  JOURNAL   J Am Soc Nephrol 24 (1), 66-76 (2013)
   PUBMED   23184054
  REMARK    GeneRIF: WISE contributes to renal dysfunction by promoting tubular
            atrophy and interstitial fibrosis.
REFERENCE   6  (bases 1 to 1618)
  AUTHORS   Kassai,Y., Munne,P., Hotta,Y., Penttila,E., Kavanagh,K.,
            Ohbayashi,N., Takada,S., Thesleff,I., Jernvall,J. and Itoh,N.
  TITLE     Regulation of mammalian tooth cusp patterning by ectodin
  JOURNAL   Science 309 (5743), 2067-2070 (2005)
   PUBMED   16179481
REFERENCE   7  (bases 1 to 1618)
  AUTHORS   O'Shaughnessy,R.F., Yeo,W., Gautier,J., Jahoda,C.A. and
            Christiano,A.M.
  TITLE     The WNT signalling modulator, Wise, is expressed in an
            interaction-dependent manner during hair-follicle cycling
  JOURNAL   J Invest Dermatol 123 (4), 613-621 (2004)
   PUBMED   15373764
  REMARK    GeneRIF: Rat homologue of the Xenopus-secreted WNT modulator Wise
            is expressed in the dermal papilla and not in the non-inductive
            dermal sheath and was additionally expressed at high levels in the
            precortex and in the putative bulge region [WISE].
REFERENCE   8  (bases 1 to 1618)
  AUTHORS   Yanagita,M., Oka,M., Watabe,T., Iguchi,H., Niida,A., Takahashi,S.,
            Akiyama,T., Miyazono,K., Yanagisawa,M. and Sakurai,T.
  TITLE     USAG-1: a bone morphogenetic protein antagonist abundantly
            expressed in the kidney
  JOURNAL   Biochem Biophys Res Commun 316 (2), 490-500 (2004)
   PUBMED   15020244
REFERENCE   9  (bases 1 to 1618)
  AUTHORS   Laurikkala,J., Kassai,Y., Pakkasjarvi,L., Thesleff,I. and Itoh,N.
  TITLE     Identification of a secreted BMP antagonist, ectodin, integrating
            BMP, FGF, and SHH signals from the tooth enamel knot
  JOURNAL   Dev Biol 264 (1), 91-105 (2003)
   PUBMED   14623234
REFERENCE   10 (bases 1 to 1618)
  AUTHORS   Simmons,D.G. and Kennedy,T.G.
  TITLE     Uterine sensitization-associated gene-1: a novel gene induced
            within the rat endometrium at the time of uterine
            receptivity/sensitization for the decidual cell reaction
  JOURNAL   Biol Reprod 67 (5), 1638-1645 (2002)
   PUBMED   12390898
  REMARK    GeneRIF: we report the isolation, cloning, and characterization of
            a novel gene, uterine sensitization-associated gene-1 (UASG-1),
            that is preferentially expressed within the maximally
            sensitized/receptive rat endometrium
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_153737.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF411056.1, FQ213889.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               JAXUCZ010000006.1  58778623-58778894
            273-1618            JAXUCZ010000006.1  58781452-58782797
FEATURES             Location/Qualifiers
     source          1..1618
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..1618
                     /gene="Sostdc1"
                     /gene_synonym="Usag-1; Usag1; Wise"
                     /note="sclerostin domain containing 1"
                     /db_xref="GeneID:266803"
                     /db_xref="RGD:628877"
     exon            1..272
                     /gene="Sostdc1"
                     /gene_synonym="Usag-1; Usag1; Wise"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..688
                     /gene="Sostdc1"
                     /gene_synonym="Usag-1; Usag1; Wise"
                     /note="sclerostin domain-containing protein 1;
                     wnt-signaling modulator; uterine sensitization-associated
                     gene 1 protein; context-dependent activator and inhibitor
                     of Wnt signalling protein Wise"
                     /codon_start=1
                     /product="sclerostin domain-containing protein 1
                     precursor"
                     /protein_id="NP_714959.2"
                     /db_xref="GeneID:266803"
                     /db_xref="RGD:628877"
                     /translation="MLPPAIHLSLIPLLCILMKNCLAFKNDATEILYSHVVKPVSAHP
                     SSNSTLNQARNGGRHFSSTGLDRNSRVQVGCRELRSTKYISDGQCTSISPLKELVCAG
                     ECLPLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVV
                     TACKCKRYTRQHNESSHNFESVSPAKPAQHHRERKRASKSSKHSLS"
     exon            273..1618
                     /gene="Sostdc1"
                     /gene_synonym="Usag-1; Usag1; Wise"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagtcaata gcgcagaagc agggggaaag aattcaccgc ctcagccgag taaatcctcc
       61 actcatcatg cttcctcctg ccattcatct ctctctcatt cccctgctct gcatcctgat
      121 gaaaaactgt ttggctttta aaaatgatgc cacagaaatc ctttattcac atgtggttaa
      181 acctgtttca gcacacccca gcagcaacag caccttgaat caagccagga atggaggcag
      241 gcacttcagt agcacgggac tggatcgaaa tagtcgagtt caagtgggct gcagggaact
      301 gcggtccacc aaatacatct cggatggcca gtgcaccagc atcagccctc tgaaggagct
      361 ggtgtgcgcg ggtgagtgct tgcccttgcc agtgcttccc aactggatcg gaggaggcta
      421 cggaacaaag tactggagcc ggaggagctc ccaggagtgg cggtgtgtca acgacaagac
      481 gcgcacccag agaatccagc tgcagtgtca ggacggcagc acacgcacct acaaaatcac
      541 cgtggtcaca gcgtgcaagt gcaagaggta cacccggcag cacaacgagt ccagccacaa
      601 ctttgaaagc gtgtctcccg ccaagcccgc ccagcaccac agagagcgga agagagccag
      661 caaatccagc aagcacagtc tgagctagag ctggactgac tagaaagcat ctgctcccca
      721 gatttgattg cgtggaagac tcgctcgagc ctgccattgc tcttttctca cttgaaagta
      781 tatgctttct gctttgatca ggcccagcag gctgtccttc tctgggacct tctctgggac
      841 tagcttttcc tttgcaagtt tctcaagatg taatgagtag tttgcagtga aagccaggca
      901 tcccatagtt tcaccccctc ccccagtcat ttctttcaaa agcacctgat gctgcatcct
      961 gttacagttt aaaccgcgct ccattcccta gcccaccctt tacccttccc aaactaaatc
     1021 cctccgaacc ggagaagttc aatcaaaaaa aaaatgtatc ttcacagaac atttcacaaa
     1081 ggggcttttc cagtagtttt tatgggaata gtttgacagc caggggttag cttcctttga
     1141 aagagaggca aaccttgtga catttcactt caaaaataag cccggtggca ttttccagtc
     1201 tcagtgtgaa attatccccc tcgtgttgac ctctcttgga gtggaatgcc agcaatgcaa
     1261 ggcagcagct agtaggtaaa gccggttatt tatttgtcga tgttgttatt taatgagctc
     1321 gcgcatgtga ttttttttcc aaatgttaat tttttttata ttttgaagct ttttcatgta
     1381 cctaaatatt tcccaatacg atttgtggtt ggtctagaaa tatgaaaata catgttgtag
     1441 atatgtaaaa ataaatattt tagactcctt atatattaca cggttcctca tacactttgt
     1501 cattagcgtg gttccctgta aagctgaagt tatgtaatac tttattattt agtccatgaa
     1561 atcagaaggc agcttgacct tcggtaccat cggtttcttt taataaacat aaatatcc
//
